Detailed information for compound 111011

Basic information

Technical information
  • TDR Targets ID: 111011
  • Name: 1-chloro-4-methyl-10,10-dioxothioxanthen-9-on e
  • MW: 292.737 | Formula: C14H9ClO3S
  • H donors: 0 H acceptors: 3 LogP: 3.22 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(c2c1C(=O)c1ccccc1S2(=O)=O)C
  • InChi: 1S/C14H9ClO3S/c1-8-6-7-10(15)12-13(16)9-4-2-3-5-11(9)19(17,18)14(8)12/h2-7H,1H3
  • InChiKey: FQDQBRFAVATXBZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-chloro-4-methyl-10,10-dioxo-thioxanthen-9-one
  • 1-chloro-4-methyl-10,10-dioxo-9-thioxanthenone
  • 1-chloro-10,10-diketo-4-methyl-thioxanthen-9-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis dna polymerase eta 0.0092 0.038 0.1159
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.006
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0034 0.0106 0.2991
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.0017 0.003 0.0545
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0041 0.0141 0.398
Plasmodium vivax thioredoxin reductase, putative 0.0106 0.0445 1
Mycobacterium ulcerans DNA polymerase IV 0.0063 0.0244 0.0243
Schistosoma mansoni hypothetical protein 0.0017 0.0029 0.0089
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0274 0.0836
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0077 0.2185
Echinococcus multilocularis GPCR, family 2 0.0017 0.0029 0.0089
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0071 0.0282 0.086
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0179 0.3947
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0282 0.6295
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0086 0.0354 0.108
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0071 0.0282 0.6349
Loa Loa (eye worm) hypothetical protein 0.0142 0.0616 0.2289
Plasmodium falciparum thioredoxin reductase 0.0037 0.012 0.2703
Echinococcus granulosus thioredoxin glutathione reductase 0.0106 0.0445 0.1355
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0282 0.1015
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0244 0.5422
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0063 0.0244 0.0744
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0086 0.0354 1
Echinococcus multilocularis chromobox protein 1 0.0067 0.0265 0.0807
Giardia lamblia Myb 1-like protein 0.0041 0.0141 0.0488
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0282 0.7968
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0071 0.0282 0.1197
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0027 0.0077 0.2185
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0027 0.0077 0.2185
Trichomonas vaginalis pc-MYB2, putative 0.0041 0.014 0.3954
Trichomonas vaginalis cation-transporting ATPase, putative 0.0028 0.008 0.2245
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0282 0.1015
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0037 0.012 0.2596
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0041 0.0141 0.0507
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0071 0.0264
Entamoeba histolytica deoxycytidyl transferase, putative 0.0063 0.0244 0.5266
Mycobacterium tuberculosis Probable metal cation transporter P-type ATPase A CtpF 0.0011 0.0002 0.0002
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0016 0.0026 0.072
Loa Loa (eye worm) transcription factor SMAD2 0.0384 0.1754 0.6513
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0037 0.012 0.2596
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0071 0.0282 0.086
Echinococcus granulosus bloom syndrome protein 0.0023 0.0057 0.0175
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0244 0.5422
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0282 0.7968
Echinococcus multilocularis 0.0115 0.0487 0.1484
Schistosoma mansoni smad 0.0012 0.0003 0.001
Plasmodium falciparum phosphodiesterase gamma, putative 0.0071 0.0282 0.6349
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.0013 0.001 0.0031
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0071 0.0282 0.086
Loa Loa (eye worm) hypothetical protein 0.0038 0.0126 0.0467
Echinococcus granulosus neuroendocrine convertase 2 0.0089 0.0368 0.1122
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0016 0.0026 0.0025
Brugia malayi ImpB/MucB/SamB family protein 0.0092 0.038 0.1612
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0071 0.0282 0.1197
Brugia malayi MH1 domain containing protein 0.0014 0.0016 0.0069
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0282 0.7968
Loa Loa (eye worm) hypothetical protein 0.003 0.0087 0.0324
Echinococcus granulosus geminin 0.0708 0.3282 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0071 0.0217
Schistosoma mansoni terminal deoxycytidyl transferase 0.0063 0.0244 0.0744
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0282 0.7968
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0205 0.0868
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.0463 0.1412
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0282 0.7968
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0071 0.0282 0.1197
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0282 0.7968
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0057 0.1617
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0583 0.2693 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0071 0.0282 0.7968
Schistosoma mansoni DNA polymerase IV / kappa 0.002 0.004 0.0122
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0037 0.012 0.0119
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0282 0.1015
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0077 0.2185
Trypanosoma cruzi DNA polymerase kappa, putative 0.0063 0.0244 0.5422
Brugia malayi Smad1 0.0026 0.0071 0.0302
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0071 0.0282 0.086
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0179 0.3947
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0268 0.1207 0.1683
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.004 0.0765
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0071 0.0217
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0282 0.1015
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0282 0.7968
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.012 0.2596
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0265 0.7477
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0179 0.4035
Echinococcus multilocularis dna polymerase kappa 0.0063 0.0244 0.0744
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0071 0.0282 0.7968
Brugia malayi hypothetical protein 0.0049 0.0179 0.076
Trichomonas vaginalis pc-MYB2, putative 0.0041 0.014 0.3954
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0282 0.6349
Echinococcus multilocularis chromobox protein 1 0.0067 0.0265 0.0807
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0041 0.014 0.3954
Entamoeba histolytica recQ family helicase, putative 0.0012 0.0006 0.0139
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0028 0.008 0.0242
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0041 0.014 0.3023
Trypanosoma brucei calcium motive p-type ATPase, putative 0.0013 0.001 0.0082
Echinococcus granulosus chromobox protein 1 0.0067 0.0265 0.0807
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2136 1 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0071 0.0282 0.7968
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0071 0.0282 0.086
Leishmania major DNA damage repair protein, putative 0.002 0.004 0.0765
Trypanosoma brucei DNA damage repair protein, putative 0.002 0.004 0.0765
Brugia malayi MH2 domain containing protein 0.0384 0.1754 0.7436
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0244 0.5422
Echinococcus granulosus Furin 1 0.0034 0.0106 0.0323
Loa Loa (eye worm) hypothetical protein 0.0071 0.0282 0.1048
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0274 0.0836
Trypanosoma cruzi DNA polymerase kappa, putative 0.0063 0.0244 0.5422
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0241 0.1081 0.1507
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0052 0.0158
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0071 0.0282 0.6295
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0282 0.1015
Brugia malayi MH1 domain containing protein 0.0014 0.0016 0.0069
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0071 0.0264
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0282 0.1015
Onchocerca volvulus 0.003 0.0087 0.6189
Trypanosoma cruzi DNA polymerase eta, putative 0.0092 0.038 0.8534
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0037 0.012 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0282 0.7968
Plasmodium vivax phosphodiesterase gamma, putative 0.0071 0.0282 0.6349
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0074 0.2085
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.0013 0.001 0.0031
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0244 0.5422
Trypanosoma cruzi trypanothione reductase, putative 0.0106 0.0445 1
Brugia malayi proprotein convertase 2 0.0089 0.0368 0.156
Brugia malayi neuroendocrine convertase 1 precursor 0.0089 0.0368 0.156
Giardia lamblia hypothetical protein 0.0071 0.0282 0.1015
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0028 0.008 0.1789
Giardia lamblia High cysteine membrane protein Group 2 0.0053 0.0196 0.0695
Loa Loa (eye worm) hypothetical protein 0.0071 0.0282 0.1048
Onchocerca volvulus 0.0016 0.0026 0.1644
Brugia malayi polk-prov protein 0.002 0.004 0.017
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0041 0.014 0.3023
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2136 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0282 0.6295
Trypanosoma brucei hypothetical protein, conserved 0.002 0.004 0.0765
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0282 0.7968
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.004 0.0765
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0071 0.0282 0.7968
Plasmodium vivax calcium-transporting ATPase, putative 0.0028 0.008 0.1789
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0602 0.2782 1
Brugia malayi MH1 domain containing protein 0.0026 0.0071 0.0302
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0071 0.0282 0.7968
Leishmania major DNA polymerase eta, putative 0.0092 0.038 0.8534
Plasmodium vivax DNA repair protein REV1, putative 0.002 0.004 0.09
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0512 0.2359 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0034 0.0105
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0071 0.0282 0.086
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.0463 0.1412
Schistosoma mansoni hypothetical protein 0.0708 0.3282 1
Echinococcus granulosus dna polymerase eta 0.0092 0.038 0.1159
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0071 0.0282 0.086
Leishmania major cAMP-specific phosphodiesterase, putative 0.0071 0.0282 0.6295
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0583 0.2693 0.9681
Loa Loa (eye worm) Smad1 0.0026 0.0071 0.0264
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0282 0.1015
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0071 0.0282 0.086
Echinococcus granulosus smad 0.0026 0.0071 0.0217
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0282 0.6295
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0071 0.0282 0.1197
Loa Loa (eye worm) MH1 domain-containing protein 0.0012 0.0003 0.0012
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0282 0.7968
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0282 0.1015
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0086 0.0354 0.108
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0063 0.0244 0.0744
Giardia lamblia Furin precursor putative serine protease 0.0027 0.0077 0.0251
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0071 0.0282 0.6349
Trypanosoma brucei DNA polymerase eta, putative 0.0092 0.038 0.8534
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0029 0.0124
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0205 0.0868
Schistosoma mansoni smad 0.0026 0.0071 0.0217
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0016 0.0026 0.0078
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0282 0.1015
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0071 0.0282 0.6295
Entamoeba histolytica hypothetical protein 0.0109 0.0463 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0034 0.0106 0.2991
Loa Loa (eye worm) glutathione reductase 0.0106 0.0445 0.1651
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0037 0.012 0.0167
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.0013 0.001 0.0031
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0602 0.2782 0.3881
Loa Loa (eye worm) nuclear factor I 0.0014 0.0016 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0077 0.2185
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0025 0.0064 0.0195
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0071 0.0282 0.6295
Leishmania major hypothetical protein, conserved 0.0071 0.0282 0.6295
Schistosoma mansoni furin-1 (S08 family) 0.0062 0.0239 0.0728
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0179 0.0645
Schistosoma mansoni smad1 5 8 and 0.0026 0.0071 0.0217
Leishmania major calcium motive p-type ATPase, putative 0.0013 0.001 0.0082
Schistosoma mansoni ATPase 0.0028 0.008 0.0242
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0016 0.0026 0.0078
Toxoplasma gondii NADPH-glutathione reductase 0.0037 0.012 0.0432
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.0013 0.001 0.0031
Trypanosoma brucei unspecified product 0.0043 0.0152 0.3326
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0016 0.0026 0.072
Loa Loa (eye worm) hypothetical protein 0.0028 0.008 0.0295
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0028 0.008 0.1668
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0274 0.0836
Loa Loa (eye worm) PDE1B protein 0.0071 0.0282 0.1048
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0016 0.0026 0.0435
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0512 0.2359 0.7189
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0282 0.1015
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0077 0.2185
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0179 0.4035
Brugia malayi glutathione reductase 0.0106 0.0445 0.1885
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0077 0.2185
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0071 0.0217
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0028 0.008 0.0242
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0016 0.0026 0.0435
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0037 0.012 0.2703
Echinococcus multilocularis calcium transporting atpase 0.0025 0.0064 0.0195
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0016 0.0026 0.0435
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0282 0.1015
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0071 0.0282 0.6349
Trypanosoma brucei DNA damage repair protein, putative 0.002 0.004 0.0765
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2136 1 1
Echinococcus multilocularis mothers against decapentaplegic 2 0.0012 0.0003 0.001
Brugia malayi celfurPC protein 0.0115 0.0487 0.2065
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0037 0.012 0.2596
Plasmodium vivax glutathione reductase, putative 0.0106 0.0445 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0037 0.012 0.2703
Loa Loa (eye worm) hypothetical protein 0.0092 0.038 0.1412
Loa Loa (eye worm) hypothetical protein 0.0583 0.2693 1
Plasmodium falciparum glutathione reductase 0.0037 0.012 0.2703
Mycobacterium tuberculosis Probable reductase 0.0241 0.1081 0.1507
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0282 0.6295
Echinococcus granulosus tar DNA binding protein 0.0069 0.0274 0.0836
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0044 0.099
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0029 0.0089
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0041 0.014 0.3954
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0034 0.0106 0.2991
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0126 0.3548
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0071 0.0282 0.086
Echinococcus granulosus Na:K ATPase alpha subunit 0.0013 0.001 0.0031
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0241 0.1081 0.1507
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0037 0.012 0.2596
Loa Loa (eye worm) hypothetical protein 0.0017 0.0029 0.0109
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.012 0.2596
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0139 1
Schistosoma mansoni hypothetical protein 0.0017 0.0029 0.0089
Echinococcus multilocularis thioredoxin glutathione reductase 0.0106 0.0445 0.1355
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0022 0.0494
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0071 0.0282 0.7968
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0037 0.012 0.2703
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0052 0.0158
Schistosoma mansoni hypothetical protein 0.0037 0.0124 0.0377
Leishmania major DNA polymerase eta, putative 0.0048 0.0176 0.3877
Giardia lamblia Hypothetical protein 0.0071 0.0282 0.1015
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0282 0.7968
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0282 0.6295
Brugia malayi Na,K-ATPase alpha subunit 0.0016 0.0026 0.0108
Plasmodium falciparum glutathione reductase 0.0106 0.0445 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0021 0.0076
Loa Loa (eye worm) MH2 domain-containing protein 0.0012 0.0003 0.0012
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0071 0.0282 0.6295
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0057 0.1617
Echinococcus multilocularis Furin 1 0.0034 0.0106 0.0323
Echinococcus granulosus chromobox protein 1 0.0067 0.0265 0.0807
Schistosoma mansoni smad1 5 8 and 0.0026 0.0071 0.0217
Trichomonas vaginalis mercuric reductase, putative 0.0037 0.012 0.3393
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0071 0.0282 0.7968
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0016 0.0026 0.0435
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0583 0.2693 0.8207
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0602 0.2782 0.2694
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0071 0.0282 0.086
Echinococcus granulosus Smad4 0.0026 0.0071 0.0217
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0583 0.2693 0.8207
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0071 0.0282 0.086
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0142 0.0616 0.1878
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0028 0.008 0.0242
Echinococcus granulosus mothers against decapentaplegic 2 0.0012 0.0003 0.001
Loa Loa (eye worm) thioredoxin reductase 0.0106 0.0445 0.1651
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0071 0.0282 0.7968
Brugia malayi Heterochromatin protein 1 0.0067 0.0265 0.1123
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0282 0.7968
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0077 0.2185
Schistosoma mansoni hypothetical protein 0.0017 0.0029 0.0089
Loa Loa (eye worm) heterochromatin protein 1 0.0067 0.0265 0.0983
Trichomonas vaginalis MYB72, putative 0.0041 0.014 0.3954
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0028 0.008 0.0079
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0086 0.0354 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0063 0.0244 0.034
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0152 0.3326
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0037 0.012 0.2703
Trypanosoma brucei DNA polymerase IV, putative 0.0063 0.0244 0.5422
Brugia malayi Membrane calcium atpase protein 3 0.0013 0.001 0.0043
Giardia lamblia DINP protein human, muc B family 0.0063 0.0244 0.0872
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0016 0.0026 0.0092
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.0013 0.001 0.0036
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.012 0.2596
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0029 0.0089
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0282 0.7968
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0282 0.6295
Mycobacterium ulcerans hypothetical protein 0.002 0.004 0.0039
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0025 0.0064 0.0272
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0071 0.0282 0.6295
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0063 0.0244 0.034
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0071 0.0282 0.086
Plasmodium falciparum DNA repair protein REV1, putative 0.002 0.004 0.09
Loa Loa (eye worm) proprotein convertase 2 0.0034 0.0106 0.0393
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0241 0.1081 0.1507
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0037 0.012 0.0119
Loa Loa (eye worm) endoprotease bli-4 0.0142 0.0616 0.2289
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0282 0.7968
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0063 0.0244 0.5422
Toxoplasma gondii ImpB/MucB/SamB family protein 0.002 0.004 0.0144
Brugia malayi MH1 domain containing protein 0.0026 0.0071 0.0302
Echinococcus granulosus dna polymerase kappa 0.0063 0.0244 0.0744
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0041 0.014 0.3023
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0029 0.0089
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0071 0.0282 0.7968
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0027 0.0075 0.0316
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0029 0.0109
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0016 0.0026 0.072
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0037 0.012 0.0366
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1534 0.7166 1
Loa Loa (eye worm) RecQ helicase 0.0023 0.0057 0.0213
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.0463 0.1412
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0205 0.076
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0028 0.008 0.0286
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0268 0.1207 0.1683
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0016 0.0026 0.072
Trypanosoma brucei unspecified product 0.0063 0.0244 0.5422
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0037 0.012 0.0432
Toxoplasma gondii P-type ATPase4, putative 0.0016 0.0026 0.0092
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0016 0.0026 0.0435
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0071 0.0282 0.086
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0012
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.012 0.2596
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0037 0.012 0.0366
Entamoeba histolytica hypothetical protein 0.0109 0.0463 1
Loa Loa (eye worm) calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0019 0.0039 0.0146
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0028 0.008 0.0242
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0244 0.5422
Schistosoma mansoni hypothetical protein 0.0708 0.3282 1
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0077 0.2185
Toxoplasma gondii thioredoxin reductase 0.0106 0.0445 0.1598
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0016 0.0026 0.0095
Brugia malayi hypothetical protein 0.0032 0.0097 0.0413
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0583 0.2693 0.8207
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.002 0.004 0.0144
Schistosoma mansoni hypothetical protein 0.0109 0.0463 0.1412
Leishmania major calcium-transporting ATPase, putative 0.0013 0.001 0.0082
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.004 0.0765
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.0149
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0029 0.0089
Brugia malayi chromobox protein homolog 3 0.0038 0.0126 0.0533
Loa Loa (eye worm) hypothetical protein 0.0071 0.0282 0.1048
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0037 0.012 0.2596
Schistosoma mansoni chromobox protein 0.0067 0.0265 0.0807
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0071 0.0282 0.086
Loa Loa (eye worm) hypothetical protein 0.0016 0.0026 0.0095
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0016 0.0026 0.0435
Schistosoma mansoni ATPase 0.0028 0.008 0.0242
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0282 0.7968
Brugia malayi MH2 domain containing protein 0.0012 0.0003 0.0013
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0071 0.0282 0.6295
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0583 0.2693 0.8207
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.004 0.0765
Plasmodium vivax P-type ATPase4, putative 0.0028 0.008 0.1789
Schistosoma mansoni smad1 5 8 and 0.0026 0.0071 0.0217
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0077 0.2185
Schistosoma mansoni na+/k+ atpase alpha subunit 0.0013 0.001 0.0031
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0282 0.7968
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0016 0.0026 0.0058
Brugia malayi Probable calcium-transporting ATPase KIAA0703 0.0019 0.0039 0.0167
Loa Loa (eye worm) hypothetical protein 0.0056 0.021 0.0781
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0071 0.0282 0.7968
Trypanosoma brucei calcium-translocating P-type ATPase 0.0025 0.0064 0.1316
Trypanosoma brucei chrX additional, unordered contigs 0.002 0.004 0.0765
Plasmodium falciparum calcium-transporting ATPase 0.0025 0.0064 0.1442
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0071 0.0282 0.7968
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0071 0.0282 0.086
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0583 0.2693 0.8207
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.012 0.2596
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0244 0.5422
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0013 0.001 0.0284
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0071 0.0282 0.6295
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0025 0.0064 0.0195
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.01
Trichomonas vaginalis C-MYB, putative 0.0041 0.014 0.3954
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0071 0.0282 0.086
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0016 0.0026 0.0078
Trypanosoma brucei unspecified product 0.0043 0.0152 0.3326
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0071 0.0217
Schistosoma mansoni Smad4 0.0026 0.0071 0.0217
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0244 0.5422
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0179 0.3947
Brugia malayi Thioredoxin reductase 0.0106 0.0445 0.1885
Schistosoma mansoni hypothetical protein 0.0017 0.0029 0.0089
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0016 0.0026 0.0551
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0244 0.5422
Trichomonas vaginalis glutathione reductase, putative 0.0037 0.012 0.3393
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0126 0.3548
Echinococcus multilocularis neuroendocrine convertase 2 0.0089 0.0368 0.1122
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0282 0.1015
Schistosoma mansoni chromobox protein 0.0067 0.0265 0.0807
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0241 0.1081 0.1507
Mycobacterium tuberculosis Probable dehydrogenase 0.0241 0.1081 0.1507
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0282 0.1015
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0071 0.0282 0.086
Echinococcus multilocularis mothers against decapentaplegic 6 0.0012 0.0003 0.001
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0282 0.1015
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0037 0.012 0.2596
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0048 0.0176 0.0634
Mycobacterium tuberculosis Probable oxidoreductase 0.0268 0.1207 0.1683
Mycobacterium ulcerans DNA polymerase IV 0.0063 0.0244 0.0243
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0282 0.6295
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0071 0.0282 0.086
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0071 0.0282 0.6295
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0282 0.7968
Leishmania major trypanothione reductase 0.0106 0.0445 1
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0071 0.0282 0.6295
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0037 0.012 0.0366
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0071 0.0217
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0025 0.0064 0.0195
Loa Loa (eye worm) MH2 domain-containing protein 0.0384 0.1754 0.6513
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0071 0.0282 0.6295
Trichomonas vaginalis cation-transporting ATPase, putative 0.0028 0.008 0.2245
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0274 0.0836
Schistosoma mansoni hypothetical protein 0.0027 0.0077 0.0236
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0071 0.0282 0.6295
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0274 0.0836
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0071 0.0282 0.7968
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0041 0.0141 0.398
Leishmania major calcium-translocating P-type ATPase 0.0028 0.008 0.1668
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0041 0.014 0.3954
Brugia malayi MH2 domain containing protein 0.0026 0.0071 0.0302
Loa Loa (eye worm) hypothetical protein 0.0055 0.0205 0.076
Echinococcus granulosus calcium transporting atpase 0.0025 0.0064 0.0195
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0041 0.014 0.3954
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0282 0.6349
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0282 0.1015
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0282 0.7968
Trypanosoma brucei DNA polymerase IV, putative 0.0063 0.0244 0.5422
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0139 0.3929
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0282 0.1015
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0282 0.7968
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0013 0.001 0.0082
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0034 0.0106 0.2991
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0037 0.012 0.2596
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0244 0.5422
Trichomonas vaginalis hypothetical protein 0.0027 0.0077 0.2185
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0077 0.2185
Trypanosoma brucei trypanothione reductase 0.0106 0.0445 1
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0027 0.0077 0.2185
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0016 0.0026 0.072
Trypanosoma cruzi DNA damage repair protein, putative 0.002 0.004 0.0765
Trichomonas vaginalis cation-transporting ATPase, putative 0.0016 0.0026 0.072
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0274 0.1162
Leishmania major DNA polymerase kappa, putative 0.0063 0.0244 0.5422
Brugia malayi endoprotease bli-4 precursor 0.0142 0.0616 0.2613
Brugia malayi TAR-binding protein 0.0069 0.0274 0.1162
Giardia lamblia NADH oxidase lateral transfer candidate 0.0037 0.012 0.041
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0282 0.7968
Schistosoma mansoni DNA polymerase eta 0.0092 0.038 0.1159
Loa Loa (eye worm) hypothetical protein 0.0117 0.0497 0.1847
Brugia malayi ImpB/MucB/SamB family protein 0.0063 0.0244 0.1034
Trichomonas vaginalis DNA polymerase eta, putative 0.0063 0.0244 0.6889
Trichomonas vaginalis C-MYB, putative 0.0041 0.014 0.3954
Trypanosoma cruzi DNA damage repair protein, putative 0.002 0.004 0.0765
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0016 0.0026 0.072
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0071 0.0282 0.7968
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0282 0.7968
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0041 0.014 0.3023
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0282 0.7968
Echinococcus multilocularis geminin 0.0708 0.3282 1
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0124 0.0524
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0016 0.0026 0.0551
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0282 0.7968
Trichomonas vaginalis MYB3r3, putative 0.0041 0.014 0.3954
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0282 0.6295
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0077 0.2185
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0512 0.2359 0.8759
Echinococcus granulosus GPCR family 2 0.0017 0.0029 0.0089
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0274 0.1018
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.012 0.2596
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0034 0.0106 0.2991
Plasmodium falciparum phosphodiesterase delta, putative 0.0071 0.0282 0.6349
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0244 0.5422
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0063 0.0244 0.0906
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0282 0.6349
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0041 0.014 0.3023
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0602 0.2782 0.2781
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0071 0.0282 0.7968
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0027 0.0075 0.0316
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0282 0.7968
Leishmania major DNA polymerase kappa, putative 0.002 0.004 0.0765
Brugia malayi MH2 domain containing protein 0.0026 0.0071 0.0302
Leishmania major hypothetical protein, conserved 0.0049 0.0179 0.3947
Schistosoma mansoni Smad4 0.0012 0.0003 0.001
Trypanosoma cruzi DNA polymerase eta, putative 0.0048 0.0176 0.3877
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0041 0.014 0.3954
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0241 0.1081 0.1507
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0057 0.0243
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0037 0.012 0.2596
Schistosoma mansoni hypothetical protein 0.0022 0.0052 0.0158
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.0006 0.0182
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0106 0.0445 0.0619
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0071 0.0282 0.7968
Leishmania major P-type ATPase, putative 0.0013 0.001 0.0082
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0282 0.6295
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0071 0.0282 0.1197
Trypanosoma brucei hypothetical protein, conserved 0.002 0.004 0.0765
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0282 0.7968
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0074 0.2085
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0152 0.3326
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0265 0.7477
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0011 0.0001 0.0003
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0011 0.0001 0.0003
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0282 0.7968
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0139 0.3929
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0016 0.0026 0.0435
Trypanosoma cruzi DNA polymerase kappa, putative 0.0063 0.0244 0.5422
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0282 0.6349
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0077 0.2185
Entamoeba histolytica hypothetical protein 0.0109 0.0463 1
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0274 0.0836
Loa Loa (eye worm) RNA binding protein 0.0069 0.0274 0.1018
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0282 0.7968
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0179 0.4035
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0282 0.1015
Brugia malayi RNA binding protein 0.0069 0.0274 0.1162
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0041 0.014 0.3954
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0126 0.9009
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0037 0.012 0.2596
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0034 0.0106 0.0323
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0274 0.1018
Trichomonas vaginalis MYB, putative 0.0041 0.0141 0.398
Schistosoma mansoni Smad4 0.0012 0.0003 0.001
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0071 0.0282 0.7968
Echinococcus multilocularis Smad4 0.0026 0.0071 0.0217
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0282 0.7968
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0034 0.0106 0.2991
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0071 0.0282 0.1197
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0152 0.3326
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.0013 0.001 0.0031
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0029 0.0124
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1534 0.7166 1
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0071 0.0282 0.086
Echinococcus granulosus furin 0.0142 0.0616 0.1878
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0071 0.0282 0.086
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0071 0.0282 0.7968
Giardia lamblia DNA damage repair protein 0.002 0.004 0.0112
Plasmodium falciparum thioredoxin reductase 0.0106 0.0445 1
Trypanosoma brucei DNA polymerase IV, putative 0.0063 0.0244 0.5422
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0013 0.001 0.0031
Trypanosoma cruzi DNA polymerase kappa, putative 0.0063 0.0244 0.5422
Echinococcus granulosus mothers against decapentaplegic 6 0.0012 0.0003 0.001
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0016 0.0026 0.0551
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0063 0.0244 0.0744
Brugia malayi mothers against decapentaplegic homolog 3 0.0012 0.0003 0.0013
Loa Loa (eye worm) hypothetical protein 0.0049 0.0179 0.0666
Entamoeba histolytica hypothetical protein 0.0109 0.0463 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0037 0.012 0.2596
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0037 0.012 0.051
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0013 0.001 0.0031
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0071 0.0282 0.086
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0071 0.0282 0.1048
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0512 0.2359 0.7189
Echinococcus multilocularis smad 0.0026 0.0071 0.0217
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0013 0.001 0.0082
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0071 0.0282 0.6295
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0016 0.0026 0.0551
Brugia malayi hypothetical protein 0.0109 0.0463 0.1964
Loa Loa (eye worm) hypothetical protein 0.0037 0.0124 0.0459
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0071 0.0282 0.086
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0063 0.0244 0.6889
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0057 0.0175
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0282 0.7968
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.012 0.2596
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0268 0.1207 0.1683
Leishmania major hypothetical protein, conserved 0.0071 0.0282 0.6295
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0071 0.0282 0.6295

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 0 % Percentage inhibition of Monoamine oxidase B (MAO-B) at 1 microM concentration ChEMBL. 9622553
Inhibition (binding) = 0 % Percentage inhibition of Monoamine oxidase B (MAO-B) at 1 microM concentration ChEMBL. 9622553
Inhibition (binding) = 40 % Percent inhibition against monoamine oxidase A at 1 microM concentration. ChEMBL. 9622553
Inhibition (binding) = 40 % Percent inhibition against monoamine oxidase A at 1 microM concentration. ChEMBL. 9622553

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.