Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0784 | 0.1214 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0784 | 0.1214 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0011 | 0.024 | 0.0372 |
Echinococcus multilocularis | zinc finger protein | 0.0023 | 0.1 | 0.0975 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0023 | 0.096 | 0.0887 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0784 | 0.1214 |
Trypanosoma cruzi | ISWI complex protein | 0.0017 | 0.0592 | 0.0566 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0027 | 0.1251 | 0.1625 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0133 | 0.7919 | 1 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0023 | 0.1011 | 0.1239 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.002 | 0.0784 | 0.0875 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0784 | 0.1214 |
Trichomonas vaginalis | CAMK family protein kinase | 0.011 | 0.6461 | 1 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.002 | 0.0784 | 0.071 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0784 | 0.1214 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0784 | 0.1214 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0133 | 0.7919 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0133 | 0.7919 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0133 | 0.7919 | 0.5 |
Echinococcus granulosus | muscleblind protein | 0.0166 | 1 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0026 | 0.1205 | 0.118 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.024 | 0.0161 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0011 | 0.024 | 0.0372 |
Trichomonas vaginalis | CAMK family protein kinase | 0.011 | 0.6461 | 1 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.002 | 0.0784 | 0.071 |
Trichomonas vaginalis | CAMK family protein kinase | 0.011 | 0.6461 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0784 | 0.1214 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0012 | 0.0321 | 0.0496 |
Echinococcus granulosus | phosphatidylinositol 3 and 4 kinase | 0.002 | 0.0784 | 0.0758 |
Trichomonas vaginalis | CAMK family protein kinase | 0.011 | 0.6461 | 1 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.002 | 0.0784 | 0.0875 |
Trypanosoma brucei | phosphatidylinositol kinase related protein, putative | 0.0027 | 0.1251 | 0.1515 |
Schistosoma mansoni | zinc finger protein | 0.0017 | 0.0592 | 0.0714 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0757 | 0.0682 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0067 | 0.3741 | 0.4705 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0784 | 0.1214 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.011 | 0.6461 | 1 |
Trypanosoma brucei | phosphatidylinositol 3-related kinase, putative | 0.002 | 0.0784 | 0.0755 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0592 | 0.0714 |
Giardia lamblia | Kinase, PLK | 0.011 | 0.6461 | 1 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0027 | 0.1251 | 0.118 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0784 | 0.1214 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.002 | 0.0784 | 0.0755 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.002 | 0.0784 | 0.0875 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0133 | 0.7919 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0133 | 0.7919 | 0.7913 |
Trypanosoma brucei | polo-like protein kinase | 0.011 | 0.6461 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0784 | 0.1214 |
Trypanosoma cruzi | ISWI complex protein | 0.0017 | 0.0592 | 0.0566 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0133 | 0.7919 | 1 |
Echinococcus multilocularis | serine protein kinase ATM | 0.0027 | 0.1251 | 0.1226 |
Trichomonas vaginalis | CAMK family protein kinase | 0.011 | 0.6461 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0784 | 0.1214 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0166 | 1 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0062 | 0.3455 | 0.4126 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.1763 | 0.2199 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.002 | 0.0784 | 0.0263 |
Brugia malayi | CXXC zinc finger family protein | 0.0031 | 0.1519 | 0.145 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0067 | 0.377 | 0.3752 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0011 | 0.024 | 0.0372 |
Echinococcus multilocularis | cpg binding protein | 0.0035 | 0.1763 | 0.174 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.002 | 0.0784 | 0.071 |
Echinococcus granulosus | serine:threonine protein kinase SMG1 | 0.0011 | 0.024 | 0.0212 |
Schistosoma mansoni | kinase | 0.0056 | 0.3055 | 0.3836 |
Trypanosoma brucei | ISWI complex protein | 0.0017 | 0.0592 | 0.0442 |
Echinococcus multilocularis | serine:threonine protein kinase SMG1 | 0.0011 | 0.024 | 0.0212 |
Toxoplasma gondii | target of rapamycin (TOR), putative | 0.002 | 0.0784 | 0.0611 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.1011 | 0.0938 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0133 | 0.7919 | 0.7913 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0011 | 0.024 | 0.0372 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0039 | 0.2016 | 0.1993 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0011 | 0.024 | 0.0372 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0784 | 0.1214 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.1519 | 0.1888 |
Trypanosoma cruzi | phosphatidylinositol 3-related kinase, putative | 0.002 | 0.0784 | 0.0875 |
Schistosoma mansoni | serine/threonine protein kinase | 0.011 | 0.6461 | 0.8152 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.011 | 0.6461 | 0.801 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0026 | 0.1205 | 0.1491 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0784 | 0.1214 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.2185 | 0.2121 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.096 | 0.1181 |
Echinococcus multilocularis | PIK kinase, FAT and Armadillo domain containing protein | 0.0009 | 0.008 | 0.0052 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0012 | 0.0273 | 0.0195 |
Toxoplasma gondii | FATC domain-containing protein | 0.0027 | 0.1251 | 0.1224 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0067 | 0.377 | 0.3752 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.011 | 0.6461 | 0.6451 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0019 | 0.0757 | 0.0923 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.002 | 0.0787 | 0.0879 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0784 | 0.1214 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.011 | 0.6461 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.001 | 0.0149 | 0.0121 |
Leishmania major | target of rapamycin kinase (TOR) kinase 3 | 0.002 | 0.0784 | 0.0263 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0019 | 0.0757 | 0.073 |
Echinococcus multilocularis | phosphatidylinositol 3 and 4 kinase | 0.002 | 0.0784 | 0.0758 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0784 | 0.1214 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0019 | 0.0713 | 0.0687 |
Echinococcus granulosus | cpg binding protein | 0.0035 | 0.1763 | 0.174 |
Brugia malayi | Bromodomain containing protein | 0.0042 | 0.218 | 0.2116 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0009 | 0.008 | 0.0124 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0012 | 0.0321 | 0.0496 |
Schistosoma mansoni | bromodomain containing protein | 0.0071 | 0.4017 | 0.5055 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.002 | 0.0784 | 0.0958 |
Schistosoma mansoni | fkbp-rapamycin associated protein | 0.0011 | 0.024 | 0.0268 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0133 | 0.7919 | 0.5 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.002 | 0.0784 | 0.0755 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0031 | 0.1519 | 0.145 |
Loa Loa (eye worm) | histone methyltransferase | 0.001 | 0.0149 | 0.007 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0019 | 0.0757 | 0.0923 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.002 | 0.0784 | 0.0758 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0321 | 0.0242 |
Leishmania major | phosphatidylinositol 3-kinase, putative | 0.002 | 0.0784 | 0.0263 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0784 | 0.1214 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0784 | 0.1214 |
Schistosoma mansoni | phosphatidylinositol 3-and 4-kinase | 0.002 | 0.0784 | 0.0958 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0784 | 0.1214 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0784 | 0.1214 |
Trypanosoma cruzi | phosphatidylinositol 3-related kinase, putative | 0.002 | 0.0784 | 0.0875 |
Trichomonas vaginalis | CAMK family protein kinase | 0.011 | 0.6461 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.1251 | 0.1936 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.011 | 0.6461 | 0.6432 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0011 | 0.024 | 0.0161 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0026 | 0.1205 | 0.118 |
Echinococcus multilocularis | muscleblind protein | 0.0166 | 1 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0023 | 0.1 | 0.1232 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0784 | 0.1214 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0784 | 0.1214 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0019 | 0.0713 | 0.0868 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.4418 | 0.4373 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.2348 | 0.2286 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0784 | 0.1214 |
Schistosoma mansoni | hypothetical protein | 0.0009 | 0.008 | 0.0066 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0784 | 0.1214 |
Trypanosoma brucei | phosphatidylinositol 3-kinase, putative | 0.002 | 0.0784 | 0.0755 |
Echinococcus granulosus | zinc finger protein | 0.0023 | 0.1 | 0.0975 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.011 | 0.6461 | 0.6451 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.002 | 0.0784 | 0.071 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0054 | 0.2964 | 0.4588 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.002 | 0.0784 | 0.0875 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0054 | 0.2964 | 0.4588 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0784 | 0.1214 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm) | 0.0027 | 0.1251 | 0.1549 |
Leishmania major | phosphatidylinositol kinase related protein, putative | 0.002 | 0.0787 | 0.0266 |
Echinococcus granulosus | PIK kinase FAT and Armadillo domain containing protein | 0.0009 | 0.008 | 0.0052 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.002 | 0.0784 | 0.0755 |
Leishmania major | phosphatidylinositol 3-related kinase, putative | 0.002 | 0.0784 | 0.0263 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2593 | 0.2533 |
Echinococcus granulosus | serine protein kinase ATM | 0.0027 | 0.1251 | 0.1226 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0784 | 0.1214 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0039 | 0.2016 | 0.1993 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.001 | 0.0149 | 0.0121 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0019 | 0.0713 | 0.0868 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.011 | 0.6461 | 0.6432 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0019 | 0.0757 | 0.073 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.011 | 0.6461 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0784 | 0.1214 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0011 | 0.024 | 0.0372 |
Trichomonas vaginalis | CAMK family protein kinase | 0.011 | 0.6461 | 1 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0019 | 0.0756 | 0.0681 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.1763 | 0.2199 |
Brugia malayi | Bromodomain containing protein | 0.0084 | 0.4826 | 0.4784 |
Brugia malayi | PHD-finger family protein | 0.0029 | 0.1369 | 0.1299 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0784 | 0.1214 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.011 | 0.6461 | 1 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.002 | 0.0784 | 0.0875 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0133 | 0.7919 | 1 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0019 | 0.0713 | 0.0687 |
Entamoeba histolytica | hypothetical protein | 0.0027 | 0.1251 | 0.1625 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0784 | 0.1214 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.002 | 0.0784 | 0.0758 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0011 | 0.024 | 0.0372 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.002 | 0.0784 | 0.0263 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.0784 | 0.1214 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | < 10 mm | Antimicrobial activity against Escherichia coli IFO 3301 at 200 ug/disc after 24 hrs by agar disc diffusion method | ChEMBL. | 21849221 |
IZ (functional) | < 10 mm | Antifungal activity against Candida albicans IFO 0583 at 200 ug/disc after 48 hrs by agar disc diffusion method | ChEMBL. | 21849221 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.