Detailed information for compound 1112480

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 544.731 | Formula: C18H18ClIN6O4
  • H donors: 4 H acceptors: 6 LogP: 1.53 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: CNC(=O)[C@H]1OC([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1Cl)I
  • InChi: 1S/C18H18ClIN6O4/c1-21-17(29)14-12(27)13(28)18(30-14)26-7-25-11-15(23-6-24-16(11)26)22-5-8-3-2-4-9(20)10(8)19/h2-4,6-7,12-14,18,27-28H,5H2,1H3,(H,21,29)(H,22,23,24)/t12-,13+,14-,18?/m0/s1
  • InChiKey: AJASMUGOIFKXOZ-CDJKEZFESA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Adenosine A1 receptor Starlite/ChEMBL References
Rattus norvegicus Adenosine A3 receptor Starlite/ChEMBL References
Rattus norvegicus Adenosine A2a receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni neuropeptide receptor Adenosine A3 receptor   320 aa 306 aa 23.5 %
Schistosoma japonicum Alpha-1A adrenergic receptor, putative Adenosine A3 receptor   320 aa 325 aa 24.9 %
Onchocerca volvulus Adenosine A3 receptor   320 aa 282 aa 20.6 %
Onchocerca volvulus Ubiquinol-cytochrome-c reductase complex assembly factor 1 homolog Adenosine A1 receptor   326 aa 286 aa 22.7 %
Echinococcus granulosus tachykinin peptides receptor 99D Adenosine A3 receptor   320 aa 297 aa 26.6 %
Loa Loa (eye worm) hypothetical protein Adenosine A3 receptor   320 aa 309 aa 24.9 %
Schistosoma japonicum 5-hydroxytryptamine receptor 4, putative Adenosine A3 receptor   320 aa 311 aa 27.3 %
Onchocerca volvulus Adenosine A2a receptor   410 aa 337 aa 23.1 %
Schistosoma mansoni peptide (allatostatin)-like receptor Adenosine A3 receptor   320 aa 296 aa 27.0 %
Schistosoma japonicum ko:K04255 opsin 4 (melanopsin), putative Adenosine A3 receptor   320 aa 370 aa 21.4 %
Schistosoma mansoni opsin-like receptor Adenosine A3 receptor   320 aa 300 aa 22.0 %
Echinococcus multilocularis neuropeptide receptor Adenosine A3 receptor   320 aa 282 aa 24.1 %
Echinococcus granulosus allatostatin A receptor Adenosine A2a receptor   410 aa 368 aa 22.6 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Adenosine A3 receptor   320 aa 332 aa 24.4 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Adenosine A2a receptor   410 aa 340 aa 27.9 %
Brugia malayi hypothetical protein Adenosine A1 receptor   326 aa 305 aa 21.0 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Adenosine A2a receptor   410 aa 342 aa 23.1 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Adenosine A2a receptor   410 aa 346 aa 28.3 %
Echinococcus granulosus thyrotropin releasing hormone receptor Adenosine A2a receptor   410 aa 342 aa 23.1 %
Onchocerca volvulus Adenosine A3 receptor   320 aa 308 aa 20.5 %
Echinococcus multilocularis tachykinin peptides receptor 99D Adenosine A3 receptor   320 aa 297 aa 26.6 %
Schistosoma japonicum Rhodopsin, putative Adenosine A3 receptor   320 aa 320 aa 23.8 %
Onchocerca volvulus Adenosine A3 receptor   320 aa 350 aa 24.9 %
Onchocerca volvulus Adenosine A3 receptor   320 aa 311 aa 23.5 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Adenosine A2a receptor   410 aa 352 aa 23.6 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Adenosine A2a receptor   410 aa 366 aa 25.4 %
Loa Loa (eye worm) hypothetical protein Adenosine A1 receptor   326 aa 300 aa 24.3 %
Schistosoma mansoni biogenic amine (5HT) receptor Adenosine A2a receptor   410 aa 399 aa 28.1 %
Echinococcus granulosus neuropeptide receptor Adenosine A3 receptor   320 aa 290 aa 23.4 %
Onchocerca volvulus Adenosine A3 receptor   320 aa 295 aa 23.4 %
Loa Loa (eye worm) neuropeptide F receptor Adenosine A3 receptor   320 aa 321 aa 24.0 %
Onchocerca volvulus Adenosine A3 receptor   320 aa 288 aa 20.8 %
Schistosoma mansoni opsin-like receptor Adenosine A3 receptor   320 aa 307 aa 26.4 %
Schistosoma mansoni adenoreceptor Adenosine A3 receptor   320 aa 319 aa 27.9 %
Echinococcus multilocularis allatostatin A receptor Adenosine A2a receptor   410 aa 372 aa 22.8 %
Schistosoma mansoni neuropeptide receptor Adenosine A3 receptor   320 aa 286 aa 21.3 %
Onchocerca volvulus Adenosine A3 receptor   320 aa 320 aa 24.4 %
Schistosoma mansoni dro/myosuppressin receptor Adenosine A1 receptor   326 aa 326 aa 22.1 %
Onchocerca volvulus Adenosine A2a receptor   410 aa 356 aa 23.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni inositol monophosphatase 0.0078 0.0055 0.0055
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0027 0.0027
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0025 0.0038
Echinococcus multilocularis tar DNA binding protein 0.0222 0.0186 0.0186
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4 0.1499 0.1342 0.3528
Brugia malayi latrophilin 2 splice variant baaae 0.0146 0.0117 0.0119
Echinococcus granulosus dna polymerase eta 0.0019 0.0002 0.0002
Echinococcus multilocularis inositol monophosphatase 1 0.0078 0.0055 0.0055
Mycobacterium leprae Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) 0.1499 0.1342 0.35
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0067 0.0045 0.0115
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0025 0.0038
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0067 0.0045 0.0115
Schistosoma mansoni dihydrolipoamide S-acetyltransferase 0.0387 0.0335 0.0335
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.001 0.0009
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0067 0.0045 0.0115
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0067 0.0046 0.0045
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0028 0.0028
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0067 0.0045 0.0115
Plasmodium falciparum histone acetyltransferase GCN5 0.0081 0.0058 0.0077
Mycobacterium ulcerans pyruvate kinase 0.0038 0.0019 0.0044
Trypanosoma brucei glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative 0.0952 0.0847 0.0845
Schistosoma mansoni hypothetical protein 0.0552 0.0484 0.0484
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0067 0.0046 0.0046
Echinococcus multilocularis pyruvate kinase 0.0038 0.0019 0.0019
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0028 0.1224
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0067 0.0046 0.0046
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0122 0.0095 0.0095
Echinococcus multilocularis high affinity choline transporter 1 0.1106 0.0986 0.0986
Schistosoma mansoni cpg binding protein 0.0032 0.0013 0.0013
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0169 0.0138 0.5912
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0002 0.0002
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0019 0.0017
Brugia malayi Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor 0.0387 0.0335 0.0346
Plasmodium falciparum lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex 0.0387 0.0335 0.0461
Brugia malayi Cytochrome P450 family protein 0.0205 0.017 0.0175
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0387 0.0335 0.0539
Loa Loa (eye worm) hypothetical protein 0.0049 0.0029 0.0028
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0169 0.0138 0.5912
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.4214 0.38 0.3798
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0014 0.0012
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.4335 0.3909 0.3909
Trypanosoma cruzi importin beta-1 subunit, putative 0.0051 0.0031 0.0047
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0067 0.0045 0.0115
Plasmodium vivax dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative 0.0387 0.0335 0.0461
Echinococcus multilocularis dna polymerase eta 0.0019 0.0002 0.0002
Echinococcus multilocularis lamin 0.0059 0.0038 0.0038
Echinococcus multilocularis pyruvate kinase 0.0038 0.0019 0.0019
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0952 0.0847 0.0847
Leishmania major mitochondrial DNA polymerase beta 0.032 0.0274 0.0273
Schistosoma mansoni inositol transporter 0.0122 0.0095 0.0095
Wolbachia endosymbiont of Brugia malayi Acetyl-CoA carboxylase, carboxyltransferase component 0.1499 0.1342 0.3436
Trypanosoma brucei importin beta-1 subunit, putative 0.0063 0.0042 0.004
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0003 0.0001
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.4214 0.38 1
Trichomonas vaginalis glutaminase, putative 0.0273 0.0231 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.0055 0.0086
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0067 0.0045 0.0115
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0671 0.0592 0.0611
Echinococcus granulosus sodium:glucose cotransporter 2 0.0122 0.0095 0.0095
Trypanosoma brucei importin beta-1 subunit, putative 0.0063 0.0042 0.004
Mycobacterium ulcerans aldehyde dehydrogenase 0.0128 0.01 0.0259
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0067 0.0045 0.0115
Trichomonas vaginalis pyruvate kinase, putative 0.0038 0.0019 0.073
Loa Loa (eye worm) pyruvate kinase-PB 0.0026 0.0008 0.0007
Schistosoma mansoni cytochrome P450 0.0067 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0122 0.0095 0.0097
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0115 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0028 0.001 0.0009
Plasmodium vivax lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative 0.0387 0.0335 0.0461
Schistosoma mansoni hypothetical protein 0.0671 0.0592 0.0592
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0034 0.0034
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0096 0.0072 0.0072
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0169 0.0138 0.5912
Mycobacterium tuberculosis Probable branched-chain keto acid dehydrogenase E2 component BkdC 0.0387 0.0335 0.0878
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0006 0.0006
Mycobacterium leprae Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex SucB 0.0387 0.0335 0.0838
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0151 0.0122 0.0194
Echinococcus granulosus RUN 0.0019 0.0002 0.0002
Loa Loa (eye worm) transcription factor SMAD2 0.0238 0.02 0.0205
Chlamydia trachomatis acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 0.1499 0.1342 0.3858
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0781 0.0692 0.1817
Loa Loa (eye worm) CYP4Cod1 0.0086 0.0063 0.0063
Leishmania major pyruvate kinase 0.0038 0.0019 0.0017
Entamoeba histolytica hypothetical protein 0.0051 0.0031 0.0171
Leishmania major dihydrolipoamide acetyltransferase precursorlike protein 0.0387 0.0335 0.0334
Loa Loa (eye worm) hypothetical protein 0.0038 0.0019 0.0018
Echinococcus granulosus intermediate filament protein 0.0059 0.0038 0.0038
Echinococcus multilocularis pyruvate kinase 0.003 0.0011 0.0011
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.8005 0.7232 1
Trypanosoma cruzi glutamine-dependent carbamoyl-phosphate synthetase, putative 0.0952 0.0847 0.1367
Brugia malayi Latrophilin receptor protein 2 0.0067 0.0046 0.0045
Loa Loa (eye worm) bromodomain containing protein 0.0025 0.0007 0.0006
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0067 0.0045 0.0115
Brugia malayi Cytochrome P450 family protein 0.0086 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0051 0.0031 0.003
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0219 0.0183 0.0188
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0091 0.0067 0.0089
Onchocerca volvulus 0.0047 0.0028 0.1224
Giardia lamblia Fructose-bisphosphate aldolase 0.0169 0.0138 0.0802
Trypanosoma brucei pyruvate kinase 1, putative 0.0038 0.0019 0.0017
Toxoplasma gondii HEAT repeat-containing protein 0.0063 0.0042 0.0039
Echinococcus granulosus importin subunit beta 1 0.0063 0.0042 0.0042
Schistosoma mansoni hypothetical protein 0.0146 0.0117 0.0117
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0078 0.0055 0.0315
Echinococcus granulosus pyruvate kinase 0.0019 0.0002 0.0002
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0026 0.0008 0.0007
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0067 0.0046 0.0046
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0019 0.0017
Toxoplasma gondii cytochrome p450 superfamily protein 0.0067 0.0045 0.0043
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0952 0.0847 0.0847
Giardia lamblia Histone acetyltransferase GCN5 0.0081 0.0058 0.0331
Onchocerca volvulus 0.0059 0.0038 0.1715
Toxoplasma gondii pyruvate kinase PyK1 0.0038 0.0019 0.0017
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.4214 0.38 0.3798
Echinococcus granulosus dihydrolipoyllysine residue acetyltransferase 0.0387 0.0335 0.0335
Brugia malayi RNA, U transporter 1 0.0179 0.0146 0.015
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 1.1062 1 1
Echinococcus multilocularis geminin 0.0552 0.0484 0.0484
Mycobacterium ulcerans hypothetical protein 0.0169 0.0137 0.0356
Schistosoma mansoni ran 0.0046 0.0026 0.0026
Plasmodium falciparum importin beta, putative 0.0063 0.0042 0.0055
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0017 0.0017
Giardia lamblia Pyruvate kinase 0.0019 0.0002 0.0001
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0027 0.0027
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0067 0.0045 0.0115
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0019 0.0792
Loa Loa (eye worm) hypothetical protein 0.0058 0.0037 0.0036
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0034 0.0034
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.4214 0.38 1
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0067 0.0045 0.0115
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0067 0.0045 0.0115
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0781 0.0692 0.178
Mycobacterium tuberculosis Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) 0.1499 0.1342 0.3528
Mycobacterium ulcerans carbamoyl phosphate synthase large subunit 0.0952 0.0847 0.2225
Brugia malayi cytochrome P450 0.0067 0.0045 0.0045
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0002 0.0002
Mycobacterium ulcerans aldehyde dehydrogenase 0.0128 0.01 0.0259
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0067 0.0045 0.0115
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.4214 0.38 1
Toxoplasma gondii hypothetical protein 0.0052 0.0031 0.0029
Brugia malayi mbt repeat family protein 0.0047 0.0028 0.0027
Brugia malayi dihydrolipoamide S-acetyltransferase precursor, putative 0.0387 0.0335 0.0346
Toxoplasma gondii dihydrolipoamide acyltransferase, putative 0.0387 0.0335 0.0333
Trypanosoma brucei cytochrome P450, putative 0.0086 0.0063 0.0061
Echinococcus multilocularis importin subunit beta 1 0.0063 0.0042 0.0042
Brugia malayi Sodium:solute symporter family protein 0.0122 0.0095 0.0097
Schistosoma mansoni cpg binding protein 0.0028 0.001 0.001
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0067 0.0045 0.0115
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0169 0.0138 0.0802
Loa Loa (eye worm) hypothetical protein 0.0387 0.0335 0.0346
Trypanosoma brucei acetyl-CoA carboxylase 1.1062 1 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.007 0.0048 0.0077
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0122 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0000028542
Loa Loa (eye worm) cytochrome P450 family protein 0.0086 0.0063 0.0063
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0078 0.0055 0.0053
Schistosoma mansoni tar DNA-binding protein 0.0222 0.0186 0.0186
Leishmania major cytochrome p450-like protein 0.0086 0.0063 0.0061
Schistosoma mansoni sodium/solute symporter 0.0122 0.0095 0.0095
Trypanosoma brucei pyruvate dehydrogenase complex E3 binding protein, putative 0.0387 0.0335 0.0334
Chlamydia trachomatis dihydrolipoamide acetyltransferase 0.0387 0.0335 0.0924
Plasmodium vivax SET domain protein, putative 0.0032 0.0014 0.0016
Trypanosoma brucei unspecified product 0.277 0.2493 0.2491
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0028 0.0028
Loa Loa (eye worm) MH2 domain-containing protein 0.0238 0.02 0.0205
Loa Loa (eye worm) hypothetical protein 0.0149 0.0119 0.0122
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0108 0.0082 0.0168
Brugia malayi Thioredoxin reductase 0.0047 0.0027 0.0026
Entamoeba histolytica Ran family GTPase 0.0046 0.0026 0.0146
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.4214 0.38 1
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0067 0.0045 0.0115
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.0093 0.024
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0222 0.0186 0.0191
Echinococcus multilocularis dihydrolipoyllysine residue succinyltransferase 0.0387 0.0335 0.0335
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0067 0.0045 0.0115
Plasmodium vivax carbamoyl phosphate synthetase, putative 0.0952 0.0847 0.1168
Schistosoma mansoni hypothetical protein 0.0067 0.0046 0.0046
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0002 0.0002
Toxoplasma gondii 2-oxo acid dehydrogenases acyltransferase (catalytic domain) domain-containing protein 0.0387 0.0335 0.0333
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0029 0.0029
Echinococcus multilocularis survival motor neuron protein 1 0.075 0.0664 0.0664
Loa Loa (eye worm) hypothetical protein 0.1106 0.0986 0.102
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.075 0.0664 0.0686
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0387 0.0335 0.0539
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0151 0.0122 0.012
Onchocerca volvulus 0.0059 0.0038 0.1715
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0012 0.0012
Echinococcus granulosus dna polymerase kappa 0.0019 0.0002 0.0002
Echinococcus multilocularis neuropeptide receptor A26 0.047 0.041 0.041
Brugia malayi Importin beta-1 subunit 0.0063 0.0042 0.0041
Loa Loa (eye worm) hypothetical protein 0.0067 0.0046 0.0045
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0046 0.0026 0.0034
Leishmania major acetyl-CoA carboxylase, putative 1.1062 1 1
Trichomonas vaginalis set domain proteins, putative 0.0249 0.021 0.909
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0046 0.0026 0.0034
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0046 0.0026 0.0026
Mycobacterium ulcerans glutaminase 0.0273 0.0231 0.0604
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0043 0.0041
Trypanosoma cruzi cytochrome P450, putative 0.0086 0.0063 0.0098
Loa Loa (eye worm) RNA binding protein 0.0222 0.0186 0.0191
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0017 0.0017
Schistosoma mansoni tar DNA-binding protein 0.0222 0.0186 0.0186
Toxoplasma gondii pyruvate carboxylase 0.4214 0.38 0.3798
Leishmania major 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.1499 0.1342 0.134
Leishmania major carbamoyl-phosphate synthase, putative 0.0952 0.0847 0.0845
Toxoplasma gondii acetyl-coA carboxylase ACC2 1.1062 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0213 0.0178 0.0182
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0046 0.0026 0.0024
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.4214 0.38 0.6142
Trypanosoma brucei mitochondrial DNA polymerase beta 0.032 0.0274 0.0273
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0025 0.0038
Trypanosoma cruzi acetyl-CoA carboxylase 0.6849 0.6185 1
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0028 0.0028
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0302 0.0258 0.0258
Toxoplasma gondii carbamoylphosphate synthetase 0.0952 0.0847 0.0845
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0029 0.0029
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0302 0.0258 0.0258
Echinococcus granulosus dnaJ subfamily B 0.04 0.0347 0.0347
Loa Loa (eye worm) MBCTL1 0.0054 0.0034 0.0033
Trichomonas vaginalis bromodomain-containing protein, putative 0.0091 0.0067 0.2822
Plasmodium falciparum pyruvate kinase 0.0038 0.0019 0.0023
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0067 0.0045 0.0115
Schistosoma mansoni high-affinity choline transporter 0.1106 0.0986 0.0986
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0781 0.0692 0.1817
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0013 0.0012
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0067 0.0045 0.0115
Echinococcus multilocularis snurportin 1 0.0671 0.0592 0.0592
Loa Loa (eye worm) hypothetical protein 0.0387 0.0335 0.0346
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0187 0.0154 0.0154
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0038 0.0019 0.0044
Echinococcus granulosus lamin dm0 0.0059 0.0038 0.0038
Echinococcus multilocularis muscleblind protein 1 0.0149 0.0119 0.0119
Brugia malayi Bromodomain containing protein 0.0045 0.0026 0.0025
Echinococcus granulosus neuropeptide receptor A26 0.047 0.041 0.041
Brugia malayi Bromodomain containing protein 0.0084 0.006 0.0061
Echinococcus multilocularis musashi 0.0059 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0059 0.0038 0.0037
Toxoplasma gondii aldehyde dehydrogenase 0.0128 0.01 0.0098
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.0055 0.0053
Schistosoma mansoni hypothetical protein 0.0552 0.0484 0.0484
Schistosoma mansoni hypothetical protein 0.0153 0.0123 0.0123
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.0093 0.024
Echinococcus granulosus snurportin 1 0.0671 0.0592 0.0592
Leishmania major propionyl-coa carboxylase beta chain, putative 0.1499 0.1342 0.134
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0067 0.0045 0.007
Trypanosoma cruzi glutamine dependent carbamoyl-phosphate synthase, putative 0.0952 0.0847 0.1367
Schistosoma mansoni hypothetical protein 0.04 0.0347 0.0347
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.0082 0.0211
Trichomonas vaginalis importin beta-1, putative 0.0051 0.0031 0.1259
Schistosoma mansoni hypothetical protein 0.0019 0.0002 0.0002
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.0093 0.0196
Trypanosoma brucei pyruvate kinase 1 0.0038 0.0019 0.0017
Treponema pallidum pyruvate carboxylase subunit B 0.0387 0.0335 1
Echinococcus multilocularis GPCR, family 2 0.0067 0.0046 0.0046
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0067 0.0045 0.0115
Loa Loa (eye worm) hypothetical protein 0.007 0.0048 0.0048
Schistosoma mansoni importin beta-1 0.0063 0.0042 0.0042
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0151 0.0122 0.012
Schistosoma mansoni loxhd1 0.0019 0.0002 0.0002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0169 0.0138 0.5912
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0028 0.0028
Schistosoma mansoni lipoxygenase 0.0115 0.0089 0.0089
Schistosoma mansoni dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase 0.0387 0.0335 0.0335
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.1499 0.1342 0.2167
Schistosoma mansoni hypothetical protein 0.0067 0.0046 0.0046
Schistosoma mansoni pyruvate carboxylase 0.4214 0.38 0.38
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0169 0.0138 0.5912
Echinococcus granulosus pyruvate kinase 0.0019 0.0002 0.0002
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0067 0.0045 0.0115
Plasmodium falciparum carbamoyl phosphate synthetase 0.0952 0.0847 0.1168
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0019 0.0792
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0013 0.0012
Brugia malayi TAR-binding protein 0.0222 0.0186 0.0191
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0067 0.0045 0.007
Brugia malayi hypothetical protein 0.075 0.0664 0.0686
Entamoeba histolytica pyruvate kinase, putative 0.0026 0.0008 0.0038
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.032 0.0274 0.0441
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0169 0.0138 0.5912
Brugia malayi acetyltransferase, GNAT family protein 0.0302 0.0258 0.0266
Loa Loa (eye worm) cytochrome P450 family protein 0.0086 0.0063 0.0063
Mycobacterium ulcerans acetyl/propionyl CoA carboxylase subunit beta 0.1499 0.1342 0.3528
Plasmodium falciparum dihydrolipoamide acyltransferase component E2 0.0387 0.0335 0.0461
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.0082 0.0211
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0034 0.0034
Brugia malayi Carboxyl transferase domain containing protein 1.0675 0.9649 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0169 0.0137 0.0356
Brugia malayi intermediate filament protein 0.0059 0.0038 0.0037
Echinococcus granulosus geminin 0.0552 0.0484 0.0484
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0051 0.0031 0.1259
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0072 0.0072
Schistosoma mansoni hypothetical protein 0.0067 0.0046 0.0046
Leishmania major GTP-binding protein, putative 0.0046 0.0026 0.0025
Leishmania major dihydrolipoamide branched chain transacylase, putative 0.0387 0.0335 0.0334
Echinococcus granulosus Biotin lipoyl attachment 0.0387 0.0335 0.0335
Toxoplasma gondii thioredoxin reductase 0.0047 0.0027 0.0025
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.4214 0.38 0.38
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.0082 0.0211
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0014 0.0014
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.032 0.0274 0.0441
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0002 0.0002
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.007 0.0048 0.0121
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0002 0.0002
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0002 0.0002
Chlamydia trachomatis acetyl-CoA carboxylase biotin carboxyl carrier protein 0.0387 0.0335 0.0924
Schistosoma mansoni aldehyde dehydrogenase 0.0128 0.01 0.01
Echinococcus multilocularis RUN 0.0019 0.0002 0.0002
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.1499 0.1342 0.2167
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0128 0.01 0.0259
Echinococcus granulosus dihydrolipoyllysine residue succinyltransferase 0.0387 0.0335 0.0335
Schistosoma mansoni lamin 0.0059 0.0038 0.0038
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0067 0.0045 0.0115
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0078 0.0055 0.2321
Trypanosoma cruzi cytochrome P450, putative 0.0086 0.0063 0.0098
Loa Loa (eye worm) hypothetical protein 0.0387 0.0335 0.0346
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0128 0.01 0.0098
Trypanosoma brucei 2-oxoglutarate dehydrogenase E2 component, putative 0.0387 0.0335 0.0334
Leishmania major importin beta-1 subunit, putative 0.0051 0.0031 0.0029
Trypanosoma cruzi dihydrolipoamide acetyltransferase, putative 0.0387 0.0335 0.0539
Leishmania major cytochrome p450-like protein 0.0067 0.0045 0.0044
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0128 0.01 0.01
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0067 0.0045 0.0115
Schistosoma mansoni bromodomain containing protein 0.0072 0.005 0.005
Schistosoma mansoni polycystin 1-related 0.0019 0.0002 0.0002
Mycobacterium ulcerans acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 0.1499 0.1342 0.3528
Mycobacterium tuberculosis Probable reductase 0.0108 0.0082 0.0211
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0387 0.0335 0.0539
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0002 0.0002
Echinococcus granulosus GTP binding nuclear protein Ran 0.0046 0.0026 0.0026
Schistosoma mansoni pyruvate kinase 0.0038 0.0019 0.0019
Toxoplasma gondii acetyl-CoA carboxylase ACC1 1.1062 1 1
Loa Loa (eye worm) acetyltransferase 0.0302 0.0258 0.0266
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0187 0.0154 0.0154
Trypanosoma brucei 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.1499 0.1342 0.134
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0067 0.0045 0.0115
Schistosoma mansoni survival motor neuron protein 0.0153 0.0123 0.0123
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.0055 0.0053
Echinococcus multilocularis zinc finger protein 0.0028 0.001 0.001
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0067 0.0045 0.0115
Mycobacterium leprae Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) 0.1499 0.1342 0.35
Entamoeba histolytica acetyltransferase, GNAT family 0.0081 0.0058 0.0331
Schistosoma mansoni hypothetical protein 0.0021 0.0003 0.0003
Onchocerca volvulus 0.0028 0.001 0.0383
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0072 0.0072
Schistosoma mansoni rab6-interacting 0.0019 0.0002 0.0002
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0091 0.0067 0.2822
Echinococcus granulosus cpg binding protein 0.0032 0.0013 0.0013
Wolbachia endosymbiont of Brugia malayi branched-chain alpha-keto acid dehydrogenase subunit E2 0.0387 0.0335 0.0749
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0153 0.0123 0.0126
Brugia malayi Pre-SET motif family protein 0.0032 0.0014 0.0012
Schistosoma mansoni zinc finger protein 0.0028 0.001 0.001
Echinococcus granulosus propionyl coenzyme A carboxylase beta chain 0.1499 0.1342 0.1342
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0067 0.0045 0.0115
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.4214 0.38 0.38
Loa Loa (eye worm) cytochrome P450 family protein 0.0205 0.017 0.0175
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0034 0.0034
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0067 0.0045 0.0115
Echinococcus granulosus zinc finger protein 0.0028 0.001 0.001
Toxoplasma gondii dihydrolipoyllysine-residue succinyltransferase component of oxoglutarate dehydrogenase 0.0387 0.0335 0.0333
Brugia malayi Pre-SET motif family protein 0.0219 0.0183 0.0188
Loa Loa (eye worm) hypothetical protein 0.0213 0.0178 0.0182
Mycobacterium ulcerans pyruvate carboxylase 0.4214 0.38 1
Echinococcus multilocularis pyruvate kinase 0.0019 0.0002 0.0002
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0067 0.0045 0.0115
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.0082 0.0211
Brugia malayi glutaminase DH11.1 0.0273 0.0231 0.0238
Loa Loa (eye worm) hypothetical protein 0.0047 0.0028 0.0027
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0122 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0054 0.0034 0.0033
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0067 0.0045 0.0115
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0002 0.000005625
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0006 0.0006
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0067 0.0045 0.0115
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0068 0.0047 0.0047
Chlamydia trachomatis dihydrolipoamide succinyltransferase 0.0387 0.0335 0.0924
Leishmania major 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0387 0.0335 0.0334
Trypanosoma cruzi pyruvate kinase 2, putative 0.0038 0.0019 0.0027
Plasmodium vivax glutathione reductase, putative 0.0047 0.0027 0.0035
Schistosoma mansoni cpg binding protein 0.0032 0.0013 0.0013
Mycobacterium tuberculosis Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 0.1499 0.1342 0.3528
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0055 0.0034 0.0052
Schistosoma mansoni intermediate filament proteins 0.0059 0.0038 0.0038
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0072 0.0072
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.0082 0.0211
Toxoplasma gondii acyl-CoA carboxyltransferase beta chain, putative 0.1499 0.1342 0.134
Loa Loa (eye worm) hypothetical protein 0.0149 0.0119 0.0122
Schistosoma mansoni propionyl-CoA carboxylase beta chain mitochondrial precursor 0.1499 0.1342 0.1342
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0067 0.0045 0.0115
Echinococcus multilocularis dnaJ subfamily B 0.04 0.0347 0.0347
Schistosoma mansoni aspartate carbamoyltransferase 0.0952 0.0847 0.0847
Loa Loa (eye worm) hypothetical protein 0.0146 0.0117 0.0119
Echinococcus granulosus sodium:glucose cotransporter 0.0122 0.0095 0.0095
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0078 0.0055 0.014
Schistosoma mansoni tar DNA-binding protein 0.0222 0.0186 0.0186
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0059 0.0038 0.0037
Echinococcus multilocularis dihydrolipoyllysine residue acetyltransferase 0.0387 0.0335 0.0335
Echinococcus multilocularis Biotin lipoyl attachment 0.0387 0.0335 0.0335
Mycobacterium tuberculosis DlaT, dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase 0.0387 0.0335 0.0878
Echinococcus multilocularis 0.0067 0.0045 0.0045
Echinococcus granulosus neuropeptide s receptor 0.047 0.041 0.041
Loa Loa (eye worm) carboxyl transferase domain-containing protein 1.0675 0.9649 1
Mycobacterium leprae putative cytochrome p450 0.0067 0.0045 0.0071
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0014 0.0014
Echinococcus granulosus inositol monophosphatase 1 0.0078 0.0055 0.0055
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0028 0.0028
Trichomonas vaginalis pyruvate kinase, putative 0.0038 0.0019 0.073
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0072 0.0072
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.0093 0.024
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0387 0.0335 0.0539
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0067 0.0045 0.0115
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0169 0.0138 0.5912
Loa Loa (eye worm) latrophilin receptor protein 2 0.0067 0.0046 0.0045
Schistosoma mansoni hypothetical protein 0.0067 0.0045 0.0045
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.4214 0.38 1
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0025 0.0024
Schistosoma mansoni aldehyde dehydrogenase 0.0128 0.01 0.01
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0067 0.0046 0.0046
Echinococcus multilocularis propionyl coenzyme A carboxylase beta chain 0.1499 0.1342 0.1342
Brugia malayi glutathione reductase 0.0047 0.0027 0.0026
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0002 0.0002
Schistosoma mansoni lipoxygenase 0.0081 0.0058 0.0058
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0387 0.0335 0.0335
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0027 0.0041
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0046 0.0026 0.0146
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0006 0.0006
Echinococcus multilocularis pyruvate kinase 0.0019 0.0002 0.0002
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0086 0.0063 0.016
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.4214 0.38 1
Mycobacterium tuberculosis Biotinylated protein TB7.3 0.0387 0.0335 0.0878
Schistosoma mansoni lamin 0.0059 0.0038 0.0038
Echinococcus granulosus muscleblind protein 0.0149 0.0119 0.0119
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4_2 0.1499 0.1342 0.3528
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0067 0.0046 0.0046
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0027 0.0026
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0128 0.01 0.01
Brugia malayi Inositol-1 0.0078 0.0055 0.0055
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.001 0.001
Echinococcus granulosus tar DNA binding protein 0.0222 0.0186 0.0186
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0169 0.0138 0.5912
Trypanosoma brucei dihydrolipoamide branched chain transacylase, putative 0.0387 0.0335 0.0334
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0046 0.0026 0.0026
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.004 0.004
Onchocerca volvulus 0.0153 0.0123 0.581
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0091 0.0067 0.0065
Loa Loa (eye worm) hypothetical protein 0.0027 0.0009 0.0008
Mycobacterium ulcerans hypothetical protein 0.0387 0.0335 0.0878
Echinococcus multilocularis cpg binding protein 0.0032 0.0013 0.0013
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0046 0.0026 0.0026
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0213 0.0178 0.0182
Leishmania major carboxylase, putative 0.4214 0.38 0.3798
Loa Loa (eye worm) hypothetical protein 0.0048 0.0028 0.0027
Echinococcus multilocularis lamin dm0 0.0059 0.0038 0.0038
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0002 0.0002
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0067 0.0045 0.0044
Brugia malayi mbt repeat family protein 0.0047 0.0028 0.0027
Brugia malayi Cytochrome P450 family protein 0.0067 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0027 0.0009 0.0008
Echinococcus granulosus sodium:myo inositol cotransporter 0.0122 0.0095 0.0095
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.4214 0.38 0.38
Plasmodium falciparum thioredoxin reductase 0.0047 0.0027 0.0035
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0387 0.0335 0.0539
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0387 0.0335 0.0335
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0027 0.0067
Schistosoma mansoni ran 0.0046 0.0026 0.0026
Trichomonas vaginalis inositol monophosphatase, putative 0.0078 0.0055 0.2321
Leishmania major pyruvate kinase 0.0038 0.0019 0.0017
Schistosoma mansoni tar DNA-binding protein 0.0222 0.0186 0.0186
Plasmodium falciparum glutathione reductase 0.0047 0.0027 0.0035
Giardia lamblia Pyruvate kinase 0.0038 0.0019 0.0099
Brugia malayi PHD-finger family protein 0.0034 0.0015 0.0014
Brugia malayi Cytochrome P450 family protein 0.0086 0.0063 0.0063
Echinococcus granulosus high affinity choline transporter 1 0.1106 0.0986 0.0986
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0029 0.0029
Onchocerca volvulus 0.0122 0.0095 0.4462
Loa Loa (eye worm) glutaminase 2 0.0273 0.0231 0.0238
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0019 0.0792
Loa Loa (eye worm) inositol-1 0.0078 0.0055 0.0055
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0029 0.0029
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0072 0.0072
Mycobacterium ulcerans dihydrolipoamide acetyltransferase 0.0387 0.0335 0.0878
Mycobacterium leprae Probable biotinylated protein homolog TB7.3 0.0387 0.0335 0.0838
Schistosoma mansoni pyruvate kinase 0.0019 0.0002 0.0002
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0067 0.0045 0.0115
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.4214 0.38 0.38
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.0055 0.0086
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E2 0.0387 0.0335 0.0333
Mycobacterium ulcerans aldehyde dehydrogenase 0.0128 0.01 0.0259
Giardia lamblia Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative 0.1887 0.1693 1
Chlamydia trachomatis biotin carboxylase 0.3826 0.3449 1
Brugia malayi Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta 0.0387 0.0335 0.0346
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0072 0.0072
Loa Loa (eye worm) cytochrome P450 0.0067 0.0045 0.0045
Echinococcus granulosus survival motor neuron protein 1 0.075 0.0664 0.0664
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0067 0.0045 0.0115
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0051 0.0031 0.1259
Leishmania major trypanothione reductase 0.0047 0.0027 0.0025
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0387 0.0335 0.0539
Brugia malayi RNA binding protein 0.0222 0.0186 0.0191
Wolbachia endosymbiont of Brugia malayi carbamoyl phosphate synthase large subunit 0.0952 0.0847 0.2115
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0067 0.0045 0.0115
Loa Loa (eye worm) TAR-binding protein 0.0222 0.0186 0.0191
Schistosoma mansoni tar DNA-binding protein 0.0222 0.0186 0.0186
Schistosoma mansoni hypothetical protein 0.0289 0.0246 0.0246
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0067 0.0045 0.0115
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0078 0.0055 0.2321
Schistosoma mansoni DNA polymerase eta 0.0019 0.0002 0.0002
Schistosoma mansoni inositol monophosphatase 0.0078 0.0055 0.0055
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0169 0.0138 0.0802
Echinococcus multilocularis muscleblind protein 0.0149 0.0119 0.0119
Leishmania major dihydrolipoamide acetyltransferase precursor, putative 0.0387 0.0335 0.0334
Loa Loa (eye worm) hypothetical protein 0.0063 0.0042 0.0041
Brugia malayi Muscleblind-like protein 0.0149 0.0119 0.0122
Brugia malayi Intermediate filament tail domain containing protein 0.0059 0.0038 0.0037
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.4214 0.38 1
Echinococcus multilocularis pyruvate kinase 0.0019 0.0002 0.0002
Brugia malayi Calcitonin receptor-like protein seb-1 0.0213 0.0178 0.0182
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide acyltransferase E2 component 0.0387 0.0335 0.0749
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0115 0.0089 0.0089
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0068 0.0047 0.0047
Echinococcus multilocularis neuropeptide s receptor 0.047 0.041 0.041
Toxoplasma gondii biotin-requiring enzyme domain-containing protein 0.0387 0.0335 0.0333
Echinococcus granulosus histone acetyltransferase KAT2B 0.0091 0.0067 0.0067
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0034 0.0034
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0028 0.0028
Schistosoma mansoni inositol transporter 0.0122 0.0095 0.0095
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0028 0.0027
Echinococcus granulosus histone acetyltransferase KAT2B 0.0292 0.0249 0.0249
Echinococcus granulosus GPCR family 2 0.0067 0.0046 0.0046
Trypanosoma brucei trypanothione reductase 0.0047 0.0027 0.0025
Loa Loa (eye worm) glutathione reductase 0.0047 0.0027 0.0026
Onchocerca volvulus 0.0249 0.021 1
Brugia malayi MH2 domain containing protein 0.0238 0.02 0.0205
Echinococcus granulosus pyruvate kinase 0.0038 0.0019 0.0019
Mycobacterium ulcerans branched-chain alpha-keto acid dehydrogenase subunit E2 0.0387 0.0335 0.0878
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0067 0.0045 0.007
Chlamydia trachomatis dihydrolipoamide succinyltransferase 0.0387 0.0335 0.0924
Schistosoma mansoni pyruvate kinase 0.0038 0.0019 0.0019
Echinococcus granulosus lamin 0.0059 0.0038 0.0038
Trichomonas vaginalis ran, putative 0.0046 0.0026 0.1073
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0034 0.0033
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0122 0.0095 0.0093
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0067 0.0045 0.0115
Trypanosoma brucei dihydrolipoamide acetyltransferase E2 subunit, putative 0.0387 0.0335 0.0334
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0122 0.0095 0.0095
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 5 AccD5 0.1499 0.1342 0.3528
Entamoeba histolytica acetyl-coA carboxylase, putative 0.1887 0.1693 1
Brugia malayi Pyruvate kinase, M2 isozyme 0.0038 0.0019 0.0017
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0067 0.0045 0.0115
Schistosoma mansoni acetyl-CoA carboxylase 1.1062 1 1
Schistosoma mansoni rab6-interacting 0.0019 0.0002 0.0002
Plasmodium vivax pyruvate kinase, putative 0.0038 0.0019 0.0023
Brugia malayi Pyruvate kinase, muscle isozyme 0.0038 0.0019 0.0017
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0067 0.0045 0.0115
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.4214 0.38 0.6142
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0027 0.0035
Mycobacterium ulcerans acetyl-/propionyl-CoA carboxylase subunit beta 0.1499 0.1342 0.3528
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0091 0.0067 0.0065
Echinococcus granulosus pyruvate kinase 0.0019 0.0002 0.0002
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0067 0.0045 0.0115
Trypanosoma cruzi acetyl-CoA carboxylase, putative 0.1499 0.1342 0.2167
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0002 0.000005625
Mycobacterium leprae Conserved hypothetical protein 0.0067 0.0045 0.0071
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0019 0.0017
Trypanosoma cruzi pyruvate kinase 2, putative 0.0038 0.0019 0.0027
Schistosoma mansoni glutaminase 0.0273 0.0231 0.0231
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0096 0.0072 0.0072
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0067 0.0045 0.0044
Loa Loa (eye worm) intermediate filament protein 0.0059 0.0038 0.0037
Brugia malayi GH02984p 0.1106 0.0986 0.102
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.8005 0.7232 1
Echinococcus granulosus solute carrier family 5 0.0122 0.0095 0.0095
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0046 0.0026 0.0025
Plasmodium vivax importin-beta 2, putative 0.0063 0.0042 0.0055
Leishmania major cytochrome p450-like protein 0.0067 0.0045 0.0044
Mycobacterium leprae ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 0.1499 0.1342 0.35
Brugia malayi CXXC zinc finger family protein 0.0028 0.001 0.0009
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0046 0.0026 0.004
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0028 0.0028
Echinococcus granulosus pyruvate kinase 0.0038 0.0019 0.0019
Onchocerca volvulus 0.0032 0.0014 0.055
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0067 0.0045 0.0115
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.4214 0.38 0.3798
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0046 0.0026 0.004
Echinococcus granulosus cytochrome P450 2K1 0.0067 0.0045 0.0045
Loa Loa (eye worm) glutaminase 0.0273 0.0231 0.0238
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0002 0.0000028542
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0038 0.0019 0.0017
Echinococcus multilocularis solute carrier family 5 0.0122 0.0095 0.0095
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0067 0.0045 0.0115
Plasmodium falciparum dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 0.0387 0.0335 0.0461
Brugia malayi RNA recognition motif domain containing protein 0.0222 0.0186 0.0191
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0002 0.0002

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.33 nM Binding affinity against rat adenosine A3 receptor expressed in CHO cells using [125I]-. ChEMBL. 9703463
Ki (binding) = 470 nM Binding affinity against adenosine A2A receptor in rat striatal membranes using [3H]-CGS- 21680. ChEMBL. 9703463
Ki (binding) = 820 nM Binding affinity against adenosine A1 receptor in rat brain membranes using [3H]-R-PIA. ChEMBL. 9703463

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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