Detailed information for compound 1114107

Basic information

Technical information
  • TDR Targets ID: 1114107
  • Name: 4-[(4-methylphenyl)amino]-4-oxobut-2-enoic ac id
  • MW: 205.21 | Formula: C11H11NO3
  • H donors: 2 H acceptors: 3 LogP: 1.23 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1)C)/C=C/C(=O)O
  • InChi: 1S/C11H11NO3/c1-8-2-4-9(5-3-8)12-10(13)6-7-11(14)15/h2-7H,1H3,(H,12,13)(H,14,15)/b7-6+
  • InChiKey: VLWFSWMZGGZHGD-VOTSOKGWSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (E)-4-[(4-methylphenyl)amino]-4-oxobut-2-enoic acid
  • 4-[(4-methylphenyl)amino]-4-oxo-but-2-enoic acid
  • (E)-4-[(4-methylphenyl)amino]-4-oxo-but-2-enoic acid
  • 4-keto-4-[(4-methylphenyl)amino]but-2-enoic acid
  • (E)-4-keto-4-[(4-methylphenyl)amino]but-2-enoic acid
  • 37904-03-3
  • NSC166476
  • ALD-N033151

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi RNA binding protein 0.0103 0.006 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0024 0.0021
Brugia malayi Synaptic glycoprotein SC2 0.4035 0.2725 0.2723
Echinococcus granulosus cysteine protease 0.002 0.0003 0.0004
Plasmodium vivax glutathione reductase, putative 0.0035 0.0013 0.0044
Leishmania major cysteine peptidase A (CPA) 0.004 0.0017 0.0014
Trypanosoma cruzi cysteine peptidase, putative 0.0151 0.0092 0.009
Loa Loa (eye worm) matrixin family protein 0.012 0.0071 0.0069
Plasmodium falciparum plasmepsin VIII, putative 0.0021 0.0004 0.0005
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 1.4767 1 1
Plasmodium falciparum plasmepsin X 0.0021 0.0004 0.0005
Entamoeba histolytica prolyl oligopeptidase family protein 0.0031 0.0011 0.0008
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0048 0.0022 0.0021
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.4035 0.2725 1
Trichomonas vaginalis histone deacetylase, putative 0.01 0.0057 0.0055
Echinococcus granulosus cytochrome P450 2K1 0.0033 0.0012 0.0035
Toxoplasma gondii RNA-directed DNA polymerase 0.0203 0.0127 0.0126
Brugia malayi Doublecortin family protein 0.0063 0.0033 0.003
Onchocerca volvulus Prolyl endopeptidase homolog 0.0298 0.0191 0.0689
Trypanosoma brucei histone deacetylase, putative 0.0112 0.0066 0.0063
Schistosoma mansoni cytochrome P450 0.0033 0.0012 0.0033
Plasmodium falciparum metacaspase-like protein 0.005 0.0024 0.0078
Plasmodium vivax plasmepsin IV, putative 0.0048 0.0022 0.0078
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0709 0.047 0.0468
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0017 0.0014
Brugia malayi nuclear receptor NHR-88 0.0335 0.0216 0.0214
Schistosoma mansoni histone deacetylase 0.01 0.0057 0.0158
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.01 0.0057 0.0055
Brugia malayi nuclear hormone receptor family member nhr-6 0.0335 0.0216 0.0214
Schistosoma mansoni zinc finger protein 0.0335 0.0216 0.06
Echinococcus granulosus cathepsin L 0.002 0.0003 0.0004
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0226 0.0143 0.014
Brugia malayi hypothetical protein 0.0047 0.0021 0.0019
Mycobacterium tuberculosis Probable reductase 0.0079 0.0043 0.1155
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0033 0.0012 0.001
Loa Loa (eye worm) glutathione reductase 0.0035 0.0013 0.0011
Echinococcus granulosus Nuclear hormone receptor HR96 0.0335 0.0216 0.0786
Leishmania major cathepsin L-like protease 0.0151 0.0092 0.009
Brugia malayi nuclear hormone receptor family member odr-7 0.0335 0.0216 0.0214
Entamoeba histolytica hypothetical protein 0.0051 0.0024 0.0022
Schistosoma mansoni rab6-interacting 0.0063 0.0033 0.009
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0038 0.0015 0.0042
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0118 0.007 0.0067
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0709 0.047 0.0468
Loa Loa (eye worm) hypothetical protein 1.4767 1 1
Echinococcus multilocularis 0.0033 0.0012 0.0035
Brugia malayi Cathepsin L-like precursor 0.0027 0.0008 0.0005
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0048 0.0022 0.0061
Plasmodium vivax metacaspase 1, putative 0.005 0.0024 0.0083
Echinococcus multilocularis protein dispatched 1 0.0111 0.0064 0.0228
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0151 0.0092 0.009
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.005 0.0023 0.0064
Treponema pallidum signal peptidase I 0.0566 0.0373 1
Trypanosoma brucei histone deacetylase 1 0.01 0.0057 0.0055
Schistosoma mansoni histone deacetylase hda2 0.0119 0.007 0.0195
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0038 0.0015 0.0047
Loa Loa (eye worm) hypothetical protein 0.0097 0.0056 0.0053
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0088 0.0049 0.1134
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0028 0.0008 0.0008
Echinococcus multilocularis apoptotic protease activating factor 1 0.0047 0.0021 0.007
Brugia malayi photoreceptor-specific nuclear receptor 0.0709 0.047 0.0468
Schistosoma mansoni hypothetical protein 0.0044 0.0019 0.0053
Brugia malayi histone deacetylase 1 (HD1) 0.01 0.0057 0.0055
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.004 0.0017 0.0014
Toxoplasma gondii aspartyl protease 0.0021 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.005 0.0024 0.0021
Onchocerca volvulus 0.0335 0.0216 0.0781
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0151 0.0092 0.009
Leishmania major cytochrome p450-like protein 0.0033 0.0012 0.001
Brugia malayi nuclear hormone receptor 0.0709 0.047 0.0468
Mycobacterium leprae Conserved hypothetical protein 0.0033 0.0012 0.0119
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.4035 0.2725 0.2723
Trypanosoma brucei histone deacetylase 2 0.0048 0.0022 0.002
Trypanosoma brucei cytochrome P450, putative 0.0068 0.0036 0.0033
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0349 0.0226 0.0224
Mycobacterium tuberculosis Probable dehydrogenase 0.0079 0.0043 0.1155
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0375 0.0244 0.0675
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.002 0.0003 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0005 0.0003
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0709 0.047 0.1718
Entamoeba histolytica cysteine proteinase, putative 0.004 0.0017 0.0014
Brugia malayi MH2 domain containing protein 0.0193 0.0121 0.0118
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.005 0.0024 0.0023
Brugia malayi Cathepsin L-like cysteine proteinase 0.0027 0.0008 0.0005
Brugia malayi aspartic protease BmAsp-1, identical 0.0021 0.0004 0.0001
Schistosoma mansoni steroid hormone receptor ad4bp 0.0709 0.047 0.1305
Plasmodium falciparum glutathione reductase 0.0035 0.0013 0.0039
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0349 0.0226 0.0224
Schistosoma mansoni hypothetical protein 0.0093 0.0053 0.0146
Echinococcus granulosus thyroid hormone receptor alpha 0.0335 0.0216 0.0786
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0033 0.0012 0.0012
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0048 0.0022 0.0073
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0298 0.0191 0.0531
Plasmodium vivax aspartyl protease, putative 0.0021 0.0004 0.001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0027 0.0073
Echinococcus multilocularis caspase 0.0133 0.008 0.0285
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0031 0.0011 0.0031
Trichomonas vaginalis rotamase, putative 0.002 0.0003 0.0001
Echinococcus multilocularis expressed conserved protein 0.0212 0.0133 0.0481
Toxoplasma gondii histone deacetylase HDAC3 0.01 0.0057 0.0056
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0044 0.0019 0.0017
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0068 0.0036 0.0036
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0003 0.0001
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 1.4767 1 1
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0031 0.0011 0.0008
Schistosoma mansoni hypothetical protein 0.0044 0.0019 0.0053
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 1.4767 1 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0709 0.047 0.0468
Brugia malayi Pre-SET motif family protein 0.0251 0.0159 0.0157
Loa Loa (eye worm) hypothetical protein 0.0375 0.0244 0.0241
Entamoeba histolytica cysteine proteinase, putative 0.004 0.0017 0.0014
Loa Loa (eye worm) hypothetical protein 0.0709 0.047 0.0468
Echinococcus multilocularis synaptic glycoprotein sc2 0.4035 0.2725 1
Brugia malayi Latrophilin receptor protein 2 0.0044 0.0019 0.0017
Entamoeba histolytica cysteine protease, putative 0.004 0.0017 0.0014
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0709 0.047 0.1718
Loa Loa (eye worm) hypothetical protein 0.0375 0.0244 0.0241
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0017 0.0014
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0349 0.0226 0.0224
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0969 0.0646 0.1794
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0035 0.0013 0.0349
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0709 0.047 0.1305
Echinococcus granulosus lipoxygenase domain containing protein 0.0063 0.0033 0.0111
Echinococcus multilocularis ecdysone induced protein 78C 0.0709 0.047 0.1718
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0003 0.0001
Onchocerca volvulus Cathepsin F homolog 0.004 0.0017 0.0046
Schistosoma mansoni tar DNA-binding protein 0.0103 0.006 0.0165
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0038 0.0015 0.0042
Echinococcus multilocularis prolyl endopeptidase 0.0298 0.0191 0.0694
Giardia lamblia Telomerase catalytic subunit 0.0203 0.0127 0.0459
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.002 0.0003 0.0001
Entamoeba histolytica signal peptidase, putative 0.0027 0.0008 0.0005
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0088 0.0049 0.1315
Schistosoma mansoni cpg binding protein 0.0107 0.0062 0.0171
Loa Loa (eye worm) cytochrome P450 family protein 0.0116 0.0068 0.0066
Onchocerca volvulus 0.0063 0.0033 0.0105
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0033 0.0012 0.0321
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0026 0.0007 0.002
Onchocerca volvulus Matrilysin homolog 0.011 0.0064 0.0222
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0017 0.0014
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0079 0.0043 0.1155
Echinococcus granulosus synaptic glycoprotein sc2 0.4035 0.2725 1
Loa Loa (eye worm) histone deacetylase 1 0.01 0.0057 0.0055
Trypanosoma cruzi histone deacetylase, putative 0.0048 0.0022 0.002
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0005 0.0003
Plasmodium vivax aspartyl proteinase, putative 0.0021 0.0004 0.001
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0033 0.0012 0.0012
Echinococcus granulosus Polycystic kidney disease protein 0.0063 0.0033 0.0111
Trypanosoma cruzi metacaspase, putative 0.005 0.0024 0.0021
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0027 0.0089
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0335 0.0216 0.0214
Mycobacterium tuberculosis Probable oxidoreductase 0.0088 0.0049 0.1315
Schistosoma mansoni hypothetical protein 0.0093 0.0053 0.0146
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0026 0.0007 0.0018
Trypanosoma cruzi metacaspase 5, putative 0.005 0.0024 0.0021
Trypanosoma cruzi metacaspase, putative 0.005 0.0024 0.0021
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0335 0.0216 0.0786
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0005 0.0003
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.005 0.0024 0.0023
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.4035 0.2725 0.2723
Leishmania major oligopeptidase b 0.0118 0.007 0.0067
Onchocerca volvulus Phospholipase A2 homolog 0.0057 0.0028 0.0089
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0118 0.007 0.0067
Brugia malayi Thioredoxin reductase 0.0035 0.0013 0.0011
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0033 0.0012 0.0321
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0349 0.0226 0.0224
Loa Loa (eye worm) DR-78 0.0335 0.0216 0.0214
Trypanosoma cruzi histone deacetylase, putative 0.0112 0.0066 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0709 0.047 0.0468
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0335 0.0216 0.0781
Loa Loa (eye worm) aspartyl protease 6 0.0021 0.0004 0.0001
Echinococcus multilocularis transcription factor btf3 0.0081 0.0045 0.0155
Echinococcus multilocularis cathepsin L cysteine protease 0.004 0.0017 0.0052
Echinococcus multilocularis acylamino acid releasing enzyme 0.0031 0.0011 0.0031
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0021 0.0004 0.001
Schistosoma mansoni thyroid hormone receptor 0.0709 0.047 0.1305
Echinococcus granulosus histone deacetylase 8 0.0048 0.0022 0.0073
Brugia malayi Histone deacetylase 1 0.01 0.0057 0.0055
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0005 0.0003
Onchocerca volvulus Cathepsin L homolog 0.004 0.0017 0.0046
Echinococcus granulosus RUN 0.0063 0.0033 0.0111
Brugia malayi Cathepsin L-like precursor 0.004 0.0017 0.0014
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0335 0.0216 0.0781
Schistosoma mansoni signalase (S26 family) 0.0027 0.0008 0.002
Loa Loa (eye worm) hypothetical protein 0.0335 0.0216 0.0214
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0033 0.0012 0.0321
Plasmodium falciparum plasmepsin IV 0.0048 0.0022 0.0073
Brugia malayi Histone deacetylase family protein 0.0112 0.0066 0.0063
Echinococcus multilocularis neuropeptide s receptor 0.0555 0.0366 0.1335
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0036 0.0034
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0099 0.0057 0.0054
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.4035 0.2725 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.004 0.0017 0.0052
Plasmodium vivax thioredoxin reductase, putative 0.0035 0.0013 0.0044
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0033 0.0012 0.0321
Brugia malayi Matrixin family protein 0.005 0.0023 0.0021
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0031 0.0011 0.0008
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0033 0.0012 0.0321
Brugia malayi CHE-14 protein 0.0097 0.0055 0.0053
Loa Loa (eye worm) RNA binding protein 0.0103 0.006 0.0057
Onchocerca volvulus 0.4035 0.2725 1
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0033 0.0012 0.0321
Echinococcus multilocularis caspase 8 0.005 0.0024 0.0078
Loa Loa (eye worm) hypothetical protein 0.0709 0.047 0.0468
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0033 0.0012 0.0012
Schistosoma mansoni nuclear receptor nhr-48 0.0335 0.0216 0.06
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0709 0.047 0.1718
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0024 0.0021
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.002 0.0003 0.0001
Onchocerca volvulus 0.0027 0.0008 0.0014
Brugia malayi Matrixin family protein 0.005 0.0023 0.0021
Brugia malayi Hemopexin family protein 0.0071 0.0037 0.0035
Brugia malayi hypothetical protein 0.0111 0.0065 0.0062
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0033 0.0012 0.001
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0061 0.0031 0.0821
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.004 0.0017 0.0014
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0069 0.0036 0.0034
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.4035 0.2725 0.2723
Brugia malayi Peptidase S24-like domain containing protein 0.0027 0.0008 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0024 0.0021
Trypanosoma brucei histone deacetylase 4 0.0112 0.0066 0.0063
Onchocerca volvulus 0.004 0.0017 0.0046
Loa Loa (eye worm) hypothetical protein 0.0111 0.0065 0.0062
Entamoeba histolytica cysteine protease, putative 0.002 0.0003 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0335 0.0216 0.0214
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0031 0.0011 0.0008
Schistosoma mansoni nuclear hormone receptor 0.0709 0.047 0.1305
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0033 0.0012 0.0012
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.4035 0.2725 1
Loa Loa (eye worm) fibroinase 0.004 0.0017 0.0014
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0267 0.017 0.4563
Echinococcus multilocularis dnaJ subfamily B 0.1437 0.0963 0.353
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0203 0.0127 0.0125
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0038 0.0015 0.0014
Entamoeba histolytica hypothetical protein, conserved 0.0031 0.0011 0.0008
Echinococcus multilocularis cathepsin L 0.002 0.0003 0.0004
Schistosoma mansoni nuclear receptor 0.0335 0.0216 0.06
Brugia malayi RNA recognition motif domain containing protein 0.0103 0.006 0.0057
Schistosoma mansoni polycystin 1-related 0.0063 0.0033 0.009
Echinococcus multilocularis histone deacetylase 7 0.0112 0.0066 0.0232
Leishmania major cathepsin L-like protease 0.004 0.0017 0.0014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0017 0.0014
Brugia malayi nuclear receptor NHR-88 0.0709 0.047 0.0468
Echinococcus multilocularis Niemann Pick C1 protein 0.0322 0.0208 0.0756
Loa Loa (eye worm) hypothetical protein 0.0335 0.0216 0.0214
Plasmodium vivax polyprenol reductase, putative 0.4035 0.2725 1
Brugia malayi Cytochrome P450 family protein 0.0033 0.0012 0.001
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0003 0.0001
Trypanosoma brucei Metacaspase-4 0.005 0.0024 0.0021
Schistosoma mansoni coup transcription factor 0.0709 0.047 0.1305
Plasmodium falciparum peptidase, putative 0.0031 0.0011 0.0031
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0709 0.047 0.1718
Schistosoma mansoni memapsin-2 (A01 family) 0.0324 0.0209 0.0581
Echinococcus granulosus Protein patched homolog 1 0.0097 0.0055 0.0194
Plasmodium vivax histone deacetylase, putative 0.0048 0.0022 0.0078
Brugia malayi nuclear receptor RXR 0.0375 0.0244 0.0241
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0709 0.047 0.1305
Schistosoma mansoni cathepsin F (C01 family) 0.004 0.0017 0.0045
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0033 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0027 0.0008 0.0005
Loa Loa (eye worm) hypothetical protein 0.0298 0.0191 0.0189
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0151 0.0092 0.009
Echinococcus granulosus caspase 8 0.005 0.0024 0.0078
Brugia malayi Niemann-Pick C1 protein precursor 0.0226 0.0143 0.014
Toxoplasma gondii cytochrome p450 superfamily protein 0.0033 0.0012 0.0011
Toxoplasma gondii histone lysine methyltransferase SET1 0.0192 0.012 0.0119
Loa Loa (eye worm) hypothetical protein 0.084 0.0559 0.0557
Loa Loa (eye worm) hypothetical protein 0.0063 0.0033 0.003
Echinococcus granulosus signal peptidase complex catalytic subunit 0.0027 0.0008 0.0019
Plasmodium falciparum LCCL domain-containing protein 0.0063 0.0033 0.0111
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0013 0.0038
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0033 0.0012 0.0321
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0024 0.0021
Brugia malayi hypothetical protein 0.0282 0.0181 0.0179
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0033 0.0012 0.0034
Echinococcus granulosus cpg binding protein 0.0107 0.0062 0.0218
Loa Loa (eye worm) cytochrome P450 family protein 0.0068 0.0036 0.0033
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0033 0.0012 0.0321
Brugia malayi Cell death protein 3 precursor 0.0097 0.0056 0.0053
Loa Loa (eye worm) cytochrome P450 family protein 0.0068 0.0036 0.0033
Echinococcus multilocularis cathepsin L cysteine protease 0.004 0.0017 0.0052
Mycobacterium leprae PROBABLE SIGNAL PEPTIDASE I LEPB (SPASE I) (LEADER PEPTIDASE I). 0.0566 0.0373 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0024 0.0021
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0007 0.0004
Schistosoma mansoni tar DNA-binding protein 0.0103 0.006 0.0165
Brugia malayi hypothetical protein 0.0335 0.0216 0.0214
Brugia malayi hypothetical protein 0.0375 0.0244 0.0241
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0744 0.0494 0.1801
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0151 0.0092 0.009
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.4035 0.2725 0.2723
Brugia malayi Pepsin A precursor 0.0021 0.0004 0.0001
Schistosoma mansoni histone deacetylase 4 5 0.0112 0.0066 0.0182
Trichomonas vaginalis helicase, putative 0.0023 0.0005 0.0003
Brugia malayi orphan nuclear receptor NR2E1 0.0335 0.0216 0.0214
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0021 0.0004 0.0003
Trypanosoma cruzi cysteine proteinase, putative 0.002 0.0003 0.0001
Brugia malayi hypothetical protein 0.0063 0.0033 0.003
Loa Loa (eye worm) hypothetical protein 0.0375 0.0244 0.0241
Toxoplasma gondii thioredoxin reductase 0.0035 0.0013 0.0012
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0079 0.0043 0.1155
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0033 0.0012 0.0012
Echinococcus granulosus histone lysine methyltransferase setb 0.0038 0.0015 0.0047
Schistosoma mansoni tar DNA-binding protein 0.0103 0.006 0.0165
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0024 0.0021
Onchocerca volvulus Protein ultraspiracle homolog 0.0709 0.047 0.1714
Trypanosoma cruzi signal peptidase type I, putative 0.0027 0.0008 0.0005
Trypanosoma brucei transcription factor BTF3, putative 0.0081 0.0045 0.0042
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0002 0.0065
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.004 0.0017 0.0014
Echinococcus granulosus Niemann Pick C1 protein 0.0322 0.0208 0.0756
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0151 0.0092 0.009
Plasmodium falciparum cysteine proteinase falcipain 3 0.004 0.0017 0.0052
Wolbachia endosymbiont of Brugia malayi Signal peptidase I 0.0566 0.0373 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0335 0.0216 0.0786
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0017 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0005 0.0003
Onchocerca volvulus 0.0071 0.0037 0.0123
Loa Loa (eye worm) hypothetical protein 0.0335 0.0216 0.0214
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0709 0.047 0.1305
Schistosoma mansoni caspase-3 (C14 family) 0.0133 0.008 0.0221
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0033 0.0012 0.0321
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0003 0.0001
Schistosoma mansoni transcription factor btf3 0.0081 0.0045 0.0123
Loa Loa (eye worm) hypothetical protein 0.0709 0.047 0.0468
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.4035 0.2725 0.2724
Loa Loa (eye worm) transcription factor SMAD2 0.0193 0.0121 0.0118
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0033 0.0012 0.0012
Echinococcus multilocularis geminin 0.0277 0.0177 0.0641
Trichomonas vaginalis histone deacetylase, putative 0.01 0.0057 0.0055
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0031 0.0011 0.0008
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0027 0.0073
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.004 0.0017 0.0014
Entamoeba histolytica cysteine proteinase 1, putative 0.002 0.0003 0.0001
Entamoeba histolytica hypothetical protein 0.0081 0.0045 0.0042
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0118 0.007 0.1872
Loa Loa (eye worm) hypothetical protein 0.0335 0.0216 0.0214
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0709 0.047 0.0468
Plasmodium falciparum basic transcription factor 3b, putative 0.0081 0.0045 0.0155
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.0036 0.0124
Echinococcus multilocularis expressed protein 0.002 0.0003 0.0003
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0031 0.0011 0.001
Toxoplasma gondii signal peptidase I protein 0.0027 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.0709 0.047 0.0468
Entamoeba histolytica hypothetical protein 0.0028 0.0008 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0005 0.0003
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0033 0.0012 0.0012
Brugia malayi Papain family cysteine protease containing protein 0.004 0.0017 0.0014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0151 0.0092 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0005 0.0003
Chlamydia trachomatis signal peptidase I 0.0566 0.0373 1
Toxoplasma gondii histone deacetylase HDAC4 0.0048 0.0022 0.0021
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0053 0.0025 0.0069
Brugia malayi Nuclear hormone receptor-like 1 0.0375 0.0244 0.0241
Echinococcus multilocularis Niemann Pick C1 protein 0.0226 0.0143 0.0515
Leishmania major cathepsin L-like protease 0.004 0.0017 0.0014
Plasmodium vivax vivapain-3 0.002 0.0003 0.0009
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0008 0.0005
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0003 0.0001
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 1.4767 1 1
Plasmodium vivax aspartyl protease, putative 0.0021 0.0004 0.001
Mycobacterium leprae putative cytochrome p450 0.0033 0.0012 0.0119
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0031 0.0011 0.0008
Plasmodium vivax histone deacetylase 1, putative 0.01 0.0057 0.0206
Brugia malayi prolyl oligopeptidase family protein 0.0031 0.0011 0.0008
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0028 0.0008 0.0008
Leishmania major cathepsin L-like protease 0.004 0.0017 0.0014
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.002 0.0003 0.0001
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0133 0.008 0.0285
Loa Loa (eye worm) hypothetical protein 0.0031 0.0011 0.0008
Onchocerca volvulus 0.005 0.0023 0.0071
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0138 0.0083 0.0081
Echinococcus granulosus expressed protein 0.002 0.0003 0.0003
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0024 0.0021
Echinococcus granulosus histone deacetylase 1 0.01 0.0057 0.0202
Trichomonas vaginalis histone deacetylase, putative 0.01 0.0057 0.0055
Entamoeba histolytica cysteine protease, putative 0.002 0.0003 0.0001
Loa Loa (eye worm) cysteine protease 0.004 0.0017 0.0014
Trypanosoma cruzi prolyl endopeptidase 0.0298 0.0191 0.0189
Onchocerca volvulus 0.004 0.0017 0.0046
Echinococcus granulosus cathepsin l cysteine peptidase 0.004 0.0017 0.0052
Brugia malayi Cathepsin L-like precursor 0.004 0.0017 0.0014
Brugia malayi Microsomal signal peptidase 21 kDa subunit 0.0027 0.0008 0.0005
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0007 0.0004
Brugia malayi glutathione reductase 0.0035 0.0013 0.0011
Onchocerca volvulus 0.0111 0.0065 0.0223
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0709 0.047 0.0468
Entamoeba histolytica cysteine protease, putative 0.002 0.0003 0.0001
Toxoplasma gondii peptidylprolyl isomerase 0.002 0.0003 0.0002
Schistosoma mansoni hypothetical protein 0.0071 0.0037 0.0103
Loa Loa (eye worm) hypothetical protein 0.0071 0.0038 0.0035
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0036 0.0036
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0005 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0045 0.0042
Onchocerca volvulus 0.0709 0.047 0.1714
Brugia malayi TAR-binding protein 0.0103 0.006 0.0057
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0033 0.0012 0.0321
Echinococcus granulosus caspase 3 0.0083 0.0046 0.0159
Onchocerca volvulus Cathepsin L homolog 0.004 0.0017 0.0046
Loa Loa (eye worm) hypothetical protein 0.01 0.0057 0.0055
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.005 0.0024 0.0023
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0028 0.0008 0.0008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0017 0.0014
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0001
Plasmodium vivax vivapain-2 0.004 0.0017 0.0057
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0709 0.047 0.1718
Schistosoma mansoni hypothetical protein 0.0044 0.0019 0.0053
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0709 0.047 0.1718
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0709 0.047 0.0468
Toxoplasma gondii prolyl endopeptidase 0.0298 0.0191 0.019
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0028 0.0008 0.0164
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.002 0.0003 0.0001
Echinococcus multilocularis mitochondrial inner membrane protease subunit 0.0027 0.0008 0.0019
Echinococcus multilocularis histone deacetylase 6 0.0112 0.0066 0.0232
Loa Loa (eye worm) hypothetical protein 0.004 0.0017 0.0014
Schistosoma mansoni synaptic glycoprotein sc2 related 0.4035 0.2725 0.7566
Echinococcus granulosus tar DNA binding protein 0.0103 0.006 0.021
Leishmania major metacaspase, putative 0.005 0.0024 0.0021
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0079 0.0043 0.1155
Echinococcus multilocularis nuclear receptor nhr 48 0.0335 0.0216 0.0786
Trypanosoma cruzi histone deacetylase 1, putative 0.01 0.0057 0.0055
Loa Loa (eye worm) ICD-1 protein 0.0081 0.0045 0.0042
Brugia malayi aspartic protease BmAsp-2, identical 0.0021 0.0004 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.002 0.0003 0.0001
Echinococcus granulosus caspase 0.0133 0.008 0.0285
Trypanosoma cruzi cruzipain precursor, putative 0.0151 0.0092 0.009
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0044 0.0019 0.0062
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0027 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0011 0.0008
Leishmania major cathepsin L-like protease 0.004 0.0017 0.0014
Echinococcus granulosus caspase 2 0.0097 0.0056 0.0195
Loa Loa (eye worm) hypothetical protein 0.0057 0.0028 0.0026
Trypanosoma cruzi cysteine peptidase, putative 0.0151 0.0092 0.009
Trichomonas vaginalis histone deacetylase, putative 0.01 0.0057 0.0055
Entamoeba histolytica cysteine protease, putative 0.002 0.0003 0.0001
Entamoeba histolytica steroid 5-alpha reductase, putative 1.4767 1 1
Toxoplasma gondii exonuclease III APE 0.0019 0.0002 0.0001
Entamoeba histolytica prolyl oligopeptidase family protein 0.0031 0.0011 0.0008
Brugia malayi CXXC zinc finger family protein 0.0101 0.0058 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0005 0.0003
Trypanosoma cruzi serine peptidase clan SF, family S26B, putative 0.0027 0.0008 0.0005
Entamoeba histolytica cysteine protease, putative 0.002 0.0003 0.0001
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.002 0.0003 0.0001
Loa Loa (eye worm) papain family cysteine protease containing protein 0.004 0.0017 0.0014
Loa Loa (eye worm) latrophilin receptor protein 2 0.0044 0.0019 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0709 0.047 0.0468
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0028 0.0008 0.0228
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0033 0.0012 0.0321
Echinococcus multilocularis thyroid hormone receptor alpha 0.0709 0.047 0.1718
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0349 0.0226 0.0224
Trypanosoma cruzi histone deacetylase, putative 0.0112 0.0066 0.0063
Echinococcus granulosus histone deacetylase 7 0.0112 0.0066 0.0232
Leishmania major cytochrome p450-like protein 0.0033 0.0012 0.001
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0033 0.0012 0.0321
Schistosoma mansoni rotamase 0.002 0.0003 0.0009
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0024 0.0021
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0007 0.0004
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0069 0.0036 0.0976
Giardia lamblia Alanyl dipeptidyl peptidase 0.0031 0.0011 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0005 0.0003
Trypanosoma cruzi metacaspase, putative 0.005 0.0024 0.0021
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0118 0.007 0.1702
Echinococcus multilocularis protein patched 0.0097 0.0055 0.0194
Echinococcus granulosus histone deacetylase 3 0.01 0.0057 0.0202
Loa Loa (eye worm) RecQ helicase 0.0025 0.0007 0.0004
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.0036 0.0034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0017 0.0014
Brugia malayi Cathepsin L-like precursor 0.004 0.0017 0.0014
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.0036 0.0034
Echinococcus granulosus GPCR family 2 0.0044 0.0019 0.0062
Loa Loa (eye worm) histone deacetylase 11 0.0048 0.0022 0.002
Echinococcus multilocularis L aminoadipate semialdehyde 0.0099 0.0057 0.02
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0038 0.0015 0.0042
Leishmania major cathepsin L-like protease 0.004 0.0017 0.0014
Loa Loa (eye worm) ctsf protein 0.004 0.0017 0.0014
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0375 0.0244 0.0886
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0033 0.0012 0.0012
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.005 0.0024 0.0065
Echinococcus multilocularis cysteine protease 0.004 0.0017 0.0052
Trypanosoma cruzi metacaspase, putative 0.005 0.0024 0.0021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0151 0.0092 0.009
Loa Loa (eye worm) hypothetical protein 0.0335 0.0216 0.0214
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0298 0.0191 0.0189
Echinococcus granulosus L aminoadipate semialdehyde 0.0099 0.0057 0.02
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0709 0.047 0.0468
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0709 0.047 0.0468
Plasmodium falciparum plasmepsin VII 0.0021 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0038 0.0015 0.0013
Leishmania major histone deacetylase, putative 0.01 0.0057 0.0055
Leishmania major cathepsin L-like protease 0.0151 0.0092 0.009
Loa Loa (eye worm) TAR-binding protein 0.0103 0.006 0.0057
Schistosoma mansoni cpg binding protein 0.0107 0.0062 0.0171
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0151 0.0092 0.009
Plasmodium falciparum histone deacetylase 2 0.0112 0.0066 0.0232
Toxoplasma gondii aspartyl protease ASP1 0.0048 0.0022 0.0021
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0027 0.0089
Mycobacterium ulcerans LexA repressor 0.0027 0.0008 0.0008
Plasmodium vivax SET domain protein, putative 0.0038 0.0015 0.0052
Echinococcus granulosus cathepsin l1 0.0027 0.0008 0.0019
Trypanosoma cruzi cysteine peptidase, putative 0.004 0.0017 0.0014
Plasmodium vivax telomerase reverse transcriptase, putative 0.0203 0.0127 0.0463
Onchocerca volvulus Phospholipase A2 homolog 0.0057 0.0028 0.0089
Schistosoma mansoni cathepsin D (A01 family) 0.0118 0.007 0.0193
Trypanosoma brucei metacaspase 0.005 0.0024 0.0021
Brugia malayi Nuclear hormone receptor-like 1 0.0375 0.0244 0.0241
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0709 0.047 0.0468
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.004 0.0017 0.0014
Onchocerca volvulus 0.0027 0.0008 0.0014
Brugia malayi Cathepsin L-like precursor 0.004 0.0017 0.0014
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0349 0.0226 0.0224
Brugia malayi nuclear receptor RXR 0.0335 0.0216 0.0214
Echinococcus multilocularis RUN 0.0063 0.0033 0.0111
Loa Loa (eye worm) hypothetical protein 0.0709 0.047 0.0468
Schistosoma mansoni histone deacetylase hda2 0.0048 0.0022 0.0061
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0036 0.0036
Trypanosoma brucei metacaspase MCA2 0.005 0.0024 0.0021
Loa Loa (eye worm) hypothetical protein 0.0027 0.0008 0.0005
Plasmodium falciparum polyprenol reductase, putative 0.4035 0.2725 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0349 0.0226 0.0224
Loa Loa (eye worm) histone deacetylase 0.0112 0.0066 0.0063
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.002 0.0003 0.0009
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0003 0.0008
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0033 0.0012 0.0012
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0033 0.0012 0.0012
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0021 0.0004 0.001
Onchocerca volvulus 0.0285 0.0183 0.0657
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0031 0.0011 0.001
Echinococcus multilocularis lipoxygenase domain containing protein 0.0063 0.0033 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0045 0.0042
Echinococcus multilocularis histone deacetylase 0.0112 0.0066 0.0232
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0044 0.0019 0.0062
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0151 0.0092 0.009
Mycobacterium ulcerans hydrolase 0.0061 0.0031 0.0031
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 1.4767 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0097 0.0055 0.0053
Loa Loa (eye worm) nuclear receptor NHR-67 0.0335 0.0216 0.0214
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0709 0.047 0.1718
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0033 0.0012 0.0012
Trypanosoma cruzi cysteine proteinase, putative 0.002 0.0003 0.0001
Loa Loa (eye worm) hypothetical protein 0.0138 0.0083 0.0081
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0079 0.0043 0.1155
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0033 0.0012 0.001
Loa Loa (eye worm) hypothetical protein 0.0064 0.0033 0.0031
Schistosoma mansoni synaptic glycoprotein sc2 related 0.4035 0.2725 0.7566
Loa Loa (eye worm) hypothetical protein 0.005 0.0023 0.0021
Brugia malayi prolyl oligopeptidase family protein 0.0298 0.0191 0.0189
Leishmania major phosphopantetheinyl transferase-like protein 0.0028 0.0008 0.0006
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0335 0.0216 0.0786
Echinococcus multilocularis neuropeptide receptor A26 0.0555 0.0366 0.1335
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0033 0.0012 0.0321
Loa Loa (eye worm) hypothetical protein 0.0709 0.047 0.0468
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0031 0.0011 0.0029
Loa Loa (eye worm) hypothetical protein 0.0335 0.0216 0.0214
Echinococcus granulosus ecdysone induced protein 78C 0.0709 0.047 0.1718
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.4035 0.2725 0.2723
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0151 0.0092 0.009
Loa Loa (eye worm) hypothetical protein 0.0119 0.007 0.0068
Brugia malayi latrophilin 2 splice variant baaae 0.0094 0.0054 0.0051
Entamoeba histolytica cysteine protease, putative 0.002 0.0003 0.0001
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0375 0.0244 0.0675
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0027 0.0025
Echinococcus multilocularis tar DNA binding protein 0.0103 0.006 0.021
Brugia malayi cytochrome P450 0.0033 0.0012 0.001
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0335 0.0216 0.0786
Schistosoma mansoni patched 1 0.0097 0.0055 0.0153
Schistosoma mansoni histone deacetylase 0.01 0.0057 0.0158
Plasmodium falciparum cysteine proteinase falcipain 2a 0.004 0.0017 0.0052
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0709 0.047 0.0468
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0298 0.0191 0.0531
Leishmania major histone deacetylase, putative 0.0112 0.0066 0.0063
Echinococcus granulosus Niemann Pick C1 protein 0.0226 0.0143 0.0515
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0036 0.0034
Loa Loa (eye worm) hypothetical protein 0.0097 0.0055 0.0053
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0003 0.0001
Treponema pallidum signal peptidase I (sip) 0.0566 0.0373 1
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0033 0.0012 0.0012
Leishmania major trypanothione reductase 0.0035 0.0013 0.0011
Echinococcus multilocularis lipoxygenase domain containing protein 0.0063 0.0033 0.0111
Plasmodium vivax vivapain-1 0.002 0.0003 0.0009
Echinococcus granulosus mixed lineage leukemia protein mll 0.0026 0.0007 0.0018
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0008 0.0006
Schistosoma mansoni hypothetical protein 0.0277 0.0177 0.0491
Echinococcus multilocularis signal peptidase complex catalytic subunit 0.0027 0.0008 0.0019
Schistosoma mansoni transcription factor LCR-F1 0.0051 0.0024 0.0066
Schistosoma mansoni hypothetical protein 0.0058 0.0029 0.0079
Echinococcus granulosus histone deacetylase 6 0.0119 0.007 0.025
Toxoplasma gondii NAC domain-containing protein 0.0081 0.0045 0.0044
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0033 0.0012 0.0321
Toxoplasma gondii histone deacetylase HDAC5 0.0048 0.0022 0.0021
Brugia malayi Steroid receptor seven-up type 2 0.0709 0.047 0.0468
Plasmodium vivax signal peptidase 21 kDa subunit, putative 0.0027 0.0008 0.0024
Brugia malayi beta-NAC-like protein 0.0081 0.0045 0.0042
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0033 0.0012 0.0012
Brugia malayi Nuclear hormone receptor E75 0.0335 0.0216 0.0214
Brugia malayi histone deacetylase 11 0.0048 0.0022 0.002
Loa Loa (eye worm) histone deacetylase 7A 0.0112 0.0066 0.0063
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0017 0.0014
Echinococcus multilocularis caspase 3 0.0083 0.0046 0.0159
Echinococcus multilocularis cpg binding protein 0.0107 0.0062 0.0218
Giardia lamblia Alanyl dipeptidyl peptidase 0.0031 0.0011 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0709 0.047 0.0468
Schistosoma mansoni caspase-7 (C14 family) 0.0097 0.0056 0.0154
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0709 0.047 0.1305
Loa Loa (eye worm) hypothetical protein 0.0061 0.0031 0.0028
Brugia malayi Cathepsin L-like precursor 0.0027 0.0008 0.0005
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.017 0.0105 0.2816
Entamoeba histolytica cysteine protease, putative 0.002 0.0003 0.0001
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0716 0.0475 0.1736
Echinococcus multilocularis GPCR, family 2 0.0044 0.0019 0.0062
Plasmodium vivax aspartyl proteinase, putative 0.0048 0.0022 0.0078
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0007 0.0015
Onchocerca volvulus 0.0038 0.0015 0.0042
Brugia malayi Matrixin family protein 0.012 0.0071 0.0069
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0003 0.0001
Plasmodium falciparum plasmepsin I 0.0048 0.0022 0.0073
Brugia malayi prolyl oligopeptidase family protein 0.0031 0.0011 0.0008
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0118 0.007 0.007
Plasmodium vivax vivapain-2 0.004 0.0017 0.0057
Echinococcus granulosus sterol regulatory element binding protein 0.0097 0.0055 0.0194
Loa Loa (eye worm) microsomal signal peptidase 21 kDa subunit 0.0027 0.0008 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0045 0.0042
Loa Loa (eye worm) hypothetical protein 0.005 0.0023 0.0021
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0024 0.0021
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.004 0.0017 0.0014
Loa Loa (eye worm) hypothetical protein 0.0335 0.0216 0.0214
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0011 0.0008
Echinococcus granulosus transcription factor btf3 0.0081 0.0045 0.0155
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.0036 0.0124
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.002 0.0003 0.0001
Plasmodium falciparum metacaspase 1 0.005 0.0024 0.0078
Echinococcus multilocularis FTZ F1 alpha 0.0709 0.047 0.1718
Onchocerca volvulus 0.0099 0.0057 0.0195
Entamoeba histolytica prolyl oligopeptidase family protein 0.0031 0.0011 0.0008
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0021 0.0004 0.001
Brugia malayi histone deacetylase 3 (HD3) 0.01 0.0057 0.0055
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0709 0.047 0.1718
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0033 0.0012 0.001
Toxoplasma gondii cathepsin CPL 0.004 0.0017 0.0016
Entamoeba histolytica hypothetical protein 0.0051 0.0024 0.0022
Brugia malayi nuclear hormone receptor 0.0335 0.0216 0.0214
Plasmodium vivax plasmepsin V, putative 0.0021 0.0004 0.001
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.4035 0.2725 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0017 0.0014
Entamoeba histolytica cysteine protease, putative 0.002 0.0003 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0017 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0024 0.0021
Echinococcus multilocularis histone deacetylase 6 0.0119 0.007 0.025
Entamoeba histolytica hypothetical protein 0.0051 0.0024 0.0022
Echinococcus granulosus prolyl endopeptidase 0.0298 0.0191 0.0694
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0005 0.0003
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0118 0.007 0.0067
Plasmodium falciparum plasmepsin II 0.0048 0.0022 0.0073
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0008 0.0027
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0021 0.0004 0.001
Brugia malayi Cathepsin L-like precursor 0.004 0.0017 0.0014
Echinococcus granulosus cathepsin L cysteine proteinase 0.004 0.0017 0.0052
Brugia malayi conserved hypotetical protein 0.0335 0.0216 0.0214
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0061 0.0031 0.0028
Loa Loa (eye worm) hypothetical protein 0.0094 0.0054 0.0051
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0048 0.0022 0.002
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0709 0.047 0.0468
Brugia malayi Calcitonin receptor-like protein seb-1 0.0138 0.0083 0.0081
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0001
Trypanosoma brucei prolyl oligopeptidase, putative 0.0118 0.007 0.0067
Trypanosoma cruzi cytochrome P450, putative 0.0068 0.0036 0.0033
Toxoplasma gondii histone deacetylase HDAC2 0.01 0.0057 0.0056
Trypanosoma brucei oligopeptidase b 0.0118 0.007 0.0067
Loa Loa (eye worm) hypothetical protein 0.0282 0.0181 0.0179
Plasmodium falciparum telomerase reverse transcriptase 0.0203 0.0127 0.0459
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0011 0.0008
Trypanosoma cruzi histone deacetylase, putative 0.0048 0.0022 0.002
Mycobacterium ulcerans hypothetical protein 1.4767 1 1
Brugia malayi Eukaryotic aspartyl protease family protein 0.0021 0.0004 0.0001
Schistosoma mansoni hypothetical protein 0.0033 0.0012 0.0033
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0002 0.0002
Loa Loa (eye worm) doublecortin family protein 0.0063 0.0033 0.003
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0031 0.0011 0.0029
Brugia malayi nuclear receptor NHR-67 0.0335 0.0216 0.0214
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0031 0.0011 0.0008
Loa Loa (eye worm) hypothetical protein 0.0335 0.0216 0.0214
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0048 0.0022 0.002
Trypanosoma brucei trypanothione reductase 0.0035 0.0013 0.0011
Onchocerca volvulus 0.0335 0.0216 0.0781
Echinococcus granulosus neuropeptide s receptor 0.0555 0.0366 0.1335
Echinococcus granulosus expressed conserved protein 0.0212 0.0133 0.0481
Leishmania major cathepsin L-like protease 0.0151 0.0092 0.009
Loa Loa (eye worm) MH2 domain-containing protein 0.0193 0.0121 0.0118
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0026 0.0007 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.4035 0.2725 0.2723
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0079 0.0043 0.097
Giardia lamblia Fructose-bisphosphate aldolase 0.0349 0.0226 0.0821
Loa Loa (eye worm) hypothetical protein 0.0063 0.0033 0.003
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0033 0.0012 0.0012
Brugia malayi hypothetical protein 0.0021 0.0004 0.0001
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0335 0.0216 0.06
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0033 0.0012 0.001
Entamoeba histolytica histone deacetylase, putative 0.01 0.0057 0.0055
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.4035 0.2725 0.2723
Brugia malayi cathepsin L-like precursor 0.0027 0.0008 0.0005
Onchocerca volvulus Bile acid receptor homolog 0.084 0.0559 0.204
Schistosoma mansoni nuclear hormone receptor 0.0335 0.0216 0.06
Schistosoma mansoni hypothetical protein 0.0044 0.0019 0.0053
Loa Loa (eye worm) prolyl oligopeptidase 0.0031 0.0011 0.0008
Loa Loa (eye worm) thioredoxin reductase 0.0035 0.0013 0.0011
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0181 0.0112 0.0403
Schistosoma mansoni cathepsin D (A01 family) 0.0118 0.007 0.0193
Onchocerca volvulus 0.0058 0.0029 0.0091
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0349 0.0226 0.0224
Brugia malayi Matrixin family protein 0.005 0.0023 0.0021
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0027 0.0024
Loa Loa (eye worm) hypothetical protein 0.0047 0.0021 0.0019
Mycobacterium tuberculosis Probable signal peptidase I LepB (SPASE I) (leader peptidase I). 0.0566 0.0373 1
Loa Loa (eye worm) histone deacetylase 3 0.01 0.0057 0.0055
Loa Loa (eye worm) hypothetical protein 0.002 0.0003 0.0001
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0024 0.0021
Schistosoma mansoni hypothetical protein 0.0051 0.0024 0.0066
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.0036 0.0034
Trichomonas vaginalis histone deacetylase, putative 0.01 0.0057 0.0055
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0033 0.0012 0.0321
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0038 0.0015 0.0047
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0033 0.0012 0.0321
Echinococcus multilocularis histone deacetylase 1 0.01 0.0057 0.0202
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.5328 0.3601 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0044 0.0019 0.0062
Loa Loa (eye worm) hypothetical protein 0.0375 0.0244 0.0241
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0027 0.0089
Echinococcus multilocularis histone deacetylase 6 0.0112 0.0066 0.0232
Giardia lamblia Histone deacetylase 0.01 0.0057 0.0202
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.002 0.0003 0.0001
Onchocerca volvulus Matrilysin homolog 0.005 0.0023 0.0071
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0002 0.0005
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.004 0.0017 0.0014
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0118 0.007 0.0067
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.004 0.0017 0.0014
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.017 0.0105 0.0105
Giardia lamblia Synaptic glycoprotein SC2 0.4035 0.2725 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0709 0.047 0.1718
Echinococcus multilocularis thioredoxin glutathione reductase 0.0035 0.0013 0.0039
Echinococcus multilocularis survival motor neuron protein 1 0.0282 0.0181 0.0656
Plasmodium falciparum plasmepsin VI 0.0048 0.0022 0.0073
Toxoplasma gondii signal peptidase 0.0027 0.0008 0.0007
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0051 0.0024 0.008
Brugia malayi Histone deacetylase family protein 0.0112 0.0066 0.0063
Entamoeba histolytica cysteine protease, putative 0.002 0.0003 0.0001
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0375 0.0244 0.0241
Onchocerca volvulus 0.004 0.0017 0.0046
Echinococcus multilocularis histone deacetylase 8 0.0048 0.0022 0.0073
Schistosoma mansoni rab6-interacting 0.0063 0.0033 0.009
Schistosoma mansoni cpg binding protein 0.0101 0.0058 0.016
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0031 0.0011 0.0008
Plasmodium falciparum histone deacetylase, putative 0.0112 0.0066 0.0232
Loa Loa (eye worm) matrix metalloproteinase 0.005 0.0023 0.0021
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0229 0.0145 0.0402
Echinococcus granulosus Nuclear hormone receptor HR96 0.0335 0.0216 0.0786
Loa Loa (eye worm) CYP4Cod1 0.0068 0.0036 0.0033
Trypanosoma cruzi cysteine peptidase, putative 0.0151 0.0092 0.009
Schistosoma mansoni nuclear hormone receptor 0.0335 0.0216 0.06
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0005 0.0003
Echinococcus granulosus histone deacetylase 6 0.0112 0.0066 0.0232
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0097 0.0055 0.0053
Schistosoma mansoni mitochondrial signal peptidase (S26 family) 0.0027 0.0008 0.002
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.4035 0.2725 0.2723
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0069 0.0036 0.0034
Echinococcus granulosus lipoxygenase domain containing protein 0.0063 0.0033 0.0111
Schistosoma mansoni cathepsin F (C01 family) 0.004 0.0017 0.0045
Trypanosoma cruzi major cysteine proteinase, putative 0.0119 0.007 0.0068
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.4035 0.2725 0.2723
Loa Loa (eye worm) hypothetical protein 0.0335 0.0216 0.0214
Echinococcus granulosus mitochondrial inner membrane protease subunit 0.0027 0.0008 0.0019
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.01 0.0057 0.0055
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0036 0.0034
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.0159 0.0157
Schistosoma mansoni tar DNA-binding protein 0.0103 0.006 0.0165
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0709 0.047 0.1714
Onchocerca volvulus 0.004 0.0017 0.0046
Echinococcus granulosus microtubule associated protein 2 0.16 0.1074 0.3937
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 1.4767 1 1
Brugia malayi prolyl oligopeptidase family protein 0.0031 0.0011 0.0008
Schistosoma mansoni microtubule-associated protein tau 0.16 0.1074 0.2983
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0033 0.0012 0.0321
Echinococcus multilocularis sterol regulatory element binding protein 0.0097 0.0055 0.0194
Brugia malayi Pre-SET motif family protein 0.0038 0.0015 0.0013
Onchocerca volvulus 0.0047 0.0021 0.0064
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0036 0.0125
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0335 0.0216 0.0786
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0029 0.0026
Loa Loa (eye worm) hypothetical protein 0.0375 0.0244 0.0241
Plasmodium vivax hypothetical protein, conserved 0.005 0.0024 0.0083
Plasmodium falciparum cysteine proteinase falcipain 1 0.002 0.0003 0.0004
Toxoplasma gondii aspartyl protease ASP3 0.0021 0.0004 0.0003
Schistosoma mansoni histone deacetylase 4 5 0.0112 0.0066 0.0182
Brugia malayi Nuclear hormone receptor E75 0.0335 0.0216 0.0214
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0709 0.047 0.1718
Trypanosoma brucei prolyl endopeptidase 0.0298 0.0191 0.0189
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 1.4767 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0709 0.047 0.0468
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0033 0.0012 0.0012
Trypanosoma cruzi mitochondrial inner membrane signal peptidase, putative 0.0027 0.0008 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0709 0.047 0.0468
Schistosoma mansoni hypothetical protein 0.1437 0.0963 0.2675
Schistosoma mansoni thyroid hormone receptor 0.0709 0.047 0.1305
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0044 0.0019 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0709 0.047 0.0468
Brugia malayi F/Y-rich N-terminus family protein 0.0032 0.0011 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0024 0.0021
Leishmania major cytochrome p450-like protein 0.0068 0.0036 0.0033
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0203 0.0127 0.0125
Schistosoma mansoni cathepsin F (C01 family) 0.0027 0.0008 0.002
Leishmania major histone deacetylase, putative 0.01 0.0057 0.0055
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0005 0.0008
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0028 0.0008 0.0164
Echinococcus granulosus survival motor neuron protein 1 0.0282 0.0181 0.0656
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0709 0.047 0.0468
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.002 0.0003 0.0009
Schistosoma mansoni lipoxygenase 0.0137 0.0083 0.0229
Schistosoma mansoni hypothetical protein 0.0093 0.0053 0.0146
Schistosoma mansoni ap endonuclease 0.0019 0.0002 0.0006
Echinococcus granulosus geminin 0.0277 0.0177 0.0641
Leishmania major basic transcription factor 3a, putative 0.0081 0.0045 0.0042
Loa Loa (eye worm) hypothetical protein 0.4035 0.2725 0.2723
Schistosoma mansoni tar DNA-binding protein 0.0103 0.006 0.0165
Loa Loa (eye worm) matrixin family protein 0.011 0.0064 0.0062
Loa Loa (eye worm) steroid hormone receptor 0.0709 0.047 0.0468
Plasmodium vivax basic transcription factor 3b, putative 0.0081 0.0045 0.0159
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0017 0.0014
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0088 0.0049 0.1315
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0033 0.0012 0.0012
Trypanosoma cruzi transcription factor btf3, putative 0.0081 0.0045 0.0042
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0036 0.0125
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0031 0.0011 0.0008
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0099 0.0057 0.0157
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0335 0.0216 0.0786
Schistosoma mansoni RAR-like nuclear receptor 0.0709 0.047 0.1305
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0138 0.0083 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0024 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0709 0.047 0.0468
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0017 0.0052
Echinococcus granulosus cathepsin l1 0.004 0.0017 0.0052
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0709 0.047 0.1305
Plasmodium vivax aspartyl protease, putative 0.0021 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.0044 0.0019 0.0017
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.004 0.0017 0.0014
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 1.4767 1 1
Brugia malayi prolyl oligopeptidase family protein 0.0031 0.0011 0.0008
Entamoeba histolytica cysteine protease, putative 0.002 0.0003 0.0001
Loa Loa (eye worm) hypothetical protein 0.0057 0.0028 0.0026
Echinococcus multilocularis cysteine protease 0.004 0.0017 0.0052
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0709 0.047 0.1718
Loa Loa (eye worm) hypothetical protein 0.0335 0.0216 0.0214
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0017 0.0014
Leishmania major histone deacetylase, putative 0.0112 0.0066 0.0063
Loa Loa (eye worm) hypothetical protein 0.0226 0.0143 0.014
Entamoeba histolytica cysteine proteinase 2 0.002 0.0003 0.0001
Leishmania major mitochondrial inner membrane signal peptidase, putative,serine peptidase clan SF, family S26B, putative 0.0027 0.0008 0.0005
Schistosoma mansoni caspase-7 (C14 family) 0.0133 0.008 0.0221
Entamoeba histolytica transcription factor BTF3, putative 0.0081 0.0045 0.0042
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0215 0.0136 0.0376
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.0036 0.0034
Echinococcus granulosus acylamino acid releasing enzyme 0.0031 0.0011 0.0031
Plasmodium vivax histone deacetylase, putative 0.0112 0.0066 0.0237
Loa Loa (eye worm) hypothetical protein 0.0048 0.0022 0.002
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0021 0.0004 0.001
Onchocerca volvulus Cell death protein 3 homolog 0.0097 0.0056 0.019
Brugia malayi Cytochrome P450 family protein 0.0116 0.0068 0.0066
Schistosoma mansoni lipoxygenase 0.0251 0.016 0.0444
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0335 0.0216 0.0214
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.004 0.0017 0.0014
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0251 0.016 0.0579
Echinococcus granulosus nuclear receptor nhr 48 0.0335 0.0216 0.0786
Plasmodium falciparum signal peptidase 21 kDa subunit 0.0027 0.0008 0.0019
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0031 0.0011 0.0008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0349 0.0226 0.0224
Leishmania major telomerase reverse transcriptase, putative 0.0203 0.0127 0.0125
Echinococcus granulosus dnaJ subfamily B 0.1437 0.0963 0.353
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.017 0.0105 0.2666
Trichomonas vaginalis conserved hypothetical protein 0.4035 0.2725 0.2723
Loa Loa (eye worm) inner mitochondrial membrane protease family member 0.0027 0.0008 0.0005
Loa Loa (eye worm) hypothetical protein 0.0048 0.0022 0.002
Brugia malayi Cathepsin L-like precursor 0.004 0.0017 0.0014
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0051 0.0024 0.008
Trypanosoma cruzi cysteine protease, putative 0.002 0.0003 0.0001
Brugia malayi hypothetical protein 0.0335 0.0216 0.0214
Schistosoma mansoni hypothetical protein 0.0277 0.0177 0.0491
Schistosoma mansoni survival motor neuron protein 0.0058 0.0029 0.0079
Trichomonas vaginalis histone deacetylase, putative 0.01 0.0057 0.0055
Echinococcus granulosus FTZ F1 alpha 0.0709 0.047 0.1718
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0103 0.006 0.0057
Schistosoma mansoni hypothetical protein 0.0063 0.0033 0.009
Mycobacterium tuberculosis Probable peptidase 0.0118 0.007 0.1872
Loa Loa (eye worm) hypothetical protein 0.0709 0.047 0.0468
Trypanosoma cruzi signal peptidase type I, putative 0.0027 0.0008 0.0005
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0021 0.0004 0.001
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0138 0.0083 0.0081
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0028 0.0008 0.0008
Loa Loa (eye worm) CXXC zinc finger family protein 0.0101 0.0058 0.0056
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0033 0.0012 0.0012
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0033 0.0012 0.0321
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.002 0.0003 0.0009
Trichomonas vaginalis rotamase, putative 0.002 0.0003 0.0001
Brugia malayi ecdysteroid receptor 0.084 0.0559 0.0557
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0151 0.0092 0.009
Schistosoma mansoni retinoic acid receptor RXR 0.0709 0.047 0.1305
Echinococcus granulosus transcription factor Dp 1 0.004 0.0017 0.0052
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0349 0.0226 0.0224
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0709 0.047 0.1305
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0033 0.0012 0.0012
Echinococcus granulosus bloom syndrome protein 0.0025 0.0007 0.0015
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0026 0.0007 0.0018
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0099 0.0057 0.0054
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0008 0.0022
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0005 0.0003
Trypanosoma cruzi transcription factor btf3, putative 0.0081 0.0045 0.0042
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0038 0.0015 0.0042
Echinococcus granulosus Dipeptidyl peptidase 9 0.0031 0.0011 0.0031
Plasmodium vivax multidomain scavenger receptor, putative 0.0063 0.0033 0.0115
Plasmodium falciparum histone deacetylase 1 0.01 0.0057 0.0202
Schistosoma mansoni nuclear receptor 0.0335 0.0216 0.06
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0048 0.0022 0.0073
Trypanosoma cruzi histone deacetylase, putative 0.0112 0.0066 0.0063
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0709 0.047 0.1718
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0069 0.0036 0.01
Toxoplasma gondii hypothetical protein 0.0031 0.0011 0.001
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0024 0.0021
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0709 0.047 0.0468
Echinococcus granulosus histone deacetylase 6 0.0112 0.0066 0.0232
Onchocerca volvulus 0.0063 0.0033 0.0105
Onchocerca volvulus 0.004 0.0017 0.0046
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0031 0.0011 0.0025
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0133 0.008 0.0285
Treponema pallidum fructose-bisphosphate aldolase 0.0349 0.0226 0.6032
Loa Loa (eye worm) hypothetical protein 0.0335 0.0216 0.0214
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0031 0.0011 0.0008
Trypanosoma cruzi histone deacetylase 1, putative 0.01 0.0057 0.0055
Entamoeba histolytica hypothetical protein 0.0051 0.0024 0.0022
Echinococcus multilocularis histone deacetylase 3 0.01 0.0057 0.0202
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.002 0.0003 0.0001
Plasmodium falciparum cysteine proteinase falcipain 2b 0.004 0.0017 0.0052
Brugia malayi hypothetical protein 0.0375 0.0244 0.0241
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.01 0.0057 0.0055
Trichomonas vaginalis set domain proteins, putative 0.0285 0.0183 0.018
Loa Loa (eye worm) hypothetical protein 0.005 0.0023 0.0021
Trypanosoma cruzi oligopeptidase b 0.0118 0.007 0.0067
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.4035 0.2725 0.2724
Loa Loa (eye worm) hypothetical protein 0.0335 0.0216 0.0214
Brugia malayi Matrixin family protein 0.005 0.0023 0.0021
Plasmodium falciparum plasmepsin V 0.0021 0.0004 0.0005
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0021 0.0004 0.001
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0003 0.0001
Echinococcus multilocularis cathepsin l cysteine peptidase 0.004 0.0017 0.0052
Plasmodium falciparum plasmepsin III 0.0021 0.0004 0.0005
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0033 0.0012 0.0321
Schistosoma mansoni hypothetical protein 0.0094 0.0054 0.0148
Entamoeba histolytica hypothetical protein 0.4035 0.2725 0.2723
Leishmania major signal peptidase type I, putative 0.0027 0.0008 0.0005
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0021 0.0004 0.001
Entamoeba histolytica cysteine protease, putative 0.002 0.0003 0.0001
Trypanosoma brucei metacaspase MCA3 0.005 0.0024 0.0021
Brugia malayi Cytochrome P450 family protein 0.0068 0.0036 0.0033
Echinococcus granulosus histone deacetylase 0.0112 0.0066 0.0232
Echinococcus multilocularis caspase 2 0.0097 0.0056 0.0195
Onchocerca volvulus 0.004 0.0017 0.0046
Echinococcus multilocularis microtubule associated protein 2 0.16 0.1074 0.3937
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0033 0.0012 0.0321
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0031 0.0011 0.0031
Loa Loa (eye worm) hypothetical protein 0.0027 0.0008 0.0005
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.0036 0.01
Onchocerca volvulus Histone deacetylase 10 homolog 0.0048 0.0022 0.0067
Trypanosoma cruzi trypanothione reductase, putative 0.0035 0.0013 0.0011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0027 0.0073
Echinococcus granulosus neuropeptide receptor A26 0.0555 0.0366 0.1335
Trypanosoma cruzi oligopeptidase b 0.0118 0.007 0.0067
Trypanosoma brucei telomerase reverse transcriptase 0.0203 0.0127 0.0125
Trypanosoma brucei mitochondrial inner membrane signal peptidase, putative 0.0027 0.0008 0.0005
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0033 0.0012 0.0034
Loa Loa (eye worm) nuclear hormone receptor 0.0335 0.0216 0.0214
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0375 0.0244 0.0886
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0181 0.0112 0.0403
Onchocerca volvulus 0.0101 0.0058 0.0199
Schistosoma mansoni hypothetical protein 0.0093 0.0053 0.0146
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0011 0.0035
Mycobacterium leprae conserved hypothetical protein 0.0028 0.0008 0.0024
Trypanosoma brucei histone deacetylase 3 0.0112 0.0066 0.0063
Loa Loa (eye worm) histone methyltransferase 0.0033 0.0012 0.0009
Brugia malayi ecdysone receptor 0.0335 0.0216 0.0214
Schistosoma mansoni histone deacetylase 1 2 3 0.0048 0.0022 0.0061
Schistosoma mansoni hypothetical protein 0.0047 0.0021 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0008 0.0005
Loa Loa (eye worm) hypothetical protein 0.0035 0.0013 0.0011
Plasmodium vivax histone deacetylase 2, putative 0.0112 0.0066 0.0237
Brugia malayi Telomerase reverse transcriptase 0.0541 0.0356 0.0354
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0709 0.047 0.1718
Schistosoma mansoni ap endonuclease 0.0019 0.0002 0.0006
Trypanosoma brucei signal peptidase type I, putative 0.0027 0.0008 0.0005
Mycobacterium tuberculosis Repressor LexA 0.0027 0.0008 0.0204
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0031 0.0011 0.0029
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.004 0.0017 0.0014
Mycobacterium leprae PROBABLE HYDROLASE 0.0061 0.0031 0.063
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0024 0.0021
Echinococcus granulosus cathepsin L cysteine protease 0.002 0.0003 0.0004
Brugia malayi Phospholipase A2 family protein 0.0057 0.0028 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0003 0.0001
Brugia malayi hypothetical protein 0.0063 0.0033 0.003
Mycobacterium ulcerans signal peptidase I LepB 0.0566 0.0373 0.0373
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0017 0.0014
Schistosoma mansoni loxhd1 0.0063 0.0033 0.009
Onchocerca volvulus Matrix metalloproteinase homolog 0.011 0.0064 0.0222
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0005 0.0003
Trypanosoma cruzi metacaspase 5, putative 0.005 0.0024 0.0021
Plasmodium falciparum thioredoxin reductase 0.0035 0.0013 0.0039
Trypanosoma cruzi cytochrome P450, putative 0.0068 0.0036 0.0033
Echinococcus granulosus thioredoxin glutathione reductase 0.0035 0.0013 0.0039
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0251 0.016 0.0579
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0335 0.0216 0.06
Echinococcus multilocularis Polycystic kidney disease protein 0.0063 0.0033 0.0111
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0027 0.0089
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.005 0.0024 0.0021
Entamoeba histolytica cysteine protease, putative 0.002 0.0003 0.0001
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0335 0.0216 0.0786
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0709 0.047 0.0468
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0017 0.0014
Loa Loa (eye worm) hypothetical protein 0.4035 0.2725 0.2723
Brugia malayi hypothetical protein 0.0051 0.0024 0.0022
Loa Loa (eye worm) cytochrome P450 0.0033 0.0012 0.001
Loa Loa (eye worm) hypothetical protein 0.0027 0.0008 0.0005
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0033 0.0012 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0008 0.0005
Brugia malayi steroid hormone receptor 0.0709 0.047 0.0468
Trypanosoma brucei metacaspase 5, putative 0.005 0.0024 0.0021
Loa Loa (eye worm) prolyl oligopeptidase 0.0031 0.0011 0.0008
Brugia malayi tailless protein 0.0335 0.0216 0.0214
Plasmodium vivax unspecified product 0.002 0.0003 0.0009
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.004 0.0017 0.0014
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0005 0.0003
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0031 0.0011 0.0029
Brugia malayi Cytochrome P450 family protein 0.0068 0.0036 0.0033
Echinococcus granulosus apoptotic protease activating factor 1 0.0047 0.0021 0.007
Plasmodium falciparum plasmepsin IX 0.0021 0.0004 0.0005
Brugia malayi hypothetical protein 0.0021 0.0004 0.0001
Onchocerca volvulus 0.004 0.0017 0.0046
Toxoplasma gondii histone deacetylase HDAC1 0.0112 0.0066 0.0065
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0021 0.0004 0.0001
Entamoeba histolytica cysteine protease, putative 0.002 0.0003 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0003 0.0001
Loa Loa (eye worm) hypothetical protein 0.0031 0.0011 0.0008
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0031 0.0011 0.0031

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 8.35 mM Inhibition of human NMT expressed in Escherichia coli DH5alpha cells ChEMBL. 20149656
IC50 (functional) > 500 uM Cytotoxicity against mouse L1210 cells ChEMBL. 20149656
IC50 (functional) > 500 uM Cytotoxicity against human CEM cells ChEMBL. 20149656

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.