Detailed information for compound 1110546

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 383.464 | Formula: C20H21N3O3S
  • H donors: 0 H acceptors: 3 LogP: 4.27 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OC)C(=O)CSc1cnnn1c1ccc(cc1C)C
  • InChi: 1S/C20H21N3O3S/c1-13-5-7-16(14(2)9-13)23-20(11-21-22-23)27-12-17(24)15-6-8-18(25-3)19(10-15)26-4/h5-11H,12H2,1-4H3
  • InChiKey: KIHMDGFVVCGYHU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens hydroxysteroid (11-beta) dehydrogenase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans short chain dehydrogenase Get druggable targets OG5_132866 All targets in OG5_132866
Mycobacterium tuberculosis Probable oxidoreductase Get druggable targets OG5_132866 All targets in OG5_132866
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum steroid dehydrogenase, putative hydroxysteroid (11-beta) dehydrogenase 1 292 aa 250 aa 24.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax alpha/beta hydrolase, putative 0.0066 0.0239 0.0352
Trypanosoma cruzi cysteine peptidase, putative 0.0204 0.1098 0.1617
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0162 0.0238
Toxoplasma gondii cathepsin CPL 0.0054 0.0162 0.2542
Mycobacterium leprae PROBABLE AMIDASE AMIC (AMINOHYDROLASE) 0.0197 0.1055 0.1477
Schistosoma mansoni peptidase 0.0066 0.0239 0.0239
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0162 0.0238
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.021 0.021
Leishmania major cathepsin L-like protease 0.0054 0.0162 0.0149
Mycobacterium tuberculosis Conserved protein 0.0039 0.0071 0.0062
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0071 0.0062
Loa Loa (eye worm) latrophilin receptor protein 2 0.0082 0.0341 0.0291
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.1118 0.6789 1
Plasmodium falciparum alpha/beta-hydrolase, putative 0.0066 0.0239 0.0352
Leishmania major hypothetical protein, conserved 0.0197 0.1055 0.1477
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0054 0.0162 0.0238
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0088 0.0375 0.0553
Brugia malayi AMP-binding enzyme family protein 0.0127 0.0622 0.0622
Plasmodium falciparum exported lipase 1 0.0066 0.0239 0.0352
Schistosoma mansoni hypothetical protein 0.0082 0.0341 0.0341
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0197 0.1055 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.0985 0.1451
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0162 0.0238
Echinococcus granulosus fatty acid amide hydrolase 1 0.0197 0.1055 0.1055
Loa Loa (eye worm) hypothetical protein 0.0039 0.0071 0.002
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0197 0.1055 0.1055
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0037 0.0061 0.009
Mycobacterium leprae PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) 0.0197 0.1055 0.1477
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0162 0.0238
Entamoeba histolytica acyl-CoA synthetase, putative 0.0127 0.0622 0.0916
Mycobacterium ulcerans hypothetical protein 0.0127 0.0622 0.0833
Mycobacterium ulcerans peptide amidase, GatA 0.0197 0.1055 0.1477
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.0066 0.0239 0.0352
Trypanosoma cruzi cysteine peptidase, putative 0.0204 0.1098 0.1617
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0066 0.0239 0.0352
Echinococcus multilocularis fatty acid amide hydrolase 1 0.1634 1 1
Echinococcus multilocularis GPCR, family 2 0.0082 0.0341 0.0341
Echinococcus multilocularis cathepsin L cysteine protease 0.0054 0.0162 0.0162
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0066 0.0239 0.0352
Echinococcus multilocularis ankyrin repeat protein 0.1217 0.7406 0.7406
Plasmodium vivax acetyl-CoA synthetase, putative 0.0037 0.0061 0.009
Loa Loa (eye worm) hypothetical protein 0.0037 0.0061 0.001
Mycobacterium ulcerans aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0197 0.1055 0.1477
Onchocerca volvulus 0.0061 0.021 0.0563
Loa Loa (eye worm) amidase 0.0197 0.1055 0.1009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0162 0.0238
Loa Loa (eye worm) hypothetical protein 0.0054 0.0162 0.0111
Mycobacterium tuberculosis Possible lysophospholipase 0.1118 0.6789 1
Onchocerca volvulus Cathepsin F homolog 0.0054 0.0162 0.0392
Echinococcus multilocularis Phospholipase carboxylesterase 0.0066 0.0239 0.0239
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0162 0.0238
Brugia malayi MH2 domain containing protein 0.0131 0.0643 0.0643
Loa Loa (eye worm) hypothetical protein 0.0107 0.0493 0.0444
Plasmodium falciparum lysophospholipase, putative 0.1118 0.6789 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0338 0.1932 0.2816
Onchocerca volvulus 0.0054 0.0162 0.0392
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0239 0.0352
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0239 0.0352
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0127 0.0622 0.0833
Brugia malayi Cathepsin L-like precursor 0.0054 0.0162 0.0162
Onchocerca volvulus 0.0127 0.0622 0.2028
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.021 0.021
Brugia malayi Protein C20orf22 0.0066 0.0239 0.0239
Mycobacterium ulcerans hydrolase 0.0066 0.0239 0.0264
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0071 0.0062
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.1118 0.6789 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0104 0.0104
Mycobacterium ulcerans lipase LipD 0.0039 0.0071 0.0015
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0197 0.1055 0.1554
Brugia malayi Cathepsin L-like precursor 0.0036 0.0051 0.0051
Plasmodium falciparum acyl-CoA synthetase 0.0095 0.0421 0.062
Plasmodium vivax hypothetical protein, conserved 0.0066 0.0239 0.0352
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0037 0.0061 0.0048
Entamoeba histolytica hypothetical protein 0.0066 0.0239 0.0352
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0037 0.0061 0.009
Mycobacterium tuberculosis Probable amidase AmiA2 (aminohydrolase) 0.0197 0.1055 0.1518
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0427 0.2487 0.2448
Plasmodium vivax vivapain-2 0.0054 0.0162 0.0238
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0296 0.1668 0.2458
Echinococcus multilocularis tar DNA binding protein 0.041 0.238 0.238
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.021 0.021
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0625 0.3716 0.5474
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.009 0.0389 0.0532
Mycobacterium ulcerans hypothetical protein 0.0039 0.0071 0.0015
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0066 0.0239 0.0352
Plasmodium vivax lysophospholipase, putative 0.0066 0.0239 0.0352
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.1118 0.6789 1
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0071 0.0105
Brugia malayi AMP-binding enzyme family protein 0.0127 0.0622 0.0622
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0239 0.0352
Toxoplasma gondii hypothetical protein 0.0066 0.0239 0.4499
Leishmania major cathepsin L-like protease 0.0204 0.1098 0.154
Brugia malayi AMP-binding enzyme family protein 0.0037 0.0061 0.0061
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0162 0.0238
Mycobacterium leprae Probable lipase LipE 0.0039 0.0071 0.0015
Loa Loa (eye worm) transcription factor SMAD2 0.0131 0.0643 0.0595
Echinococcus granulosus tar DNA binding protein 0.041 0.238 0.238
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.1591 0.2343
Toxoplasma gondii phospholipase/carboxylesterase 0.0066 0.0239 0.4499
Trichomonas vaginalis valacyclovir hydrolase, putative 0.1118 0.6789 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0066 0.0239 0.031
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0071 0.002
Toxoplasma gondii phospholipase 0.0066 0.0239 0.4499
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0082 0.0341 0.0341
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0162 0.0238
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.009 0.0389 0.0532
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.021 0.021
Plasmodium vivax PST-A protein 0.0066 0.0239 0.0352
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0071 0.0105
Plasmodium vivax PST-A protein 0.0066 0.0239 0.0352
Onchocerca volvulus Cathepsin L homolog 0.0054 0.0162 0.0392
Brugia malayi Cathepsin L-like precursor 0.0054 0.0162 0.0162
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0037 0.0061 0.0061
Toxoplasma gondii peptidase S15, putative 0.0066 0.0239 0.4499
Brugia malayi RNA binding protein 0.041 0.238 0.238
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0104 0.0104
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0204 0.1098 0.1617
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0197 0.1055 0.1055
Mycobacterium ulcerans hypothetical protein 0.0066 0.0239 0.0264
Plasmodium falciparum esterase, putative 0.0066 0.0239 0.0352
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0054 0.0162 0.0238
Brugia malayi MGC83647 protein 0.0066 0.0239 0.0239
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0197 0.1055 0.1055
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0186 0.0987 0.1455
Onchocerca volvulus 0.0042 0.009 0.0139
Echinococcus granulosus fatty acid amide hydrolase 1 0.1634 1 1
Loa Loa (eye worm) hypothetical protein 0.0214 0.1158 0.1113
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0204 0.1098 0.1617
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.1591 0.2343
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0204 0.1098 0.1617
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0204 0.1098 0.1617
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0162 0.0238
Trypanosoma cruzi amidase, putative 0.0197 0.1055 0.1554
Trypanosoma cruzi cruzipain precursor, putative 0.0204 0.1098 0.1617
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.026 0.1447 0.1447
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0127 0.0622 0.0833
Loa Loa (eye worm) hypothetical protein 0.0095 0.0421 0.0372
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0082 0.0341 0.0341
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0051 0.0076
Echinococcus granulosus cathepsin L cysteine proteinase 0.0054 0.0162 0.0162
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0239 0.0352
Loa Loa (eye worm) hypothetical protein 0.0066 0.0239 0.0188
Brugia malayi AMP-binding enzyme family protein 0.0037 0.0061 0.0061
Schistosoma mansoni acetyl-CoA synthetase 0.0037 0.0061 0.0061
Entamoeba histolytica hypothetical protein 0.0066 0.0239 0.0352
Loa Loa (eye worm) hypothetical protein 0.0061 0.021 0.0159
Plasmodium vivax hypothetical protein, conserved 0.0066 0.0239 0.0352
Mycobacterium ulcerans amidase 0.0197 0.1055 0.1477
Mycobacterium tuberculosis Probable amidase AmiC (aminohydrolase) 0.0197 0.1055 0.1518
Brugia malayi Papain family cysteine protease containing protein 0.0054 0.0162 0.0162
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0037 0.0061 0.0048
Mycobacterium ulcerans hypothetical protein 0.0066 0.0239 0.0264
Plasmodium vivax unspecified product 0.0066 0.0239 0.0352
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0066 0.0239 0.4499
Plasmodium vivax alpha/beta hydrolase, putative 0.0066 0.0239 0.0352
Entamoeba histolytica ;Alias 0.0066 0.0239 0.0352
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0204 0.1098 0.1617
Trypanosoma cruzi amidase, putative 0.0197 0.1055 0.1554
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0162 0.0238
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0071 0.0105
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.0985 0.1451
Mycobacterium ulcerans beta-lactamase 0.0039 0.0071 0.0015
Onchocerca volvulus 0.0039 0.0071 0.007
Leishmania major cathepsin L-like protease 0.0204 0.1098 0.154
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0066 0.0239 0.0352
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0239 0.0352
Mycobacterium ulcerans amidase 0.0197 0.1055 0.1477
Echinococcus granulosus geminin 0.018 0.0948 0.0948
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0037 0.0061 0.009
Trypanosoma cruzi Serine peptidase, Clan SC, Family S09X, putative 0.0066 0.0239 0.0352
Echinococcus multilocularis microtubule associated protein 2 0.0757 0.4538 0.4538
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0239 0.0352
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0071 0.0062
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0104 0.0104
Plasmodium falciparum cysteine proteinase falcipain 3 0.0054 0.0162 0.0238
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0037 0.0061 0.0048
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0037 0.0061 0.0048
Leishmania major mitochondrial DNA polymerase beta 0.0625 0.3716 0.5433
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0162 0.0238
Plasmodium falciparum alpha/beta hydrolase, putative 0.0066 0.0239 0.0352
Mycobacterium ulcerans amidase 0.0197 0.1055 0.1477
Loa Loa (eye worm) hypothetical protein 0.0095 0.0421 0.0372
Brugia malayi Cathepsin L-like precursor 0.0054 0.0162 0.0162
Loa Loa (eye worm) RNA binding protein 0.041 0.238 0.2341
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.1118 0.6789 1
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0061 0.0048
Entamoeba histolytica cysteine proteinase, putative 0.0054 0.0162 0.0238
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0082 0.0341 0.0341
Loa Loa (eye worm) TAR-binding protein 0.041 0.238 0.2341
Brugia malayi beta-lactamase 0.0039 0.0071 0.0071
Plasmodium falciparum lysophospholipase, putative 0.0066 0.0239 0.0352
Schistosoma mansoni cathepsin F (C01 family) 0.0054 0.0162 0.0162
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0071 0.0062
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.1591 0.2343
Plasmodium vivax vivapain-2 0.0054 0.0162 0.0238
Leishmania major cathepsin L-like protease 0.0204 0.1098 0.154
Loa Loa (eye worm) hypothetical protein 0.026 0.1447 0.1403
Echinococcus granulosus Phospholipase carboxylesterase 0.0066 0.0239 0.0239
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0296 0.1668 0.2458
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0066 0.0239 0.0352
Plasmodium vivax PST-A protein 0.1118 0.6789 1
Plasmodium vivax hypothetical protein, conserved 0.0066 0.0239 0.0352
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0071 0.0105
Plasmodium vivax PST-A protein 0.0066 0.0239 0.0352
Toxoplasma gondii esterase/lipase/thioesterase domain-containing protein 0.0066 0.0239 0.4499
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0104 0.0104
Brugia malayi Cathepsin L-like precursor 0.0054 0.0162 0.0162
Loa Loa (eye worm) MH2 domain-containing protein 0.0131 0.0643 0.0595
Schistosoma mansoni hypothetical protein 0.0178 0.0935 0.0935
Mycobacterium ulcerans amidase 0.0197 0.1055 0.1477
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0197 0.1055 0.1554
Onchocerca volvulus Glucosylceramidase homolog 0.0186 0.0985 0.3319
Echinococcus granulosus cathepsin l1 0.0036 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0127 0.0622 0.0573
Echinococcus granulosus neuropeptide receptor A26 0.1471 0.8987 0.8987
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0066 0.0239 0.0352
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0095 0.0421 0.0535
Plasmodium falciparum prodrug activation and resistance esterase 0.0066 0.0239 0.0352
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.1047 0.1542
Entamoeba histolytica acyl-CoA synthetase, putative 0.0127 0.0622 0.0916
Loa Loa (eye worm) hypothetical protein 0.0066 0.0239 0.0188
Echinococcus multilocularis tumor protein p63 0.0729 0.4368 0.4368
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0204 0.1098 0.1617
Loa Loa (eye worm) hypothetical protein 0.0066 0.0239 0.0188
Mycobacterium tuberculosis Conserved protein 0.0039 0.0071 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0239 0.0352
Trichomonas vaginalis antibiotic synthetase, putative 0.0037 0.0061 0.009
Leishmania major 4-coumarate:coa ligase-like protein 0.0127 0.0622 0.0833
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0071 0.0015
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0054 0.0162 0.0238
Schistosoma mansoni fatty-acid amide hydrolase 0.1634 1 1
Schistosoma mansoni amidase 0.1634 1 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0127 0.0622 0.0916
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.041 0.238 0.2341
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0239 0.0352
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0197 0.1055 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.0985 0.1451
Loa Loa (eye worm) hypothetical protein 0.0039 0.0071 0.002
Brugia malayi Latrophilin receptor protein 2 0.0082 0.0341 0.0341
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.0985 0.1451
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0162 0.0238
Onchocerca volvulus Cathepsin L homolog 0.0054 0.0162 0.0392
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0054 0.0162 0.0111
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0162 0.0238
Mycobacterium tuberculosis Conserved hypothetical protein 0.0329 0.1876 0.2733
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0037 0.0061 0.0061
Mycobacterium tuberculosis Probable amidase AmiB2 (aminohydrolase) 0.0197 0.1055 0.1518
Echinococcus granulosus tumor protein p63 0.0729 0.4368 0.4368
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.021 0.021
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.1118 0.6789 1
Trypanosoma cruzi serine peptidase, putative 0.0066 0.0239 0.0352
Trypanosoma cruzi monoglyceride lipase, putative 0.1118 0.6789 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0296 0.1668 0.2389
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0037 0.0061 0.001
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0071 0.0071
Loa Loa (eye worm) beta-lactamase 0.0039 0.0071 0.002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.009 0.0389 0.0532
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0104 0.0053
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0088 0.0375 0.0553
Trypanosoma brucei monoglyceride lipase, putative 0.1118 0.6789 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0088 0.0375 0.0553
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0071 0.0105
Schistosoma mansoni tar DNA-binding protein 0.041 0.238 0.238
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0066 0.0239 0.0352
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.1047 0.1542
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0066 0.0239 0.0188
Echinococcus multilocularis cysteine protease 0.0054 0.0162 0.0162
Plasmodium vivax PST-A protein 0.0066 0.0239 0.0352
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0104 0.0104
Brugia malayi AMP-binding enzyme family protein 0.0037 0.0061 0.0061
Trypanosoma cruzi cysteine peptidase, putative 0.0204 0.1098 0.1617
Echinococcus granulosus abhydrolase domain containing protein 13 0.0066 0.0239 0.0239
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0071 0.0105
Brugia malayi putative amidase 0.0197 0.1055 0.1055
Loa Loa (eye worm) hypothetical protein 0.0039 0.0071 0.002
Plasmodium vivax PST-A protein 0.0066 0.0239 0.0352
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0204 0.1098 0.1617
Loa Loa (eye worm) hypothetical protein 0.0095 0.0421 0.0372
Echinococcus multilocularis transient receptor potential cation channel 0.1244 0.7569 0.7569
Schistosoma mansoni cathepsin F (C01 family) 0.0054 0.0162 0.0162
Onchocerca volvulus 0.0054 0.0162 0.0392
Schistosoma mansoni hypothetical protein 0.0082 0.0341 0.0341
Echinococcus multilocularis neuropeptide receptor A26 0.1471 0.8987 0.8987
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.1591 0.2343
Brugia malayi RNA recognition motif domain containing protein 0.041 0.238 0.238
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0197 0.1055 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0127 0.0622 0.0833
Leishmania major monoglyceride lipase, putative 0.1118 0.6789 1
Leishmania major hypothetical protein, conserved 0.0066 0.0239 0.0264
Mycobacterium ulcerans short chain dehydrogenase 0.0338 0.1932 0.2781
Schistosoma mansoni microtubule-associated protein tau 0.0757 0.4538 0.4538
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0162 0.0238
Onchocerca volvulus 0.0037 0.0061 0.0035
Loa Loa (eye worm) hypothetical protein 0.0095 0.0421 0.0372
Loa Loa (eye worm) pigment dispersing factor receptor c 0.026 0.1447 0.1403
Brugia malayi MGC79044 protein 0.0066 0.0239 0.0239
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0082 0.0341 0.0341
Loa Loa (eye worm) hypothetical protein 0.0037 0.0061 0.001
Plasmodium falciparum esterase, putative 0.0066 0.0239 0.0352
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0054 0.0162 0.0238
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0066 0.0239 0.0352
Schistosoma mansoni tar DNA-binding protein 0.041 0.238 0.238
Leishmania major 4-coumarate:coa ligase-like protein 0.0127 0.0622 0.0833
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.021 0.3763
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0066 0.0239 0.0352
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0071 0.0105
Plasmodium falciparum epoxide hydrolase 2 0.0066 0.0239 0.0352
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0037 0.0061 0.009
Onchocerca volvulus 0.0039 0.0071 0.007
Brugia malayi Cathepsin L-like precursor 0.0036 0.0051 0.0051
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0196 0.0196
Mycobacterium ulcerans lysophospholipase 0.1118 0.6789 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0625 0.3716 0.5474
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0054 0.0162 0.0162
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0037 0.0061 0.009
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0214 0.1158 0.1158
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0162 0.0238
Plasmodium falciparum alpha/beta hydrolase, putative 0.0066 0.0239 0.0352
Loa Loa (eye worm) hypothetical protein 0.1634 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0071 0.0105
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0066 0.0239 0.0352
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0095 0.0421 0.058
Loa Loa (eye worm) hypothetical protein 0.0095 0.0421 0.0372
Schistosoma mansoni fatty-acid amide hydrolase 0.0197 0.1055 0.1055
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0095 0.0421 0.2235
Brugia malayi latrophilin 2 splice variant baaae 0.0178 0.0935 0.0935
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.009 0.0389 0.0532
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0162 0.0238
Trichomonas vaginalis conserved hypothetical protein 0.1118 0.6789 1
Onchocerca volvulus 0.0037 0.0061 0.0035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0204 0.1098 0.1617
Mycobacterium ulcerans acyl-CoA synthetase 0.0127 0.0622 0.0833
Echinococcus granulosus neuropeptide s receptor 0.1471 0.8987 0.8987
Onchocerca volvulus 0.0037 0.0061 0.0035
Brugia malayi Cathepsin L-like cysteine proteinase 0.0036 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0178 0.0935 0.0888
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.1591 0.2343
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.1118 0.6789 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0066 0.0239 0.0352
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0037 0.0061 0.0061
Schistosoma mansoni tar DNA-binding protein 0.041 0.238 0.238
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.021 0.021
Loa Loa (eye worm) oxidoreductase 0.0037 0.0061 0.001
Brugia malayi Pre-SET motif family protein 0.0427 0.2487 0.2487
Loa Loa (eye worm) fibroinase 0.0054 0.0162 0.0111
Leishmania major cathepsin L-like protease 0.0054 0.0162 0.0149
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0249 0.1379 0.1997
Echinococcus granulosus transient receptor potential cation channel 0.1242 0.7558 0.7558
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.1118 0.6789 1
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0066 0.0239 0.0352
Echinococcus granulosus fatty acid amide hydrolase 1 0.1634 1 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0071 0.002
Trypanosoma brucei monoglyceride lipase, putative 0.1118 0.6789 1
Echinococcus multilocularis cysteine protease 0.0054 0.0162 0.0162
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.0985 0.1451
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0051 0.0076
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0037 0.0061 0.0048
Brugia malayi Pre-SET motif family protein 0.0061 0.021 0.021
Plasmodium falciparum lysophospholipase, putative 0.1118 0.6789 1
Brugia malayi beta-lactamase family protein 0.0039 0.0071 0.0071
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0071 0.0015
Trichomonas vaginalis esterase, putative 0.0039 0.0071 0.0105
Brugia malayi Cathepsin L-like precursor 0.0054 0.0162 0.0162
Trichomonas vaginalis antibiotic synthetase, putative 0.0037 0.0061 0.009
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0066 0.0239 0.4499
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0071 0.0062
Echinococcus multilocularis neuropeptide s receptor 0.1471 0.8987 0.8987
Leishmania major hypothetical protein, conserved 0.0066 0.0239 0.0264
Leishmania major hypothetical protein, conserved 0.0039 0.0071 0.0015
Loa Loa (eye worm) ctsf protein 0.0054 0.0162 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.0189 0.1006 0.1481
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0071 0.0062
Echinococcus granulosus monoacylglycerol lipase abhd12 0.0066 0.0239 0.0239
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0071 0.0015
Mycobacterium tuberculosis Possible amidase (aminohydrolase) 0.0197 0.1055 0.1518
Echinococcus granulosus ankyrin repeat protein 0.1217 0.7406 0.7406
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0107 0.0495 0.0729
Echinococcus granulosus cathepsin l cysteine peptidase 0.0054 0.0162 0.0162
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0204 0.1098 0.1617
Mycobacterium ulcerans acyl-CoA synthetase 0.0127 0.0622 0.0833
Toxoplasma gondii hypothetical protein 0.0066 0.0239 0.4499
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0037 0.0061 0.0061
Plasmodium falciparum alpha/beta hydrolase, putative 0.0066 0.0239 0.0352
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0127 0.0622 0.0833
Brugia malayi Cathepsin L-like precursor 0.0054 0.0162 0.0162
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0162 0.0238
Leishmania major cathepsin L-like protease 0.0054 0.0162 0.0149
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0283 0.1591 0.1591
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0061 0.0048
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.0985 0.1451
Echinococcus granulosus abhydrolase domain containing 3 0.0066 0.0239 0.0239
Toxoplasma gondii ABC1 family protein 0.0039 0.0071 0.0248
Plasmodium vivax lysophospholipase, putative 0.0066 0.0239 0.0352
Trypanosoma brucei Serine peptidase, Clan SC, Family S09X 0.0066 0.0239 0.0352
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.1591 0.2343
Echinococcus granulosus microtubule associated protein 2 0.0757 0.4538 0.4538
Toxoplasma gondii hypothetical protein 0.0066 0.0239 0.4499
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.1217 0.7406 0.7406
Trichomonas vaginalis conserved hypothetical protein 0.1118 0.6789 1
Plasmodium falciparum lysophospholipase, putative 0.0066 0.0239 0.0352
Plasmodium falciparum alpha/beta hydrolase, putative 0.0066 0.0239 0.0352
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0197 0.1055 0.1554
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0037 0.0061 0.009
Loa Loa (eye worm) hypothetical protein 0.0066 0.0239 0.0188
Schistosoma mansoni cathepsin F (C01 family) 0.0036 0.0051 0.0051
Trypanosoma cruzi cysteine peptidase, putative 0.0054 0.0162 0.0238
Schistosoma mansoni tar DNA-binding protein 0.041 0.238 0.238
Plasmodium falciparum alpha/beta hydrolase, putative 0.0066 0.0239 0.0352
Onchocerca volvulus 0.0488 0.2864 1
Entamoeba histolytica cysteine protease, putative 0.0054 0.0162 0.0238
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.1118 0.6789 1
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0037 0.0061 0.009
Schistosoma mansoni hypothetical protein 0.018 0.0948 0.0948
Brugia malayi Calcitonin receptor-like protein seb-1 0.026 0.1447 0.1447
Echinococcus multilocularis monoacylglycerol lipase abhd12 0.0066 0.0239 0.0239
Brugia malayi TAR-binding protein 0.041 0.238 0.238
Plasmodium vivax acyl-CoA synthetase, putative 0.0095 0.0421 0.062
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0071 0.0062
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0204 0.1098 0.1617
Onchocerca volvulus 0.0107 0.0493 0.157
Trichomonas vaginalis set domain proteins, putative 0.0486 0.2854 0.4204
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0071 0.0071
Toxoplasma gondii hypothetical protein 0.0066 0.0239 0.4499
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0104 0.0104
Echinococcus granulosus cathepsin l1 0.0054 0.0162 0.0162
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0127 0.0622 0.0833
Loa Loa (eye worm) hypothetical protein 0.0082 0.0341 0.0291
Brugia malayi cathepsin L-like precursor 0.0036 0.0051 0.0051
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0127 0.0622 0.0877
Toxoplasma gondii protein c14orf29, putative 0.0066 0.0239 0.4499
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0162 0.0238
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.0985 0.1451
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0162 0.0238
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0127 0.0622 0.0833
Echinococcus multilocularis abhydrolase domain containing 3 0.0066 0.0239 0.0239
Schistosoma mansoni cellular tumor antigen P53 0.0107 0.0493 0.0493
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0283 0.1591 0.1547
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0088 0.0375 0.0553
Onchocerca volvulus 0.0054 0.0162 0.0392
Mycobacterium tuberculosis Probable amidase AmiD (acylamidase) (acylase) 0.0197 0.1055 0.1518
Plasmodium falciparum alpha/beta hydrolase fold domain containing protein, putative 0.0066 0.0239 0.0352
Trypanosoma cruzi major cysteine proteinase, putative 0.016 0.0826 0.1217
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0127 0.0622 0.0877
Onchocerca volvulus 0.0054 0.0162 0.0392
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0162 0.0238
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0037 0.0061 0.0048
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0066 0.0239 0.0239
Mycobacterium ulcerans hypothetical protein 0.1118 0.6789 1
Leishmania major cathepsin L-like protease 0.0054 0.0162 0.0149
Onchocerca volvulus 0.0054 0.0162 0.0392
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0197 0.1055 0.1055
Mycobacterium ulcerans amidase 0.0197 0.1055 0.1477
Brugia malayi Amidase family protein 0.0197 0.1055 0.1055
Loa Loa (eye worm) cysteine protease 0.0054 0.0162 0.0111
Schistosoma mansoni tar DNA-binding protein 0.041 0.238 0.238
Echinococcus multilocularis cathepsin L cysteine protease 0.0054 0.0162 0.0162
Echinococcus multilocularis geminin 0.018 0.0948 0.0948
Plasmodium falciparum BEM46-like protein, putative 0.0066 0.0239 0.0352
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0162 0.0238
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0066 0.0239 0.0352
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0162 0.0238
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0071 0.0071
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0066 0.0239 0.0352
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0162 0.0238
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0625 0.3716 0.5474
Schistosoma mansoni hypothetical protein 0.0082 0.0341 0.0341
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0066 0.0239 0.0352
Schistosoma mansoni hypothetical protein 0.018 0.0948 0.0948
Plasmodium vivax SET domain protein, putative 0.0061 0.021 0.0309
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0071 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0239 0.0352
Entamoeba histolytica cysteine proteinase, putative 0.0054 0.0162 0.0238
Echinococcus multilocularis fatty acid amide hydrolase 1 0.1634 1 1
Loa Loa (eye worm) hypothetical protein 0.0127 0.0622 0.0573
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0071 0.0105
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0104 0.0104
Echinococcus granulosus GPCR family 2 0.0082 0.0341 0.0341
Plasmodium falciparum exported lipase 2 0.0066 0.0239 0.0352
Giardia lamblia Cgi67 serine protease precursor-like protein 0.0066 0.0239 0.5
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0037 0.0061 0.0048
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0061 0.0048
Plasmodium vivax lysophospholipase, putative 0.0066 0.0239 0.0352
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0054 0.0162 0.0162
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0061 0.0048
Loa Loa (eye worm) amidase 0.0197 0.1055 0.1009
Leishmania major Bem46-like serine peptidase,Serine peptidase, Clan SC, Family S09X 0.0066 0.0239 0.0264
Brugia malayi Amidase family protein 0.0197 0.1055 0.1055
Brugia malayi beta-lactamase family protein 0.0039 0.0071 0.0071
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0127 0.0622 0.0833
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0082 0.0341 0.0341
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0071 0.0071
Onchocerca volvulus 0.0054 0.0162 0.0392
Plasmodium vivax unspecified product 0.0066 0.0239 0.0352
Onchocerca volvulus 0.0039 0.0071 0.007
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0037 0.0061 0.001
Brugia malayi AMP-binding enzyme family protein 0.0037 0.0061 0.0061
Plasmodium falciparum esterase, putative 0.1118 0.6789 1
Leishmania major cysteine peptidase A (CPA) 0.0054 0.0162 0.0149
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0054 0.0162 0.0111
Trypanosoma cruzi serine peptidase, putative 0.0066 0.0239 0.0352
Loa Loa (eye worm) hypothetical protein 0.0039 0.0071 0.002
Leishmania major cathepsin L-like protease 0.0054 0.0162 0.0149
Onchocerca volvulus 0.0054 0.0162 0.0392
Entamoeba histolytica cysteine proteinase, putative 0.0036 0.0051 0.0076
Mycobacterium ulcerans hypothetical protein 0.0329 0.1876 0.2698
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0039 0.0071 0.002
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0066 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0127 0.0622 0.0573
Toxoplasma gondii hypothetical protein 0.0101 0.0455 1
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0037 0.0061 0.009
Brugia malayi AMP-binding enzyme family protein 0.0127 0.0622 0.0622
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0204 0.1098 0.1617
Schistosoma mansoni hypothetical protein 0.0082 0.0341 0.0341
Mycobacterium ulcerans acyl-CoA synthetase 0.0127 0.0622 0.0833
Plasmodium falciparum lysophospholipase, putative 0.1118 0.6789 1
Mycobacterium tuberculosis Conserved protein 0.0039 0.0071 0.0062

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1000 nM Inhibition of human 11beta-HSD1 expressed in HEK293 cells by scintillation proximity assay ChEMBL. 20452767
INH (binding) = 3 uM Inhibition of human 11beta-HSD2 expressed in HEK293 cells at 10 uM by scintillation proximity assay ChEMBL. 20452767

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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