Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.015 | 0.7983 | 0.7899 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.1082 | 0.1355 |
Brugia malayi | nuclear receptor RXR | 0.0071 | 0.2531 | 0.317 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.1082 | 0.1355 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.7983 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.7983 | 1 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0071 | 0.2531 | 0.2219 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.015 | 0.7983 | 0.7899 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0071 | 0.2531 | 0.2219 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.015 | 0.7983 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.2531 | 0.317 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0079 | 0.3115 | 0.2827 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.004 | 0.0401 | 0.0401 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0071 | 0.2531 | 0.317 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.2531 | 0.317 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.015 | 0.7983 | 0.7983 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.2531 | 0.317 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.015 | 0.7983 | 1 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0071 | 0.2531 | 0.317 |
Echinococcus multilocularis | FTZ F1 alpha | 0.015 | 0.7983 | 0.7899 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.015 | 0.7983 | 0.7899 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.015 | 0.7983 | 0.7899 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.7983 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.2531 | 0.317 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.015 | 0.7983 | 0.7899 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0071 | 0.2531 | 0.2219 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.3115 | 0.3902 |
Schistosoma mansoni | nuclear receptor | 0.0071 | 0.2531 | 0.2531 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.015 | 0.7983 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.3115 | 0.3902 |
Brugia malayi | nuclear hormone receptor | 0.0071 | 0.2531 | 0.317 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0071 | 0.2531 | 0.317 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.015 | 0.7983 | 1 |
Brugia malayi | nuclear hormone receptor | 0.015 | 0.7983 | 1 |
Echinococcus multilocularis | geminin | 0.0179 | 1 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0071 | 0.2531 | 0.2219 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.2531 | 0.317 |
Brugia malayi | nuclear receptor RXR | 0.0079 | 0.3115 | 0.3902 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.015 | 0.7983 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0079 | 0.3115 | 0.3902 |
Loa Loa (eye worm) | DR-78 | 0.0071 | 0.2531 | 0.317 |
Brugia malayi | tailless protein | 0.0071 | 0.2531 | 0.317 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0071 | 0.2531 | 0.2219 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0071 | 0.2531 | 0.2531 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.2531 | 0.317 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.2531 | 0.317 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.1082 | 0.1355 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.004 | 0.0401 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.2531 | 0.317 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.004 | 0.0401 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.015 | 0.7983 | 0.7899 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.015 | 0.7983 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.2531 | 0.317 |
Schistosoma mansoni | hypothetical protein | 0.0179 | 1 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0071 | 0.2531 | 0.2531 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.015 | 0.7983 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.3115 | 0.3902 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.015 | 0.7983 | 0.7983 |
Brugia malayi | ecdysteroid receptor | 0.015 | 0.7983 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.015 | 0.7983 | 0.7983 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.015 | 0.7983 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.1082 | 0.1355 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.015 | 0.7983 | 0.7899 |
Brugia malayi | nuclear receptor NHR-88 | 0.015 | 0.7983 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0071 | 0.2531 | 0.2219 |
Brugia malayi | hypothetical protein | 0.0079 | 0.3115 | 0.3902 |
Schistosoma mansoni | nuclear hormone receptor | 0.0071 | 0.2531 | 0.2531 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0071 | 0.2531 | 0.2219 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0071 | 0.2531 | 0.2219 |
Loa Loa (eye worm) | steroid hormone receptor | 0.015 | 0.7983 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.2531 | 0.317 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0071 | 0.2531 | 0.2219 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.015 | 0.7983 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.015 | 0.7983 | 0.7983 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0071 | 0.2531 | 0.2531 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0071 | 0.2531 | 0.2531 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.004 | 0.0401 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.015 | 0.7983 | 0.7899 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.015 | 0.7983 | 0.7899 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.015 | 0.7983 | 1 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.004 | 0.0401 | 0.0401 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0071 | 0.2531 | 0.2219 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.015 | 0.7983 | 0.7899 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.004 | 0.0401 | 0.5 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.004 | 0.0401 | 0.0502 |
Brugia malayi | hypothetical protein | 0.0071 | 0.2531 | 0.317 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0079 | 0.3115 | 0.3902 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.015 | 0.7983 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.7983 | 1 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.004 | 0.0401 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.015 | 0.7983 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.015 | 0.7983 | 0.7899 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0079 | 0.3115 | 0.3115 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.015 | 0.7983 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.015 | 0.7983 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.015 | 0.7983 | 1 |
Schistosoma mansoni | nuclear receptor | 0.0071 | 0.2531 | 0.2531 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.7983 | 1 |
Brugia malayi | hypothetical protein | 0.0079 | 0.3115 | 0.3902 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.015 | 0.7983 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.015 | 0.7983 | 0.7899 |
Onchocerca volvulus | Bile acid receptor homolog | 0.015 | 0.7983 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0079 | 0.3115 | 0.3115 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0079 | 0.3115 | 0.2827 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.015 | 0.7983 | 1 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.004 | 0.0401 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0179 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.015 | 0.7983 | 0.7983 |
Brugia malayi | ecdysone receptor | 0.0071 | 0.2531 | 0.317 |
Schistosoma mansoni | nuclear hormone receptor | 0.0071 | 0.2531 | 0.2531 |
Schistosoma mansoni | nuclear hormone receptor | 0.015 | 0.7983 | 0.7983 |
Schistosoma mansoni | thyroid hormone receptor | 0.015 | 0.7983 | 0.7983 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.7983 | 1 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.004 | 0.0401 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.015 | 0.7983 | 1 |
Brugia malayi | conserved hypotetical protein | 0.0071 | 0.2531 | 0.317 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.015 | 0.7983 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.015 | 0.7983 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.015 | 0.7983 | 0.7899 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.015 | 0.7983 | 0.7899 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.015 | 0.7983 | 0.7899 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0071 | 0.2531 | 0.317 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.015 | 0.7983 | 0.7983 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.004 | 0.0401 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.2531 | 0.317 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.3115 | 0.3902 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.015 | 0.7983 | 1 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0071 | 0.2531 | 0.2219 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.7983 | 1 |
Onchocerca volvulus | 0.015 | 0.7983 | 1 | |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.015 | 0.7983 | 0.7983 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.015 | 0.7983 | 0.7899 |
Brugia malayi | nuclear receptor NHR-67 | 0.0071 | 0.2531 | 0.317 |
Brugia malayi | nuclear receptor NHR-88 | 0.0071 | 0.2531 | 0.317 |
Brugia malayi | hypothetical protein | 0.0071 | 0.2531 | 0.317 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.015 | 0.7983 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.004 | 0.0401 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0071 | 0.2531 | 0.2219 |
Schistosoma mansoni | coup transcription factor | 0.015 | 0.7983 | 0.7983 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0401 | 0.0502 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.015 | 0.7983 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.7983 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.015 | 0.7983 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.3115 | 0.3902 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.2531 | 0.317 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0079 | 0.3115 | 0.3902 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.2531 | 0.317 |
Schistosoma mansoni | thyroid hormone receptor | 0.015 | 0.7983 | 0.7983 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.015 | 0.7983 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.015 | 0.7983 | 0.7983 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.015 | 0.7983 | 0.7899 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0071 | 0.2531 | 0.317 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.015 | 0.7983 | 0.7983 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0071 | 0.2531 | 0.317 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0071 | 0.2531 | 0.317 |
Brugia malayi | steroid hormone receptor | 0.015 | 0.7983 | 1 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0071 | 0.2531 | 0.317 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0071 | 0.2531 | 0.317 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ID50 (functional) | = 75.5 uM | Compound was tested for its antitumor activity to inhibit 50% of tumor cell growth in mouse leukemia P388 cell lines. | ChEMBL. | 2066996 |
ID50 (functional) | = 94.4 uM | Compound was tested for its antitumor activity to inhibit 50% of tumor cell growth in mouse leukemia L1210 cell lines. | ChEMBL. | 2066996 |
Ki (binding) | M | Compound was tested for the inhibition of Adenosine deaminase from calf intestine; NA indicates not active | ChEMBL. | 2066996 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.