Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | kinesin family member 11 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0215 | 0.8668 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0012 | 0.0244 | 0.2267 |
Schistosoma mansoni | tar DNA-binding protein | 0.0077 | 0.2932 | 0.3383 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0077 | 0.2932 | 0.5035 |
Schistosoma mansoni | tar DNA-binding protein | 0.0077 | 0.2932 | 0.3383 |
Loa Loa (eye worm) | RNA binding protein | 0.0077 | 0.2932 | 0.5035 |
Brugia malayi | RNA binding protein | 0.0077 | 0.2932 | 1 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0016 | 0.0391 | 0.5 |
Plasmodium falciparum | kinesin-5 | 0.0032 | 0.1078 | 1 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0012 | 0.0244 | 0.042 |
Schistosoma mansoni | tar DNA-binding protein | 0.0077 | 0.2932 | 0.3383 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0244 | 0.042 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0077 | 0.2932 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0019 | 0.0553 | 0.5127 |
Treponema pallidum | ATP-dependent DNA helicase | 0.0006 | 0.00000000020551 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0077 | 0.2932 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.5824 | 1 |
Echinococcus multilocularis | bloom syndrome protein | 0.0029 | 0.0953 | 0.0727 |
Schistosoma mansoni | tar DNA-binding protein | 0.0077 | 0.2932 | 0.3383 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0029 | 0.0953 | 0.2638 |
Echinococcus multilocularis | tar DNA binding protein | 0.0077 | 0.2932 | 0.2755 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0023 | 0.0699 | 0.0807 |
Schistosoma mansoni | tar DNA-binding protein | 0.0077 | 0.2932 | 0.3383 |
Brugia malayi | Kinesin motor domain containing protein | 0.0032 | 0.1078 | 0.3102 |
Schistosoma mansoni | DNA helicase recq1 | 0.0012 | 0.0244 | 0.0282 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0029 | 0.0953 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0012 | 0.0244 | 0.2267 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0016 | 0.0391 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0077 | 0.2932 | 0.5035 |
Echinococcus multilocularis | kinesin family 1 | 0.0247 | 1 | 1 |
Loa Loa (eye worm) | RecQ helicase | 0.0029 | 0.0953 | 0.1637 |
Schistosoma mansoni | kinesin eg-5 | 0.0032 | 0.1078 | 0.1244 |
Echinococcus granulosus | bloom syndrome protein | 0.0029 | 0.0953 | 0.0727 |
Giardia lamblia | Kinesin-5 | 0.0032 | 0.1078 | 1 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0016 | 0.0391 | 0.5 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0032 | 0.1078 | 0.1851 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0032 | 0.1078 | 1 |
Plasmodium vivax | kinesin-5 | 0.0032 | 0.1078 | 1 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0029 | 0.0953 | 1 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0026 | 0.0807 | 0.6745 |
Entamoeba histolytica | recQ family helicase, putative | 0.0016 | 0.0391 | 0.3627 |
Entamoeba histolytica | kinesin, putative | 0.0032 | 0.1078 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0077 | 0.2932 | 0.2755 |
Schistosoma mansoni | DNA helicase recq5 | 0.0012 | 0.0244 | 0.0282 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.14 uM | Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay | ChEMBL. | 21899292 |
IC50 (functional) | = 1.36 uM | Anticancer activity against human COLO205 cells after 72 hrs by MTS/PMS assay | ChEMBL. | 21899292 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 21899292 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.