Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0.0157 | 0.5 |
Echinococcus granulosus | chromobox protein 1 | 0.0079 | 0.901 | 1 |
Brugia malayi | PHD-finger family protein | 0.0028 | 0.161 | 0.1476 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0019 | 0.0294 | 0.0155 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0019 | 0.0294 | 0.0326 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.2523 | 0.2593 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0157 | 0.5 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0023 | 0.0894 | 0.0807 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0019 | 0.0294 | 0.0155 |
Schistosoma mansoni | chromobox protein | 0.0079 | 0.901 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.4696 | 0.5212 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.0157 | 0.5 |
Trichomonas vaginalis | chromobox protein, putative | 0.0047 | 0.4417 | 0.4812 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0068 | 0.7437 | 0.8224 |
Schistosoma mansoni | bromodomain containing protein | 0.0072 | 0.8037 | 0.892 |
Brugia malayi | Heterochromatin protein 1 | 0.0079 | 0.901 | 0.8994 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4261 | 0.4497 |
Echinococcus multilocularis | chromobox protein 1 | 0.0079 | 0.901 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0044 | 0.3925 | 0.7399 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.0157 | 0.5 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0026 | 0.1214 | 0.1193 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0026 | 0.1214 | 0.1193 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0019 | 0.0294 | 0.0326 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.4696 | 0.5127 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0019 | 0.0294 | 0.0155 |
Brugia malayi | Bromodomain containing protein | 0.0044 | 0.3853 | 0.3755 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.3925 | 0.4256 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0019 | 0.0294 | 0.0326 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0157 | 0.5 |
Trichomonas vaginalis | chromobox protein, putative | 0.0047 | 0.4417 | 0.4812 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.0157 | 0.5 |
Echinococcus granulosus | zinc finger protein | 0.0022 | 0.0717 | 0.0632 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.0157 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.4696 | 0.5212 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0047 | 0.4417 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0031 | 0.203 | 0.2116 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0019 | 0.0294 | 0.0326 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0026 | 0.1214 | 0.1347 |
Loa Loa (eye worm) | bromodomain containing protein | 0.002 | 0.0397 | 0.0263 |
Brugia malayi | chromobox protein homolog 3 | 0.0044 | 0.3925 | 0.3828 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0068 | 0.7437 | 0.8224 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.3864 | 0.4062 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.4696 | 0.5127 |
Echinococcus multilocularis | zinc finger protein | 0.0022 | 0.0717 | 0.0632 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0157 | 0.0174 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0041 | 0.3456 | 0.3727 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.4696 | 0.5127 |
Echinococcus multilocularis | chromobox protein 1 | 0.0079 | 0.901 | 1 |
Schistosoma mansoni | chromobox protein | 0.0079 | 0.901 | 1 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0079 | 0.901 | 0.9701 |
Echinococcus granulosus | chromobox protein 1 | 0.0079 | 0.901 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0079 | 0.901 | 1 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0019 | 0.0294 | 0.0155 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.3925 | 0.4128 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0157 | 0.0174 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0294 | 0.015 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.0157 | 0.5 |
Schistosoma mansoni | zinc finger protein | 0.0022 | 0.0717 | 0.0795 |
Trichomonas vaginalis | chromobox protein, putative | 0.0079 | 0.901 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.4696 | 0.4612 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.4696 | 0.5127 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0157 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0157 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.4696 | 0.5212 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.0157 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.9283 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.0157 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0041 | 0.3456 | 0.3727 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0031 | 0.203 | 0.2116 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0894 | 0.0992 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.4696 | 0.4974 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.0157 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.4581 | 0.4847 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.3925 | 0.4256 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | = 61.96 uM | Cytotoxicity against human PBMC after 72 hrs by Alamar blue assay | ChEMBL. | 21820768 |
MIC (functional) | = 83.3 uM | Antitubercular activity against rifampicin-resistant Mycobacterium tuberculosis ATCC 35338 harboring His-526-Tri mutation in rpoB gene after 9 days by resazurin reduction assay | ChEMBL. | 21820768 |
MIC (functional) | = 83.3 uM | Antitubercular activity against isoniazid-resistant Mycobacterium tuberculosis ATCC 35822 harboring Ser-315-Tri mutation in katG gene after 9 days by resazurin reduction assay | ChEMBL. | 21820768 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.