Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0016 | 0.0081 | 0.0081 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0021 | 0.0133 | 0.0133 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.1603 | 0.1605 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.1603 | 0.1605 |
Onchocerca volvulus | 0.0095 | 0.0971 | 0.5846 | |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0081 | 0.0081 |
Schistosoma mansoni | acetylcholinesterase | 0.0151 | 0.1603 | 0.1605 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0016 | 0.0081 | 0.0081 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0151 | 0.1603 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.0971 | 0.0972 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0016 | 0.0081 | 0.0081 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.1603 | 0.1605 |
Echinococcus granulosus | serotonin transporter | 0.0095 | 0.0971 | 0.0972 |
Loa Loa (eye worm) | carboxylesterase | 0.0891 | 0.9986 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0067 | 0.0655 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0067 | 0.0655 | 0.3552 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0016 | 0.0081 | 0.0081 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.0133 | 0.0133 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0133 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0891 | 0.9986 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0891 | 0.9986 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0891 | 0.9986 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0891 | 0.9986 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0016 | 0.0081 | 0.0081 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0151 | 0.1603 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0016 | 0.0081 | 0.0081 |
Schistosoma mansoni | sodium-dependent amino acid transporter | 0.0016 | 0.0081 | 0.0081 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0067 | 0.0655 | 0.0656 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0.0133 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0151 | 0.1603 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0891 | 0.9986 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0151 | 0.1603 | 0.1605 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0021 | 0.0133 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0067 | 0.0655 | 0.3552 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0016 | 0.0081 | 0.0081 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0151 | 0.1603 | 1 |
Onchocerca volvulus | 0.0151 | 0.1603 | 1 | |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0095 | 0.0971 | 0.0972 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0133 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0067 | 0.0655 | 0.0656 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0067 | 0.0655 | 0.3552 |
Brugia malayi | hypothetical protein | 0.0151 | 0.1603 | 0.1605 |
Onchocerca volvulus | 0.0151 | 0.1603 | 1 | |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0067 | 0.0655 | 0.3552 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0016 | 0.0081 | 0.0081 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0095 | 0.0971 | 1 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0151 | 0.1603 | 0.1605 |
Loa Loa (eye worm) | carboxylesterase | 0.0151 | 0.1603 | 0.1605 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.0971 | 0.0972 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0133 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0891 | 0.9986 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0133 | 0.0133 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0151 | 0.1603 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0891 | 0.9986 | 1 |
Schistosoma mansoni | gliotactin | 0.0151 | 0.1603 | 0.1605 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0081 | 0.0081 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0016 | 0.0081 | 0.0081 |
Echinococcus multilocularis | acetylcholinesterase | 0.0891 | 0.9986 | 0.9986 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.1603 | 0.1605 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0095 | 0.0971 | 0.0972 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0016 | 0.0081 | 0.0081 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0151 | 0.1603 | 0.1605 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0131 | 0.1386 | 0.1388 |
Echinococcus multilocularis | neuroligin | 0.0151 | 0.1603 | 0.1603 |
Brugia malayi | Carboxylesterase family protein | 0.0151 | 0.1603 | 0.1605 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0081 | 0.0081 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0151 | 0.1603 | 0.1603 |
Brugia malayi | Carboxylesterase family protein | 0.0891 | 0.9986 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0016 | 0.0081 | 0.0081 |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.0016 | 0.0081 | 0.0081 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0021 | 0.0133 | 0.0133 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0.0133 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0081 | 0.0081 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0016 | 0.0081 | 0.0081 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0016 | 0.0081 | 0.0081 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.0016 | 0.0081 | 0.0081 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0151 | 0.1603 | 0.1603 |
Brugia malayi | Carboxylesterase family protein | 0.0151 | 0.1603 | 0.1605 |
Echinococcus multilocularis | acetylcholinesterase | 0.0891 | 0.9986 | 0.9986 |
Toxoplasma gondii | exonuclease III APE | 0.0021 | 0.0133 | 0.0911 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0016 | 0.0081 | 0.0081 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0067 | 0.0655 | 0.0656 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0151 | 0.1603 | 0.1605 |
Loa Loa (eye worm) | serotonin transporter b | 0.0095 | 0.0971 | 0.0972 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0151 | 0.1603 | 0.1605 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0095 | 0.0971 | 0.0972 |
Brugia malayi | MH2 domain containing protein | 0.0131 | 0.1386 | 0.1388 |
Brugia malayi | Carboxylesterase family protein | 0.0151 | 0.1603 | 0.1605 |
Echinococcus multilocularis | sodium dependent neurotransmitter transporter | 0.0016 | 0.0081 | 0.0081 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.0133 | 0.0133 |
Echinococcus granulosus | neuroligin | 0.0151 | 0.1603 | 0.1605 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0021 | 0.0133 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0081 | 0.0081 |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.0016 | 0.0081 | 0.0081 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0131 | 0.1386 | 0.1388 |
Echinococcus granulosus | sodium dependent neurotransmitter transporter | 0.0016 | 0.0081 | 0.0081 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0016 | 0.0081 | 0.0081 |
Loa Loa (eye worm) | hypothetical protein | 0.0891 | 0.9986 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0151 | 0.1603 | 0.1605 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.1603 | 0.1605 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0016 | 0.0081 | 0.0081 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0151 | 0.1603 | 0.1605 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0151 | 0.1603 | 0.1605 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0151 | 0.1603 | 0.1603 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0095 | 0.0971 | 0.0972 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0016 | 0.0081 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0133 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0081 | 0.0081 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0151 | 0.1603 | 0.1605 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0081 | 0.0081 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0016 | 0.0081 | 0.0081 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.1603 | 0.1605 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.1603 | 0.1605 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0151 | 0.1603 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.0971 | 0.0972 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0016 | 0.0081 | 0.0081 |
Onchocerca volvulus | 0.0151 | 0.1603 | 1 | |
Onchocerca volvulus | 0.0151 | 0.1603 | 1 | |
Echinococcus multilocularis | uncharacterized sodium dependent transporter | 0.0016 | 0.0081 | 0.0081 |
Loa Loa (eye worm) | carboxylesterase | 0.0151 | 0.1603 | 0.1605 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0067 | 0.0655 | 0.0655 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0067 | 0.0655 | 1 |
Onchocerca volvulus | 0.0151 | 0.1603 | 1 | |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0095 | 0.0971 | 0.0972 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0016 | 0.0081 | 0.0081 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0016 | 0.0081 | 0.0081 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0016 | 0.0081 | 0.0081 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0891 | 0.9986 | 0.9986 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0081 | 0.0081 |
Echinococcus multilocularis | serotonin transporter | 0.0095 | 0.0971 | 0.0971 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0133 | 0.0133 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.