Detailed information for compound 111040

Basic information

Technical information
  • TDR Targets ID: 111040
  • Name: N-(2-chloro-6-methylphenyl)-2-[(2-phenylcyclo propanecarbonyl)amino]-1,3-benzothiazole-6-ca rboxamide
  • MW: 461.963 | Formula: C25H20ClN3O2S
  • H donors: 2 H acceptors: 3 LogP: 5.56 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1CC1c1ccccc1)Nc1sc2c(n1)ccc(c2)C(=O)Nc1c(C)cccc1Cl
  • InChi: 1S/C25H20ClN3O2S/c1-14-6-5-9-19(26)22(14)28-23(30)16-10-11-20-21(12-16)32-25(27-20)29-24(31)18-13-17(18)15-7-3-2-4-8-15/h2-12,17-18H,13H2,1H3,(H,28,30)(H,27,29,31)
  • InChiKey: NVXBXEICHMKNPN-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2-chloro-6-methyl-phenyl)-2-[(2-phenylcyclopropanecarbonyl)amino]-1,3-benzothiazole-6-carboxamide
  • N-(2-chloro-6-methylphenyl)-2-[[oxo-(2-phenylcyclopropyl)methyl]amino]-1,3-benzothiazole-6-carboxamide
  • N-(2-chloro-6-methyl-phenyl)-2-[(2-phenylcyclopropyl)carbonylamino]-1,3-benzothiazole-6-carboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens LCK proto-oncogene, Src family tyrosine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0107 0.2754 0.4343
Loa Loa (eye worm) hypothetical protein 0.0011 0.0017 0.0027
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0189 0.0687
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0017 0.0027
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0061 0.0061
Echinococcus multilocularis Niemann Pick C1 protein 0.0106 0.2708 0.2708
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0017 0.0027
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.1049 0.1049
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0431 0.1397
Schistosoma mansoni hypothetical protein 0.0017 0.0189 0.0299
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0431 0.1397
Brugia malayi ecdysteroid receptor 0.0011 0.0017 0.0061
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0045 0.0996 0.157
Schistosoma mansoni aminopeptidase A (M01 family) 0.0012 0.0061 0.0097
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0189 0.0687
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.1227 0.445
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.1049 0.3804
Brugia malayi Peptidase family M1 containing protein 0.0012 0.0061 0.0223
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0189 0.0189
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0431 0.4968
Onchocerca volvulus 0.0039 0.0806 0.6581
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0017 0.0027
Mycobacterium tuberculosis Conserved protein 0.0039 0.0806 0.0903
Onchocerca volvulus 0.0039 0.0806 0.6581
Brugia malayi hypothetical protein 0.0039 0.0805 0.2918
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0806 1
Mycobacterium ulcerans beta-lactamase 0.0039 0.0806 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0017 0.0061
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0012 0.0061 0.0061
Schistosoma mansoni hypothetical protein 0.0017 0.0189 0.0299
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0017 0.0027
Leishmania major hypothetical protein, conserved 0.0039 0.0806 1
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0747 0.2708
Brugia malayi beta-lactamase family protein 0.0039 0.0806 0.2921
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0806 0.0903
Loa Loa (eye worm) hypothetical protein 0.0011 0.0017 0.0027
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0017 0.0027
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0431 0.4968
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0061 0.0061
Mycobacterium ulcerans hypothetical protein 0.0025 0.0431 0.4968
Echinococcus multilocularis sterol regulatory element binding protein 0.0045 0.0996 0.0996
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0431 0.4968
Loa Loa (eye worm) TATA binding protein associated factor 0.0012 0.0061 0.0097
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0017 0.0017
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0017 0.0017
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0017 0.0061
Mycobacterium ulcerans hypothetical protein 0.0039 0.0806 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0249 0.2515
Loa Loa (eye worm) hypothetical protein 0.0011 0.0017 0.0027
Loa Loa (eye worm) hypothetical protein 0.0039 0.0806 0.127
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0806 0.0806
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0431 0.1563
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0431 0.1397
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0234 0.6341 0.6341
Entamoeba histolytica hypothetical protein 0.0039 0.0805 0.2809
Loa Loa (eye worm) hypothetical protein 0.0106 0.2708 0.427
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0017 0.0027
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1049 0.1655
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0431 0.0326
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0017 0.0017
Onchocerca volvulus 0.0039 0.0806 0.6581
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0012 0.0061 0.0097
Loa Loa (eye worm) hypothetical protein 0.0054 0.1227 0.1935
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0017 0.0017
Echinococcus multilocularis protein dispatched 1 0.0052 0.1178 0.1178
Loa Loa (eye worm) hypothetical protein 0.0019 0.0249 0.0392
Loa Loa (eye worm) hypothetical protein 0.0039 0.0806 0.127
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0061 0.0061
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0061 0.0061
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0017 0.0027
Loa Loa (eye worm) aminopeptidase N 0.0012 0.0061 0.0097
Echinococcus granulosus Niemann Pick C1 protein 0.0106 0.2708 0.2708
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.1049 0.1049
Loa Loa (eye worm) hypothetical protein 0.0012 0.0061 0.0097
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0017 0.0017
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0017 0.0027
Loa Loa (eye worm) hypothetical protein 0.0056 0.1285 0.2027
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0431 0.4968
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.1049 0.1049
Toxoplasma gondii ABC1 family protein 0.0039 0.0806 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0017 0.0017
Brugia malayi CHE-14 protein 0.0045 0.0996 0.361
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0061 0.0061
Brugia malayi TATA binding protein associated factor 0.0012 0.0061 0.0223
Schistosoma mansoni hypothetical protein 0.0044 0.0949 0.1497
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0431 0.4968
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0017 0.0061
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0806 0.7964
Loa Loa (eye worm) hypothetical protein 0.0039 0.0806 0.127
Schistosoma mansoni hypothetical protein 0.0017 0.0189 0.0299
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0061 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0996 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0017 0.0027
Echinococcus granulosus GPCR family 2 0.0017 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0045 0.0996 0.157
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0017 0.0017
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0805 0.1269
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0806 0.127
Loa Loa (eye worm) hypothetical protein 0.0012 0.0061 0.0097
Loa Loa (eye worm) hypothetical protein 0.0017 0.0189 0.0299
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0017 0.0017
Mycobacterium tuberculosis Conserved protein 0.0039 0.0806 0.0903
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.1227 0.445
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0017 0.0017
Brugia malayi Peptidase family M1 containing protein 0.0012 0.0061 0.0223
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0189 0.0189
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0806 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0017 0.0061
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0431 0.4968
Brugia malayi nuclear hormone receptor 0.0011 0.0017 0.0061
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0431 0.1563
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1049 0.1655
Onchocerca volvulus 0.0053 0.1215 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0017 0.0027
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0017 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0017 0.0061
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0017 0.0027
Loa Loa (eye worm) hypothetical protein 0.0025 0.0431 0.068
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0805 0.0805
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0017 0.0061
Schistosoma mansoni hypothetical protein 0.0044 0.0949 0.1497
Entamoeba histolytica hypothetical protein 0.0039 0.0805 0.2809
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0017 0.0017
Echinococcus granulosus expressed conserved protein 0.0099 0.2526 0.2526
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0017 0.0061
Onchocerca volvulus 0.0012 0.0061 0.0372
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0017 0.0061
Brugia malayi hypothetical protein 0.0107 0.2758 1
Schistosoma mansoni hypothetical protein 0.0017 0.0189 0.0299
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0431 0.1563
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0806 1
Brugia malayi hypothetical protein 0.0012 0.0061 0.0223
Schistosoma mansoni coup transcription factor 0.0011 0.0017 0.0027
Echinococcus multilocularis protein patched 0.0045 0.0996 0.0996
Loa Loa (eye worm) hypothetical protein 0.0011 0.0017 0.0027
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0017 0.0027
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0431 0.4968
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0805 0.0805
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0806 0.7964
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0806 1
Echinococcus granulosus sterol regulatory element binding protein 0.0045 0.0996 0.0996
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0431 0.0326
Onchocerca volvulus 0.0012 0.0061 0.0372
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0806 0.0903
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0234 0.6341 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0061 0.0061
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0189 0.0189
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0806 0.0903
Loa Loa (eye worm) hypothetical protein 0.0039 0.0806 0.127
Loa Loa (eye worm) peptidase family M1 containing protein 0.0012 0.0061 0.0097
Brugia malayi nuclear receptor NHR-88 0.0011 0.0017 0.0061
Loa Loa (eye worm) hypothetical protein 0.0011 0.0017 0.0027
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0017 0.0027
Schistosoma mansoni patched 1 0.0045 0.0996 0.157
Trichomonas vaginalis esterase, putative 0.0039 0.0806 0.7964
Loa Loa (eye worm) hypothetical protein 0.0039 0.0806 0.127
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0017 0.0027
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.1227 0.1935
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0806 0.0903
Entamoeba histolytica hypothetical protein 0.0039 0.0805 0.2809
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0249 0.5
Brugia malayi hypothetical protein 0.0012 0.0061 0.0223
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0017 0.0061
Echinococcus granulosus leukotriene A 4 hydrolase 0.0234 0.6341 0.6341
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0019 0.0249 0.0392
Loa Loa (eye worm) hypothetical protein 0.0011 0.0017 0.0027
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1049 0.1655
Loa Loa (eye worm) beta-lactamase 0.0039 0.0806 0.127
Loa Loa (eye worm) hypothetical protein 0.0011 0.0017 0.0027
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0249 0.0045
Loa Loa (eye worm) hypothetical protein 0.0025 0.0431 0.068
Onchocerca volvulus 0.0025 0.0431 0.3457
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0806 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0017 0.0017
Brugia malayi steroid hormone receptor 0.0011 0.0017 0.0061
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.1049 0.1049
Loa Loa (eye worm) hypothetical protein 0.0011 0.0017 0.0027
Brugia malayi beta-lactamase family protein 0.0039 0.0806 0.2921
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0061 0.0061
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0017 0.0061
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0017 0.0061
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0017 0.0017
Mycobacterium tuberculosis Conserved protein 0.0039 0.0806 0.0903
Echinococcus granulosus Protein patched homolog 1 0.0045 0.0996 0.0996
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0061 0.0061
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0017 0.0027
Entamoeba histolytica hypothetical protein 0.0039 0.0805 0.2809
Loa Loa (eye worm) hypothetical protein 0.0053 0.1215 0.1917
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0806 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0061 0.0061
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0017 0.0027
Loa Loa (eye worm) hypothetical protein 0.0019 0.0249 0.0392
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0806 0.0903
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0017 0.0027
Loa Loa (eye worm) hypothetical protein 0.0012 0.0061 0.0097
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0017 0.0027
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0247 0.6715 1
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0806 0.0903
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0012 0.0061 0.0097
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0431 0.4968
Loa Loa (eye worm) hypothetical protein 0.0019 0.0249 0.0392
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0806 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.1049 0.1655
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0189 0.0299
Schistosoma mansoni hypothetical protein 0.0037 0.0747 0.1178
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0017 0.0027
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0017 0.0027
Brugia malayi Niemann-Pick C1 protein precursor 0.0106 0.2708 0.9816
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0017 0.0017
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0017 0.0017
Echinococcus multilocularis Niemann Pick C1 protein 0.0151 0.3994 0.3994
Brugia malayi beta-lactamase 0.0039 0.0806 0.2921
Loa Loa (eye worm) hypothetical protein 0.0019 0.0249 0.0392
Loa Loa (eye worm) hypothetical protein 0.0039 0.0806 0.127
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0017 0.0061
Onchocerca volvulus 0.0012 0.0061 0.0372
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0017 0.0061
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0017 0.0017
Echinococcus granulosus Niemann Pick C1 protein 0.0151 0.3994 0.3994
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0017 0.0061
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0431 0.4968
Echinococcus multilocularis expressed conserved protein 0.0099 0.2526 0.2526
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0431 0.4968
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0806 0.0903
Schistosoma mansoni hypothetical protein 0.0039 0.0805 0.1269
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0249 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0017 0.0017
Brugia malayi Peptidase family M1 containing protein 0.0012 0.0061 0.0223
Loa Loa (eye worm) hypothetical protein 0.0025 0.0431 0.068
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0806 0.127
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0061 0.0061
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0017 0.0017
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0806 0.127
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0806 0.2921
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0806 0.7964
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.1215 0.1917
Echinococcus multilocularis aminopeptidase N 0.0012 0.0061 0.0061
Mycobacterium leprae Probable lipase LipE 0.0039 0.0806 1
Schistosoma mansoni hypothetical protein 0.0044 0.0949 0.1497
Schistosoma mansoni hypothetical protein 0.0044 0.0949 0.1497
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0012 0.0061 0.0097
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0806 0.0806
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0106 0.2708 1
Mycobacterium ulcerans lipase LipD 0.0039 0.0806 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0747 0.1178
Echinococcus multilocularis tumor protein p63 0.0363 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0017 0.0061
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0806 0.7964
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0234 0.6341 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0249 0.2515
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0806 0.7964
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0017 0.0061
Echinococcus multilocularis GPCR, family 2 0.0017 0.0189 0.0189
Echinococcus granulosus aminopeptidase N 0.0012 0.0061 0.0061

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.027 uM Inhibition of human Lck protein tyrosine kinase ChEMBL. 12798323
IC50 (binding) = 0.027 uM Inhibition of human Lck protein tyrosine kinase ChEMBL. 12798323

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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