Detailed information for compound 1112261

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 441.565 | Formula: C28H31N3O2
  • H donors: 1 H acceptors: 1 LogP: 5.78 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Oc1ccc2c(c1)[C@]1(C)CCN([C@@H]1N2C)CCc1ccccc1)NCc1ccccc1
  • InChi: 1S/C28H31N3O2/c1-28-16-18-31(17-15-21-9-5-3-6-10-21)26(28)30(2)25-14-13-23(19-24(25)28)33-27(32)29-20-22-11-7-4-8-12-22/h3-14,19,26H,15-18,20H2,1-2H3,(H,29,32)/t26-,28-/m0/s1
  • InChiKey: GIMROWNJLOPMDK-XCZPVHLTSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus butyrylcholinesterase Starlite/ChEMBL References
Mus musculus acetylcholinesterase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus carboxylesterase 5A Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) carboxylesterase Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Brugia malayi Carboxylesterase family protein Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) acetylcholinesterase 1 Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma japonicum Acetylcholinesterase 1 precursor, putative Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126875 All targets in OG5_126875
Brugia malayi Carboxylesterase family protein Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma japonicum ko:K01049 acetylcholinesterase [EC3.1.1.7], putative Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis carboxylesterase 5A Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Carboxylesterase family protein acetylcholinesterase 614 aa 507 aa 26.0 %
Brugia malayi Carboxylesterase family protein butyrylcholinesterase 603 aa 548 aa 28.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax asparagine--tRNA ligase, putative 0.0031 0.0099 0.0422
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0023 0.0024
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0023 0.0008
Trypanosoma brucei aspartyl-tRNA synthetase, putative 0.0031 0.0099 0.0447
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0043 0.0169 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.0021 0.0074
Schistosoma mansoni aspartyl-tRNA synthetase 0.0031 0.0099 0.0159
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0073 0.03
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0028 0.0077 0.0179
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0023 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0031
Echinococcus multilocularis acetylcholinesterase 0.0164 0.0906 0.0897
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0063 0.0068
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0045 0.0035
Schistosoma mansoni replication factor A 1 rfa1 0.0633 0.3764 0.7656
Brugia malayi beta-lactamase 0.0039 0.0144 0.0344
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.022 0.0211
Brugia malayi Serine/threonine protein phosphatase PP1-alpha catalytic subunit 0.0025 0.0058 0.0116
Schistosoma mansoni aspartyl-tRNA synthetase 0.0031 0.0099 0.0159
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0026 0.0043
Brugia malayi Carboxylesterase family protein 0.0028 0.0077 0.0166
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0008
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0058 0.0263 0.0282
Plasmodium vivax serine/threonine protein phosphatase PP1, putative 0.004 0.015 0.0715
Trichomonas vaginalis protein phosphatase-1, putative 0.0025 0.0058 0.0129
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0021 0.0023
Onchocerca volvulus Putative replication factor A 73 kDa subunit 0.0567 0.3359 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0022 0.0045 0.0035
Brugia malayi serine/threonine-protein kinase plk-2 0.0106 0.0556 0.1443
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0043 0.0169 0.0424
Schistosoma mansoni aspartyl-tRNA synthetase 0.0031 0.0099 0.0159
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0008
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0023 0.0021
Schistosoma mansoni ran 0.0024 0.0055 0.0069
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0295 0.1702 0.3438
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0055 0.0045
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0055 0.0195
Mycobacterium tuberculosis Probable DNA polymerase III (alpha chain) DnaE1 (DNA nucleotidyltransferase) 0.0031 0.0099 0.0548
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0033 0.0061
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0028 0.0077 0.0114
Toxoplasma gondii OB-fold nucleic acid binding domain-containing protein 0.0159 0.0878 0.4934
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0602 0.3574 0.9494
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0349 0.2032 0.5387
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0031
Giardia lamblia DINP protein human, muc B family 0.0019 0.0023 0.0238
Echinococcus multilocularis lysyl tRNA synthetase 0.0031 0.0099 0.0089
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0295 0.1702 0.4507
Plasmodium falciparum asparagine--tRNA ligase 0.0031 0.0099 0.0422
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0169 0.0828
Schistosoma mansoni hypothetical protein 0.0821 0.491 1
Leishmania major GTP-binding protein, putative 0.0024 0.0055 0.0195
Echinococcus multilocularis acetylcholinesterase 0.0164 0.0906 0.0897
Echinococcus multilocularis leucyl tRNA synthetase 0.0043 0.0169 0.0159
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0023 0.0013
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0031 0.0099 0.0447
Trypanosoma cruzi Replication factor A protein 1 0.0304 0.1757 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0033 0.0061
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0269 0.1544 0.1653
Schistosoma mansoni lysyl-tRNA synthetase 0.0031 0.0099 0.0159
Loa Loa (eye worm) multisynthetase complex auxiliary component p43 0.0226 0.1284 0.3393
Schistosoma mansoni gliotactin 0.0028 0.0077 0.0114
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0031 0.0099 0.0089
Echinococcus granulosus snurportin 1 0.0349 0.2032 0.2176
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0073 0.03
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0031
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0021 0.0017
Wolbachia endosymbiont of Brugia malayi leucyl-tRNA synthetase 0.0043 0.0169 1
Trichomonas vaginalis helicase, putative 0.002 0.0033 0.0061
Entamoeba histolytica serine/threonine protein kinase, putative 0.0106 0.0556 0.3508
Loa Loa (eye worm) replication factor A 73 kDa subunit 0.0633 0.3764 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0033 0.0061
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0031
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0633 0.3764 1
Brugia malayi Serine/threonine protein phosphatase PP1-gamma catalytic subunit 0.0025 0.0058 0.0116
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-beta catalytic subunit 0.004 0.015 0.0372
Plasmodium falciparum importin beta, putative 0.0033 0.0108 0.0473
Trichomonas vaginalis protein phosphatase, caeel, putative 0.004 0.015 0.0372
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0026 0.0026
Toxoplasma gondii hypothetical protein 0.0067 0.0314 0.1685
Brugia malayi Serine/threonine protein phosphatase PP1-beta catalytic subunit 0.004 0.015 0.0359
Echinococcus granulosus serine:threonine protein phosphatase PP1 gamma 0.004 0.015 0.016
Mycobacterium leprae Probable methionyl-tRNA synthase MetS 0.0043 0.0169 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0085
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0023 0.0083
Plasmodium falciparum asparagine--tRNA ligase 0.0031 0.0099 0.0422
Schistosoma mansoni apoptosis regulator bax 0.0276 0.159 0.321
Toxoplasma gondii replication factor-a protein 1 (rpa1) subfamily protein 0.0304 0.1757 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0144 0.0872
Brugia malayi Carboxylesterase family protein 0.0028 0.0077 0.0166
Loa Loa (eye worm) BRCA2 repeat family protein 0.0128 0.0687 0.1805
Echinococcus granulosus BC026374 protein S09 family 0.0028 0.0077 0.0083
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0023 0.0003
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0247 0.1411 1
Schistosoma mansoni protein phosphatase-1 0.004 0.015 0.0262
Toxoplasma gondii aspartate-tRNA ligase 0.0031 0.0099 0.0447
Entamoeba histolytica Ran family GTPase 0.0024 0.0055 0.0291
Loa Loa (eye worm) hypothetical protein 0.0039 0.0144 0.0357
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0033 0.0061
Echinococcus granulosus asparaginyl tRNA synthetase, cytoplasmic 0.0031 0.0099 0.0106
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0033 0.0061
Leishmania major serine/threonine protein phosphatase catalytic subunit, putative 0.004 0.015 0.0739
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0031 0.0099 0.5198
Echinococcus granulosus acetylcholinesterase 0.0164 0.0906 0.0969
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0144 0.0154
Mycobacterium ulcerans hypothetical protein 0.0039 0.0144 0.8271
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0028 0.0078 0.0084
Schistosoma mansoni hypothetical protein 0.0031 0.0099 0.0159
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0023 0.0003
Entamoeba histolytica replication factor A, putative 0.0061 0.0283 0.1751
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0031
Entamoeba histolytica asparaginyl-tRNA synthetase, putative 0.0031 0.0099 0.0572
Schistosoma mansoni hypothetical protein 0.0349 0.2032 0.4114
Echinococcus granulosus protein phosphatase 1 catalytic subunit 0.004 0.015 0.016
Brugia malayi F/Y-rich N-terminus family protein 0.0027 0.0076 0.0163
Schistosoma mansoni hypothetical protein 0.0276 0.159 0.321
Echinococcus granulosus glycyl tRNA synthetase 0.0209 0.1179 0.1262
Loa Loa (eye worm) carboxylesterase 0.0164 0.0906 0.2386
Echinococcus multilocularis replication protein A 70 kDa DNA binding 0.0633 0.3764 0.3758
Echinococcus granulosus protein phosphatase 1 catalytic subunit 0.0017 0.001 0.0011
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0269 0.1544 0.1536
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0031 0.0099 0.0447
Trichomonas vaginalis ran, putative 0.0024 0.0055 0.0121
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.0556 0.1455
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0633 0.3764 1
Brugia malayi Serine/threonine protein phosphatase F56C9.1 in chromosomeIII 0.004 0.015 0.0359
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0028 0.0077 0.0179
Onchocerca volvulus 0.0039 0.0144 0.0203
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0028 0.0077 0.0114
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0025 0.0058 0.0213
Schistosoma mansoni BC026374 protein (S09 family) 0.0028 0.0077 0.0114
Echinococcus granulosus asparaginyl tRNA synthetase cytoplasmic 0.0031 0.0099 0.0106
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0031
Trypanosoma cruzi polo-like protein kinase, putative 0.0106 0.0556 0.3081
Schistosoma mansoni DNA polymerase eta 0.0019 0.0023 0.0003
Trichomonas vaginalis aspartyl/lysyl-tRNA synthetase, putative 0.0031 0.0099 0.0237
Brugia malayi RNA, U transporter 1 0.0093 0.0474 0.1225
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0023 0.0035
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0022 0.0045 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0033 0.0061
Mycobacterium tuberculosis Conserved protein 0.0039 0.0144 0.0872
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0209 0.1179 0.3114
Schistosoma mansoni lysyl-tRNA synthetase 0.0031 0.0099 0.0159
Mycobacterium leprae Probable lipase LipE 0.0039 0.0144 0.64
Loa Loa (eye worm) hypothetical protein 0.0051 0.022 0.056
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0108 0.0498
Giardia lamblia Lysyl-tRNA synthetase 0.0031 0.0099 0.163
Schistosoma mansoni aspartyl-tRNA synthetase 0.0031 0.0099 0.0159
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0304 0.1757 0.4653
Toxoplasma gondii histone lysine methyltransferase SET1 0.0171 0.0947 0.5333
Schistosoma mansoni hypothetical protein 0.0315 0.1826 0.3691
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0055 0.083
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0033 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0033 0.0061
Echinococcus granulosus geminin 0.0355 0.2071 0.2217
Echinococcus granulosus serine:threonine protein phosphatase PP1 gamma 0.004 0.015 0.016
Echinococcus granulosus serine:threonine protein phosphatase PP1 beta 0.004 0.015 0.016
Leishmania major serine/threonine protein phosphatase pp1(5.9), putative 0.0025 0.0058 0.0213
Trichomonas vaginalis bsu-protein phosphatase, putative 0.004 0.015 0.0372
Leishmania major lysyl-tRNA synthetase, putative 0.0031 0.0099 0.0447
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.0043 0.0169 0.1054
Giardia lamblia Kinase, PLK 0.0106 0.0556 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0033 0.0061
Echinococcus multilocularis serine:threonine protein phosphatase PP1 isozyme 0.004 0.015 0.014
Mycobacterium ulcerans beta-lactamase 0.0039 0.0144 0.8271
Plasmodium falciparum serine/threonine protein phosphatase PP1 0.004 0.015 0.0715
Trichomonas vaginalis serine/threonine protein phosphatase, putative 0.0025 0.0058 0.0129
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0295 0.1702 0.3438
Loa Loa (eye worm) hypothetical protein 0.0028 0.0077 0.0179
Plasmodium falciparum aspartate--tRNA ligase 0.0031 0.0099 0.0422
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0055 0.0169
Brugia malayi Importin beta-1 subunit 0.0033 0.0108 0.0247
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0023 0.0035
Echinococcus multilocularis para nitrobenzyl esterase 0.0028 0.0077 0.0067
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0205 0.116 0.1241
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0008
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0055 0.0107
Trypanosoma cruzi serine/threonine-protein phosphatase PP1 alpha 0.0025 0.0058 0.0213
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0031
Leishmania major phosphatidylinositol kinase related protein, putative 0.0019 0.0022 0.0001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0295 0.1702 0.1822
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0023 0.0013
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0031 0.0099 0.0422
Schistosoma mansoni protein phosphatase type 1 0.0025 0.0058 0.0076
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0045 0.0048
Schistosoma mansoni methionine-tRNA synthetase 0.0043 0.0169 0.0302
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0144 0.0357
Trichomonas vaginalis spcc417.12 protein, putative 0.0028 0.0077 0.0179
Schistosoma mansoni ran 0.0024 0.0055 0.0069
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0237
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0026 0.0206
Loa Loa (eye worm) hypothetical protein 0.0028 0.0077 0.0179
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0031 0.0099 0.0447
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.022 0.056
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0026 0.0026
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0023 0.0035
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0021 0.0012
Brugia malayi CXXC zinc finger family protein 0.009 0.0457 0.1178
Entamoeba histolytica aspartyl-tRNA synthetase, putative 0.0031 0.0099 0.0572
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0031
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0144 0.0357
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0008
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0033 0.0061
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0031 0.0099 0.0447
Toxoplasma gondii ABC1 family protein 0.0039 0.0144 0.0706
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0276 0.159 0.1702
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0144 0.0357
Brugia malayi lysyl-tRNA synthetase 0.0031 0.0099 0.0224
Loa Loa (eye worm) serine/threonine protein phosphatase PP1 isozyme 1 0.0025 0.0058 0.0129
Leishmania major methionyl-tRNA synthetase, putative 0.0043 0.0169 0.0852
Schistosoma mansoni aspartyl-tRNA synthetase 0.0031 0.0099 0.0159
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0031
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0144 0.0872
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0021 0.0012
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.1549 0.9342 1
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-alpha catalytic subunit 0.0025 0.0058 0.0129
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0055 0.0121
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0031 0.0099 0.5198
Echinococcus multilocularis serine:threonine protein phosphatase PP1 beta 0.004 0.015 0.014
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0063 0.0242
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0025 0.0058 0.0213
Schistosoma mansoni importin beta-1 0.0033 0.0108 0.0177
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0008
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0026 0.0026
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0055 0.0195
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-gamma catalytic subunit 0.0025 0.0058 0.0129
Loa Loa (eye worm) aspartyl-tRNA synthetase 0.0031 0.0099 0.0237
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0021 0.0031
Plasmodium vivax replication protein A1, large subunit, putative 0.0304 0.1757 1
Loa Loa (eye worm) carboxylesterase 0.0028 0.0077 0.0179
Schistosoma mansoni kinase 0.0054 0.0238 0.0443
Echinococcus multilocularis histone acetyltransferase MYST2 0.0058 0.0263 0.0254
Loa Loa (eye worm) hypothetical protein 0.0028 0.0077 0.0179
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0031
Loa Loa (eye worm) CXXC zinc finger family protein 0.009 0.0457 0.119
Loa Loa (eye worm) hypothetical protein 0.0269 0.1544 0.4086
Mycobacterium tuberculosis Carboxylesterase LipT 0.0028 0.0077 0.0392
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0028 0.0077 0.0083
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.007 0.0281
Brugia malayi protein ZK524.3 0.0043 0.0169 0.0411
Leishmania major hypothetical protein, conserved 0.0039 0.0144 0.0706
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0144 0.0872
Loa Loa (eye worm) hypothetical protein 0.0028 0.0077 0.0179
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0031
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0043 0.0169 0.0424
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0058 0.0263 0.0662
Mycobacterium tuberculosis Probable DNA polymerase III (alpha chain) DnaE2 (DNA nucleotidyltransferase) 0.0031 0.0099 0.0548
Schistosoma mansoni leucyl-tRNA synthetase 0.0043 0.0169 0.0302
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0026 0.0293
Plasmodium falciparum lysine--tRNA ligase 0.0031 0.0099 0.0422
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0073 0.03
Treponema pallidum leucyl-tRNA synthetase 0.0043 0.0169 0.0944
Trypanosoma brucei serine threonine-protein phosphatase PP1, putative 0.0025 0.0058 0.0213
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0144 0.64
Schistosoma mansoni protein phosphatase type 1 0.004 0.015 0.0262
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0031
Loa Loa (eye worm) hypothetical protein 0.0164 0.0906 0.2386
Schistosoma mansoni protein phosphatase-1 0.004 0.015 0.0262
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0144 0.0357
Brugia malayi Carboxylesterase family protein 0.0028 0.0077 0.0166
Trypanosoma brucei protein phosphatase 1, putative 0.004 0.015 0.0739
Schistosoma mansoni ap endonuclease 0.0019 0.0026 0.0009
Toxoplasma gondii lysine-tRNA ligase 0.0031 0.0099 0.0447
Mycobacterium ulcerans carboxylesterase, LipT 0.0028 0.0077 0.3715
Mycobacterium ulcerans leucyl-tRNA synthetase 0.0043 0.0169 1
Trichomonas vaginalis serine/threonine protein phosphatase, putative 0.0025 0.0058 0.0129
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0008
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0063 0.0054
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0144 0.0682
Toxoplasma gondii exonuclease III APE 0.0019 0.0026 0.0026
Toxoplasma gondii tRNA ligases class I (M) protein 0.0043 0.0169 0.0852
Brugia malayi Carboxylesterase family protein 0.0164 0.0906 0.2375
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0295 0.1702 0.1822
Loa Loa (eye worm) hypothetical protein 0.0039 0.0144 0.0357
Treponema pallidum methionyl-tRNA synthetase 0.0269 0.1544 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0023 0.0008
Entamoeba histolytica replication factor A protein 1, putative 0.0272 0.1567 1
Loa Loa (eye worm) hypothetical protein 0.004 0.015 0.0372
Entamoeba histolytica serine/threonine protein phosphatase PP1, putative 0.0025 0.0058 0.0312
Echinococcus granulosus protein phosphatase 1, catalytic subunit, beta isozyme 0.004 0.015 0.016
Trypanosoma brucei polo-like protein kinase 0.0106 0.0556 0.3081
Schistosoma mansoni hypothetical protein 0.0276 0.159 0.321
Loa Loa (eye worm) acetylcholinesterase 1 0.0164 0.0906 0.2386
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0144 0.0134
Schistosoma mansoni aspartyl-tRNA synthetase 0.0031 0.0099 0.0159
Schistosoma mansoni hypothetical protein 0.0355 0.2071 0.4193
Plasmodium vivax lysine--tRNA ligase, putative 0.0031 0.0099 0.0422
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0295 0.1702 0.1694
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0144 0.0706
Loa Loa (eye worm) hypothetical protein 0.0033 0.0108 0.0261
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0026 0.0028
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0229 0.0584
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0026 0.0022
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.0269 0.1544 0.9855
Mycobacterium ulcerans aspartyl-tRNA synthetase 0.0031 0.0099 0.5198
Leishmania major importin beta-1 subunit, putative 0.0026 0.007 0.0281
Schistosoma mansoni hypothetical protein 0.0276 0.159 0.321
Brugia malayi Carboxylesterase family protein 0.0028 0.0077 0.0166
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.022 0.0211
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0063 0.0242
Schistosoma mansoni aspartyl-tRNA synthetase 0.0031 0.0099 0.0159
Wolbachia endosymbiont of Brugia malayi aspartyl-tRNA synthetase 0.0031 0.0099 0.5097
Entamoeba histolytica hypothetical protein 0.0031 0.0099 0.0572
Echinococcus granulosus neuroligin 0.0028 0.0077 0.0083
Mycobacterium ulcerans methionyl-tRNA synthetase 0.0043 0.0169 1
Echinococcus multilocularis cpg binding protein 0.0095 0.0488 0.0479
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0021 0.0017
Brugia malayi BRCA2 repeat family protein 0.0128 0.0687 0.1793
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.0556 0.1455
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.1549 0.9342 0.9341
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0063 0.0086
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0164 0.0906 0.1809
Echinococcus multilocularis glycyl tRNA synthetase 0.0209 0.1179 0.117
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-alpha catalytic subunit 0.0025 0.0058 0.0129
Leishmania major DNA polymerase eta, putative 0.0019 0.0023 0.0008
Giardia lamblia Hypothetical protein 0.0093 0.0473 0.8473
Schistosoma mansoni aspartyl-tRNA synthetase 0.0031 0.0099 0.0159
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.0556 0.1455
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0144 0.0706
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0031
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0063 0.0129
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0031 0.0099 0.0447
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0031
Plasmodium falciparum nucleic acid binding protein, putative 0.0031 0.0099 0.0422
Leishmania major replication Factor A 28 kDa subunit, putative 0.0031 0.0099 0.0447
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0033 0.0061
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0144 0.0706
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0026 0.0043
Loa Loa (eye worm) carboxylesterase 0.0028 0.0077 0.0179
Trypanosoma brucei serine threonine-protein phosphatase PP1, putative 0.0025 0.0058 0.0213
Loa Loa (eye worm) hypothetical protein 0.0043 0.0169 0.0424
Trichomonas vaginalis protein phosphatase-1, putative 0.0025 0.0058 0.0129
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0033 0.0061
Echinococcus granulosus aspartyl tRNA synthetase cytoplasmic 0.0031 0.0099 0.0106
Chlamydia trachomatis methionine--tRNA ligase 0.0269 0.1544 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0295 0.1702 0.1694
Brugia malayi Carboxylesterase family protein 0.0164 0.0906 0.2375
Loa Loa (eye worm) beta-lactamase 0.0039 0.0144 0.0357
Brugia malayi beta-lactamase family protein 0.0039 0.0144 0.0344
Trichomonas vaginalis esterase, putative 0.0039 0.0144 0.0357
Echinococcus multilocularis neuroligin 0.0028 0.0077 0.0067
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0023 0.0008
Trypanosoma cruzi serine/threonine protein phosphatase catalytic subunit, putative 0.004 0.015 0.0739
Echinococcus multilocularis serine:threonine protein phosphatase PP1 gamma 0.004 0.015 0.014
Mycobacterium ulcerans lipase LipD 0.0039 0.0144 0.8271
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0031 0.0099 0.0447
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0106 0.0556 0.0547
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0023 0.0008
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0023 0.0008
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.0035
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0021 0.0023
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0073 0.0275
Trichomonas vaginalis protein phosphatase-1, putative 0.004 0.015 0.0372
Brugia malayi Serine/threonine protein phosphatase PP1 isozyme 1, putative 0.0025 0.0058 0.0116
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0055 0.0169
Trypanosoma brucei Replication factor A protein 1 0.0304 0.1757 1
Leishmania major asparaginyl-tRNA synthetase, putative 0.0031 0.0099 0.0447
Loa Loa (eye worm) hypothetical protein 0.0039 0.0144 0.0357
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.022 0.0436
Loa Loa (eye worm) hypothetical protein 0.0039 0.0144 0.0357
Echinococcus multilocularis dna polymerase eta 0.0019 0.0023 0.0013
Loa Loa (eye worm) hypothetical protein 0.0028 0.0077 0.0179
Echinococcus multilocularis carboxylesterase 5A 0.0164 0.0906 0.0897
Brugia malayi methionyl-tRNA synthetase 0.0269 0.1544 0.4078
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0209 0.1179 0.3104
Loa Loa (eye worm) hypothetical protein 0.0276 0.159 0.421
Plasmodium vivax aspartate--tRNA ligase, putative 0.0031 0.0099 0.0422
Entamoeba histolytica hypothetical protein 0.0025 0.0063 0.0344
Leishmania major replication factor A, 51kDa subunit, putative 0.0304 0.1757 1
Schistosoma mansoni aspartyl-tRNA synthetase 0.0031 0.0099 0.0159
Giardia lamblia Aspartyl-tRNA synthetase 0.0031 0.0099 0.163
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0144 0.0344
Onchocerca volvulus 0.009 0.0457 0.1156
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0025 0.0058 0.0213
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0042 0.0118
Trichomonas vaginalis bsu-protein phosphatase, putative 0.004 0.015 0.0372
Schistosoma mansoni ap endonuclease 0.0019 0.0026 0.0009
Trypanosoma cruzi asparaginyl-tRNA synthetase, putative 0.0031 0.0099 0.0447
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0033 0.0061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0031
Toxoplasma gondii serine/threonine phosophatase PP1 0.004 0.015 0.0739
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.0043 0.0169 0.0852
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0295 0.1702 0.3438
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0144 0.8271
Schistosoma mansoni acetylcholinesterase 0.0028 0.0077 0.0114
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.0043 0.0169 0.0852
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0028 0.0077 0.0114
Schistosoma mansoni glycyl-tRNA synthetase 0.0209 0.1179 0.2368
Loa Loa (eye worm) hypothetical protein 0.0039 0.0144 0.0357
Brugia malayi methionyl-tRNA synthetase 0.0043 0.0169 0.0411
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0023 0.0008
Loa Loa (eye worm) histone methyltransferase 0.0028 0.0078 0.0182
Plasmodium falciparum replication protein A1, large subunit 0.0304 0.1757 1
Schistosoma mansoni neuroligin 3 (S09 family) 0.0028 0.0077 0.0114
Loa Loa (eye worm) hypothetical protein 0.0039 0.0144 0.0357
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0025 0.0058 0.0213
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0058 0.0263 0.0254
Trypanosoma brucei asparaginyl-tRNA synthetase, putative 0.0031 0.0099 0.0447
Echinococcus granulosus histone acetyltransferase MYST2 0.0058 0.0263 0.0282
Entamoeba histolytica hypothetical protein 0.0026 0.007 0.0387
Brugia malayi mbt repeat family protein 0.0051 0.022 0.0547
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0099 0.0447
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.0556 0.1455
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0023 0.0008
Brugia malayi beta-lactamase family protein 0.0039 0.0144 0.0344
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0031
Echinococcus multilocularis BC026374 protein (S09 family) 0.0028 0.0077 0.0067
Treponema pallidum aspartyl-tRNA synthetase 0.0031 0.0099 0.0481
Brugia malayi replication factor A 73 kDa subunit 0.0633 0.3764 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0144 0.0251
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0026 0.0103
Echinococcus multilocularis geminin 0.0355 0.2071 0.2063
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0033 0.0061
Schistosoma mansoni cpg binding protein 0.0095 0.0488 0.0954
Trichomonas vaginalis bsu-protein phosphatase, putative 0.0025 0.0058 0.0129
Echinococcus granulosus cpg binding protein 0.0095 0.0488 0.0522
Loa Loa (eye worm) hypothetical protein 0.0043 0.0169 0.0424
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0025 0.0058 0.0213
Onchocerca volvulus Putative replication factor A 73 kDa subunit 0.0061 0.0283 0.0626
Schistosoma mansoni cpg binding protein 0.009 0.0457 0.0891
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0073 0.0275
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0026 0.0029
Giardia lamblia Methionyl-tRNA synthetase 0.0043 0.0169 0.2917
Schistosoma mansoni protein phosphatase type 1 0.004 0.015 0.0262
Onchocerca volvulus 0.0039 0.0144 0.0203
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0073 0.0275
Trypanosoma cruzi replication Factor A 28 kDa subunit, putative 0.0031 0.0099 0.0447
Echinococcus multilocularis serine:threonine protein phosphatase PP1 gamma 0.004 0.015 0.014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0031
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0144 0.0872
Trypanosoma brucei aspartyl-tRNA synthetase, putative 0.0031 0.0099 0.0447
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0073 0.03
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0063 0.0143
Brugia malayi hypothetical protein 0.0028 0.0077 0.0166
Brugia malayi putative serine/threonine phosphatase 0.0025 0.0058 0.0116
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0144 0.0357
Leishmania major DNA polymerase kappa, putative 0.0019 0.0023 0.0008
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.022 0.0236
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0031
Echinococcus multilocularis snurportin 1 0.0349 0.2032 0.2025
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0031 0.0099 0.0089
Leishmania major aspartyl-tRNA synthetase, putative 0.0031 0.0099 0.0447
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.007 0.016
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.0556 0.1455
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0025 0.0058 0.0213
Schistosoma mansoni cpg binding protein 0.0095 0.0488 0.0954
Giardia lamblia Asparaginyl-tRNA synthetase 0.0031 0.0099 0.163
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.007 0.016
Echinococcus granulosus methionine tRNA synthetase 0.0043 0.0169 0.0181
Giardia lamblia GTOR 0.0018 0.0021 0.0211
Loa Loa (eye worm) hypothetical protein 0.0028 0.0077 0.0179
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0028 0.0077 0.0392
Loa Loa (eye worm) hypothetical protein 0.0027 0.0073 0.0169
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0031
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0205 0.116 0.1151
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.022 0.0407
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0031
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0276 0.159 0.4202
Echinococcus granulosus dnaJ subfamily B 0.0821 0.491 0.5256
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0028 0.0077 0.0392
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0144 0.0357
Schistosoma mansoni methionine-tRNA synthetase 0.0269 0.1544 0.3115
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0106 0.0556 0.3081
Echinococcus multilocularis dnaJ subfamily B 0.0821 0.491 0.4905
Echinococcus multilocularis methionine tRNA synthetase 0.0043 0.0169 0.0159
Plasmodium vivax methionine--tRNA ligase, putative 0.0043 0.0169 0.0828
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0144 0.8271
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0055 0.0059
Schistosoma mansoni serine/threonine protein kinase 0.0106 0.0556 0.1094
Loa Loa (eye worm) apoptosis regulator protein 0.0276 0.159 0.421
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0108 0.0498
Echinococcus granulosus mixed lineage leukemia protein mll 0.0022 0.0045 0.0048
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0108 0.0098
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0108 0.0498
Chlamydia trachomatis leucine--tRNA ligase 0.0043 0.0169 0.0486
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0033 0.0061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0031
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0063 0.0242
Giardia lamblia Ser/Thr protein phosphatase PP1-alpha 2 catalytic subunit 0.004 0.015 0.2558
Leishmania major aspartyl-tRNA synthetase, putative 0.0031 0.0099 0.0447
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0031
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.022 0.0407
Plasmodium falciparum methionine--tRNA ligase 0.0043 0.0169 0.0828
Plasmodium vivax methionine--tRNA ligase, putative 0.0043 0.0169 0.0828
Loa Loa (eye worm) hypothetical protein 0.0061 0.0283 0.0726
Loa Loa (eye worm) MBCTL1 0.0058 0.0263 0.0675
Leishmania major leucyl-tRNA synthetase, putative 0.0043 0.0169 0.0852
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0023 0.0021
Echinococcus multilocularis protein phosphatase 1 catalytic subunit 0.004 0.015 0.014
Echinococcus granulosus replication protein A 70 kDa DNA binding 0.0633 0.3764 0.4029
Echinococcus multilocularis aspartyl tRNA synthetase, cytoplasmic 0.0031 0.0099 0.0089
Mycobacterium tuberculosis Conserved protein 0.0039 0.0144 0.0872
Loa Loa (eye worm) 63kd antigen 0.0031 0.0099 0.0237
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0025 0.0058 0.0213
Brugia malayi hypothetical protein 0.0027 0.0073 0.0156
Giardia lamblia Leucyl-tRNA synthetase 0.0043 0.0169 0.2917
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0106 0.0556 0.1455
Brugia malayi Asparaginyl-tRNA synthetase, cytoplasmic 0.0031 0.0099 0.0224
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0191 0.1071 0.2147
Loa Loa (eye worm) hypothetical protein 0.0164 0.0906 0.2386
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0031 0.0099 0.0237
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0055 0.0195
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0144 0.0872
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0295 0.1702 0.45
Leishmania major lysyl-tRNA synthetase, putative 0.0031 0.0099 0.0447
Trypanosoma brucei unspecified product 0.0019 0.0023 0.0008
Schistosoma mansoni protein phosphatase-1 0.0025 0.0058 0.0076
Echinococcus granulosus para nitrobenzyl esterase 0.0028 0.0077 0.0083
Echinococcus granulosus acetylcholinesterase 0.0164 0.0906 0.0969
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0019 0.0022 0.0001
Trichomonas vaginalis protein phosphatase-5, putative 0.0025 0.0058 0.0129
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0028 0.0077 0.0067
Schistosoma mansoni hypothetical protein 0.0355 0.2071 0.4193
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0209 0.1179 0.3114
Trichomonas vaginalis bsu-protein phosphatase, putative 0.004 0.015 0.0372
Loa Loa (eye worm) serine/threonine protein phosphatase PP1 isozyme 1 0.0025 0.0058 0.0129
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0008
Onchocerca volvulus 0.0039 0.0144 0.0203
Brugia malayi glycyl-tRNA synthetase 0.0209 0.1179 0.3104
Loa Loa (eye worm) hypothetical protein 0.0025 0.0058 0.0129
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0026 0.0016
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0028 0.0078 0.0069
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0025 0.0058 0.0213
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0023 0.0008
Echinococcus granulosus dna polymerase eta 0.0019 0.0023 0.0024
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.0021 0.0074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0031
Trypanosoma brucei protein phosphatase 1 0.0025 0.0058 0.0213
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0276 0.159 0.321
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0021 0.0031
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0229 0.0584
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0031 0.0099 0.0447
Toxoplasma gondii methionyl-tRNA synthetase 0.0043 0.0169 0.0852
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0033 0.0061
Entamoeba histolytica hypothetical protein 0.0031 0.0099 0.0572
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0026 0.0043
Plasmodium vivax importin-beta 2, putative 0.0033 0.0108 0.0473
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0276 0.159 0.1582
Schistosoma mansoni protein phosphatase-1 0.0025 0.0058 0.0076
Brugia malayi Serine/threonine protein phosphatase PP1 isozyme 1, putative 0.0025 0.0058 0.0116
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0106 0.0556 0.0595
Brugia malayi mbt repeat family protein 0.0051 0.022 0.0547
Treponema pallidum asparaginyl-tRNA synthetase 0.0031 0.0099 0.0481
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0144 0.0251
Echinococcus granulosus dna polymerase kappa 0.0019 0.0023 0.0024
Echinococcus multilocularis asparaginyl tRNA synthetase 0.0031 0.0099 0.0089
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0031 0.0099 0.0447
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.0556 0.1455
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0144 0.0872
Brugia malayi Aspartyl-tRNA synthetase 0.0031 0.0099 0.0224
Mycobacterium tuberculosis Conserved protein 0.0039 0.0144 0.0872
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0055 0.0195
Onchocerca volvulus 0.0051 0.022 0.0436
Trichomonas vaginalis protein phosphatase, caeel, putative 0.0025 0.0058 0.0129
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.022 0.0407
Leishmania major hypothetical protein, conserved 0.0027 0.0073 0.03
Echinococcus granulosus lysyl tRNA synthetase 0.0031 0.0099 0.0106
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0031 0.0099 0.0447
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.022 0.0236
Schistosoma mansoni myelin transcription factor 1 myt1 0.0058 0.0263 0.0495
Trypanosoma brucei protein phosphatase 1 0.0025 0.0058 0.0213
Trypanosoma brucei serine threonine-protein phosphatase PP1, putative 0.0025 0.0058 0.0213
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0008
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0144 0.0872
Echinococcus granulosus importin subunit beta 1 0.0033 0.0108 0.0115
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0031 0.0099 0.0447
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0033 0.0061
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0023 0.0008
Plasmodium vivax asparagine--tRNA ligase, putative 0.0031 0.0099 0.0422
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0031
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.0556 0.1455
Trichomonas vaginalis importin beta-1, putative 0.0026 0.007 0.016
Loa Loa (eye worm) hypothetical protein 0.0058 0.0263 0.0675
Trypanosoma cruzi polo-like protein kinase, putative 0.0106 0.0556 0.3081
Onchocerca volvulus Serine\/threonine kinase homolog 0.0106 0.0556 0.1459
Echinococcus granulosus carboxylesterase 5A 0.0164 0.0906 0.0969
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0021 0.0031
Trichomonas vaginalis serine/threonine protein phosphatase, putative 0.004 0.015 0.0372
Plasmodium falciparum methionine--tRNA ligase, putative 0.0043 0.0169 0.0828

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 6.6 nM Inhibition of mouse serum BChE after 1 hr by modified Ellman's colorimetric method ChEMBL. 20137941
IC50 (binding) = 180 nM Inhibition of mouse brain AChE after 1 hr by modified Ellman's colorimetric method ChEMBL. 20137941

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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