TDR Targets

Basic information

Technical information

TDR Targets ID: 111040
Name: N-(2-chloro-6-methylphenyl)-2-[(2-phenylcyclo propanecarbonyl)amino]-1,3-benzothiazole-6-ca rboxamide
MW: 461.963 | Formula: C25H20ClN3O2S
H donors: 2 H acceptors: 3 LogP: 5.56 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C(C1CC1c1ccccc1)Nc1sc2c(n1)ccc(c2)C(=O)Nc1c(C)cccc1Cl
InChi: 1S/C25H20ClN3O2S/c1-14-6-5-9-19(26)22(14)28-23(30)16-10-11-20-21(12-16)32-25(27-20)29-24(31)18-13-17(18)15-7-3-2-4-8-15/h2-12,17-18H,13H2,1H3,(H,28,30)(H,27,29,31)
InChiKey: NVXBXEICHMKNPN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(2-chloro-6-methyl-phenyl)-2-[(2-phenylcyclopropanecarbonyl)amino]-1,3-benzothiazole-6-carboxamide
N-(2-chloro-6-methylphenyl)-2-[[oxo-(2-phenylcyclopropyl)methyl]amino]-1,3-benzothiazole-6-carboxamide
N-(2-chloro-6-methyl-phenyl)-2-[(2-phenylcyclopropyl)carbonylamino]-1,3-benzothiazole-6-carboxamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	LCK proto-oncogene, Src family tyrosine kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0107	0.2754	0.4343
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0017	0.0027
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0189	0.0687
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0011	0.0017	0.0027
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0012	0.0061	0.0061
Echinococcus multilocularis	Niemann Pick C1 protein	0.0106	0.2708	0.2708
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0011	0.0017	0.0027
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.1049	0.1049
Entamoeba histolytica	acyl-coA synthetase, putative	0.0025	0.0431	0.1397
Schistosoma mansoni	hypothetical protein	0.0017	0.0189	0.0299
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.0431	0.1397
Brugia malayi	ecdysteroid receptor	0.0011	0.0017	0.0061
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0045	0.0996	0.157
Schistosoma mansoni	aminopeptidase A (M01 family)	0.0012	0.0061	0.0097
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0189	0.0687
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0054	0.1227	0.445
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0047	0.1049	0.3804
Brugia malayi	Peptidase family M1 containing protein	0.0012	0.0061	0.0223
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0189	0.0189
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0431	0.4968
Onchocerca volvulus		0.0039	0.0806	0.6581
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0011	0.0017	0.0027
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0806	0.0903
Onchocerca volvulus		0.0039	0.0806	0.6581
Brugia malayi	hypothetical protein	0.0039	0.0805	0.2918
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0806	1
Mycobacterium ulcerans	beta-lactamase	0.0039	0.0806	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0011	0.0017	0.0061
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0012	0.0061	0.0061
Schistosoma mansoni	hypothetical protein	0.0017	0.0189	0.0299
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0011	0.0017	0.0027
Leishmania major	hypothetical protein, conserved	0.0039	0.0806	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0037	0.0747	0.2708
Brugia malayi	beta-lactamase family protein	0.0039	0.0806	0.2921
Mycobacterium tuberculosis	Probable lipase LipE	0.0039	0.0806	0.0903
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0017	0.0027
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0011	0.0017	0.0027
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0025	0.0431	0.4968
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0012	0.0061	0.0061
Mycobacterium ulcerans	hypothetical protein	0.0025	0.0431	0.4968
Echinococcus multilocularis	sterol regulatory element binding protein	0.0045	0.0996	0.0996
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0431	0.4968
Loa Loa (eye worm)	TATA binding protein associated factor	0.0012	0.0061	0.0097
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0011	0.0017	0.0017
Echinococcus granulosus	FTZ F1 alpha	0.0011	0.0017	0.0017
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0017	0.0061
Mycobacterium ulcerans	hypothetical protein	0.0039	0.0806	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0019	0.0249	0.2515
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0017	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0806	0.127
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0039	0.0806	0.0806
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0431	0.1563
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.0431	0.1397
Echinococcus multilocularis	leukotriene A 4 hydrolase	0.0234	0.6341	0.6341
Entamoeba histolytica	hypothetical protein	0.0039	0.0805	0.2809
Loa Loa (eye worm)	hypothetical protein	0.0106	0.2708	0.427
Loa Loa (eye worm)	steroid hormone receptor	0.0011	0.0017	0.0027
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.1049	0.1655
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0025	0.0431	0.0326
Echinococcus multilocularis	FTZ F1 alpha	0.0011	0.0017	0.0017
Onchocerca volvulus		0.0039	0.0806	0.6581
Schistosoma mansoni	Tata binding protein associated factor (M01 family)	0.0012	0.0061	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1227	0.1935
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0011	0.0017	0.0017
Echinococcus multilocularis	protein dispatched 1	0.0052	0.1178	0.1178
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0249	0.0392
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0806	0.127
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0012	0.0061	0.0061
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0012	0.0061	0.0061
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0011	0.0017	0.0027
Loa Loa (eye worm)	aminopeptidase N	0.0012	0.0061	0.0097
Echinococcus granulosus	Niemann Pick C1 protein	0.0106	0.2708	0.2708
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.1049	0.1049
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0061	0.0097
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0011	0.0017	0.0017
Schistosoma mansoni	retinoic acid receptor RXR	0.0011	0.0017	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1285	0.2027
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0025	0.0431	0.4968
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.1049	0.1049
Toxoplasma gondii	ABC1 family protein	0.0039	0.0806	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0011	0.0017	0.0017
Brugia malayi	CHE-14 protein	0.0045	0.0996	0.361
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0012	0.0061	0.0061
Brugia malayi	TATA binding protein associated factor	0.0012	0.0061	0.0223
Schistosoma mansoni	hypothetical protein	0.0044	0.0949	0.1497
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0431	0.4968
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0011	0.0017	0.0061
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0806	0.7964
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0806	0.127
Schistosoma mansoni	hypothetical protein	0.0017	0.0189	0.0299
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0012	0.0061	0.0061
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0996	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0011	0.0017	0.0027
Echinococcus granulosus	GPCR family 2	0.0017	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0996	0.157
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0011	0.0017	0.0017
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.0805	0.1269
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0039	0.0806	0.127
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0061	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0189	0.0299
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0017	0.0017
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0806	0.0903
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0054	0.1227	0.445
Echinococcus granulosus	ecdysone induced protein 78C	0.0011	0.0017	0.0017
Brugia malayi	Peptidase family M1 containing protein	0.0012	0.0061	0.0223
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.0189	0.0189
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0806	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0017	0.0061
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0431	0.4968
Brugia malayi	nuclear hormone receptor	0.0011	0.0017	0.0061
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0431	0.1563
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.1049	0.1655
Onchocerca volvulus		0.0053	0.1215	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0011	0.0017	0.0027
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0011	0.0017	0.0017
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0011	0.0017	0.0061
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0017	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0431	0.068
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.0805	0.0805
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0011	0.0017	0.0061
Schistosoma mansoni	hypothetical protein	0.0044	0.0949	0.1497
Entamoeba histolytica	hypothetical protein	0.0039	0.0805	0.2809
Echinococcus multilocularis	ecdysone induced protein 78C	0.0011	0.0017	0.0017
Echinococcus granulosus	expressed conserved protein	0.0099	0.2526	0.2526
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0017	0.0061
Onchocerca volvulus		0.0012	0.0061	0.0372
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0017	0.0061
Brugia malayi	hypothetical protein	0.0107	0.2758	1
Schistosoma mansoni	hypothetical protein	0.0017	0.0189	0.0299
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0431	0.1563
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0039	0.0806	1
Brugia malayi	hypothetical protein	0.0012	0.0061	0.0223
Schistosoma mansoni	coup transcription factor	0.0011	0.0017	0.0027
Echinococcus multilocularis	protein patched	0.0045	0.0996	0.0996
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0017	0.0027
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0017	0.0027
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0431	0.4968
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.0805	0.0805
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0806	0.7964
Trypanosoma brucei	hypothetical protein, conserved	0.0039	0.0806	1
Echinococcus granulosus	sterol regulatory element binding protein	0.0045	0.0996	0.0996
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0025	0.0431	0.0326
Onchocerca volvulus		0.0012	0.0061	0.0372
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0039	0.0806	0.0903
Loa Loa (eye worm)	leukotriene A4 hydrolase	0.0234	0.6341	1
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0012	0.0061	0.0061
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0189	0.0189
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0039	0.0806	0.0903
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0806	0.127
Loa Loa (eye worm)	peptidase family M1 containing protein	0.0012	0.0061	0.0097
Brugia malayi	nuclear receptor NHR-88	0.0011	0.0017	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0017	0.0027
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0011	0.0017	0.0027
Schistosoma mansoni	patched 1	0.0045	0.0996	0.157
Trichomonas vaginalis	esterase, putative	0.0039	0.0806	0.7964
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0806	0.127
Schistosoma mansoni	RAR-like nuclear receptor	0.0011	0.0017	0.0027
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0054	0.1227	0.1935
Mycobacterium tuberculosis	Probable lipase LipD	0.0039	0.0806	0.0903
Entamoeba histolytica	hypothetical protein	0.0039	0.0805	0.2809
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0019	0.0249	0.5
Brugia malayi	hypothetical protein	0.0012	0.0061	0.0223
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0011	0.0017	0.0061
Echinococcus granulosus	leukotriene A 4 hydrolase	0.0234	0.6341	0.6341
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0249	0.0392
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0017	0.0027
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.1049	0.1655
Loa Loa (eye worm)	beta-lactamase	0.0039	0.0806	0.127
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0017	0.0027
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0019	0.0249	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0431	0.068
Onchocerca volvulus		0.0025	0.0431	0.3457
Mycobacterium leprae	conserved hypothetical protein	0.0039	0.0806	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0017	0.0017
Brugia malayi	steroid hormone receptor	0.0011	0.0017	0.0061
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.1049	0.1049
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0017	0.0027
Brugia malayi	beta-lactamase family protein	0.0039	0.0806	0.2921
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0012	0.0061	0.0061
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0017	0.0061
Brugia malayi	Steroid receptor seven-up type 2	0.0011	0.0017	0.0061
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0011	0.0017	0.0017
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0806	0.0903
Echinococcus granulosus	Protein patched homolog 1	0.0045	0.0996	0.0996
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0012	0.0061	0.0061
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0011	0.0017	0.0027
Entamoeba histolytica	hypothetical protein	0.0039	0.0805	0.2809
Loa Loa (eye worm)	hypothetical protein	0.0053	0.1215	0.1917
Mycobacterium ulcerans	esterase/lipase LipP	0.0039	0.0806	1
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0012	0.0061	0.0061
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0011	0.0017	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0249	0.0392
Mycobacterium tuberculosis	Probable hydrolase	0.0039	0.0806	0.0903
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0011	0.0017	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0061	0.0097
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0011	0.0017	0.0027
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0247	0.6715	1
Mycobacterium tuberculosis	Probable esterase LipL	0.0039	0.0806	0.0903
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0012	0.0061	0.0097
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0431	0.4968
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0249	0.0392
Plasmodium vivax	hypothetical protein, conserved	0.0039	0.0806	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0047	0.1049	0.1655
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0189	0.0299
Schistosoma mansoni	hypothetical protein	0.0037	0.0747	0.1178
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.0017	0.0027
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0017	0.0027
Brugia malayi	Niemann-Pick C1 protein precursor	0.0106	0.2708	0.9816
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0011	0.0017	0.0017
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0017	0.0017
Echinococcus multilocularis	Niemann Pick C1 protein	0.0151	0.3994	0.3994
Brugia malayi	beta-lactamase	0.0039	0.0806	0.2921
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0249	0.0392
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0806	0.127
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0011	0.0017	0.0061
Onchocerca volvulus		0.0012	0.0061	0.0372
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0011	0.0017	0.0061
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0011	0.0017	0.0017
Echinococcus granulosus	Niemann Pick C1 protein	0.0151	0.3994	0.3994
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0017	0.0061
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0025	0.0431	0.4968
Echinococcus multilocularis	expressed conserved protein	0.0099	0.2526	0.2526
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0025	0.0431	0.4968
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0039	0.0806	0.0903
Schistosoma mansoni	hypothetical protein	0.0039	0.0805	0.1269
Plasmodium falciparum	acyl-CoA synthetase	0.0019	0.0249	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0017	0.0017
Brugia malayi	Peptidase family M1 containing protein	0.0012	0.0061	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0431	0.068
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0806	0.127
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0012	0.0061	0.0061
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0011	0.0017	0.0017
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0806	0.127
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0039	0.0806	0.2921
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0806	0.7964
Schistosoma mansoni	cellular tumor antigen P53	0.0053	0.1215	0.1917
Echinococcus multilocularis	aminopeptidase N	0.0012	0.0061	0.0061
Mycobacterium leprae	Probable lipase LipE	0.0039	0.0806	1
Schistosoma mansoni	hypothetical protein	0.0044	0.0949	0.1497
Schistosoma mansoni	hypothetical protein	0.0044	0.0949	0.1497
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0012	0.0061	0.0097
Echinococcus granulosus	beta LACTamase domain containing family member	0.0039	0.0806	0.0806
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0106	0.2708	1
Mycobacterium ulcerans	lipase LipD	0.0039	0.0806	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0747	0.1178
Echinococcus multilocularis	tumor protein p63	0.0363	1	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0017	0.0061
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0806	0.7964
Schistosoma mansoni	leukotriene A4 hydrolase (M01 family)	0.0234	0.6341	1
Plasmodium vivax	acyl-CoA synthetase, putative	0.0019	0.0249	0.2515
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0806	0.7964
Brugia malayi	photoreceptor-specific nuclear receptor	0.0011	0.0017	0.0061
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0189	0.0189
Echinococcus granulosus	aminopeptidase N	0.0012	0.0061	0.0061

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.027 uM	Inhibition of human Lck protein tyrosine kinase	ChEMBL.	12798323
IC50 (binding)	= 0.027 uM	Inhibition of human Lck protein tyrosine kinase	ChEMBL.	12798323

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 22634523

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 111040