Detailed information for compound 111188

Basic information

Technical information
  • TDR Targets ID: 111188
  • Name: 1-[(3,5-dimethylphenyl)methoxy]-3-naphthalen- 1-ylpropan-2-amine
  • MW: 319.44 | Formula: C22H25NO
  • H donors: 1 H acceptors: 0 LogP: 4.63 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(Cc1cccc2c1cccc2)COCc1cc(C)cc(c1)C
  • InChi: 1S/C22H25NO/c1-16-10-17(2)12-18(11-16)14-24-15-21(23)13-20-8-5-7-19-6-3-4-9-22(19)20/h3-12,21H,13-15,23H2,1-2H3
  • InChiKey: WPIIEURLXPCWTN-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • 1-[(3,5-dimethylphenyl)methoxy]-3-(1-naphthyl)propan-2-amine
  • 1-[(3,5-dimethylphenyl)methoxy]-3-(1-naphthalenyl)-2-propanamine
  • 1-[(3,5-dimethylphenyl)methoxy]-3-naphthalen-1-yl-propan-2-amine
  • [1-[(3,5-dimethylbenzyl)oxymethyl]-2-(1-naphthyl)ethyl]amine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tachykinin receptor 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04224 tachykinin receptor 3, putative Get druggable targets OG5_137770 All targets in OG5_137770

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0037 0.0105 0.0227
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.01 0.1045 0.1039
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0305 0.4126 1
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0066 0.0534 0.1067
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0041 0.016 0.0153
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0102 0.0096
Loa Loa (eye worm) hypothetical protein 0.0055 0.037 0.0364
Loa Loa (eye worm) hypothetical protein 0.0055 0.037 0.0364
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0149 0.1785 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0055 0.037 0.0838
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0217 0.2809 0.2804
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0102 0.0096
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0305 0.4126 1
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0185 0.0179
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0084 0.0816 0.0811
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0041 0.016 0.0136
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0037 0.0105 0.0099
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0066 0.0534 0.0528
Brugia malayi excitatory GABA receptor EXP-1A 0.0055 0.037 0.0838
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0055 0.037 0.0364
Onchocerca volvulus 0.0247 0.3259 1
Loa Loa (eye worm) peptidase family M1 containing protein 0.0037 0.0105 0.0099
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0102 0.0102
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0055 0.037 0.0838
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0041 0.016 0.0136
Schistosoma mansoni jumonji domain containing protein 0.0079 0.0738 0.0732
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0041 0.016 0.1892
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0084 0.0816 0.1966
Echinococcus granulosus glycine receptor subunit beta 0.0055 0.037 0.037
Plasmodium vivax proteasome subunit beta type-5, putative 0.0084 0.0816 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0037 0.0105 0.0099
Onchocerca volvulus 0.0031 0.0017 0.0034
Toxoplasma gondii proteasome subunit beta type, putative 0.0084 0.0816 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0055 0.037 0.037
Leishmania major proteasome beta 2 subunit, putative 0.0041 0.016 0.0767
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0055 0.037 0.037
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0492 0.0486
Plasmodium vivax proteasome subunit beta type-1, putative 0.0066 0.0534 0.6512
Toxoplasma gondii aminopeptidase N protein 0.0037 0.0105 0.1218
Loa Loa (eye worm) hypothetical protein 0.0055 0.037 0.0364
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0055 0.037 0.0838
Brugia malayi proteasome subunit beta type 1 0.0066 0.0534 0.1213
Loa Loa (eye worm) hypothetical protein 0.0052 0.0332 0.0326
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0102 0.0096
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0066 0.0534 0.6512
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0084 0.0816 0.1769
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0055 0.037 0.0364
Brugia malayi Peptidase family M1 containing protein 0.0037 0.0105 0.0227
Loa Loa (eye worm) hypothetical protein 0.0055 0.037 0.0364
Schistosoma mansoni nAChR subunit 0.0055 0.037 0.0364
Brugia malayi Pre-SET motif family protein 0.0031 0.0017 0.0025
Brugia malayi Peptidase family M1 containing protein 0.0037 0.0105 0.0227
Schistosoma mansoni hypothetical protein 0.0177 0.2203 0.2198
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0037 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0031 0.0017 0.0011
Schistosoma mansoni hypothetical protein 0.0177 0.2203 0.2198
Brugia malayi jmjC domain containing protein 0.01 0.1045 0.2389
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0055 0.037 0.0364
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0037 0.0105 0.0105
Onchocerca volvulus 0.0055 0.037 0.112
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0055 0.037 0.0364
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0017 0.0011
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0037 0.0105 0.0105
Loa Loa (eye worm) proteasome subunit beta type 2 0.0041 0.016 0.0153
Loa Loa (eye worm) TATA binding protein associated factor 0.0037 0.0105 0.0099
Trichomonas vaginalis set domain proteins, putative 0.0247 0.3259 0.7843
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0066 0.0534 0.6029
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0037 0.0105 0.0099
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0084 0.0816 1
Brugia malayi Cation transporter family protein 0.0055 0.037 0.0838
Brugia malayi Cation transporter family protein 0.0055 0.037 0.0838
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.4126 1
Echinococcus multilocularis nAChR subunit 0.0055 0.037 0.0364
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0084 0.0816 1
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0037 0.0105 0.1218
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0041 0.016 0.0153
Echinococcus granulosus proteasome prosome macropain 0.0084 0.0816 0.0816
Loa Loa (eye worm) hypothetical protein 0.0055 0.037 0.0364
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0055 0.037 0.0364
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0055 0.037 0.0838
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0066 0.0534 0.0534
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0084 0.0816 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.4126 1
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0041 0.016 0.0153
Brugia malayi hypothetical protein 0.0037 0.0105 0.0227
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0055 0.037 0.0838
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0017 0.0135
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.4126 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0037 0.0105 0.0099
Echinococcus multilocularis glycine receptor subunit beta 0.0055 0.037 0.0364
Echinococcus granulosus nAChR subunit 0.0055 0.037 0.037
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0055 0.037 0.0364
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0055 0.037 0.037
Plasmodium falciparum proteasome subunit beta type-5 0.0084 0.0816 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0149 0.1785 1
Echinococcus granulosus glycine receptor subunit beta 0.0055 0.037 0.037
Echinococcus multilocularis geminin 0.0177 0.2203 0.2198
Brugia malayi proteasome subunit beta type 2 0.0041 0.016 0.0353
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0055 0.037 0.0838
Loa Loa (eye worm) hypothetical protein 0.0055 0.037 0.0364
Loa Loa (eye worm) hypothetical protein 0.0055 0.037 0.0364
Plasmodium vivax SET domain protein, putative 0.0031 0.0017 0.0135
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0055 0.037 0.0364
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0055 0.037 0.0364
Loa Loa (eye worm) hypothetical protein 0.0055 0.037 0.0364
Loa Loa (eye worm) hypothetical protein 0.0055 0.037 0.0364
Loa Loa (eye worm) hypothetical protein 0.0055 0.037 0.0364
Onchocerca volvulus 0.0055 0.037 0.112
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0055 0.037 0.0838
Loa Loa (eye worm) hypothetical protein 0.0037 0.0105 0.0099
Loa Loa (eye worm) hypothetical protein 0.0037 0.0105 0.0099
Trypanosoma cruzi 20S proteasome subunit 0.0041 0.016 0.0767
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0055 0.037 0.0364
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0037 0.0105 0.1218
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0055 0.037 0.0364
Leishmania major proteasome beta 5 subunit, putative 0.0084 0.0816 1
Schistosoma mansoni nAChR subunit 0.0055 0.037 0.0364
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0037 0.0105 0.1218
Loa Loa (eye worm) hypothetical protein 0.0055 0.037 0.0364
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0055 0.037 0.0364
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0037 0.0105 0.0099
Onchocerca volvulus 0.0037 0.0105 0.0303
Brugia malayi jmjC domain containing protein 0.0037 0.0102 0.0221
Loa Loa (eye worm) ACC-1 protein 0.0055 0.037 0.0364
Schistosoma mansoni nAChR subunit 0.0055 0.037 0.0364
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0055 0.037 0.037
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0037 0.0105 0.0099
Onchocerca volvulus 0.0055 0.037 0.112
Loa Loa (eye worm) hypothetical protein 0.0055 0.037 0.0364
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0055 0.037 0.0364
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0017 0.0011
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0066 0.0534 0.6029
Giardia lamblia Fructose-bisphosphate aldolase 0.0305 0.4126 1
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0055 0.037 0.037
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0696 1 1
Toxoplasma gondii aminopeptidase n, putative 0.0037 0.0105 0.1218
Mycobacterium ulcerans proteasome PrcB 0.0084 0.0816 0.4234
Loa Loa (eye worm) hypothetical protein 0.0055 0.037 0.0364
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0055 0.037 0.0838
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0041 0.016 0.016
Brugia malayi Cation transporter family protein 0.0055 0.037 0.0838
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0055 0.037 0.0364
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0055 0.037 0.0364
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0037 0.0105 0.0105
Treponema pallidum fructose-bisphosphate aldolase 0.0305 0.4126 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0017 0.0011
Echinococcus granulosus peregrin 0.003 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0055 0.037 0.0364
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.4126 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0037 0.0105 0.0105
Onchocerca volvulus 0.0037 0.0105 0.0303
Onchocerca volvulus 0.0055 0.037 0.112
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0037 0.0105 0.0105
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0055 0.037 0.0838
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.4126 1
Schistosoma mansoni aminopeptidase A (M01 family) 0.0037 0.0105 0.0099
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0055 0.037 0.0838
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0017 0.0011
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.4126 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.037 0.0364
Schistosoma mansoni nAChR subunit 0.0055 0.037 0.0364
Schistosoma mansoni nAChR subunit 0.0055 0.037 0.0364
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0066 0.0534 0.6512
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0055 0.037 0.0838
Loa Loa (eye worm) aminopeptidase N 0.0037 0.0105 0.0099
Loa Loa (eye worm) LGC-31 protein 0.0055 0.037 0.0364
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0055 0.037 0.0838
Brugia malayi TATA binding protein associated factor 0.0037 0.0105 0.0227
Loa Loa (eye worm) hypothetical protein 0.0037 0.0105 0.0099
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0055 0.037 0.037
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0149 0.1785 1
Trypanosoma brucei proteasome beta 6 subunit 0.0066 0.0534 0.6029
Loa Loa (eye worm) ACC-1 protein 0.0055 0.037 0.0364
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0185 0.0185
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.4126 1
Loa Loa (eye worm) proteasome subunit beta type 1 0.0066 0.0534 0.0528
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0066 0.0534 0.6029
Echinococcus multilocularis proteasome (prosome, macropain) 0.0084 0.0816 0.0811
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0055 0.037 0.0364
Plasmodium vivax proteasome subunit beta type-2, putative 0.0041 0.016 0.1892
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0696 1 1
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0055 0.037 0.0364
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0055 0.037 0.0364
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0037 0.0105 0.0099
Echinococcus multilocularis glycine receptor subunit beta 0.0055 0.037 0.0364
Brugia malayi hypothetical protein 0.032 0.4354 1
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0055 0.037 0.0838
Onchocerca volvulus 0.0055 0.037 0.112
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0037 0.0105 0.0099
Echinococcus granulosus glycine receptor subunit alpha 1 0.0055 0.037 0.037
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.4126 1
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0055 0.037 0.0364
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0041 0.016 0.0136
Loa Loa (eye worm) hypothetical protein 0.0055 0.037 0.0364
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0055 0.037 0.0364
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0055 0.037 0.0838
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0041 0.016 0.0767
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0006 0.0006
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0041 0.016 0.0767
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0055 0.037 0.037
Loa Loa (eye worm) hypothetical protein 0.0055 0.037 0.0364
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0084 0.0816 0.0811
Echinococcus granulosus glycine receptor subunit alpha 1 0.0055 0.037 0.037
Loa Loa (eye worm) hypothetical protein 0.0055 0.037 0.0364
Brugia malayi Pre-SET motif family protein 0.0217 0.2809 0.6445
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0041 0.016 0.1892
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0055 0.037 0.0364
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0066 0.0534 0.0528
Schistosoma mansoni nAChR subunit 0.0055 0.037 0.0364
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0055 0.037 0.037
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0696 1 1
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0037 0.0105 0.0099
Onchocerca volvulus Putative nachr subunit 0.0055 0.037 0.112
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.01 0.1045 0.1045
Schistosoma mansoni nAChR subunit 0.0055 0.037 0.0364
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0055 0.037 0.0838
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0055 0.037 0.037
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0017 0.0011
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0084 0.0816 0.1769
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0102 0.0096
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0055 0.037 0.0364
Onchocerca volvulus 0.0037 0.0105 0.0303
Loa Loa (eye worm) hypothetical protein 0.0055 0.037 0.0364
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0017 0.0011
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0055 0.037 0.0364
Brugia malayi Peptidase family M1 containing protein 0.0037 0.0105 0.0227
Echinococcus granulosus aminopeptidase N 0.0037 0.0105 0.0105
Giardia lamblia Proteasome subunit beta type 2 0.0041 0.016 0.0372
Brugia malayi Proteasome A-type and B-type family protein 0.0084 0.0816 0.1863
Giardia lamblia Proteasome subunit beta type 1 0.0066 0.0534 0.1281
Toxoplasma gondii aminopeptidase N, putative 0.0037 0.0105 0.1218
Echinococcus multilocularis aminopeptidase N 0.0037 0.0105 0.0099
Onchocerca volvulus 0.0055 0.037 0.112
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0017 0.0017
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0037 0.0105 0.1218
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0055 0.037 0.0838
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0066 0.0534 0.1067
Echinococcus granulosus geminin 0.0177 0.2203 0.2203

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1160 nM Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells ChEMBL. No reference
IC50 (binding) = 1160 nM Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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