Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0019 | 0.0028 | 0.0028 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0045 | 0.084 | 1 |
Schistosoma mansoni | cell polarity protein | 0.0023 | 0.0161 | 0.0161 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0019 | 0.0028 | 1 |
Schistosoma mansoni | chondroitin sulfate proteoglycan-related | 0.0023 | 0.0161 | 0.0161 |
Brugia malayi | Carboxylesterase family protein | 0.0045 | 0.084 | 0.1075 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0045 | 0.084 | 0.084 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0053 | 0.112 | 0.112 |
Brugia malayi | Doublecortin family protein | 0.0019 | 0.0028 | 0.0036 |
Schistosoma mansoni | gliotactin | 0.0045 | 0.084 | 0.084 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0045 | 0.084 | 0.084 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.084 | 0.1075 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0045 | 0.084 | 1 |
Onchocerca volvulus | 0.0045 | 0.084 | 1 | |
Echinococcus granulosus | BC026374 protein S09 family | 0.0045 | 0.084 | 0.084 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0045 | 0.084 | 1 |
Schistosoma mansoni | loxhd1 | 0.0019 | 0.0028 | 0.0028 |
Echinococcus granulosus | slit 2 protein | 0.0023 | 0.0161 | 0.0161 |
Loa Loa (eye worm) | carboxylesterase | 0.0264 | 0.7819 | 1 |
Echinococcus multilocularis | neuroligin | 0.0045 | 0.084 | 0.084 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0264 | 0.7819 | 1 |
Onchocerca volvulus | 0.0045 | 0.084 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.084 | 0.1075 |
Schistosoma mansoni | polycystin 1-related | 0.0019 | 0.0028 | 0.0028 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0045 | 0.084 | 0.084 |
Echinococcus granulosus | pikachurin | 0.0023 | 0.0161 | 0.0161 |
Echinococcus granulosus | neuroligin | 0.0045 | 0.084 | 0.084 |
Schistosoma mansoni | acetylcholinesterase | 0.0045 | 0.084 | 0.084 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.084 | 0.1075 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0045 | 0.084 | 0.084 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0019 | 0.0028 | 0.0028 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.7819 | 1 |
Echinococcus multilocularis | pikachurin | 0.0023 | 0.0161 | 0.0161 |
Brugia malayi | EGF-like domain containing protein | 0.0023 | 0.0161 | 0.0206 |
Onchocerca volvulus | 0.0045 | 0.084 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.0045 | 0.084 | 0.1075 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | rab6-interacting | 0.0019 | 0.0028 | 0.0028 |
Schistosoma mansoni | hypothetical protein | 0.0332 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0045 | 0.084 | 0.084 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0045 | 0.084 | 0.084 |
Echinococcus granulosus | acetylcholinesterase | 0.0264 | 0.7819 | 0.7819 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0045 | 0.084 | 1 |
Schistosoma mansoni | slit | 0.0023 | 0.0161 | 0.0161 |
Echinococcus multilocularis | acetylcholinesterase | 0.0264 | 0.7819 | 0.7819 |
Brugia malayi | Carboxylesterase family protein | 0.0264 | 0.7819 | 1 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0028 | 0.0036 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0023 | 0.0161 | 0.0161 |
Onchocerca volvulus | 0.0045 | 0.084 | 1 | |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.084 | 0.1075 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0161 | 0.0206 |
Loa Loa (eye worm) | carboxylesterase | 0.0045 | 0.084 | 0.1075 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0028 | 0.0036 |
Echinococcus multilocularis | geminin | 0.0332 | 1 | 1 |
Echinococcus granulosus | RUN | 0.0019 | 0.0028 | 0.0028 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0045 | 0.084 | 0.084 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.7819 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | abnormal epIthelia family member | 0.0023 | 0.0161 | 0.0206 |
Schistosoma mansoni | lipoxygenase | 0.0053 | 0.112 | 0.112 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0023 | 0.0161 | 0.0161 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.084 | 0.1075 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0053 | 0.112 | 0.112 |
Brugia malayi | laminin alpha chain | 0.0023 | 0.0161 | 0.0206 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0045 | 0.084 | 0.084 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.084 | 0.1075 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.084 | 0.1075 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0045 | 0.084 | 0.084 |
Schistosoma mansoni | hypothetical protein | 0.0332 | 1 | 1 |
Schistosoma mansoni | rab6-interacting | 0.0019 | 0.0028 | 0.0028 |
Brugia malayi | Thrombospondin N-terminal -like domain containing protein | 0.0023 | 0.0161 | 0.0206 |
Loa Loa (eye worm) | carboxylesterase | 0.0045 | 0.084 | 0.1075 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0045 | 0.084 | 1 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0023 | 0.0161 | 0.0161 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0028 | 0.0036 |
Schistosoma mansoni | lipoxygenase | 0.0019 | 0.0028 | 0.0028 |
Loa Loa (eye worm) | doublecortin family protein | 0.0019 | 0.0028 | 0.0036 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0 | 0.5 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | RUN | 0.0019 | 0.0028 | 0.0028 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0019 | 0.0028 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0045 | 0.084 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0045 | 0.084 | 0.084 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0161 | 0.0206 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0028 | 0.0036 |
Brugia malayi | Carboxylesterase family protein | 0.0045 | 0.084 | 0.1075 |
Echinococcus granulosus | acetylcholinesterase | 0.0264 | 0.7819 | 0.7819 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0264 | 0.7819 | 0.7819 |
Echinococcus multilocularis | acetylcholinesterase | 0.0264 | 0.7819 | 0.7819 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0264 | 0.7819 | 0.7819 |
Brugia malayi | Carboxylesterase family protein | 0.0264 | 0.7819 | 1 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0019 | 0.0028 | 0.0028 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0019 | 0.0028 | 0.0028 |
Onchocerca volvulus | 0.0045 | 0.084 | 1 | |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0019 | 0.0028 | 0.0028 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0045 | 0.084 | 0.1075 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0161 | 0.0206 |
Echinococcus granulosus | carboxylesterase 5A | 0.0264 | 0.7819 | 0.7819 |
Brugia malayi | Carboxylesterase family protein | 0.0045 | 0.084 | 0.1075 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0019 | 0.0028 | 0.0028 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0028 | 0.0028 |
Brugia malayi | laminin-like protein K08C7.3 precursor | 0.0023 | 0.0161 | 0.0206 |
Echinococcus multilocularis | slit 2 protein | 0.0023 | 0.0161 | 0.0161 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 58 % | Inhibition of CD45 protein-tyrosine phosphatase of Jurkat cell membrane at 500 uM. | ChEMBL. | No reference |
Inhibition (binding) | = 58 % | Inhibition of CD45 protein-tyrosine phosphatase of Jurkat cell membrane at 500 uM. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.