Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0021 | 0.0411 | 0.0131 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0021 | 0.0411 | 0.1157 |
Trypanosoma cruzi | p450 reductase, putative | 0.0032 | 0.129 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0021 | 0.0411 | 0.0411 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0021 | 0.0411 | 0.1157 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0021 | 0.0411 | 0.0119 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0021 | 0.0411 | 0.0411 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0021 | 0.0411 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0021 | 0.0411 | 0.1157 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0032 | 0.129 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0021 | 0.0411 | 0.0131 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0021 | 0.0411 | 0.1157 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0411 | 0.1157 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0021 | 0.0411 | 0.0411 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0021 | 0.0411 | 0.0119 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0028 | 0.0994 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0021 | 0.0411 | 0.1157 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.129 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0021 | 0.0411 | 0.1157 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0021 | 0.0411 | 0.1157 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0032 | 0.129 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0411 | 0.1157 |
Brugia malayi | nuclear hormone receptor | 0.0021 | 0.0411 | 0.1157 |
Brugia malayi | ecdysteroid receptor | 0.0021 | 0.0411 | 0.1157 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0021 | 0.0411 | 0.0131 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0021 | 0.0411 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0021 | 0.0411 | 0.0131 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0032 | 0.129 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0021 | 0.0411 | 0.0131 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0021 | 0.0411 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0021 | 0.0411 | 0.1157 |
Brugia malayi | flavodoxin family protein | 0.0032 | 0.129 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0021 | 0.0411 | 0.0119 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0127 | 0.9091 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.002 | 0.0296 | 0.0296 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0411 | 0.1157 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0021 | 0.0411 | 0.0131 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0021 | 0.0411 | 0.1157 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0411 | 0.1157 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0021 | 0.0411 | 0.1157 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0032 | 0.129 | 0.129 |
Brugia malayi | nuclear receptor NHR-88 | 0.0021 | 0.0411 | 0.1157 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0032 | 0.129 | 0.1025 |
Giardia lamblia | Hypothetical protein | 0.0028 | 0.0994 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0021 | 0.0411 | 0.1157 |
Schistosoma mansoni | nuclear hormone receptor | 0.0021 | 0.0411 | 0.0411 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0032 | 0.129 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0021 | 0.0411 | 0.0119 |
Onchocerca volvulus | 0.0021 | 0.0411 | 0.5 | |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0021 | 0.0411 | 0.0131 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0021 | 0.0411 | 0.1157 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0021 | 0.0411 | 0.1157 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0032 | 0.129 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0021 | 0.0411 | 0.0119 |
Schistosoma mansoni | coup transcription factor | 0.0021 | 0.0411 | 0.0411 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0032 | 0.129 | 0.1131 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0021 | 0.0411 | 0.1157 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0032 | 0.129 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0021 | 0.0411 | 0.1157 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0021 | 0.0411 | 0.1157 |
Leishmania major | p450 reductase, putative | 0.0032 | 0.129 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0032 | 0.129 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0032 | 0.129 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0411 | 0.1157 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0021 | 0.0411 | 0.0131 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0021 | 0.0411 | 0.1157 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0021 | 0.0411 | 0.1157 |
Echinococcus granulosus | FTZ F1 alpha | 0.0021 | 0.0411 | 0.0119 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0138 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0021 | 0.0411 | 0.1157 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0032 | 0.129 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0021 | 0.0411 | 0.1157 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0021 | 0.0411 | 0.0411 |
Schistosoma mansoni | thyroid hormone receptor | 0.0021 | 0.0411 | 0.0411 |
Schistosoma mansoni | thyroid hormone receptor | 0.0021 | 0.0411 | 0.0411 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0021 | 0.0411 | 0.0119 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0032 | 0.129 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0411 | 0.1157 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0021 | 0.0411 | 0.0411 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0021 | 0.0411 | 0.1157 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0411 | 0.1157 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0032 | 0.129 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0032 | 0.129 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0032 | 0.129 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0032 | 0.129 | 0.1131 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0032 | 0.129 | 0.1025 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0021 | 0.0411 | 0.0119 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0021 | 0.0411 | 0.0411 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0021 | 0.0411 | 0.0411 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0021 | 0.0411 | 0.1157 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0021 | 0.0411 | 0.0131 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0032 | 0.129 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0021 | 0.0411 | 0.1157 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0411 | 0.1157 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0021 | 0.0411 | 0.1157 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0021 | 0.0411 | 0.1157 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0021 | 0.0411 | 0.0411 |
Chlamydia trachomatis | sulfite reductase | 0.002 | 0.0296 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | = 263 uM | In vitro cytotoxicity against mock infected MT-4 cells. | ChEMBL. | 10377217 |
CC50 (functional) | = 263 uM | In vitro cytotoxicity against mock infected MT-4 cells. | ChEMBL. | 10377217 |
IF (binding) | = 0.151 | Inhibition factor for Pneumocystis carinii Thymidylate synthase at 27 uM. | ChEMBL. | 10377217 |
IF (binding) | = 0.576 | Inhibition factor for Cryptococcus Thymidylate synthase at 27 uM. | ChEMBL. | 10377217 |
IF (binding) | = 0.781 | Inhibition factor for Lactobacillus casei Thymidylate synthase at 27 uM. | ChEMBL. | 10377217 |
IF (binding) | = 0.957 | Inhibition factor for Human Thymidylate synthase at 27 uM. | ChEMBL. | 10377217 |
IF (binding) | = 0.151 | Inhibition factor for Pneumocystis carinii Thymidylate synthase at 27 uM. | ChEMBL. | 10377217 |
IF (binding) | = 0.576 | Inhibition factor for Cryptococcus Thymidylate synthase at 27 uM. | ChEMBL. | 10377217 |
IF (binding) | = 0.781 | Inhibition factor for Lactobacillus casei Thymidylate synthase at 27 uM. | ChEMBL. | 10377217 |
IF (binding) | = 0.957 | Inhibition factor for Human Thymidylate synthase at 27 uM. | ChEMBL. | 10377217 |
Ki (binding) | = 104.7 uM | In vitro inhibition of Lactobacillus casei Thymidylate synthase. | ChEMBL. | 10377217 |
Ki (binding) | = 104.7 uM | In vitro inhibition of Lactobacillus casei Thymidylate synthase. | ChEMBL. | 10377217 |
MGC (functional) | = 263 uM | In vitro minimum concentration for germicidal effect on Streptococcus. | ChEMBL. | 10377217 |
MIC (functional) | > 18.7 uM | In vitro inhibition of Cryptococcus neoformans growth. | ChEMBL. | 10377217 |
MIC (functional) | > 18.7 uM | In vitro inhibition of Cryptococcus neoformans growth. | ChEMBL. | 10377217 |
MIC (functional) | = 171 uM | In vitro inhibition of Streptococcus growth. | ChEMBL. | 10377217 |
MIC (functional) | > 263 uM | In vitro inhibition of Stapylococcus aureus growth. | ChEMBL. | 10377217 |
SI (functional) | = 1.5 | Ratio of cytotoxic concentration to that of minimum inhibitory concentration against Steptococcus (CC50/MIC50). | ChEMBL. | 10377217 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.