Detailed information for compound 1113663

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 312.381 | Formula: C19H21FN2O
  • H donors: 2 H acceptors: 1 LogP: 3.24 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1cccc(c1)c1ccccc1C(=O)NCC1CCNCC1
  • InChi: 1S/C19H21FN2O/c20-16-5-3-4-15(12-16)17-6-1-2-7-18(17)19(23)22-13-14-8-10-21-11-9-14/h1-7,12,14,21H,8-11,13H2,(H,22,23)
  • InChiKey: FLGPCPUKBSWXEJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cholinergic receptor, muscarinic 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0013 0.0211 0.0286
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0041 0.1281 0.1965
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.1785 0.279
Echinococcus multilocularis cpg binding protein 0.0031 0.0892 0.1394
Loa Loa (eye worm) hypothetical protein 0.0077 0.2669 0.4145
Schistosoma mansoni rab6-interacting 0.0019 0.0461 0.0763
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0077 0.2669 0.4145
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.1334 0.605
Loa Loa (eye worm) hypothetical protein 0.0041 0.1281 0.1965
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0829 0.1255
Echinococcus granulosus ecdysone induced protein 78C 0.0077 0.2669 0.4172
Loa Loa (eye worm) hypothetical protein 0.0036 0.1114 0.1703
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0063 0.0053
Onchocerca volvulus 0.0026 0.0732 0.0681
Echinococcus granulosus Nuclear hormone receptor HR96 0.0036 0.1114 0.1742
Brugia malayi nuclear receptor RXR 0.0041 0.1281 0.1965
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0077 0.2669 0.4414
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.1676 0.2619
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.1334 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0968 0.1513
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0461 0.0721
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0036 0.1114 0.1742
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.2065 0.3416
Echinococcus granulosus ferritin 0.0009 0.0066 0.0103
Schistosoma mansoni polycystin 1-related 0.0019 0.0461 0.0763
Brugia malayi beta-lactamase 0.0042 0.1334 0.2049
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.3652 0.5688
Echinococcus multilocularis expressed protein 0.0009 0.0066 0.0103
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0968 0.1474
Loa Loa (eye worm) nuclear hormone receptor 0.0036 0.1114 0.1703
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.1676 0.2585
Echinococcus granulosus muscleblind protein 0.0175 0.6398 1
Schistosoma mansoni hypothetical protein 0.0033 0.0968 0.1601
Schistosoma mansoni Smad4 0.0008 0.0029 0.0049
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0968 0.1513
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0461 0.0721
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.3652 0.5688
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0036 0.1114 0.1742
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.1815 0.5813
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.1676 0.2772
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0077 0.2669 0.4172
Loa Loa (eye worm) hypothetical protein 0.0042 0.1334 0.2049
Echinococcus multilocularis RUN 0.0019 0.0461 0.0721
Schistosoma mansoni nuclear receptor 0.0036 0.1114 0.1843
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0968 0.1474
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0461 0.0721
Schistosoma mansoni lipoxygenase 0.0054 0.1785 0.2952
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0077 0.2669 0.4145
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.2162 1
Echinococcus granulosus expressed protein 0.0009 0.0066 0.0103
Schistosoma mansoni intermediate filament proteins 0.0026 0.0732 0.121
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.1334 0.5
Onchocerca volvulus 0.0042 0.1334 0.2199
Brugia malayi nuclear hormone receptor family member odr-7 0.0036 0.1114 0.1703
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0077 0.2669 0.4145
Plasmodium vivax hypothetical protein, conserved 0.0042 0.1334 1
Loa Loa (eye worm) hypothetical protein 0.0123 0.4431 0.6911
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0077 0.2669 0.4172
Brugia malayi Nuclear hormone receptor E75 0.0036 0.1114 0.1703
Onchocerca volvulus 0.0042 0.1334 0.2199
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0077 0.2669 0.4172
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.1334 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0036 0.1114 0.1742
Brugia malayi hypothetical protein 0.0036 0.1114 0.1703
Onchocerca volvulus Bile acid receptor homolog 0.0077 0.2669 0.5562
Echinococcus multilocularis muscleblind protein 1 0.0175 0.6398 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0036 0.1114 0.1742
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0077 0.2669 0.4172
Onchocerca volvulus Huntingtin homolog 0.0123 0.4431 1
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0009 0.0066 0.5
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0067 0.0059
Brugia malayi orphan nuclear receptor NR2E1 0.0036 0.1114 0.1703
Mycobacterium leprae conserved hypothetical protein 0.0042 0.1334 1
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0461 0.5
Brugia malayi hypothetical protein 0.0041 0.1281 0.1965
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0041 0.1281 0.2002
Loa Loa (eye worm) hypothetical protein 0.0036 0.1114 0.1703
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.1281 0.1965
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0077 0.2669 0.4145
Loa Loa (eye worm) hypothetical protein 0.0041 0.1281 0.1965
Loa Loa (eye worm) hypothetical protein 0.0042 0.1334 0.2049
Loa Loa (eye worm) hypothetical protein 0.0041 0.1281 0.1965
Brugia malayi Muscleblind-like protein 0.0175 0.6398 1
Schistosoma mansoni smad1 5 8 and 0.0008 0.0029 0.0049
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.241 0.3737
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0029 0.0046
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0077 0.2669 0.4145
Echinococcus multilocularis musashi 0.0026 0.0732 0.1144
Mycobacterium ulcerans hypothetical protein 0.0042 0.1334 0.605
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0077 0.2669 0.4414
Schistosoma mansoni nuclear hormone receptor 0.0077 0.2669 0.4414
Echinococcus granulosus Nuclear hormone receptor HR96 0.0036 0.1114 0.1742
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.1785 0.279
Schistosoma mansoni nuclear hormone receptor 0.0036 0.1114 0.1843
Loa Loa (eye worm) steroid hormone receptor 0.0077 0.2669 0.4145
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0265 0.037
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.1334 0.2049
Loa Loa (eye worm) beta-lactamase 0.0042 0.1334 0.2049
Loa Loa (eye worm) hypothetical protein 0.0026 0.0713 0.1074
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.1334 1
Brugia malayi Steroid receptor seven-up type 2 0.0077 0.2669 0.4145
Loa Loa (eye worm) hypothetical protein 0.0077 0.2669 0.4145
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0077 0.2669 0.4145
Echinococcus granulosus lamin dm0 0.0026 0.0732 0.1144
Schistosoma mansoni rab6-interacting 0.0019 0.0461 0.0763
Schistosoma mansoni ferritin light chain 0.0009 0.0066 0.0109
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0077 0.2669 0.4172
Schistosoma mansoni smad 0.0008 0.0029 0.0049
Echinococcus granulosus FTZ F1 alpha 0.0077 0.2669 0.4172
Brugia malayi beta-lactamase family protein 0.0042 0.1334 0.2049
Schistosoma mansoni cpg binding protein 0.0029 0.0829 0.1371
Schistosoma mansoni lamin 0.0026 0.0732 0.121
Schistosoma mansoni hypothetical protein 0.007 0.241 0.3985
Loa Loa (eye worm) hypothetical protein 0.0077 0.2669 0.4145
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0077 0.2669 0.4414
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0077 0.2669 0.4145
Onchocerca volvulus 0.0029 0.0829 0.0926
Echinococcus multilocularis muscleblind protein 0.0175 0.6398 1
Brugia malayi tailless protein 0.0036 0.1114 0.1703
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0077 0.2669 0.4145
Schistosoma mansoni ferritin 0.0009 0.0066 0.0109
Loa Loa (eye worm) hypothetical protein 0.0036 0.1114 0.1703
Schistosoma mansoni hypothetical protein 0.0019 0.0461 0.0763
Loa Loa (eye worm) hypothetical protein 0.007 0.241 0.3737
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0036 0.1114 0.1843
Schistosoma mansoni thyroid hormone receptor 0.0077 0.2669 0.4414
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0968 0.1513
Schistosoma mansoni thyroid hormone receptor 0.0077 0.2669 0.4414
Loa Loa (eye worm) hypothetical protein 0.0042 0.1334 0.2049
Schistosoma mansoni hypothetical protein 0.0033 0.0968 0.1601
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0036 0.1114 0.1645
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.1334 0.2049
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.2162 0.211
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0077 0.2669 0.4145
Echinococcus multilocularis smad 0.0008 0.0029 0.0046
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.1334 0.1276
Brugia malayi Nuclear hormone receptor-like 1 0.0077 0.2669 0.4145
Loa Loa (eye worm) hypothetical protein 0.0041 0.1281 0.1965
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0077 0.2669 0.4145
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0067 0.0105
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0041 0.1281 0.2118
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0461 0.0721
Mycobacterium leprae Probable lipase LipE 0.0042 0.1334 1
Schistosoma mansoni cpg binding protein 0.0031 0.0892 0.1475
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.1281 0.1965
Brugia malayi hypothetical protein 0.0123 0.4431 0.6911
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.2162 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.1334 0.2049
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.1334 0.1276
Echinococcus multilocularis GPCR, family 2 0.0033 0.0968 0.1513
Brugia malayi intermediate filament protein 0.0026 0.0732 0.1103
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0077 0.2669 0.4145
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.1334 0.5
Loa Loa (eye worm) hypothetical protein 0.0036 0.1114 0.1703
Echinococcus multilocularis geminin 0.0166 0.6046 0.945
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.3652 0.5688
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0732 0.1103
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0077 0.2669 0.4172
Mycobacterium tuberculosis Conserved protein 0.0042 0.1334 0.1276
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0077 0.2669 0.4172
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0461 0.0721
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.1334 0.5
Echinococcus granulosus Smad4 0.0008 0.0029 0.0046
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0036 0.1114 0.1703
Mycobacterium tuberculosis Conserved protein 0.0042 0.1334 0.1276
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0077 0.2669 0.4145
Echinococcus granulosus GPCR family 2 0.0033 0.0968 0.1513
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0029 0.0046
Loa Loa (eye worm) DR-78 0.0036 0.1114 0.1703
Echinococcus granulosus geminin 0.0166 0.6046 0.945
Brugia malayi nuclear receptor NHR-88 0.0077 0.2669 0.4145
Loa Loa (eye worm) hypothetical protein 0.0077 0.2669 0.4145
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0036 0.1114 0.1703
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0077 0.2669 0.4172
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0732 0.1103
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.1334 0.1276
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.1676 0.2619
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0077 0.2669 0.4172
Brugia malayi CXXC zinc finger family protein 0.0029 0.0829 0.1255
Onchocerca volvulus 0.0036 0.1114 0.1645
Echinococcus multilocularis thyroid hormone receptor alpha 0.0077 0.2669 0.4172
Echinococcus granulosus nuclear receptor nhr 48 0.0036 0.1114 0.1742
Brugia malayi Nuclear hormone receptor E75 0.0036 0.1114 0.1703
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.1334 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.1676 0.2619
Schistosoma mansoni apoferritin-2 0.0009 0.0066 0.0109
Brugia malayi nuclear receptor RXR 0.0036 0.1114 0.1703
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0036 0.1114 0.1742
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0077 0.2669 0.4145
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.1334 0.2085
Schistosoma mansoni hypothetical protein 0.0033 0.0968 0.1601
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.1334 0.605
Loa Loa (eye worm) hypothetical protein 0.0036 0.1114 0.1703
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.2162 1
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0461 0.0721
Echinococcus granulosus smad 0.0008 0.0029 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0077 0.2669 0.4145
Echinococcus multilocularis ferritin 0.0009 0.0066 0.0103
Loa Loa (eye worm) hypothetical protein 0.0077 0.2669 0.4145
Brugia malayi hypothetical protein 0.0019 0.0461 0.0678
Echinococcus multilocularis Smad4 0.0008 0.0029 0.0046
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0029 0.0046
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.1676 0.2772
Brugia malayi nuclear receptor NHR-67 0.0036 0.1114 0.1703
Echinococcus multilocularis ecdysone induced protein 78C 0.0077 0.2669 0.4172
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.1676 0.2585
Loa Loa (eye worm) nuclear receptor NHR-67 0.0036 0.1114 0.1703
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0077 0.2669 0.4414
Loa Loa (eye worm) hypothetical protein 0.0042 0.1334 0.2049
Schistosoma mansoni apoferritin-2 0.0009 0.0066 0.0109
Schistosoma mansoni ferritin 0.0009 0.0066 0.0109
Echinococcus granulosus thyroid hormone receptor alpha 0.0036 0.1114 0.1742
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0041 0.1281 0.2002
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0077 0.2669 0.4414
Mycobacterium tuberculosis Conserved protein 0.0042 0.1334 0.1276
Schistosoma mansoni ferritin 0.0009 0.0066 0.0109
Echinococcus multilocularis lamin dm0 0.0026 0.0732 0.1144
Loa Loa (eye worm) hypothetical protein 0.0041 0.1281 0.1965
Echinococcus multilocularis lamin 0.0026 0.0732 0.1144
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0732 0.1103
Schistosoma mansoni cpg binding protein 0.0031 0.0892 0.1475
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0077 0.2669 0.4414
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.1114 0.1742
Brugia malayi conserved hypotetical protein 0.0036 0.1114 0.1703
Schistosoma mansoni smad1 5 8 and 0.0008 0.0029 0.0049
Loa Loa (eye worm) hypothetical protein 0.0036 0.1114 0.1703
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.2162 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.2669 0.4145
Loa Loa (eye worm) hypothetical protein 0.0036 0.1114 0.1703
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0968 0.1474
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0077 0.2669 0.4145
Echinococcus multilocularis FTZ F1 alpha 0.0077 0.2669 0.4172
Schistosoma mansoni nuclear receptor 0.0036 0.1114 0.1843
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.1334 0.2207
Loa Loa (eye worm) hypothetical protein 0.0012 0.0193 0.0257
Loa Loa (eye worm) hypothetical protein 0.0019 0.0461 0.0678
Echinococcus granulosus lamin 0.0026 0.0732 0.1144
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.1281 0.2118
Brugia malayi MH2 domain containing protein 0.0117 0.4179 0.6515
Schistosoma mansoni RAR-like nuclear receptor 0.0077 0.2669 0.4414
Echinococcus granulosus RUN 0.0019 0.0461 0.0721
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0968 0.1513
Onchocerca volvulus 0.0042 0.1334 0.2199
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0077 0.2669 0.4145
Onchocerca volvulus 0.0077 0.2669 0.5562
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.2162 0.3576
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0211 0.033
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.1114 0.1742
Loa Loa (eye worm) hypothetical protein 0.0123 0.4431 0.6911
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.1334 0.2207
Loa Loa (eye worm) hypothetical protein 0.0036 0.1114 0.1703
Schistosoma mansoni coup transcription factor 0.0077 0.2669 0.4414
Loa Loa (eye worm) hypothetical protein 0.0175 0.6398 1
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.4179 0.6515
Loa Loa (eye worm) hypothetical protein 0.0036 0.1114 0.1703
Loa Loa (eye worm) hypothetical protein 0.0042 0.1334 0.2049
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.1334 0.1276
Onchocerca volvulus 0.0026 0.0732 0.0681
Loa Loa (eye worm) hypothetical protein 0.0077 0.2669 0.4145
Loa Loa (eye worm) hypothetical protein 0.0036 0.1114 0.1703
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0067 0.0105
Schistosoma mansoni hypothetical protein 0.0166 0.6046 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0077 0.2669 0.4145
Schistosoma mansoni smad1 5 8 and 0.0008 0.0029 0.0049
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.1334 0.2085
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.1334 0.1276
Onchocerca volvulus 0.0036 0.1114 0.1645
Loa Loa (eye worm) hypothetical protein 0.0019 0.0461 0.0678
Brugia malayi beta-lactamase family protein 0.0042 0.1334 0.2049
Treponema pallidum bacterioferrin (TpF1) 0.0009 0.0066 0.5
Brugia malayi nuclear receptor NHR-88 0.0036 0.1114 0.1703
Schistosoma mansoni loxhd1 0.0019 0.0461 0.0763
Loa Loa (eye worm) hypothetical protein 0.0033 0.0968 0.1474
Loa Loa (eye worm) hypothetical protein 0.0036 0.1114 0.1703
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0077 0.2669 0.4145
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.2162 1
Schistosoma mansoni zinc finger protein 0.0036 0.1114 0.1843
Schistosoma mansoni steroid hormone receptor ad4bp 0.0077 0.2669 0.4414
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0077 0.2669 0.4145
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0077 0.2669 0.4172
Schistosoma mansoni hypothetical protein 0.0166 0.6046 1
Schistosoma mansoni lamin 0.0026 0.0732 0.121
Loa Loa (eye worm) hypothetical protein 0.0026 0.0732 0.1103
Mycobacterium ulcerans beta-lactamase 0.0042 0.1334 0.605
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0461 0.0678
Brugia malayi steroid hormone receptor 0.0077 0.2669 0.4145
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0077 0.2669 0.4172
Brugia malayi hypothetical protein 0.0041 0.1281 0.1965
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0077 0.2669 0.5562
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.1334 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.2162 0.3379
Brugia malayi nuclear hormone receptor family member nhr-6 0.0036 0.1114 0.1703
Schistosoma mansoni ferritin 0.0009 0.0066 0.0109
Trichomonas vaginalis esterase, putative 0.0042 0.1334 1
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.2162 0.3576
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0036 0.1114 0.1742
Brugia malayi Doublecortin family protein 0.0019 0.0461 0.0678
Brugia malayi nuclear hormone receptor 0.0077 0.2669 0.4145
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.1676 0.2619
Schistosoma mansoni hypothetical protein 0.0033 0.0968 0.1601
Loa Loa (eye worm) hypothetical protein 0.0077 0.2669 0.4145
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0077 0.2669 0.4172
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.1334 0.1276
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0036 0.1114 0.1645
Schistosoma mansoni nuclear hormone receptor 0.0036 0.1114 0.1843
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0211 0.033
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0077 0.2669 0.4145
Schistosoma mansoni nuclear receptor nhr-48 0.0036 0.1114 0.1843
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.4179 0.6515
Loa Loa (eye worm) hypothetical protein 0.0036 0.1114 0.1703
Brugia malayi ecdysteroid receptor 0.0077 0.2669 0.4145
Loa Loa (eye worm) hypothetical protein 0.0175 0.6398 1
Brugia malayi nuclear hormone receptor 0.0036 0.1114 0.1703
Onchocerca volvulus Protein ultraspiracle homolog 0.0077 0.2669 0.5562
Mycobacterium ulcerans lipase LipD 0.0042 0.1334 0.605
Onchocerca volvulus Huntingtin homolog 0.0123 0.4431 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.1114 0.1703
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.1676 0.2772
Schistosoma mansoni lipoxygenase 0.0019 0.0461 0.0763
Loa Loa (eye worm) hypothetical protein 0.0103 0.3652 0.5688
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.2162 0.3379
Brugia malayi hypothetical protein 0.0019 0.0461 0.0678
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0265 0.037
Schistosoma mansoni retinoic acid receptor RXR 0.0077 0.2669 0.4414
Schistosoma mansoni ferritin light chain 0.0009 0.0066 0.0109
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0077 0.2669 0.4145
Brugia malayi ecdysone receptor 0.0036 0.1114 0.1703
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0077 0.2669 0.4172
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0029 0.0046
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0036 0.1114 0.1843
Loa Loa (eye worm) hypothetical protein 0.0012 0.0193 0.0257
Brugia malayi hypothetical protein 0.0036 0.1114 0.1703
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0029 0.0049
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.1334 0.1276
Echinococcus granulosus intermediate filament protein 0.0026 0.0732 0.1144
Echinococcus granulosus cpg binding protein 0.0031 0.0892 0.1394

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 5 Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay ChEMBL. 20483611

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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