TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 349.855 | Formula: C18H24ClN3O2
H donors: 0 H acceptors: 3 LogP: 4.36 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CCCCN(C(=O)Cc1onc(n1)c1ccc(cc1)Cl)CCCC
InChi: 1S/C18H24ClN3O2/c1-3-5-11-22(12-6-4-2)17(23)13-16-20-18(21-24-16)14-7-9-15(19)10-8-14/h7-10H,3-6,11-13H2,1-2H3
InChiKey: IQXAELMGXYMGIT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Peripheral-type benzodiazepine receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129542	All targets in OG5_129542
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129542	All targets in OG5_129542
Mycobacterium ulcerans	tryptophan-rich sensory protein	Get druggable targets OG5_129542	All targets in OG5_129542
Onchocerca volvulus		Get druggable targets OG5_129542	All targets in OG5_129542
Schistosoma mansoni	peripheral-type benzodiazepine receptor	Get druggable targets OG5_129542	All targets in OG5_129542
Echinococcus multilocularis	translocator protein	Get druggable targets OG5_129542	All targets in OG5_129542
Onchocerca volvulus		Get druggable targets OG5_129542	All targets in OG5_129542
Onchocerca volvulus		Get druggable targets OG5_129542	All targets in OG5_129542
Brugia malayi	TspO/MBR family protein	Get druggable targets OG5_129542	All targets in OG5_129542
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129542	All targets in OG5_129542
Echinococcus granulosus	translocator protein	Get druggable targets OG5_129542	All targets in OG5_129542
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129542	All targets in OG5_129542
Onchocerca volvulus		Get druggable targets OG5_129542	All targets in OG5_129542

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Onchocerca volvulus		Peripheral-type benzodiazepine receptor	169 aa	156 aa	25.6 %
Echinococcus granulosus	vacuolar h atpase	Peripheral-type benzodiazepine receptor	169 aa	137 aa	25.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Wolbachia endosymbiont of Brugia malayi	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0197	0.1123	1
Mycobacterium tuberculosis	Probable dehydrogenase	0.0109	0.0578	0.0838
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0121	0.0653	0.012
Trichomonas vaginalis	conserved hypothetical protein	0.0066	0.0313	0.0448
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0084	0.2522
Trichomonas vaginalis	glucosylceramidase, putative	0.0189	0.1075	0.1568
Plasmodium vivax	PST-A protein	0.0066	0.0313	0.0448
Toxoplasma gondii	hypothetical protein	0.0066	0.0313	1
Plasmodium falciparum	prodrug activation and resistance esterase	0.0066	0.0313	0.0448
Trypanosoma cruzi	serine peptidase, putative	0.0066	0.0313	0.0448
Loa Loa (eye worm)	transcription factor SMAD2	0.012	0.0649	0.0649
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.1118	0.6813	1
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0066	0.0313	0.0448
Plasmodium vivax	SET domain protein, putative	0.0029	0.0084	0.0113
Plasmodium vivax	lysophospholipase, putative	0.0066	0.0313	0.0448
Chlamydia trachomatis	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0197	0.1123	1
Echinococcus granulosus	intermediate filament protein	0.0026	0.0067	0.0067
Echinococcus granulosus	tissue type plasminogen activator	0.002	0.0027	0.0027
Trypanosoma brucei	Alpha/beta hydrolase family, putative	0.0066	0.0313	0.0448
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0121	0.0653	0.0948
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0202	0.1154	0.1154
Leishmania major	hypothetical protein, conserved	0.0066	0.0313	0.0448
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0019	0.0023	0.0023
Echinococcus granulosus	lamin	0.0026	0.0067	0.0067
Trypanosoma brucei	monoglyceride lipase, putative	0.1118	0.6813	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.0048	0.0202	0.0202
Echinococcus granulosus	abhydrolase domain containing 3	0.0066	0.0313	0.0313
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0066	0.0313	0.0448
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0053	0.0235	0.0235
Trypanosoma cruzi	hypothetical protein, conserved	0.002	0.0027	0.0029
Trypanosoma brucei	Alpha/beta hydrolase family, putative	0.0066	0.0313	0.0448
Trichomonas vaginalis	conserved hypothetical protein	0.1118	0.6813	1
Treponema pallidum	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0197	0.1123	1
Brugia malayi	putative amidase	0.0197	0.1123	0.1123
Echinococcus multilocularis	tissue type plasminogen activator	0.002	0.0027	0.0027
Plasmodium falciparum	lysophospholipase, putative	0.1118	0.6813	1
Onchocerca volvulus		0.0026	0.0067	0.0215
Toxoplasma gondii	thioredoxin reductase	0.0048	0.02	0.6312
Trypanosoma cruzi	Alpha/beta hydrolase family, putative	0.0066	0.0313	0.0448
Echinococcus multilocularis	lamin dm0	0.0026	0.0067	0.0067
Leishmania major	Bem46-like serine peptidase,Serine peptidase, Clan SC, Family S09X	0.0066	0.0313	0.0448
Trichomonas vaginalis	valacyclovir hydrolase, putative	0.1118	0.6813	1
Brugia malayi	hypothetical protein	0.013	0.0708	0.0708
Brugia malayi	TspO/MBR family protein	0.0322	0.1894	0.1894
Loa Loa (eye worm)	bromodomain containing protein	0.002	0.0027	0.0027
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0061	0.028	0.028
Trichomonas vaginalis	conserved hypothetical protein	0.0066	0.0313	0.0448
Trichomonas vaginalis	set domain proteins, putative	0.023	0.1326	0.1938
Toxoplasma gondii	esterase/lipase/thioesterase domain-containing protein	0.0066	0.0313	1
Plasmodium vivax	PST-A protein	0.0066	0.0313	0.0448
Plasmodium vivax	unspecified product	0.0066	0.0313	0.0448
Loa Loa (eye worm)	MBCTL1	0.0061	0.028	0.028
Mycobacterium ulcerans	peptide amidase, GatA	0.0197	0.1123	0.1639
Echinococcus granulosus	fetal alzheimer antigen falz	0.0025	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0061	0.028	0.028
Plasmodium falciparum	esterase, putative	0.0066	0.0313	0.0448
Mycobacterium leprae	POSSIBLE LYSOPHOSPHOLIPASE	0.1118	0.6813	1
Trypanosoma cruzi	amidase, putative	0.0197	0.1123	0.1639
Brugia malayi	Bromodomain containing protein	0.0043	0.017	0.017
Trypanosoma brucei	Serine peptidase, Clan SC, Family S09X	0.0066	0.0313	0.0448
Echinococcus granulosus	zinc finger protein	0.0022	0.004	0.004
Schistosoma mansoni	sex comb on midleg homolog	0.0053	0.0235	0.0235
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0061	0.028	0.028
Brugia malayi	Protein C20orf22	0.0066	0.0313	0.0313
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0019	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0393	0.0393
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0109	0.0578	0.0838
Onchocerca volvulus		0.0322	0.1894	1
Mycobacterium tuberculosis	Possible amidase (aminohydrolase)	0.0197	0.1123	0.1639
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0067	0.0317	0.0317
Plasmodium falciparum	epoxide hydrolase 2	0.0066	0.0313	0.0448
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0048	0.0202	0.0202
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.1118	0.6813	1
Brugia malayi	mbt repeat family protein	0.0053	0.0235	0.0235
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.1118	0.6813	1
Leishmania major	hypothetical protein, conserved	0.0197	0.1123	0.1639
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0187	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0313	0.0313
Brugia malayi	Amidase family protein	0.0197	0.1123	0.1123
Plasmodium vivax	PST-A protein	0.1118	0.6813	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0289	0.1688	0.2469
Plasmodium falciparum	esterase, putative	0.0066	0.0313	0.0448
Echinococcus granulosus	fatty acid amide hydrolase 1	0.1634	1	1
Plasmodium vivax	thioredoxin reductase, putative	0.0048	0.02	0.0283
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0197	0.1123	0.1123
Mycobacterium ulcerans	hypothetical protein	0.1118	0.6813	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0204	0.0204
Plasmodium falciparum	BEM46-like protein, putative	0.0066	0.0313	0.0448
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0061	0.028	0.028
Toxoplasma gondii	hypothetical protein	0.0066	0.0313	1
Trypanosoma brucei	fatty-acid amide hydrolase, putative	0.0197	0.1123	0.1639
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.004	0.0153	0.0153
Schistosoma mansoni	zinc finger protein	0.0017	0.0011	0.0011
Brugia malayi	Protein kinase domain containing protein	0.002	0.0027	0.0027
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.021	0.1203	0.1203
Trichomonas vaginalis	glucosylceramidase, putative	0.0289	0.1688	0.2469
Trypanosoma cruzi	Serine peptidase, Clan SC, Family S09X, putative	0.0066	0.0313	0.0448
Trichomonas vaginalis	glucosylceramidase, putative	0.0189	0.1075	0.1568
Toxoplasma gondii	peptidase S15, putative	0.0066	0.0313	1
Mycobacterium ulcerans	lysophospholipase	0.1118	0.6813	1
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0067	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0235	0.0235
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.1118	0.6813	1
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.1118	0.6813	1
Echinococcus granulosus	histone acetyltransferase MYST2	0.0061	0.028	0.028
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0048	0.02	0.02
Plasmodium falciparum	lysophospholipase, putative	0.0066	0.0313	0.0448
Mycobacterium ulcerans	hypothetical protein	0.0066	0.0313	0.0448
Plasmodium vivax	alpha/beta hydrolase, putative	0.0066	0.0313	0.0448
Loa Loa (eye worm)	hypothetical protein	0.1634	1	1
Brugia malayi	Pre-SET motif family protein	0.0202	0.1154	0.1154
Trypanosoma cruzi	hydrolase, alpha/beta fold family, putative	0.0066	0.0313	0.0448
Leishmania major	hypothetical protein, conserved	0.002	0.0027	0.0029
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0066	0.0313	0.0448
Schistosoma mansoni	peripheral-type benzodiazepine receptor	0.0322	0.1894	0.1894
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0289	0.1688	0.1688
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0109	0.0578	0.0838
Toxoplasma gondii	hypothetical protein	0.0066	0.0313	1
Mycobacterium ulcerans	amidase	0.0197	0.1123	0.1639
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0019	0.0023	0.0023
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0109	0.0578	0.0838
Schistosoma mansoni	hypothetical protein	0.002	0.0027	0.0027
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0048	0.0202	0.0202
Plasmodium falciparum	thioredoxin reductase	0.0048	0.02	0.0283
Plasmodium falciparum	lysophospholipase, putative	0.1118	0.6813	1
Mycobacterium ulcerans	amidase	0.0197	0.1123	0.1639
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0221	0.0221
Mycobacterium ulcerans	tryptophan-rich sensory protein	0.0322	0.1894	0.2771
Plasmodium falciparum	lysophospholipase, putative	0.1118	0.6813	1
Toxoplasma gondii	phospholipase/carboxylesterase	0.0066	0.0313	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.011	0.011
Mycobacterium tuberculosis	Probable oxidoreductase	0.0121	0.0653	0.0948
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.004	0.0153	0.0153
Toxoplasma gondii	protein c14orf29, putative	0.0066	0.0313	1
Trichomonas vaginalis	conserved hypothetical protein	0.0066	0.0313	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0067	0.0067
Loa Loa (eye worm)	glutathione reductase	0.0048	0.02	0.02
Mycobacterium ulcerans	amidase	0.0197	0.1123	0.1639
Mycobacterium leprae	PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A)	0.0197	0.1123	0.0875
Schistosoma mansoni	fatty-acid amide hydrolase	0.1634	1	1
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0017	0.0008	0.0008
Trypanosoma cruzi	amidase, putative	0.0197	0.1123	0.1639
Mycobacterium tuberculosis	Probable amidase AmiB2 (aminohydrolase)	0.0197	0.1123	0.1639
Trypanosoma brucei	ISWI complex protein	0.0017	0.0011	0.0005
Mycobacterium ulcerans	hydrolase	0.0066	0.0313	0.0448
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0025	0.0061	0.0061
Trichomonas vaginalis	conserved hypothetical protein	0.1118	0.6813	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0051	0.0221	0.0221
Trichomonas vaginalis	glucosylceramidase, putative	0.02	0.1138	0.1661
Trichomonas vaginalis	glucosylceramidase, putative	0.0189	0.1075	0.1568
Trichomonas vaginalis	conserved hypothetical protein	0.0066	0.0313	0.0448
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0221	0.0221
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0197	0.1123	0.1123
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0121	0.0653	0.0948
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.1118	0.6813	1
Loa Loa (eye worm)	PHD-finger family protein	0.0023	0.0048	0.0048
Toxoplasma gondii	hydrolase, alpha/beta fold family protein	0.0066	0.0313	1
Echinococcus multilocularis	abhydrolase domain containing 3	0.0066	0.0313	0.0313
Onchocerca volvulus		0.0322	0.1894	1
Brugia malayi	Kringle domain containing protein	0.002	0.0027	0.0027
Onchocerca volvulus		0.0029	0.0084	0.0308
Loa Loa (eye worm)	TK/ROR protein kinase	0.002	0.0027	0.0027
Schistosoma mansoni	hypothetical protein	0.0017	0.0011	0.0011
Leishmania major	hypothetical protein, conserved	0.0017	0.0011	0.0005
Loa Loa (eye worm)	hypothetical protein	0.002	0.0027	0.0027
Brugia malayi	mbt repeat family protein	0.0053	0.0235	0.0235
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0064	0.0064
Echinococcus multilocularis	transient receptor potential cation channel	0.066	0.3982	0.3982
Trichomonas vaginalis	glucosylceramidase, putative	0.0289	0.1688	0.2469
Loa Loa (eye worm)	amidase	0.0197	0.1123	0.1123
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0025	0.0061	0.0061
Mycobacterium tuberculosis	Possible lysophospholipase	0.1118	0.6813	1
Leishmania major	monoglyceride lipase, putative	0.1118	0.6813	1
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0053	0.0235	0.0235
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.0066	0.0313	0.0448
Brugia malayi	Amidase family protein	0.0197	0.1123	0.1123
Schistosoma mansoni	amidase	0.1634	1	1
Echinococcus granulosus	transient receptor potential cation channel	0.0659	0.3976	0.3976
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0017	0.0008	0.0008
Trypanosoma cruzi	Alpha/beta hydrolase family, putative	0.0066	0.0313	0.0448
Trichomonas vaginalis	conserved hypothetical protein	0.0066	0.0313	0.0448
Brugia malayi	glutathione reductase	0.0048	0.02	0.02
Plasmodium falciparum	exported lipase 2	0.0066	0.0313	0.0448
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0221	0.0221
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0221	0.0221
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0078	0.0078
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0204	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0313	0.0313
Echinococcus multilocularis	Phospholipase carboxylesterase	0.0066	0.0313	0.0313
Echinococcus multilocularis	musashi	0.0026	0.0067	0.0067
Echinococcus multilocularis	polycomb protein SCMH1	0.0053	0.0235	0.0235
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0053	0.0235	0.1112
Plasmodium falciparum	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0197	0.1123	0.1639
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0061	0.028	0.028
Onchocerca volvulus		0.0231	0.1332	0.6993
Brugia malayi	Pre-SET motif family protein	0.0029	0.0084	0.0084
Echinococcus multilocularis	ankyrin repeat protein	0.0647	0.39	0.39
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.002	0.0027	0.0029
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.0066	0.0313	0.0448
Mycobacterium leprae	PROBABLE AMIDASE AMIC (AMINOHYDROLASE)	0.0197	0.1123	0.0875
Brugia malayi	Bromodomain containing protein	0.0084	0.0423	0.0423
Schistosoma mansoni	family S9 unassigned peptidase (S09 family)	0.0066	0.0313	0.0313
Plasmodium vivax	hypothetical protein, conserved	0.0066	0.0313	0.0448
Leishmania major	hypothetical protein, conserved	0.0066	0.0313	0.0448
Trichomonas vaginalis	glucosylceramidase, putative	0.0189	0.1075	0.1568
Trichomonas vaginalis	glucosylceramidase, putative	0.0289	0.1688	0.2469
Brugia malayi	intermediate filament protein	0.0026	0.0067	0.0067
Trypanosoma cruzi	monoglyceride lipase, putative	0.1118	0.6813	1
Schistosoma mansoni	transient receptor potential cation channel subfamily A member	0.0647	0.39	0.39
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0221	0.0221
Trypanosoma brucei	trypanothione reductase	0.0048	0.02	0.0283
Plasmodium falciparum	cysteine repeat modular protein 1	0.002	0.0027	0.0029
Schistosoma mansoni	family S9 unassigned peptidase (S09 family)	0.0066	0.0313	0.0313
Echinococcus granulosus	SAM and MBT domain containing protein	0.0053	0.0235	0.0235
Echinococcus multilocularis	glutamyl tRNA(Gln) amidotransferase subunit A	0.0197	0.1123	0.1123
Onchocerca volvulus		0.0322	0.1894	1
Schistosoma mansoni	zinc finger protein	0.0022	0.004	0.004
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0017	0.0008	0.0008
Trichomonas vaginalis	glucosylceramidase, putative	0.0289	0.1688	0.2469
Echinococcus multilocularis	lamin	0.0026	0.0067	0.0067
Onchocerca volvulus		0.0322	0.1894	1
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0048	0.02	0.0283
Chlamydia trachomatis	acyltransferase family protein	0.0066	0.0313	0.2735
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0204	0.0204
Echinococcus multilocularis	zinc finger protein	0.0022	0.004	0.004
Loa Loa (eye worm)	amidase	0.0197	0.1123	0.1123
Chlamydia trachomatis	hydrolase	0.0066	0.0313	0.2735
Mycobacterium ulcerans	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0197	0.1123	0.1639
Mycobacterium tuberculosis	Probable amidase AmiA2 (aminohydrolase)	0.0197	0.1123	0.1639
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0067	0.0317	0.0317
Toxoplasma gondii	hydrolase, alpha/beta fold family protein	0.0066	0.0313	1
Trypanosoma cruzi	serine peptidase, putative	0.0066	0.0313	0.0448
Brugia malayi	PHD-finger family protein	0.0028	0.0077	0.0077
Mycobacterium ulcerans	amidase	0.0197	0.1123	0.1639
Plasmodium vivax	lysophospholipase, putative	0.0066	0.0313	0.0448
Trichomonas vaginalis	glucosylceramidase, putative	0.02	0.1138	0.1661
Echinococcus granulosus	monoacylglycerol lipase abhd12	0.0066	0.0313	0.0313
Trypanosoma brucei	monoglyceride lipase, putative	0.1118	0.6813	1
Mycobacterium tuberculosis	Probable reductase	0.0109	0.0578	0.0838
Schistosoma mansoni	hypothetical protein	0.0033	0.011	0.011
Plasmodium falciparum	esterase, putative	0.1118	0.6813	1
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0066	0.0313	0.0448
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0221	0.0221
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.021	0.1203	0.1203
Brugia malayi	MGC83647 protein	0.0066	0.0313	0.0313
Brugia malayi	MH2 domain containing protein	0.012	0.0649	0.0649
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0289	0.1688	0.1688
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0066	0.0313	0.0448
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0084	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0313	0.0313
Trypanosoma cruzi	ISWI complex protein	0.0017	0.0011	0.0005
Echinococcus granulosus	lamin dm0	0.0026	0.0067	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0313	0.0313
Trichomonas vaginalis	conserved hypothetical protein	0.0066	0.0313	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0322	0.1894	0.1894
Toxoplasma gondii	hypothetical protein	0.0066	0.0313	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.02	0.02
Trichomonas vaginalis	conserved hypothetical protein	0.0066	0.0313	0.0448
Toxoplasma gondii	phospholipase	0.0066	0.0313	1
Schistosoma mansoni	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0197	0.1123	0.1123
Loa Loa (eye worm)	hypothetical protein	0.0322	0.1894	0.1894
Trypanosoma cruzi	trypanothione reductase, putative	0.0048	0.02	0.0283
Loa Loa (eye worm)	mbt repeat family protein	0.0053	0.0235	0.0235
Plasmodium vivax	hypothetical protein, conserved	0.0066	0.0313	0.0448
Onchocerca volvulus	Glucosylceramidase homolog	0.0189	0.1075	0.5613
Plasmodium vivax	PST-A protein	0.0066	0.0313	0.0448
Plasmodium vivax	lysophospholipase, putative	0.0066	0.0313	0.0448
Plasmodium falciparum	lysophospholipase, putative	0.0066	0.0313	0.0448
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0066	0.0313	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0204	0.0204
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0221	0.0221
Schistosoma mansoni	hypothetical protein	0.0023	0.0048	0.0048
Echinococcus granulosus	abhydrolase domain containing protein 13	0.0066	0.0313	0.0313
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0313	0.0313
Schistosoma mansoni	bromodomain containing protein	0.0071	0.0342	0.0342
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.0066	0.0313	0.0448
Schistosoma mansoni	lamin	0.0026	0.0067	0.0067
Mycobacterium ulcerans	hypothetical protein	0.0066	0.0313	0.0448
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0017	0.0008	0.0008
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0109	0.0578	0.0838
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.1118	0.6813	1
Plasmodium vivax	glutathione reductase, putative	0.0048	0.02	0.0283
Plasmodium falciparum	glutathione reductase	0.0048	0.02	0.0283
Loa Loa (eye worm)	MH2 domain-containing protein	0.012	0.0649	0.0649
Plasmodium vivax	hypothetical protein, conserved	0.0066	0.0313	0.0448
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0067	0.0067
Onchocerca volvulus		0.0053	0.0235	0.1112
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0084	0.0084
Schistosoma mansoni	sex comb on midleg homolog	0.0053	0.0235	0.0235
Plasmodium falciparum	exported lipase 1	0.0066	0.0313	0.0448
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0066	0.0313	0.0448
Echinococcus granulosus	polycomb protein SCMH1	0.0053	0.0235	0.0235
Echinococcus granulosus	glutamyl tRNAGln amidotransferase subunit A	0.0197	0.1123	0.1123
Trichomonas vaginalis	conserved hypothetical protein	0.0066	0.0313	0.0448
Toxoplasma gondii	kringle domain-containing protein	0.002	0.0027	0.0639
Loa Loa (eye worm)	hypothetical protein	0.0043	0.017	0.017
Echinococcus multilocularis	translocator protein	0.0322	0.1894	0.1894
Plasmodium falciparum	alpha/beta-hydrolase, putative	0.0066	0.0313	0.0448
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0051	0.0221	0.0221
Echinococcus granulosus	ankyrin repeat protein	0.0647	0.39	0.39
Plasmodium vivax	PST-A protein	0.0066	0.0313	0.0448
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0084	0.0084
Brugia malayi	Thioredoxin reductase	0.0048	0.02	0.02
Mycobacterium ulcerans	amidase	0.0197	0.1123	0.1639
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0067	0.0067
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.1634	1	1
Mycobacterium tuberculosis	Probable amidase AmiC (aminohydrolase)	0.0197	0.1123	0.1639
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0048	0.0202	0.0202
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0067	0.0067
Plasmodium vivax	glutamyl-tRNA(Gln) amidotransferase subunit A, putative	0.0197	0.1123	0.1639
Brugia malayi	MGC79044 protein	0.0066	0.0313	0.0313
Trichomonas vaginalis	glucosylceramidase, putative	0.0189	0.1075	0.1568
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.0066	0.0313	0.0448
Onchocerca volvulus		0.0026	0.0067	0.0215
Plasmodium vivax	PST-A protein	0.0066	0.0313	0.0448
Plasmodium vivax	unspecified product	0.0066	0.0313	0.0448
Echinococcus granulosus	Phospholipase carboxylesterase	0.0066	0.0313	0.0313
Plasmodium falciparum	alpha/beta hydrolase fold domain containing protein, putative	0.0066	0.0313	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0322	0.1894	0.1894
Echinococcus granulosus	translocator protein	0.0322	0.1894	0.1894
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0066	0.0313	0.0448
Schistosoma mansoni	fatty-acid amide hydrolase	0.0197	0.1123	0.1123
Echinococcus granulosus	fatty acid amide hydrolase 1	0.1634	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0066	0.0313	0.0448
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0061	0.028	0.028
Trichomonas vaginalis	glucosylceramidase, putative	0.0289	0.1688	0.2469
Trichomonas vaginalis	glucosylceramidase, putative	0.0189	0.1075	0.1568
Trypanosoma cruzi	ISWI complex protein	0.0017	0.0011	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0202	0.0202
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.1634	1	1
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0066	0.0313	0.0448
Mycobacterium tuberculosis	Probable amidase AmiD (acylamidase) (acylase)	0.0197	0.1123	0.1639
Echinococcus multilocularis	monoacylglycerol lipase abhd12	0.0066	0.0313	0.0313
Loa Loa (eye worm)	thioredoxin reductase	0.0048	0.02	0.02
Schistosoma mansoni	hypothetical protein	0.0324	0.1907	0.1907
Echinococcus granulosus	thioredoxin glutathione reductase	0.0048	0.02	0.02
Leishmania major	trypanothione reductase	0.0048	0.02	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0322	0.1894	0.1894
Trichomonas vaginalis	glucosylceramidase, putative	0.0189	0.1075	0.1568
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0019	0.0023	0.0023
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.0066	0.0313	0.0448
Plasmodium vivax	alpha/beta hydrolase, putative	0.0066	0.0313	0.0448
Schistosoma mansoni	peptidase	0.0066	0.0313	0.0313
Trypanosoma cruzi	Alpha/beta hydrolase family, putative	0.0066	0.0313	0.0448
Giardia lamblia	Cgi67 serine protease precursor-like protein	0.0066	0.0313	1
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0066	0.0313	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0033	0.011	0.011
Schistosoma mansoni	lamin	0.0026	0.0067	0.0067

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 267 nM	Displacement of [3H]PK11195 from TSPO receptor in rat kidney membranes	ChEMBL.	21824692

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1830747

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1110530