TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 302.285 | Formula: C14H14N4O4
H donors: 2 H acceptors: 2 LogP: 1.69 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Oc1ccc2c(c1)oc(=O)cc2C)CNN1C=NNC1
InChi: 1S/C14H14N4O4/c1-9-4-13(19)22-12-5-10(2-3-11(9)12)21-14(20)6-17-18-7-15-16-8-18/h2-5,7,16-17H,6,8H2,1H3
InChiKey: GOQUHLXTTSPBDR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0054	0.1058	0.1641
Echinococcus multilocularis	FTZ F1 alpha	0.0033	0.0446	0.0446
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0049	0.0925	0.1435
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0037	0.0567	0.0877
Entamoeba histolytica	hypothetical protein	0.0077	0.1725	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0567	0.0567
Onchocerca volvulus		0.0037	0.0567	0.5412
Brugia malayi	photoreceptor-specific nuclear receptor	0.0033	0.0446	0.0692
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.1382	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0007
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0066	0.1395	0.1395
Onchocerca volvulus		0.0037	0.0567	0.5412
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0567	0.1264
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0054	0.1058	0.1641
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0567	0.0879
Brugia malayi	Steroid receptor seven-up type 2	0.0033	0.0446	0.0692
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.1382	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0033	0.0446	0.0996
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0077	0.1725	0.1725
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0567	0.0879
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0033	0.0446	0.0692
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0017	0.0002	0.0002
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0033	0.0446	0.0692
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0033	0.0446	0.0692
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.1382	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0567	0.0879
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0002	0.0002
Schistosoma mansoni	tar DNA-binding protein	0.014	0.3518	0.7849
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0033	0.0446	0.0692
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0033	0.0446	0.0446
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0007
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0033	0.0446	0.0446
Echinococcus granulosus	FTZ F1 alpha	0.0033	0.0446	0.0446
Echinococcus granulosus	geminin	0.0174	0.4482	0.4482
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0033	0.0446	0.0996
Echinococcus multilocularis	ecdysone induced protein 78C	0.0033	0.0446	0.0446
Trypanosoma cruzi	major cysteine proteinase, putative	0.0051	0.0981	0.7098
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0984	0.0984
Echinococcus multilocularis	survival motor neuron protein 1	0.0242	0.6448	0.6448
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0037	0.0567	0.0877
Schistosoma mansoni	tar DNA-binding protein	0.014	0.3518	0.7849
Schistosoma mansoni	transcription factor LCR-F1	0.0077	0.1725	0.3849
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0033	0.0446	0.0996
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0984	0.0984
Brugia malayi	steroid hormone receptor	0.0033	0.0446	0.0692
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0984	0.2196
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.1395	1
Onchocerca volvulus		0.0054	0.1046	1
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0002	0.0002
Trypanosoma cruzi	cysteine peptidase, putative	0.0065	0.1382	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0033	0.0446	0.0692
Onchocerca volvulus	Protein ultraspiracle homolog	0.0033	0.0446	0.4259
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0033	0.0446	0.0996
Echinococcus multilocularis	tar DNA binding protein	0.014	0.3518	0.3518
Toxoplasma gondii	aldehyde dehydrogenase	0.0066	0.1395	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0033	0.0446	0.0692
Brugia malayi	nuclear receptor NHR-88	0.0033	0.0446	0.0692
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0567	0.0879
Echinococcus multilocularis	cysteine protease	0.0017	0.0002	0.0002
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.1382	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0446	0.0692
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1046	0.1622
Brugia malayi	Nuclear hormone receptor-like 1	0.0033	0.0446	0.0692
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.1382	1
Schistosoma mansoni	hypothetical protein	0.0049	0.0925	0.2065
Brugia malayi	Nuclear hormone receptor-like 1	0.0017	0.0005	0.0007
Leishmania major	cathepsin L-like protease	0.0065	0.1382	0.9904
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0033	0.0446	0.0446
Onchocerca volvulus		0.0049	0.0925	0.8848
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0033	0.0446	0.0446
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0033	0.0446	0.0446
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0017	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0567	0.0879
Schistosoma mansoni	tar DNA-binding protein	0.014	0.3518	0.7849
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0033	0.0446	0.0692
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.1395	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0446	0.0692
Brugia malayi	TAR-binding protein	0.014	0.3518	0.5456
Brugia malayi	latrophilin 2 splice variant baaae	0.0037	0.0568	0.0881
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0033	0.0446	0.0692
Loa Loa (eye worm)	fibroinase	0.0017	0.0002	0.0002
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0066	0.1395	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0446	0.0692
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0567	0.1264
Echinococcus multilocularis	geminin	0.0174	0.4482	0.4482
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.1382	1
Schistosoma mansoni	hypothetical protein	0.0077	0.1725	0.3849
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0051	0.0984	0.1526
Mycobacterium tuberculosis	Probable lipase LipE	0.0037	0.0567	0.0877
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0033	0.0446	0.0446
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0018	0.0019	0.0019
Entamoeba histolytica	hypothetical protein	0.0077	0.1725	1
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0567	0.0879
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0054	0.1058	0.1641
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0002	0.0002
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0077	0.1725	0.1725
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0017	0.0005	0.0007
Schistosoma mansoni	cathepsin F (C01 family)	0.0017	0.0002	0.0004
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0033	0.0446	0.0692
Echinococcus multilocularis	isocitrate dehydrogenase	0.0018	0.0019	0.0019
Brugia malayi	hypothetical protein	0.0017	0.0005	0.0007
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0236	0.6259	1
Loa Loa (eye worm)	cysteine protease	0.0017	0.0002	0.0002
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0567	0.0877
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0033	0.0446	0.0446
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0017	0.0005	0.0005
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0017	0.0002	0.0002
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0567	0.4093
Brugia malayi	nuclear hormone receptor	0.0033	0.0446	0.0692
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.1382	1
Toxoplasma gondii	ABC1 family protein	0.0037	0.0567	0.4054
Schistosoma mansoni	hypothetical protein	0.0037	0.0568	0.1268
Loa Loa (eye worm)	steroid hormone receptor	0.0033	0.0446	0.0692
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0017	0.0005	0.0005
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0018	0.0019	0.0019
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0018	0.0019	0.0019
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0567	0.0879
Leishmania major	cathepsin L-like protease	0.0065	0.1382	0.9904
Echinococcus multilocularis	cathepsin L cysteine protease	0.0017	0.0002	0.0002
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0567	0.0877
Schistosoma mansoni	aldehyde dehydrogenase	0.0066	0.1395	0.3113
Onchocerca volvulus	Bile acid receptor homolog	0.0033	0.0446	0.4259
Schistosoma mansoni	retinoic acid receptor RXR	0.0033	0.0446	0.0996
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0018	0.0019	0.003
Echinococcus granulosus	cathepsin l1	0.0017	0.0002	0.0002
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0033	0.0446	0.0692
Schistosoma mansoni	cathepsin F (C01 family)	0.0017	0.0002	0.0004
Brugia malayi	beta-lactamase family protein	0.0037	0.0567	0.0879
Schistosoma mansoni	coup transcription factor	0.0033	0.0446	0.0996
Brugia malayi	hypothetical protein	0.0242	0.6448	1
Loa Loa (eye worm)	ctsf protein	0.0017	0.0002	0.0002
Mycobacterium leprae	conserved hypothetical protein	0.0037	0.0567	0.5
Trypanosoma brucei	hypothetical protein, conserved	0.0037	0.0567	0.4016
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.1382	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0002	0.0002
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.1382	1
Mycobacterium tuberculosis	Probable lipase LipD	0.0037	0.0567	0.0877
Brugia malayi	Papain family cysteine protease containing protein	0.0017	0.0002	0.0002
Brugia malayi	RNA binding protein	0.014	0.3518	0.5456
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0002	0.0002
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0984	0.0984
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0033	0.0446	0.0692
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0446	0.0692
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0002	0.0002
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.1382	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0066	0.1395	0.3113
Echinococcus granulosus	ecdysone induced protein 78C	0.0033	0.0446	0.0446
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0033	0.0446	0.0446
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0017	0.0002	0.0002
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0017	0.0005	0.0011
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0018	0.0019	0.0019
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0033	0.0446	0.0446
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0033	0.0446	0.0446
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0567	1
Entamoeba histolytica	hypothetical protein	0.0077	0.1725	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0033	0.0446	0.0996
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0002	0.0002
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0033	0.0446	0.0692
Onchocerca volvulus		0.0033	0.0446	0.4259
Schistosoma mansoni	tar DNA-binding protein	0.014	0.3518	0.7849
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0033	0.0446	0.0446
Brugia malayi	ecdysteroid receptor	0.0033	0.0446	0.0692
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0984	0.2196
Leishmania major	cathepsin L-like protease	0.0065	0.1382	0.9904
Schistosoma mansoni	survival motor neuron protein	0.0049	0.0925	0.2065
Mycobacterium leprae	Probable lipase LipE	0.0037	0.0567	0.5
Leishmania major	hypothetical protein, conserved	0.0037	0.0567	0.4054
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0984	0.2196
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0033	0.0446	0.0446
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0567	0.0877
Schistosoma mansoni	thyroid hormone receptor	0.0033	0.0446	0.0996
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.1382	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1058	0.1641
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0051	0.0984	0.1526
Brugia malayi	beta-lactamase family protein	0.0037	0.0567	0.0879
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0567	1
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0066	0.1395	0.1395
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.014	0.3518	0.5456
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0018	0.0019	0.0129
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0033	0.0446	0.0996
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0984	0.0984
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0017	0.0002	0.0002
Echinococcus multilocularis	cathepsin L cysteine protease	0.0017	0.0002	0.0002
Brugia malayi	Isocitrate dehydrogenase	0.0018	0.0019	0.003
Echinococcus multilocularis	cysteine protease	0.0017	0.0002	0.0002
Schistosoma mansoni	hypothetical protein	0.0174	0.4482	1
Toxoplasma gondii	isocitrate dehydrogenase	0.0018	0.0019	0.0128
Brugia malayi	isocitrate dehydrogenase	0.0018	0.0019	0.003
Toxoplasma gondii	isocitrate dehydrogenase	0.0018	0.0019	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0446	0.0692
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0017	0.0005	0.0011
Trypanosoma cruzi	cruzipain precursor, putative	0.0065	0.1382	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0033	0.0446	0.0692
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0018	0.0019	0.0043
Brugia malayi	hypothetical protein	0.0077	0.1725	0.2675
Entamoeba histolytica	hypothetical protein	0.0077	0.1725	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0033	0.0446	0.0692
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0033	0.0446	0.4259
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.1395	1
Trichomonas vaginalis	esterase, putative	0.0037	0.0567	1
Echinococcus granulosus	tar DNA binding protein	0.014	0.3518	0.3518
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0018	0.0019	0.0128
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0018	0.0019	0.0315
Mycobacterium tuberculosis	Probable hydrolase	0.0037	0.0567	0.0877
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0033	0.0446	0.0692
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0033	0.0446	0.0446
Loa Loa (eye worm)	TAR-binding protein	0.014	0.3518	0.5456
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0567	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0033	0.0446	0.0996
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0567	0.0567
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.006	0.122	0.8824
Echinococcus granulosus	survival motor neuron protein 1	0.0242	0.6448	0.6448
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0007
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0033	0.0446	0.0446
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0567	0.0879
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0033	0.0446	0.0692
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0007
Brugia malayi	RNA recognition motif domain containing protein	0.014	0.3518	0.5456
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0018	0.0019	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0446	0.0692
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0568	0.0881
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0007
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0018	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0446	0.0692
Echinococcus multilocularis	tumor protein p63	0.0366	1	1
Schistosoma mansoni	thyroid hormone receptor	0.0033	0.0446	0.0996
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0567	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0017	0.0005	0.0007
Brugia malayi	beta-lactamase	0.0037	0.0567	0.0879
Trypanosoma cruzi	cysteine peptidase, putative	0.0065	0.1382	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0567	0.0879
Loa Loa (eye worm)	hypothetical protein	0.0242	0.6448	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0567	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0033	0.0446	0.0996
Brugia malayi	hypothetical protein	0.0017	0.0005	0.0007
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.0567	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0033	0.0446	0.0692
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0033	0.0446	0.0692
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0446	0.0692
Brugia malayi	nuclear receptor RXR	0.0017	0.0005	0.0007
Onchocerca volvulus		0.0037	0.0567	0.5412
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0033	0.0446	0.0692
Schistosoma mansoni	cellular tumor antigen P53	0.0054	0.1046	0.2333
Mycobacterium tuberculosis	Probable esterase LipL	0.0037	0.0567	0.0877
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0066	0.1395	0.2205
Loa Loa (eye worm)	RNA binding protein	0.014	0.3518	0.5456
Schistosoma mansoni	hypothetical protein	0.0174	0.4482	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0567	0.4093
Schistosoma mansoni	tar DNA-binding protein	0.014	0.3518	0.7849
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0018	0.0019	1
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0037	0.0567	0.0877
Schistosoma mansoni	nuclear hormone receptor	0.0033	0.0446	0.0996
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0033	0.0446	0.0692
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0017	0.0002	0.0002
Trypanosoma cruzi	cysteine peptidase, putative	0.0065	0.1382	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 37 %	Analgesic activity in mouse assessed as inhibition of acetic acid-induced writhing administered 30 mins before acetic acid challenge measured after 30 mins relative to control	ChEMBL.	21816516
IZ (functional)	= 12.4 mm	Antifungal activity against Candida albicans MTCC 183 at 10 ug/ml	ChEMBL.	21816516
IZ (functional)	= 13.4 mm	Antifungal activity against Candida albicans MTCC 183 at 25 ug/ml	ChEMBL.	21816516
IZ (functional)	= 14.1 mm	Antimicrobial activity against Escherichia coli MTCC 4315 at 25 ug/ml	ChEMBL.	21816516
IZ (functional)	= 15.4 mm	Antifungal activity against Candida albicans MTCC 183 at 50 ug/ml	ChEMBL.	21816516
IZ (functional)	= 16.2 mm	Antimicrobial activity against Escherichia coli MTCC 4315 at 50 ug/ml	ChEMBL.	21816516

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1830254

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1111451