Detailed information for compound 1111642

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 705.799 | Formula: C40H43N5O7
  • H donors: 5 H acceptors: 6 LogP: 3.14 Rotable bonds: 21
    Rule of 5 violations (Lipinski): 2
  • SMILES: Oc1ccc(cc1)C[C@H](N(C(=O)[C@H](Cc1c[nH]cn1)NC(=O)OCc1ccccc1OCc1ccccc1)C)CN[C@H](C(=O)O)Cc1ccccc1
  • InChi: 1S/C40H43N5O7/c1-45(33(20-29-16-18-34(46)19-17-29)24-42-36(39(48)49)21-28-10-4-2-5-11-28)38(47)35(22-32-23-41-27-43-32)44-40(50)52-26-31-14-8-9-15-37(31)51-25-30-12-6-3-7-13-30/h2-19,23,27,33,35-36,42,46H,20-22,24-26H2,1H3,(H,41,43)(H,44,50)(H,48,49)/t33-,35-,36-/m0/s1
  • InChiKey: GNOUEZLCODIJQM-QBDOPFNQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) intermediate filament protein 0.003 0.0114 0.0119
Echinococcus granulosus thyroid hormone receptor alpha 0.0048 0.0309 0.054
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0102 0.0891 0.0962
Trichomonas vaginalis inositol monophosphatase, putative 0.0082 0.0673 0.0697
Brugia malayi Matrixin family protein 0.0061 0.0456 0.0488
Schistosoma mansoni microtubule-associated protein tau 0.03 0.3039 0.5394
Loa Loa (eye worm) hypothetical protein 0.0102 0.0891 0.0962
Brugia malayi nuclear receptor NHR-67 0.0048 0.0309 0.0329
Loa Loa (eye worm) matrixin family protein 0.0056 0.0401 0.043
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0102 0.0891 0.1575
Loa Loa (eye worm) DR-78 0.0048 0.0309 0.033
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0102 0.0891 0.0886
Giardia lamblia Synaptic glycoprotein SC2 0.0404 0.4171 1
Mycobacterium tuberculosis Conserved protein 0.0038 0.0204 0.0817
Onchocerca volvulus 0.0025 0.0065 0.0114
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0204 0.0817
Echinococcus granulosus Nuclear hormone receptor HR96 0.0048 0.0309 0.054
Echinococcus granulosus heat shock protein 0.0037 0.0185 0.032
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0114 0.0118
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0052 0.0348 0.0609
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0042 0.0244 0.0259
Mycobacterium ulcerans hypothetical protein 0.0871 0.923 1
Loa Loa (eye worm) endoplasmin 0.0037 0.0185 0.0196
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0204 0.0354
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0404 0.4171 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0204 0.0217
Leishmania major heat shock protein 83-1 0.0037 0.0185 0.0195
Trichomonas vaginalis heat shock protein, putative 0.0029 0.0105 0.0079
Schistosoma mansoni caspase-7 (C14 family) 0.0076 0.0613 0.1081
Loa Loa (eye worm) hypothetical protein 0.0038 0.0204 0.0217
Trypanosoma cruzi cysteine peptidase, putative 0.0025 0.0057 0.0062
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0244 0.0231
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0204 0.0354
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0102 0.0891 0.1575
Schistosoma mansoni alpha glucosidase 0.0042 0.0244 0.0425
Toxoplasma gondii heat shock protein 90, putative 0.0037 0.0185 0.0195
Echinococcus granulosus SAM and MBT domain containing protein 0.0052 0.0348 0.0609
Trichomonas vaginalis conserved hypothetical protein 0.0404 0.4171 0.45
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0357 0.0387
Schistosoma mansoni tar DNA-binding protein 0.0067 0.052 0.0915
Onchocerca volvulus 0.0048 0.0309 0.0702
Brugia malayi hypothetical protein 0.0022 0.0032 0.0029
Echinococcus granulosus apoptotic protease activating factor 1 0.0076 0.0613 0.1081
Echinococcus granulosus lamin dm0 0.003 0.0114 0.0193
Leishmania major cathepsin L-like protease 0.0025 0.0057 0.0056
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0104 0.0915 0.091
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0204 0.0187
Entamoeba histolytica heat shock protein 90, putative 0.0037 0.0185 0.0041
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0255 0.0271
Loa Loa (eye worm) hypothetical protein 0.0048 0.0309 0.033
Trypanosoma cruzi PAB1-binding protein , putative 0.0022 0.0032 0.0035
Brugia malayi conserved hypotetical protein 0.0048 0.0309 0.0329
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0145 0.1357 0.1465
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0102 0.0891 0.096
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0204 0.0217
Loa Loa (eye worm) hypothetical protein 0.0025 0.0065 0.0066
Loa Loa (eye worm) RNA binding protein 0.0067 0.052 0.0559
Schistosoma mansoni lozenge 0.0032 0.0137 0.0233
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0102 0.0891 0.096
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0216 0.2131 0.2127
Brugia malayi Glycosyl hydrolases family 31 protein 0.0042 0.0244 0.0259
Onchocerca volvulus Bile acid receptor homolog 0.0102 0.0891 0.2104
Loa Loa (eye worm) MH2 domain-containing protein 0.0052 0.0351 0.0376
Onchocerca volvulus Cell death protein 3 homolog 0.0076 0.0613 0.1434
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0404 0.4171 0.45
Brugia malayi Nuclear hormone receptor E75 0.0048 0.0309 0.0329
Schistosoma mansoni nuclear hormone receptor 0.0102 0.0891 0.1575
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0102 0.0891 0.0962
Brugia malayi Pre-SET motif family protein 0.0032 0.0139 0.0145
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0104 0.0915 0.1617
Trypanosoma cruzi Heat shock protein 83, putative 0.0037 0.0185 0.0201
Loa Loa (eye worm) hypothetical protein 0.0102 0.0891 0.0962
Loa Loa (eye worm) hypothetical protein 0.0048 0.0309 0.033
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0104 0.0915 0.1617
Trypanosoma cruzi cysteine peptidase, putative 0.0025 0.0057 0.0062
Trypanosoma brucei heat shock protein, putative 0.0037 0.0185 0.0195
Brugia malayi hypothetical protein 0.0048 0.0309 0.0329
Schistosoma mansoni coup transcription factor 0.0102 0.0891 0.1575
Echinococcus granulosus geminin 0.0539 0.563 1
Echinococcus multilocularis polycomb protein SCMH1 0.0052 0.0348 0.0343
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0244 0.0231
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0102 0.0891 0.096
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0064 0.0479 0.0519
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0139 0.0145
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0244 0.0265
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0025 0.0065 0.0106
Trypanosoma brucei heat shock protein, putative 0.0037 0.0185 0.0195
Loa Loa (eye worm) hypothetical protein 0.0054 0.0371 0.0398
Loa Loa (eye worm) hypothetical protein 0.0048 0.0309 0.033
Loa Loa (eye worm) matrix metalloproteinase 0.0025 0.0065 0.0066
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0048 0.0309 0.054
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0114 0.0119
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0404 0.4171 0.4516
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0029 0.0105 0.0407
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0245 0.2443 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0613 0.066
Brugia malayi Pre-SET motif family protein 0.0225 0.2228 0.2409
Schistosoma mansoni lamin 0.003 0.0114 0.0193
Schistosoma mansoni lamin 0.003 0.0114 0.0193
Schistosoma mansoni myelin transcription factor 1 myt1 0.0059 0.0425 0.0747
Brugia malayi Matrixin family protein 0.0025 0.0065 0.0064
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0048 0.0309 0.054
Trypanosoma cruzi heat shock protein 90, putative 0.0029 0.0105 0.0113
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0102 0.0891 0.096
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0151 0.1426 0.1422
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0102 0.0891 0.0962
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0102 0.0891 0.0886
Brugia malayi Matrixin family protein 0.0025 0.0065 0.0064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0057 0.0056
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0306 0.3103 0.3357
Echinococcus multilocularis lamin dm0 0.003 0.0114 0.0108
Brugia malayi hypothetical protein 0.0033 0.0148 0.0155
Brugia malayi nuclear receptor RXR 0.0054 0.0371 0.0397
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0126 0.0215
Echinococcus multilocularis inositol monophosphatase 1 0.0082 0.0673 0.0668
Leishmania major hypothetical protein, conserved 0.0022 0.0032 0.0029
Echinococcus granulosus tar DNA binding protein 0.0067 0.052 0.0915
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0204 0.0216
Brugia malayi orphan nuclear receptor NR2E1 0.0048 0.0309 0.0329
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0033 0.0148 0.0143
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0102 0.0891 0.1575
Echinococcus granulosus tumor protein p63 0.0144 0.135 0.239
Trypanosoma cruzi cruzipain precursor, putative 0.0025 0.0057 0.0062
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0204 0.0817
Leishmania major heat shock protein 83-1 0.0037 0.0185 0.0195
Trypanosoma brucei glucosidase, putative 0.0042 0.0244 0.0259
Brugia malayi Calcitonin receptor-like protein seb-1 0.0022 0.0024 0.002
Loa Loa (eye worm) hypothetical protein 0.0048 0.0309 0.033
Brugia malayi Cytochrome P450 family protein 0.004 0.022 0.0233
Loa Loa (eye worm) hypothetical protein 0.0048 0.0309 0.033
Mycobacterium tuberculosis Conserved protein 0.0038 0.0204 0.0817
Echinococcus granulosus ecdysone induced protein 78C 0.0102 0.0891 0.1575
Schistosoma mansoni heat shock protein 0.0037 0.0185 0.032
Loa Loa (eye worm) heat shock protein 90 0.0037 0.0185 0.0196
Loa Loa (eye worm) hypothetical protein 0.0048 0.0309 0.033
Loa Loa (eye worm) beta-lactamase 0.0038 0.0204 0.0217
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0082 0.0673 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0057 0.0056
Schistosoma mansoni endoplasmin 0.0037 0.0185 0.032
Onchocerca volvulus 0.0151 0.1426 0.3392
Echinococcus multilocularis snurportin 1 0.0134 0.1239 0.1234
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0052 0.0348 0.0796
Schistosoma mansoni alpha-glucosidase 0.0163 0.1555 0.2755
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0871 0.923 1
Onchocerca volvulus Matrix metalloproteinase homolog 0.0056 0.0401 0.0922
Loa Loa (eye worm) hypothetical protein 0.0404 0.4171 0.4516
Toxoplasma gondii heat shock protein HSP90 0.0037 0.0185 0.0195
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0104 0.0915 0.091
Brugia malayi beta-lactamase family protein 0.0038 0.0204 0.0216
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0064 0.0479 0.1942
Echinococcus granulosus lamin 0.003 0.0114 0.0193
Toxoplasma gondii ABC1 family protein 0.0038 0.0204 0.0216
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0102 0.0891 0.1575
Toxoplasma gondii exonuclease III APE 0.0064 0.0479 0.0513
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0204 0.0187
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0244 0.0106
Trypanosoma cruzi heat shock protein 90, putative 0.0022 0.0023 0.0025
Loa Loa (eye worm) transcription factor SMAD2 0.0052 0.0351 0.0376
Leishmania major heat shock protein 83-1 0.0037 0.0185 0.0195
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0134 0.1239 0.1338
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0069 0.054 0.095
Schistosoma mansoni heat shock protein 0.0037 0.0185 0.032
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0255 0.0276
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0404 0.4171 0.7407
Schistosoma mansoni zinc finger protein 0.0048 0.0309 0.054
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0054 0.0371 0.0398
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0204 0.0817
Onchocerca volvulus Protein ultraspiracle homolog 0.0102 0.0891 0.2104
Echinococcus multilocularis apoptotic protease activating factor 1 0.0076 0.0613 0.0608
Mycobacterium ulcerans lipase LipD 0.0038 0.0204 0.0216
Brugia malayi mbt repeat family protein 0.0052 0.0348 0.0371
Schistosoma mansoni alpha-glucosidase 0.0163 0.1555 0.2755
Echinococcus multilocularis caspase 2 0.0076 0.0613 0.0608
Plasmodium vivax heat shock protein 86, putative 0.0037 0.0185 0.037
Leishmania major heat shock protein 83-1 0.0037 0.0185 0.0195
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0255 0.0276
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0102 0.0891 0.096
Leishmania major cathepsin L-like protease 0.0025 0.0057 0.0056
Schistosoma mansoni steroid hormone receptor ad4bp 0.0102 0.0891 0.1575
Mycobacterium ulcerans hypothetical protein 0.0161 0.1534 0.1657
Onchocerca volvulus 0.0404 0.4171 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0059 0.0425 0.0747
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0404 0.4171 0.7407
Loa Loa (eye worm) hypothetical protein 0.0054 0.0371 0.0398
Trypanosoma cruzi heat shock protein 85, putative 0.0037 0.0185 0.0201
Echinococcus multilocularis nuclear receptor nhr 48 0.0048 0.0309 0.0304
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0216 0.2131 0.3779
Loa Loa (eye worm) hypothetical protein 0.0102 0.0891 0.0962
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0057 0.0056
Schistosoma mansoni glutaminase 0.031 0.3154 0.5599
Schistosoma mansoni hypothetical protein 0.0036 0.018 0.0311
Echinococcus multilocularis lysosomal alpha glucosidase 0.0189 0.1841 0.1836
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0064 0.0479 0.0474
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0102 0.0891 0.096
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0244 0.0231
Loa Loa (eye worm) hypothetical protein 0.0102 0.0891 0.0962
Trypanosoma brucei heat shock protein 90, putative 0.0037 0.0185 0.0195
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0064 0.0479 0.0842
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0057 0.0056
Onchocerca volvulus Matrilysin homolog 0.0056 0.0401 0.0922
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0057 0.0056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0102 0.0891 0.0962
Mycobacterium ulcerans hydrolase 0.0031 0.0125 0.013
Loa Loa (eye worm) nuclear receptor NHR-67 0.0048 0.0309 0.033
Onchocerca volvulus 0.0036 0.018 0.0391
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0102 0.0891 0.1575
Echinococcus multilocularis Protein lozenge 0.0032 0.0137 0.0131
Loa Loa (eye worm) glutaminase 2 0.031 0.3154 0.3414
Trichomonas vaginalis ap endonuclease, putative 0.0064 0.0479 0.0486
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0023 0.0034 0.0037
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0151 0.1426 0.2527
Schistosoma mansoni tar DNA-binding protein 0.0067 0.052 0.0915
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0204 0.0817
Onchocerca volvulus 0.0256 0.2565 0.6133
Trypanosoma brucei heat shock protein, putative 0.0037 0.0185 0.0195
Echinococcus granulosus Nuclear hormone receptor HR96 0.0048 0.0309 0.054
Trypanosoma brucei heat shock protein, putative 0.0037 0.0185 0.0195
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0225 0.2228 0.241
Loa Loa (eye worm) hypothetical protein 0.0871 0.923 1
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0151 0.1426 0.2527
Mycobacterium ulcerans glutaminase 0.031 0.3154 0.3413
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0054 0.0371 0.0651
Brugia malayi nuclear hormone receptor family member odr-7 0.0048 0.0309 0.0329
Onchocerca volvulus 0.0256 0.256 0.6121
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0102 0.0891 0.1575
Echinococcus multilocularis lysosomal alpha glucosidase 0.0189 0.1841 0.1836
Trypanosoma cruzi heat shock protein 85, putative 0.0037 0.0185 0.0201
Leishmania major heat shock protein 83-1 0.0037 0.0185 0.0195
Brugia malayi beta-lactamase 0.0038 0.0204 0.0216
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0102 0.0891 0.096
Plasmodium falciparum heat shock protein 90 0.0037 0.0185 0.037
Leishmania major heat shock protein 83-1 0.0037 0.0185 0.0195
Schistosoma mansoni endoplasmin 0.0037 0.0185 0.032
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0102 0.0891 0.096
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0244 0.0231
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0033 0.0148 0.0253
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0336 0.0588
Brugia malayi exodeoxyribonuclease III family protein 0.0064 0.0479 0.0513
Trypanosoma cruzi cytochrome p450-like protein, putative 0.002 0.0005 0.0006
Onchocerca volvulus Deterin homolog 0.0151 0.1426 0.3392
Leishmania major hypothetical protein, conserved 0.0038 0.0204 0.0216
Brugia malayi intermediate filament protein 0.003 0.0114 0.0118
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.022 0.0234
Toxoplasma gondii LsmAD domain-containing protein 0.0022 0.0032 0.0029
Trypanosoma cruzi cytochrome P450, putative 0.004 0.022 0.0239
Brugia malayi mbt repeat family protein 0.0052 0.0348 0.0371
Trichomonas vaginalis maltase-glucoamylase, putative 0.0042 0.0244 0.0231
Onchocerca volvulus 0.0032 0.0139 0.0292
Loa Loa (eye worm) hypothetical protein 0.0052 0.0348 0.0373
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0104 0.0915 0.1617
Toxoplasma gondii hypothetical protein 0.0049 0.0323 0.0345
Schistosoma mansoni tar DNA-binding protein 0.0067 0.052 0.0915
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0244 0.0265
Treponema pallidum exodeoxyribonuclease (exoA) 0.0064 0.0479 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0082 0.0673 0.0723
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0102 0.0891 0.0962
Trichomonas vaginalis heat shock protein, putative 0.0029 0.0105 0.0079
Brugia malayi photoreceptor-specific nuclear receptor 0.0102 0.0891 0.096
Schistosoma mansoni ap endonuclease 0.0064 0.0479 0.0842
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0871 0.923 1
Schistosoma mansoni hypothetical protein 0.0326 0.3326 0.5905
Echinococcus multilocularis histone acetyltransferase MYST2 0.0059 0.0425 0.042
Loa Loa (eye worm) hypothetical protein 0.0054 0.0371 0.0398
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0404 0.4171 0.4516
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0102 0.0891 0.1575
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0102 0.0891 0.096
Trypanosoma cruzi cytochrome P450, putative 0.004 0.022 0.0239
Echinococcus multilocularis heat shock protein 90 0.0029 0.0105 0.0099
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0064 0.0479 0.0513
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0048 0.0309 0.0702
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0048 0.0309 0.0304
Brugia malayi steroid hormone receptor 0.0102 0.0891 0.096
Schistosoma mansoni intermediate filament proteins 0.003 0.0114 0.0193
Leishmania major heat shock protein 83-1 0.0037 0.0185 0.0195
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0082 0.0673 0.0697
Echinococcus multilocularis heat shock protein 90 0.0037 0.0185 0.018
Brugia malayi MH2 domain containing protein 0.0052 0.0351 0.0375
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0204 0.0817
Onchocerca volvulus 0.0076 0.0613 0.1434
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0104 0.0915 0.1617
Trypanosoma brucei heat shock protein 90, putative 0.0037 0.0185 0.0195
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0048 0.0309 0.033
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0204 0.0817
Echinococcus multilocularis tumor protein p63 0.0144 0.135 0.1345
Trypanosoma cruzi heat shock protein 85, putative 0.0037 0.0185 0.0201
Schistosoma mansoni ap endonuclease 0.0064 0.0479 0.0842
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0064 0.0479 0.6585
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0102 0.0891 0.0886
Loa Loa (eye worm) hypothetical protein 0.0054 0.0371 0.0398
Loa Loa (eye worm) hypothetical protein 0.0048 0.0309 0.033
Onchocerca volvulus 0.003 0.0114 0.0232
Trichomonas vaginalis sucrase-isomaltase, putative 0.0042 0.0244 0.0231
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0102 0.0891 0.1575
Echinococcus multilocularis lamin 0.003 0.0114 0.0108
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0057 0.0056
Echinococcus granulosus inhibitor of apoptosis protein 0.0151 0.1426 0.2527
Loa Loa (eye worm) hypothetical protein 0.0038 0.0204 0.0217
Loa Loa (eye worm) runx1 0.0032 0.0137 0.0144
Onchocerca volvulus 0.0102 0.0891 0.2104
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0073 0.058 0.2358
Trypanosoma cruzi PAB1-binding protein , putative 0.0022 0.0032 0.0035
Loa Loa (eye worm) hypothetical protein 0.0038 0.0204 0.0217
Echinococcus granulosus heat shock protein 90 0.0037 0.0185 0.032
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0029 0.0105 0.0176
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0871 0.923 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0204 0.0216
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.002 0.0005 0.0006
Brugia malayi Cell death protein 3 precursor 0.0076 0.0613 0.0659
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0048 0.0309 0.0304
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0404 0.4171 0.45
Onchocerca volvulus 0.003 0.0114 0.0232
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0102 0.0891 0.0886
Plasmodium vivax SET domain protein, putative 0.0032 0.0139 0.0258
Leishmania major heat shock protein 83-1 0.0037 0.0185 0.0195
Leishmania major cytochrome p450-like protein 0.004 0.022 0.0233
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0092 0.0792 0.1398
Echinococcus multilocularis geminin 0.0539 0.563 0.5627
Loa Loa (eye worm) nuclear hormone receptor 0.0048 0.0309 0.033
Schistosoma mansoni thyroid hormone receptor 0.0102 0.0891 0.1575
Schistosoma mansoni hypothetical protein 0.0076 0.0613 0.1081
Brugia malayi glutaminase DH11.1 0.031 0.3154 0.3413
Brugia malayi nuclear receptor NHR-88 0.0102 0.0891 0.096
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0073 0.058 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0306 0.3103 0.3361
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0054 0.0371 0.0366
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0048 0.0309 0.054
Leishmania major heat shock protein 83-1 0.0037 0.0185 0.0195
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0102 0.0891 0.1575
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0139 0.0134
Loa Loa (eye worm) hypothetical protein 0.0032 0.0139 0.0146
Onchocerca volvulus Matrilysin homolog 0.0025 0.0065 0.0114
Echinococcus granulosus caspase 2 0.0076 0.0613 0.1081
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0029 0.0105 0.1726
Loa Loa (eye worm) inositol-1 0.0082 0.0673 0.0725
Brugia malayi Matrixin family protein 0.0025 0.0065 0.0064
Brugia malayi Melibiase family protein 0.0069 0.054 0.0579
Loa Loa (eye worm) cytochrome P450 family protein 0.0063 0.047 0.0505
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0102 0.0891 0.1575
Trypanosoma cruzi cysteine peptidase, putative 0.0025 0.0057 0.0062
Brugia malayi beta-lactamase family protein 0.0038 0.0204 0.0216
Onchocerca volvulus 0.0038 0.0204 0.045
Loa Loa (eye worm) MBCTL1 0.0059 0.0425 0.0457
Loa Loa (eye worm) hypothetical protein 0.0048 0.0309 0.033
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0404 0.4171 0.443
Loa Loa (eye worm) hypothetical protein 0.0025 0.0065 0.0066
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0348 0.0609
Brugia malayi hypothetical protein 0.0076 0.0613 0.0659
Brugia malayi TAR-binding protein 0.0067 0.052 0.0558
Leishmania major mitochondrial DNA polymerase beta 0.0306 0.3103 0.3357
Loa Loa (eye worm) hypothetical protein 0.0059 0.0425 0.0457
Echinococcus multilocularis neutral alpha glucosidase AB 0.0042 0.0244 0.0239
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0204 0.0187
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0031 0.0125 0.049
Echinococcus multilocularis SAM and MBT domain containing protein 0.0052 0.0348 0.0343
Loa Loa (eye worm) hypothetical protein 0.0048 0.0309 0.033
Mycobacterium ulcerans hypothetical protein 0.0038 0.0204 0.0216
Brugia malayi Nuclear hormone receptor E75 0.0048 0.0309 0.0329
Loa Loa (eye worm) matrixin family protein 0.0061 0.0456 0.0489
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0064 0.0479 0.0513
Leishmania major heat shock protein 83-1 0.0037 0.0185 0.0195
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0048 0.0309 0.0304
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0139 0.0237
Loa Loa (eye worm) hypothetical protein 0.0048 0.0309 0.033
Leishmania major alpha glucosidase II subunit, putative 0.0042 0.0244 0.0259
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0871 0.923 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0204 0.0217
Trichomonas vaginalis conserved hypothetical protein 0.0404 0.4171 0.45
Brugia malayi tailless protein 0.0048 0.0309 0.0329
Leishmania major heat shock protein 83-1 0.0037 0.0185 0.0195
Brugia malayi Endoplasmin precursor 0.0037 0.0185 0.0195
Loa Loa (eye worm) hypothetical protein 0.0038 0.0204 0.0217
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0082 0.0673 0.0697
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0139 0.0237
Brugia malayi Synaptic glycoprotein SC2 0.0404 0.4171 0.4516
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0336 0.0588
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0404 0.4171 0.4516
Echinococcus multilocularis thyroid hormone receptor alpha 0.0102 0.0891 0.0886
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0069 0.054 0.0552
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0871 0.923 1
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0027 0.008 0.0133
Brugia malayi Steroid receptor seven-up type 2 0.0102 0.0891 0.096
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0255 0.0276
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0064 0.0479 0.0364
Schistosoma mansoni inhibitor of apoptosis protein 0.0151 0.1426 0.2527
Loa Loa (eye worm) hypothetical protein 0.0151 0.1426 0.1542
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0102 0.0891 0.1575
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0204 0.3463
Plasmodium falciparum polyprenol reductase, putative 0.0404 0.4171 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0613 0.066
Trichomonas vaginalis heat shock protein, putative 0.0037 0.0185 0.0167
Schistosoma mansoni tar DNA-binding protein 0.0067 0.052 0.0915
Brugia malayi hypothetical protein 0.0054 0.0371 0.0397
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0204 0.0221
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0082 0.0673 0.0729
Schistosoma mansoni inositol monophosphatase 0.0082 0.0673 0.1187
Brugia malayi nuclear receptor RXR 0.0048 0.0309 0.0329
Loa Loa (eye worm) glutaminase 0.031 0.3154 0.3414
Echinococcus granulosus histone acetyltransferase MYST2 0.0059 0.0425 0.0747
Echinococcus multilocularis ecdysone induced protein 78C 0.0102 0.0891 0.0886
Schistosoma mansoni hypothetical protein 0.0539 0.563 1
Brugia malayi heat shock protein 90 0.0037 0.0185 0.0195
Brugia malayi Glycosyl hydrolases family 31 protein 0.0189 0.1841 0.1989
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0064 0.0479 0.0519
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0348 0.0609
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0048 0.0309 0.0329
Brugia malayi nuclear hormone receptor 0.0048 0.0309 0.0329
Schistosoma mansoni transcription factor LCR-F1 0.0033 0.0148 0.0253
Schistosoma mansoni nuclear receptor 0.0048 0.0309 0.054
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0102 0.0891 0.096
Trichomonas vaginalis set domain proteins, putative 0.0256 0.2565 0.2754
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0204 0.0216
Trypanosoma brucei heat shock protein, putative 0.0037 0.0185 0.0195
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0404 0.4171 0.45
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0404 0.4171 0.443
Loa Loa (eye worm) hypothetical protein 0.0069 0.054 0.058
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0082 0.0673 0.0723
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0057 0.0056
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0064 0.0479 0.0513
Loa Loa (eye worm) hypothetical protein 0.0151 0.1426 0.1542
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0102 0.0891 0.0962
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0048 0.0309 0.0702
Trypanosoma cruzi heat shock protein 90, putative 0.0037 0.0185 0.0201
Trypanosoma cruzi heat shock protein 85, putative 0.0029 0.0105 0.0113
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0057 0.0056
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0139 0.0237
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0244 0.0231
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0031 0.0125 0.013
Brugia malayi nuclear hormone receptor family member nhr-6 0.0048 0.0309 0.0329
Loa Loa (eye worm) hypothetical protein 0.0022 0.0024 0.0021
Loa Loa (eye worm) hypothetical protein 0.0048 0.0309 0.033
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0064 0.0479 0.092
Loa Loa (eye worm) hypothetical protein 0.0022 0.0032 0.003
Leishmania major heat shock protein 83-1 0.0037 0.0185 0.0195
Brugia malayi nuclear receptor NHR-88 0.0048 0.0309 0.0329
Schistosoma mansoni hypothetical protein 0.0539 0.563 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0102 0.0891 0.2104
Trypanosoma brucei heat shock protein, putative 0.0037 0.0185 0.0195
Brugia malayi ecdysone receptor 0.0048 0.0309 0.0329
Loa Loa (eye worm) CYP4Cod1 0.004 0.022 0.0234
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0204 0.0354
Loa Loa (eye worm) hypothetical protein 0.0102 0.0891 0.0962
Loa Loa (eye worm) hypothetical protein 0.0048 0.0309 0.033
Echinococcus granulosus heat shock protein 90 0.0029 0.0105 0.0176
Loa Loa (eye worm) cytochrome P450 0.002 0.0005 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0057 0.0056
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0404 0.4171 0.45
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0042 0.0244 0.026
Onchocerca volvulus 0.0038 0.0204 0.045
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0048 0.0309 0.0304
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0404 0.4171 0.4168
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0404 0.4171 0.4519
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0102 0.0891 0.096
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0102 0.0891 0.096
Toxoplasma gondii melibiase subfamily protein 0.0104 0.0915 0.0986
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.0014
Loa Loa (eye worm) hypothetical protein 0.0054 0.0371 0.0398
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0054 0.0371 0.0651
Echinococcus multilocularis FTZ F1 alpha 0.0102 0.0891 0.0886
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0057 0.0056
Leishmania major cathepsin L-like protease 0.0025 0.0057 0.0056
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0048 0.0309 0.054
Echinococcus granulosus neutral alpha glucosidase AB 0.0042 0.0244 0.0425
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0336 0.0359
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0139 0.0237
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0102 0.0891 0.0886
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0204 0.0216
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0064 0.0479 0.0514
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0336 0.0588
Echinococcus multilocularis musashi 0.003 0.0114 0.0108
Trichomonas vaginalis esterase, putative 0.0038 0.0204 0.0187
Loa Loa (eye worm) hypothetical protein 0.0029 0.0108 0.0112
Leishmania major heat shock protein 83-1 0.0037 0.0185 0.0195
Schistosoma mansoni inositol monophosphatase 0.0082 0.0673 0.1187
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0244 0.0231
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0092 0.0792 0.0787
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0064 0.0479 0.1079
Trypanosoma brucei cytochrome P450, putative 0.004 0.022 0.0233
Onchocerca volvulus 0.0052 0.0348 0.0796
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0204 0.0187
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0082 0.0673 0.0723
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.052 0.0559
Schistosoma mansoni hypothetical protein 0.0033 0.0148 0.0253
Onchocerca volvulus 0.0109 0.0976 0.2307
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0102 0.0891 0.1575
Trichomonas vaginalis heat shock protein, putative 0.0029 0.0105 0.0079
Entamoeba histolytica heat shock protein 90, putative 0.0037 0.0185 0.0041
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0871 0.923 1
Trichomonas vaginalis ap endonuclease, putative 0.0064 0.0479 0.0486
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0104 0.0915 0.1617
Onchocerca volvulus 0.0048 0.0309 0.0702
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0048 0.0309 0.0304
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0204 0.0199
Brugia malayi Hemopexin family protein 0.0036 0.018 0.0189
Mycobacterium ulcerans beta-lactamase 0.0038 0.0204 0.0216
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0404 0.4171 0.7407
Loa Loa (eye worm) mbt repeat family protein 0.0052 0.0348 0.0373
Trypanosoma brucei Heat shock protein 83, putative 0.0037 0.0185 0.0195
Echinococcus multilocularis tar DNA binding protein 0.0067 0.052 0.0515
Schistosoma mansoni RAR-like nuclear receptor 0.0102 0.0891 0.1575
Schistosoma mansoni nuclear receptor nhr-48 0.0048 0.0309 0.054
Loa Loa (eye worm) hypothetical protein 0.0404 0.4171 0.4516
Trypanosoma brucei PAB1-binding protein , putative 0.0022 0.0032 0.0029
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0059 0.0425 0.042
Brugia malayi RNA, U transporter 1 0.0036 0.0175 0.0184
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0082 0.0673 0.0723
Loa Loa (eye worm) TAR-binding protein 0.0067 0.052 0.0559
Brugia malayi hypothetical protein 0.0256 0.256 0.2769
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0054 0.0371 0.0651
Echinococcus granulosus FTZ F1 alpha 0.0102 0.0891 0.1575
Brugia malayi Inositol-1 0.0082 0.0673 0.0723
Mycobacterium ulcerans heat shock protein 90 0.0029 0.0105 0.0108
Schistosoma mansoni hypothetical protein 0.0134 0.1239 0.2193
Echinococcus multilocularis synaptic glycoprotein sc2 0.0404 0.4171 0.4168
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0151 0.1426 0.1541
Loa Loa (eye worm) hypothetical protein 0.0102 0.0891 0.0962
Echinococcus granulosus intermediate filament protein 0.003 0.0114 0.0193
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0102 0.0891 0.096
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0336 0.0331
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.004 0.022 0.0233
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0204 0.0187
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.022 0.0234
Echinococcus granulosus synaptic glycoprotein sc2 0.0404 0.4171 0.7407
Brugia malayi hypothetical protein 0.0048 0.0309 0.0329
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0022 0.0024 0.002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0139 0.0237
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.052 0.0558
Brugia malayi Nuclear hormone receptor-like 1 0.0054 0.0371 0.0397
Echinococcus granulosus polycomb protein SCMH1 0.0052 0.0348 0.0609
Echinococcus multilocularis heat shock protein 0.0037 0.0185 0.018
Schistosoma mansoni nuclear receptor 0.0048 0.0309 0.054
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0336 0.0331
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0082 0.0673 0.0729
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0871 0.923 1
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0204 0.0817
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.1357 0.147
Mycobacterium leprae PROBABLE HYDROLASE 0.0031 0.0125 0.2079
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0871 0.923 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0891 0.0962
Loa Loa (eye worm) hypothetical protein 0.0256 0.256 0.277
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0029 0.0105 0.0108
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0064 0.0479 0.1079
Brugia malayi nuclear hormone receptor 0.0102 0.0891 0.096
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.1357 0.1465
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0871 0.923 1
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0871 0.923 1
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0151 0.1426 0.1541
Echinococcus granulosus snurportin 1 0.0134 0.1239 0.2193
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0404 0.4171 1
Entamoeba histolytica hypothetical protein 0.0404 0.4171 0.443
Loa Loa (eye worm) hypothetical protein 0.0048 0.0309 0.033
Trichomonas vaginalis glutaminase, putative 0.031 0.3154 0.3394
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0102 0.0891 0.0962
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0057 0.0056
Schistosoma mansoni tar DNA-binding protein 0.0067 0.052 0.0915
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0102 0.0891 0.1575
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0336 0.0588
Echinococcus granulosus endoplasmin 0.0029 0.0105 0.0176
Schistosoma mansoni thyroid hormone receptor 0.0102 0.0891 0.1575
Mycobacterium tuberculosis Conserved hypothetical protein 0.0161 0.1534 0.6274
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0139 0.0134
Loa Loa (eye worm) steroid hormone receptor 0.0102 0.0891 0.0962
Onchocerca volvulus 0.0038 0.0204 0.045
Loa Loa (eye worm) hypothetical protein 0.0025 0.0065 0.0066
Schistosoma mansoni cellular tumor antigen P53 0.0021 0.0017 0.0022
Leishmania major heat shock protein 83-1 0.0037 0.0185 0.0195
Schistosoma mansoni retinoic acid receptor RXR 0.0102 0.0891 0.1575
Brugia malayi RNA binding protein 0.0067 0.052 0.0558
Plasmodium vivax endoplasmin, putative 0.0037 0.0185 0.037
Echinococcus granulosus inositol monophosphatase 1 0.0082 0.0673 0.1187
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0082 0.0673 0.0578
Brugia malayi Cytochrome P450 family protein 0.0063 0.047 0.0504
Echinococcus multilocularis endoplasmin 0.0029 0.0105 0.0099
Loa Loa (eye worm) hypothetical protein 0.003 0.0114 0.0119
Trypanosoma brucei heat shock protein, putative 0.0037 0.0185 0.0195
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0336 0.0588
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0244 0.0231
Leishmania major heat shock protein 83-1 0.0037 0.0185 0.0195
Brugia malayi Nuclear hormone receptor-like 1 0.0102 0.0891 0.096
Brugia malayi Cytochrome P450 family protein 0.004 0.022 0.0233
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0204 0.0417
Schistosoma mansoni hypothetical protein 0.0151 0.1426 0.2527
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0102 0.0891 0.0886
Loa Loa (eye worm) hypothetical protein 0.0031 0.0125 0.0131
Giardia lamblia Heat shock protein HSP 90-alpha 0.0037 0.0185 0.0198
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0204 0.0221
Plasmodium vivax polyprenol reductase, putative 0.0404 0.4171 1
Echinococcus multilocularis inhibitor of apoptosis protein 0.0151 0.1426 0.1422
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0306 0.3103 0.3361
Loa Loa (eye worm) hypothetical protein 0.0102 0.0891 0.0962
Brugia malayi hypothetical protein 0.0054 0.0371 0.0397
Trypanosoma brucei heat shock protein, putative 0.0037 0.0185 0.0195
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0336 0.0358
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.002 0.0005 0.0006
Brugia malayi Matrixin family protein 0.0025 0.0065 0.0064
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0059 0.0425 0.0455
Mycobacterium leprae Probable lipase LipE 0.0038 0.0204 0.3463
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0189 0.1841 0.199
Echinococcus granulosus nuclear receptor nhr 48 0.0048 0.0309 0.054
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0244 0.0106
Echinococcus granulosus lysosomal alpha glucosidase 0.0189 0.1841 0.3263
Leishmania major heat shock protein 83-1 0.0037 0.0185 0.0195
Echinococcus multilocularis microtubule associated protein 2 0.03 0.3039 0.3035
Brugia malayi ecdysteroid receptor 0.0102 0.0891 0.096
Leishmania major heat shock protein 83-1 0.0037 0.0185 0.0195
Mycobacterium tuberculosis Conserved protein 0.0038 0.0204 0.0817
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0069 0.054 0.095
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0022 0.0024 0.0021
Schistosoma mansoni nuclear hormone receptor 0.0048 0.0309 0.054
Echinococcus granulosus microtubule associated protein 2 0.03 0.3039 0.5394
Brugia malayi Nuclear hormone receptor-like 1 0.0054 0.0371 0.0397
Loa Loa (eye worm) hypothetical protein 0.0256 0.256 0.277
Schistosoma mansoni nuclear hormone receptor 0.0048 0.0309 0.054

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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