Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | serotonin receptor | 0.0064 | 0.0305 | 0.0305 |
Trichomonas vaginalis | set domain proteins, putative | 0.0267 | 0.1759 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0034 | 0.0086 | 0.0086 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0025 | 0.0028 | 0.0028 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0021 | 0.0021 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0028 | 0.0048 | 0.0048 |
Echinococcus granulosus | neuroligin | 0.0239 | 0.1561 | 0.1561 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0239 | 0.1561 | 0.1561 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0086 | 0.0086 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0234 | 0.1527 | 0.1527 |
Onchocerca volvulus | 0.0053 | 0.0223 | 0.082 | |
Entamoeba histolytica | hypothetical protein | 0.0027 | 0.0039 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0217 | 0.0217 |
Entamoeba histolytica | hypothetical protein | 0.0027 | 0.0039 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 0.1561 | 0.1561 |
Brugia malayi | Carboxylesterase family protein | 0.0239 | 0.1561 | 0.1561 |
Onchocerca volvulus | 0.0239 | 0.1561 | 0.8816 | |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0032 | 0.0077 | 0.0077 |
Schistosoma mansoni | hypothetical protein | 0.0027 | 0.0039 | 0.0039 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0064 | 0.0305 | 0.0305 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0239 | 0.1561 | 0.1561 |
Loa Loa (eye worm) | hypothetical protein | 0.0357 | 0.2408 | 0.2408 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0239 | 0.1561 | 0.1561 |
Schistosoma mansoni | gliotactin | 0.0239 | 0.1561 | 0.1561 |
Loa Loa (eye worm) | carboxylesterase | 0.1416 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0027 | 0.0039 | 0.0039 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0021 | 0.0021 |
Echinococcus multilocularis | musashi | 0.0053 | 0.0223 | 0.0223 |
Plasmodium vivax | SET domain protein, putative | 0.0034 | 0.0086 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0086 | 0.0086 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0034 | 0.0086 | 0.0086 |
Brugia malayi | Carboxylesterase family protein | 0.0239 | 0.1561 | 0.1561 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.0881 | 0.0881 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 0.1561 | 0.1561 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0086 | 0.0086 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0064 | 0.0305 | 0.0305 |
Echinococcus multilocularis | lamin | 0.0053 | 0.0223 | 0.0223 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.009 | 0.0489 | 0.0489 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0239 | 0.1561 | 0.5 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0144 | 0.0881 | 0.0881 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0053 | 0.0223 | 0.0223 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1416 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0239 | 0.1561 | 0.1561 |
Loa Loa (eye worm) | hypothetical protein | 0.1416 | 1 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0239 | 0.1561 | 0.1561 |
Onchocerca volvulus | 0.0053 | 0.0223 | 0.082 | |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0027 | 0.0039 | 0.0039 |
Brugia malayi | hypothetical protein | 0.0027 | 0.0039 | 0.0039 |
Brugia malayi | Carboxylesterase family protein | 0.0239 | 0.1561 | 0.1561 |
Echinococcus granulosus | intermediate filament protein | 0.0053 | 0.0223 | 0.0223 |
Echinococcus granulosus | acetylcholinesterase | 0.1416 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0027 | 0.0039 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0239 | 0.1561 | 0.1561 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.0881 | 0.0881 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0239 | 0.1561 | 0.1561 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.009 | 0.0489 | 0.0489 |
Onchocerca volvulus | 0.0239 | 0.1561 | 0.8816 | |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0223 | 0.0223 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 0.1561 | 0.1561 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.039 | 0.2639 | 0.2639 |
Echinococcus granulosus | carboxylesterase 5A | 0.1416 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 0.1561 | 0.1561 |
Echinococcus multilocularis | acetylcholinesterase | 0.1416 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 0.1561 | 0.1561 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0239 | 0.1561 | 0.5 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0028 | 0.0048 | 0.0048 |
Entamoeba histolytica | hypothetical protein | 0.0027 | 0.0039 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 0.1561 | 0.1561 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0239 | 0.1561 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0028 | 0.0028 |
Schistosoma mansoni | acetylcholinesterase | 0.0239 | 0.1561 | 0.1561 |
Echinococcus multilocularis | neuroligin | 0.0239 | 0.1561 | 0.1561 |
Echinococcus multilocularis | lamin dm0 | 0.0053 | 0.0223 | 0.0223 |
Brugia malayi | Pre-SET motif family protein | 0.0234 | 0.1527 | 0.1527 |
Schistosoma mansoni | lamin | 0.0053 | 0.0223 | 0.0223 |
Echinococcus multilocularis | expressed protein | 0.042 | 0.2861 | 0.2861 |
Echinococcus granulosus | neuropeptide s receptor | 0.039 | 0.2639 | 0.2639 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0239 | 0.1561 | 0.8874 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0025 | 0.0028 | 0.0028 |
Schistosoma mansoni | lamin | 0.0053 | 0.0223 | 0.0223 |
Onchocerca volvulus | 0.0239 | 0.1561 | 0.8816 | |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0034 | 0.0086 | 0.0086 |
Brugia malayi | hypothetical protein | 0.0137 | 0.0829 | 0.0829 |
Echinococcus multilocularis | serotonin receptor | 0.0064 | 0.0305 | 0.0305 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.0759 | 0.0759 |
Brugia malayi | Carboxylesterase family protein | 0.1416 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1416 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 0.1561 | 0.1561 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0239 | 0.1561 | 0.1561 |
Brugia malayi | MH2 domain containing protein | 0.009 | 0.0489 | 0.0489 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0053 | 0.0223 | 0.0223 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0034 | 0.0086 | 0.0086 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0239 | 0.1561 | 0.1561 |
Onchocerca volvulus | 0.0267 | 0.1759 | 1 | |
Brugia malayi | Pre-SET motif family protein | 0.0034 | 0.0086 | 0.0086 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0305 | 0.0305 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1416 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0239 | 0.1561 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.1416 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0239 | 0.1561 | 0.1561 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0239 | 0.1561 | 0.1561 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0239 | 0.1561 | 0.1561 |
Onchocerca volvulus | 0.0239 | 0.1561 | 0.8816 | |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0305 | 0.0305 |
Brugia malayi | intermediate filament protein | 0.0053 | 0.0223 | 0.0223 |
Echinococcus multilocularis | acetylcholinesterase | 0.1416 | 1 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0053 | 0.0223 | 0.0223 |
Onchocerca volvulus | 0.0239 | 0.1561 | 0.8816 | |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0239 | 0.1561 | 0.1561 |
Echinococcus granulosus | expressed protein | 0.042 | 0.2861 | 0.2861 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0239 | 0.1561 | 0.1561 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1416 | 1 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0086 | 0.0086 |
Echinococcus multilocularis | neuropeptide s receptor | 0.039 | 0.2639 | 0.2639 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0034 | 0.0086 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0239 | 0.1561 | 0.1561 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0144 | 0.0881 | 0.0881 |
Echinococcus granulosus | lamin dm0 | 0.0053 | 0.0223 | 0.0223 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0027 | 0.0039 | 0.0039 |
Loa Loa (eye worm) | intermediate filament protein | 0.0053 | 0.0223 | 0.0223 |
Echinococcus granulosus | lamin | 0.0053 | 0.0223 | 0.0223 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0239 | 0.1561 | 0.8874 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.039 | 0.2639 | 0.2639 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antimalarial activity against multi drug-resistant Plasmodium yoelii nigeriensis infected in Swiss mice (Mus musculus) assessed as protection of patent infection at 96 mg/kg, perorally daily for 4 days measured after 28 days | ChEMBL. | 20598529 | |
Activity (functional) | = 84.39 % | Antimalarial activity against multi drug-resistant Plasmodium yoelii nigeriensis infected in Swiss mice (Mus musculus) assessed as suppression of parasitaemia level at 96 mg/kg, perorally daily for 4 days | ChEMBL. | 20598529 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.