Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | glutamate receptor 2 | 0.0448 | 0.3386 | 0.3383 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.136 | 0.2701 |
Schistosoma mansoni | ATP-binding cassette transporter | 0.0462 | 0.3549 | 0.422 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0273 | 0.136 | 0.1614 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.042 | 0.0834 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0505 | 0.4056 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.1017 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0273 | 0.136 | 0.1614 |
Onchocerca volvulus | Excitatory amino acid transporter homolog | 0.0263 | 0.1235 | 0.908 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0734 | 0.672 | 0.6718 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0445 | 0.3354 | 0.5 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0294 | 0.1597 | 0.3929 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0445 | 0.3354 | 1 |
Brugia malayi | Excitatory amino acid transporter | 0.0263 | 0.1235 | 0.3037 |
Echinococcus granulosus | glutamate receptor 2 | 0.0643 | 0.5653 | 0.5651 |
Echinococcus granulosus | glutamate receptor 2 | 0.0448 | 0.3386 | 0.3383 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0306 | 0.1742 | 0.5186 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0433 | 0.3216 | 0.3213 |
Loa Loa (eye worm) | hypothetical protein | 0.0244 | 0.1021 | 0.2028 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0505 | 0.4056 | 0.4053 |
Wolbachia endosymbiont of Brugia malayi | Na+/H+-dicarboxylate symporter | 0.0263 | 0.1235 | 0.5 |
Mycobacterium ulcerans | proteasome PrcB | 0.0445 | 0.3354 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0306 | 0.1742 | 0.5186 |
Schistosoma mansoni | hypothetical protein | 0.0195 | 0.0448 | 0.0528 |
Echinococcus granulosus | proteasome prosome macropain | 0.0445 | 0.3354 | 0.335 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0445 | 0.3354 | 0.5 |
Echinococcus multilocularis | Excitatory amino acid transporter | 0.0263 | 0.1235 | 0.1231 |
Echinococcus granulosus | excitatory amino acid transporter 3 | 0.0263 | 0.1235 | 0.1231 |
Echinococcus multilocularis | neutral amino acid transporter A | 0.0263 | 0.1235 | 0.1231 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0306 | 0.1742 | 0.5186 |
Echinococcus multilocularis | glutamate receptor subunit protein glur | 0.0239 | 0.0955 | 0.095 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0462 | 0.3549 | 0.422 |
Echinococcus granulosus | Ribosomal protein S1 RNA binding domain | 0.0195 | 0.0448 | 0.0443 |
Echinococcus granulosus | glutamate receptor ionotropic kainate 3 | 0.0612 | 0.5302 | 0.53 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0445 | 0.3354 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0218 | 0.071 | 0.0706 |
Echinococcus granulosus | neutral amino acid transporter A | 0.0263 | 0.1235 | 0.1231 |
Schistosoma mansoni | glutamate receptor kainate | 0.0879 | 0.8403 | 1 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0445 | 0.3354 | 1 |
Onchocerca volvulus | Adenylate cyclase type 3 homolog | 0.0196 | 0.0455 | 0.3319 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0445 | 0.3354 | 1 |
Echinococcus granulosus | sodium:dicarboxylate symporter | 0.0263 | 0.1235 | 0.1231 |
Echinococcus granulosus | Excitatory amino acid transporter | 0.0263 | 0.1235 | 0.1231 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0445 | 0.3354 | 1 |
Brugia malayi | thymidylate synthase | 0.0218 | 0.071 | 0.1741 |
Loa Loa (eye worm) | hypothetical protein | 0.0225 | 0.08 | 0.1588 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0202 | 0.0528 | 0.105 |
Echinococcus granulosus | glutamate receptor ionotropic kainate | 0.0612 | 0.5302 | 0.53 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0462 | 0.3549 | 0.422 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.059 | 0.5035 | 0.5033 |
Brugia malayi | SWIRM domain containing protein | 0.0244 | 0.1021 | 0.2508 |
Echinococcus multilocularis | neutral amino acid transporter A | 0.0263 | 0.1235 | 0.1231 |
Echinococcus multilocularis | Excitatory amino acid transporter | 0.0263 | 0.1235 | 0.1231 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0445 | 0.3354 | 0.666 |
Loa Loa (eye worm) | glutamate receptor | 0.0498 | 0.3967 | 0.7878 |
Echinococcus granulosus | glutamate receptor subunit protein glur | 0.0239 | 0.0955 | 0.095 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0306 | 0.1742 | 0.5186 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0462 | 0.3549 | 0.3546 |
Schistosoma mansoni | glutamate receptor kainate | 0.0462 | 0.3549 | 0.422 |
Echinococcus multilocularis | Ribosomal protein S1, RNA binding domain | 0.0195 | 0.0448 | 0.0443 |
Brugia malayi | Trypsin family protein | 0.0273 | 0.136 | 0.3345 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0445 | 0.3354 | 1 |
Schistosoma mansoni | glutamate receptor kainate | 0.0879 | 0.8403 | 1 |
Echinococcus granulosus | excitatory amino acid transporter 2 | 0.0263 | 0.1235 | 0.1231 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0445 | 0.3354 | 0.3987 |
Echinococcus multilocularis | excitatory amino acid transporter 3 | 0.0263 | 0.1235 | 0.1231 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0225 | 0.08 | 0.0795 |
Echinococcus multilocularis | sodium:dicarboxylate symporter | 0.0263 | 0.1235 | 0.1231 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0218 | 0.071 | 0.084 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.059 | 0.5035 | 0.5033 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.036 | 0.237 | 0.5838 |
Loa Loa (eye worm) | excitatory amino acid transporter | 0.0263 | 0.1235 | 0.2454 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0643 | 0.5653 | 0.5651 |
Onchocerca volvulus | 0.0273 | 0.136 | 1 | |
Schistosoma mansoni | glutamate receptor NMDA | 0.0599 | 0.5146 | 0.6122 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0462 | 0.3549 | 0.422 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.136 | 0.2701 |
Onchocerca volvulus | 0.0218 | 0.071 | 0.5204 | |
Echinococcus granulosus | neutral amino acid transporter A | 0.0263 | 0.1235 | 0.1231 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0445 | 0.3354 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0294 | 0.1597 | 0.1895 |
Onchocerca volvulus | 0.0178 | 0.0255 | 0.1842 | |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0445 | 0.3354 | 1 |
Echinococcus multilocularis | excitatory amino acid transporter 2 | 0.0263 | 0.1235 | 0.1231 |
Echinococcus multilocularis | glutamate receptor ionotropic kainate | 0.0612 | 0.5302 | 0.53 |
Loa Loa (eye worm) | thymidylate synthase | 0.0218 | 0.071 | 0.1411 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0202 | 0.0528 | 0.1292 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0445 | 0.3354 | 0.8266 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.1017 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0218 | 0.071 | 0.0706 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0462 | 0.3549 | 0.3546 |
Echinococcus granulosus | neutral amino acid transporter | 0.0263 | 0.1235 | 0.1231 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0317 | 0.1866 | 0.1862 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0452 | 0.3438 | 0.4088 |
Echinococcus multilocularis | neutral amino acid transporter A | 0.0263 | 0.1235 | 0.1231 |
Loa Loa (eye worm) | adenylyl cyclase 3 | 0.0167 | 0.0119 | 0.0237 |
Echinococcus granulosus | excitatory amino acid transporter 2 | 0.0263 | 0.1235 | 0.1231 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0445 | 0.3354 | 0.335 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.1017 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.0528 | 0.105 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0202 | 0.0528 | 0.105 |
Schistosoma mansoni | solute carrier family 1 (glial high affinity glutamate transporter | 0.0263 | 0.1235 | 0.1465 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.1017 | 1 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0433 | 0.3216 | 0.3824 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0157 | 0.0005 | 0.001 |
Loa Loa (eye worm) | hypothetical protein | 0.059 | 0.5035 | 1 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0225 | 0.08 | 0.0946 |
Echinococcus multilocularis | NMDA receptor | 0.0612 | 0.5302 | 0.53 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0643 | 0.5653 | 0.5651 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0445 | 0.3354 | 1 |
Chlamydia trachomatis | glutamate symporter | 0.0263 | 0.1235 | 0.5 |
Echinococcus multilocularis | excitatory amino acid transporter 2 | 0.0263 | 0.1235 | 0.1231 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0306 | 0.1742 | 0.5186 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.0005 | 0.001 |
Loa Loa (eye worm) | hypothetical protein | 0.0225 | 0.08 | 0.1588 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0643 | 0.5653 | 0.5651 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0445 | 0.3354 | 1 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0462 | 0.3549 | 0.7049 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0498 | 0.3967 | 0.978 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0433 | 0.3216 | 0.3213 |
Onchocerca volvulus | 0.0244 | 0.1021 | 0.7498 | |
Brugia malayi | Glutamate receptor 2 precursor | 0.0505 | 0.4056 | 1 |
Mycobacterium tuberculosis | Probable C4-dicarboxylate-transport transmembrane protein DctA | 0.0263 | 0.1235 | 0.1987 |
Echinococcus granulosus | Excitatory amino acid transporter | 0.0263 | 0.1235 | 0.1231 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0225 | 0.08 | 0.0795 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.1017 | 1 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0317 | 0.1866 | 0.1862 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0505 | 0.4056 | 0.8056 |
Echinococcus multilocularis | neutral amino acid transporter excitatory amino acid transporter | 0.0263 | 0.1235 | 0.1231 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 200 uM | Inhibitory activity against recombinant human adenylate cyclase 5 expressed in HEK293 cells. | ChEMBL. | 12747789 |
IC50 (binding) | > 200 uM | Inhibitory activity against recombinant human adenylate cyclase 5 expressed in HEK293 cells. | ChEMBL. | 12747789 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.