Detailed information for compound 1114158

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 375.252 | Formula: C18H16Cl2N4O
  • H donors: 2 H acceptors: 1 LogP: 4.98 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: N=C(NC(=O)/C=C/c1ccccc1)N/N=C(/c1ccc(cc1Cl)Cl)\C
  • InChi: 1S/C18H16Cl2N4O/c1-12(15-9-8-14(19)11-16(15)20)23-24-18(21)22-17(25)10-7-13-5-3-2-4-6-13/h2-11H,1H3,(H3,21,22,24,25)/b10-7+,23-12+
  • InChiKey: MYAFJKULXGQRMC-FHWCKMEISA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.022 0.0804 0.1973
Brugia malayi CHE-14 protein 0.0088 0.0286 0.0277
Echinococcus multilocularis thyroid hormone receptor alpha 0.022 0.0804 0.1973
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0177 0.0635 0.0626
Schistosoma mansoni thyroid hormone receptor 0.022 0.0804 0.1973
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0104 0.0348 0.0846
Onchocerca volvulus Bile acid receptor homolog 0.0338 0.127 0.3102
Loa Loa (eye worm) hypothetical protein 0.022 0.0804 0.0795
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0015 0.0015
Plasmodium vivax aspartyl protease, putative 0.0054 0.0152 0.034
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0035 0.0079 0.0079
Schistosoma mansoni nAChR subunit 0.0081 0.0261 0.0631
Trichomonas vaginalis bromodomain-containing protein, putative 0.0031 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0177 0.0635 0.0626
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0054 0.0152 0.0361
Echinococcus multilocularis cpg binding protein 0.007 0.0217 0.0521
Brugia malayi Pepsin A precursor 0.0054 0.0152 0.0143
Brugia malayi Eukaryotic aspartyl protease family protein 0.0054 0.0152 0.0143
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.022 0.0804 0.1973
Echinococcus multilocularis Chromo domain 0.002 0.002 0.0035
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0081 0.0261 0.0631
Schistosoma mansoni intermediate filament proteins 0.0026 0.0044 0.0095
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0104 0.0348 0.0339
Plasmodium vivax aspartyl proteinase, putative 0.0123 0.0424 0.1015
Onchocerca volvulus 0.0177 0.0635 0.1526
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0081 0.0261 0.0252
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0104 0.0348 0.0846
Loa Loa (eye worm) hypothetical protein 0.0081 0.0261 0.0252
Trichomonas vaginalis conserved hypothetical protein 0.002 0.002 0.002
Brugia malayi hypothetical protein 0.0081 0.0261 0.0252
Brugia malayi Nuclear hormone receptor E75 0.0104 0.0348 0.0339
Brugia malayi photoreceptor-specific nuclear receptor 0.022 0.0804 0.0795
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0081 0.0261 0.0252
Trichomonas vaginalis bromodomain-containing protein, putative 0.0031 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0104 0.0348 0.0339
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0107 0.0361 0.0352
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.1046 0.4051 1
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.256 1 1
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0345 0.1296 0.1288
Brugia malayi Nuclear hormone receptor-like 1 0.0116 0.0397 0.0388
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0177 0.0635 0.1555
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0177 0.0635 0.1555
Plasmodium falciparum plasmepsin I 0.0123 0.0424 0.1015
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0177 0.0635 0.0626
Brugia malayi Nuclear hormone receptor-like 1 0.0116 0.0397 0.0388
Schistosoma mansoni nAChR subunit 0.0177 0.0635 0.1555
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0022 0.0039
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0177 0.0635 0.1555
Loa Loa (eye worm) hypothetical protein 0.0081 0.0261 0.0252
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0021 0.0024 0.0046
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0015 0.0022
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0054 0.0152 0.0361
Loa Loa (eye worm) hypothetical protein 0.0104 0.0348 0.0339
Trichomonas vaginalis bromodomain-containing protein, putative 0.0031 0.0062 0.0062
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0054 0.0152 0.0361
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0177 0.0635 0.0626
Brugia malayi nuclear receptor NHR-88 0.022 0.0804 0.0795
Loa Loa (eye worm) hypothetical protein 0.0116 0.0397 0.0388
Echinococcus granulosus thyroid hormone receptor alpha 0.0104 0.0348 0.0846
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0104 0.0348 0.0846
Brugia malayi aspartic protease BmAsp-1, identical 0.0054 0.0152 0.0143
Brugia malayi Cation transporter family protein 0.0177 0.0635 0.0626
Loa Loa (eye worm) steroid hormone receptor 0.022 0.0804 0.0795
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0024 0.0035 0.0071
Plasmodium falciparum plasmepsin II 0.0123 0.0424 0.1015
Schistosoma mansoni hypothetical protein 0.002 0.002 0.0035
Echinococcus granulosus Niemann Pick C1 protein 0.0205 0.0746 0.183
Brugia malayi conserved hypotetical protein 0.0104 0.0348 0.0339
Schistosoma mansoni nuclear hormone receptor 0.0104 0.0348 0.0846
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0015 0.0007
Onchocerca volvulus 0.0066 0.0202 0.0451
Loa Loa (eye worm) hypothetical protein 0.0095 0.0315 0.0306
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0035 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0116 0.0397 0.0388
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.022 0.0804 0.0795
Echinococcus granulosus FTZ F1 alpha 0.022 0.0804 0.1973
Schistosoma mansoni coup transcription factor 0.022 0.0804 0.1973
Loa Loa (eye worm) hypothetical protein 0.0104 0.0348 0.0339
Brugia malayi Nuclear hormone receptor family member nhr-31 0.022 0.0804 0.0795
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.002 0.002 0.0012
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0177 0.0635 0.1555
Plasmodium falciparum plasmepsin V 0.0054 0.0152 0.034
Onchocerca volvulus 0.0081 0.0261 0.0599
Onchocerca volvulus 0.0026 0.0044 0.006
Trichomonas vaginalis chromobox protein, putative 0.0123 0.0423 0.0423
Schistosoma mansoni hypothetical protein 0.0112 0.038 0.0925
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.256 1 1
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.1046 0.4051 1
Plasmodium vivax plasmepsin V, putative 0.0054 0.0152 0.034
Onchocerca volvulus 0.022 0.0804 0.1945
Plasmodium vivax aspartyl protease, putative 0.0054 0.0152 0.034
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.022 0.0804 0.0795
Loa Loa (eye worm) hypothetical protein 0.0081 0.0261 0.0252
Schistosoma mansoni synaptic glycoprotein sc2 related 0.1046 0.4051 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.0286 0.0277
Onchocerca volvulus 0.0177 0.0635 0.1526
Plasmodium falciparum plasmepsin IX 0.0054 0.0152 0.034
Plasmodium falciparum plasmepsin VI 0.0123 0.0424 0.1015
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0054 0.0152 0.0361
Loa Loa (eye worm) hypothetical protein 0.022 0.0804 0.0795
Loa Loa (eye worm) hypothetical protein 0.0054 0.0152 0.0143
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0081 0.0261 0.0631
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.002 0.002
Brugia malayi nuclear hormone receptor family member nhr-6 0.0104 0.0348 0.0339
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.022 0.0804 0.1973
Loa Loa (eye worm) hypothetical protein 0.0104 0.0348 0.0339
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0177 0.0635 0.0626
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0231 0.0231
Trichomonas vaginalis bromodomain-containing protein, putative 0.0031 0.0062 0.0062
Brugia malayi Cation transporter family protein 0.0177 0.0635 0.0626
Plasmodium falciparum plasmepsin VIII, putative 0.0054 0.0152 0.034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.022 0.0804 0.0795
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0107 0.0361 0.0878
Loa Loa (eye worm) aspartyl protease 6 0.0054 0.0152 0.0143
Loa Loa (eye worm) hypothetical protein 0.0095 0.0315 0.0306
Brugia malayi nuclear receptor RXR 0.0116 0.0397 0.0388
Trichomonas vaginalis bromodomain-containing protein, putative 0.0031 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0104 0.0348 0.0339
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.1046 0.4051 0.4051
Schistosoma mansoni cathepsin D (A01 family) 0.03 0.112 0.2755
Trichomonas vaginalis chromobox protein, putative 0.002 0.002 0.002
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0177 0.0635 0.1555
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.022 0.0804 0.1973
Schistosoma mansoni nAChR subunit 0.0177 0.0635 0.1555
Schistosoma mansoni hypothetical protein 0.0085 0.0274 0.0663
Schistosoma mansoni Tr4/Tr2 (homologue) 0.022 0.0804 0.1973
Loa Loa (eye worm) hypothetical protein 0.0494 0.1884 0.1876
Plasmodium vivax heterochromatin protein 1, putative 0.002 0.002 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.022 0.0804 0.0795
Toxoplasma gondii aspartyl protease 0.0054 0.0152 0.0144
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0177 0.0635 0.1555
Echinococcus multilocularis chromobox protein 1 0.0123 0.0423 0.103
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.022 0.0804 0.1973
Entamoeba histolytica bromodomain-containing protein 0.0031 0.0062 0.0055
Schistosoma mansoni neurotransmitter gated ion channel 0.0081 0.0261 0.0631
Schistosoma mansoni nAChR subunit 0.0177 0.0635 0.1555
Entamoeba histolytica bromodomain-containing protein 0.0031 0.0062 0.0055
Echinococcus granulosus glycine receptor subunit alpha 1 0.0177 0.0635 0.1555
Loa Loa (eye worm) hypothetical protein 0.0095 0.0315 0.0306
Trichomonas vaginalis bromodomain-containing protein, putative 0.0031 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0338 0.127 0.1262
Echinococcus multilocularis geminin 0.0112 0.038 0.0925
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.002 0.002
Trichomonas vaginalis chromobox protein, putative 0.0123 0.0423 0.0423
Trichomonas vaginalis chromobox protein, putative 0.002 0.002 0.002
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0177 0.0635 0.0626
Echinococcus multilocularis lamin dm0 0.0026 0.0044 0.0095
Brugia malayi Nuclear hormone receptor family member nhr-49 0.022 0.0804 0.0795
Trichomonas vaginalis bromodomain-containing protein, putative 0.0031 0.0062 0.0062
Schistosoma mansoni bromodomain-containing protein 3 brd3 0.0069 0.0214 0.0514
Entamoeba histolytica steroid 5-alpha reductase, putative 0.256 1 1
Brugia malayi steroid hormone receptor 0.022 0.0804 0.0795
Entamoeba histolytica bromodomain-containing protein 0.0031 0.0062 0.0055
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0088 0.0286 0.0277
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0177 0.0635 0.0626
Echinococcus granulosus chromobox protein 1 0.0123 0.0423 0.103
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.022 0.0804 0.1973
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.001
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0095 0.0315 0.0306
Brugia malayi Nuclear hormone receptor family member nhr-40 0.022 0.0804 0.0795
Echinococcus multilocularis expressed protein 0.0017 0.0009 0.0009
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0177 0.0635 0.1555
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0047 0.0047
Echinococcus granulosus nAChR subunit 0.0177 0.0635 0.1555
Brugia malayi Nuclear hormone receptor family member nhr-3 0.022 0.0804 0.0795
Onchocerca volvulus 0.0031 0.0062 0.0106
Loa Loa (eye worm) hypothetical protein 0.0177 0.0635 0.0626
Echinococcus granulosus nAChR subunit 0.0095 0.0315 0.0764
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0177 0.0635 0.1555
Onchocerca volvulus 0.1046 0.4051 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.002 0.002 0.0013
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0035 0.0079 0.0079
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0015 0.0007
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0104 0.0348 0.0846
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0107 0.0361 0.0878
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0021 0.0024 0.0046
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.1046 0.4051 0.4046
Brugia malayi Nuclear hormone receptor-like 1 0.022 0.0804 0.0795
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0177 0.0635 0.1555
Brugia malayi M-phase phosphoprotein, mpp8 0.002 0.002 0.001
Echinococcus granulosus Protein patched homolog 1 0.0088 0.0286 0.0694
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0024 0.0035 0.0071
Plasmodium falciparum plasmepsin IV 0.0123 0.0424 0.1015
Loa Loa (eye worm) hypothetical protein 0.0177 0.0635 0.0626
Trichomonas vaginalis bromodomain-containing protein 4, brd4, putative 0.0031 0.0062 0.0062
Brugia malayi hypothetical protein 0.0081 0.0261 0.0252
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0104 0.0348 0.0339
Trichomonas vaginalis bromodomain-containing protein, putative 0.0031 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0081 0.0261 0.0252
Brugia malayi Valyl-tRNA synthetase 0.002 0.002 0.001
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.002 0.002 0.0013
Echinococcus multilocularis nuclear receptor nhr 48 0.0104 0.0348 0.0846
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0116 0.0397 0.0967
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0044 0.0035
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0177 0.0635 0.0626
Plasmodium vivax hypothetical protein, conserved 0.002 0.002 0.0013
Loa Loa (eye worm) hypothetical protein 0.022 0.0804 0.0795
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0024 0.0035 0.0071
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.002 0.002 0.0012
Brugia malayi Type III restriction enzyme, res subunit family protein 0.002 0.002 0.001
Trichomonas vaginalis hypothetical protein 0.002 0.002 0.002
Schistosoma mansoni nAChR subunit 0.0177 0.0635 0.1555
Schistosoma mansoni nuclear hormone receptor 0.022 0.0804 0.1973
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0177 0.0635 0.1555
Echinococcus granulosus sterol regulatory element binding protein 0.0088 0.0286 0.0694
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.022 0.0804 0.0795
Toxoplasma gondii bromodomain-containing protein 0.0031 0.0062 0.0055
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0205 0.0746 0.0739
Trichomonas vaginalis bromodomain-containing protein, putative 0.0031 0.0062 0.0062
Echinococcus granulosus retinoic acid receptor rxr beta a 0.022 0.0804 0.1973
Schistosoma mansoni lamin 0.0026 0.0044 0.0095
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0177 0.0635 0.0626
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.001
Schistosoma mansoni cpg binding protein 0.007 0.0217 0.0521
Schistosoma mansoni nAChR subunit 0.0177 0.0635 0.1555
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0107 0.0361 0.0878
Echinococcus granulosus lamin 0.0026 0.0044 0.0095
Loa Loa (eye worm) hypothetical protein 0.0104 0.0348 0.0339
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0081 0.0261 0.0252
Loa Loa (eye worm) hypothetical protein 0.0069 0.0211 0.0202
Brugia malayi tailless protein 0.0104 0.0348 0.0339
Echinococcus multilocularis Chromobox protein 3 0.002 0.002 0.0035
Onchocerca volvulus 0.0054 0.0152 0.0328
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0132 0.0132
Schistosoma mansoni nAChR subunit 0.0081 0.0261 0.0631
Trichomonas vaginalis chromobox protein, putative 0.002 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0095 0.0315 0.0306
Echinococcus granulosus cpg binding protein 0.007 0.0217 0.0521
Toxoplasma gondii exonuclease III APE 0.0019 0.0015 0.0007
Trichomonas vaginalis rotamase, putative 0.0017 0.0009 0.0009
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.011 0.011
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0015 0.5
Echinococcus granulosus glycine receptor subunit beta 0.0177 0.0635 0.1555
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0035 0.0079 0.0079
Echinococcus granulosus Nuclear hormone receptor HR96 0.0104 0.0348 0.0846
Echinococcus granulosus expressed conserved protein 0.0192 0.0697 0.171
Brugia malayi CHD4 protein 0.0024 0.0035 0.0025
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0015 0.0005
Schistosoma mansoni hypothetical protein 0.0112 0.038 0.0925
Schistosoma mansoni neurotransmitter gated ion channel 0.0095 0.0315 0.0764
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0177 0.0635 0.1555
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0104 0.0348 0.0846
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0177 0.0635 0.1555
Brugia malayi Nuclear hormone receptor family member nhr-41 0.022 0.0804 0.0795
Onchocerca volvulus 0.0177 0.0635 0.1526
Echinococcus granulosus ecdysone induced protein 78C 0.022 0.0804 0.1973
Loa Loa (eye worm) hypothetical protein 0.0116 0.0397 0.0388
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0211 0.0211
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.002 0.002 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.1046 0.4051 0.4051
Loa Loa (eye worm) CXXC zinc finger family protein 0.0066 0.0202 0.0193
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0035 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0081 0.0261 0.0252
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.256 1 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0261 0.0252
Brugia malayi CXXC zinc finger family protein 0.0066 0.0202 0.0193
Schistosoma mansoni memapsin-2 (A01 family) 0.0824 0.3177 0.784
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0095 0.0315 0.0306
Brugia malayi nuclear receptor NHR-67 0.0104 0.0348 0.0339
Onchocerca volvulus 0.0026 0.0044 0.006
Trichomonas vaginalis bromodomain-containing protein, putative 0.0031 0.0062 0.0062
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0081 0.0261 0.0252
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0177 0.0635 0.1555
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0054 0.0152 0.0361
Loa Loa (eye worm) hypothetical protein 0.0081 0.0261 0.0252
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0177 0.0635 0.0626
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0074 0.0231 0.0525
Loa Loa (eye worm) hypothetical protein 0.0054 0.0152 0.0143
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0022 0.0012
Plasmodium falciparum heterochromatin protein 1 0.002 0.002 0.0013
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0081 0.0261 0.0631
Brugia malayi Protein cec-1. 0.002 0.002 0.001
Brugia malayi SET domain containing protein 0.0022 0.0025 0.0016
Echinococcus multilocularis glycine receptor subunit beta 0.0177 0.0635 0.1555
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0104 0.0348 0.0814
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.1046 0.4051 0.4046
Brugia malayi nuclear hormone receptor 0.0104 0.0348 0.0339
Loa Loa (eye worm) DR-78 0.0104 0.0348 0.0339
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.001
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0123 0.0424 0.0417
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0095 0.0315 0.0764
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.022 0.0804 0.0795
Brugia malayi Nuclear hormone receptor family member nhr-14 0.022 0.0804 0.0795
Trichomonas vaginalis conserved hypothetical protein 0.002 0.002 0.002
Trichomonas vaginalis conserved hypothetical protein 0.002 0.002 0.002
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0081 0.0261 0.0252
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0035 0.0079 0.0079
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0054 0.0152 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-25 0.022 0.0804 0.0795
Schistosoma mansoni zinc finger protein 0.0104 0.0348 0.0846
Schistosoma mansoni hypothetical protein 0.0085 0.0274 0.0663
Onchocerca volvulus 0.0081 0.0261 0.0599
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0177 0.0635 0.0626
Echinococcus granulosus synaptic glycoprotein sc2 0.1046 0.4051 1
Onchocerca volvulus 0.0095 0.0315 0.0732
Loa Loa (eye worm) hypothetical protein 0.0177 0.0635 0.0626
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0104 0.0348 0.0846
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0141 0.0494 0.1207
Schistosoma mansoni retinoid-x-receptor (RXR) 0.022 0.0804 0.1973
Echinococcus multilocularis musashi 0.0026 0.0044 0.0095
Loa Loa (eye worm) hypothetical protein 0.022 0.0804 0.0795
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.022 0.0804 0.1973
Schistosoma mansoni rotamase 0.0017 0.0009 0.0009
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.1046 0.4051 1
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.1046 0.4051 0.4046
Loa Loa (eye worm) hypothetical protein 0.022 0.0804 0.0795
Schistosoma mansoni nAChR subunit 0.0177 0.0635 0.1555
Entamoeba histolytica hypothetical protein 0.0021 0.0024 0.0017
Echinococcus multilocularis chromobox protein 1 0.0123 0.0423 0.103
Brugia malayi Nuclear hormone receptor family member nhr-1 0.022 0.0804 0.0795
Echinococcus granulosus glycine receptor subunit alpha 1 0.0177 0.0635 0.1555
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.256 1 1
Mycobacterium ulcerans hypothetical protein 0.256 1 1
Loa Loa (eye worm) hypothetical protein 0.022 0.0804 0.0795
Loa Loa (eye worm) hypothetical protein 0.022 0.0804 0.0795
Loa Loa (eye worm) hypothetical protein 0.0177 0.0635 0.0626
Schistosoma mansoni thyroid hormone receptor 0.022 0.0804 0.1973
Trichomonas vaginalis bromodomain-containing protein, putative 0.0031 0.0062 0.0062
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.002 0.002 0.0035
Brugia malayi ecdysteroid receptor 0.0338 0.127 0.1262
Loa Loa (eye worm) hypothetical protein 0.0104 0.0348 0.0339
Loa Loa (eye worm) hypothetical protein 0.0177 0.0635 0.0626
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0123 0.0424 0.0416
Schistosoma mansoni hypothetical protein 0.0021 0.0024 0.0046
Brugia malayi orphan nuclear receptor NR2E1 0.0104 0.0348 0.0339
Loa Loa (eye worm) LGC-31 protein 0.0177 0.0635 0.0626
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.002 0.002
Brugia malayi aspartic protease BmAsp-2, identical 0.0054 0.0152 0.0143
Loa Loa (eye worm) hypothetical protein 0.0123 0.0424 0.0416
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0015 0.5
Echinococcus multilocularis glycine receptor subunit beta 0.0177 0.0635 0.1555
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0177 0.0635 0.0626
Entamoeba histolytica hypothetical protein 0.002 0.002 0.0012
Brugia malayi hypothetical protein 0.0054 0.0152 0.0143
Entamoeba histolytica hypothetical protein 0.002 0.002 0.0012
Loa Loa (eye worm) transcription factor SMAD2 0.0062 0.0185 0.0176
Loa Loa (eye worm) hypothetical protein 0.0177 0.0635 0.0626
Giardia lamblia Kinase, putative 0.0031 0.0062 0.0118
Schistosoma mansoni acetylcholine receptor-related 0.0081 0.0261 0.0631
Schistosoma mansoni cpg binding protein 0.007 0.0217 0.0521
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0081 0.0261 0.0252
Brugia malayi Nuclear hormone receptor family member nhr-19 0.022 0.0804 0.0795
Entamoeba histolytica hypothetical protein 0.0021 0.0024 0.0017
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0116 0.0397 0.0967
Loa Loa (eye worm) hypothetical protein 0.0104 0.0348 0.0339
Loa Loa (eye worm) CHromoDomain protein family member 0.0024 0.0035 0.0025
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0035 0.0079 0.0079
Echinococcus multilocularis ecdysone induced protein 78C 0.022 0.0804 0.1973
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0015 0.0007
Echinococcus granulosus Niemann Pick C1 protein 0.0293 0.1092 0.2684
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0177 0.0635 0.1555
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0107 0.0361 0.0352
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0054 0.0152 0.0361
Echinococcus granulosus intermediate filament protein 0.0026 0.0044 0.0095
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0177 0.0635 0.0626
Trichomonas vaginalis bromodomain-containing protein, putative 0.0031 0.0062 0.0062
Echinococcus granulosus Chromobox protein 3 0.002 0.002 0.0035
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.022 0.0804 0.1973
Loa Loa (eye worm) hypothetical protein 0.1046 0.4051 0.4045
Loa Loa (eye worm) hypothetical protein 0.0069 0.0214 0.0204
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.022 0.0804 0.1973
Trichomonas vaginalis bromodomain-containing protein, putative 0.0069 0.0214 0.0214
Echinococcus granulosus nuclear receptor nhr 48 0.0104 0.0348 0.0846
Schistosoma mansoni chromodomain helicase DNA binding protein 0.002 0.002 0.0035
Onchocerca volvulus 0.0104 0.0348 0.0814
Trichomonas vaginalis conserved hypothetical protein 0.002 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0116 0.0397 0.0388
Echinococcus granulosus chromobox protein 2 0.002 0.002 0.0035
Echinococcus granulosus glycine receptor subunit alpha 1 0.0177 0.0635 0.1555
Brugia malayi hypothetical protein 0.0054 0.0152 0.0143
Brugia malayi hypothetical protein 0.0081 0.0261 0.0252
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.022 0.0804 0.1973
Schistosoma mansoni chromobox protein 0.002 0.002 0.0035
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.022 0.0804 0.1973
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0054 0.0152 0.0361
Schistosoma mansoni RAR-like nuclear receptor 0.022 0.0804 0.1973
Brugia malayi Nuclear hormone receptor family member nhr-19 0.022 0.0804 0.0795
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0107 0.0361 0.0878
Schistosoma mansoni patched 1 0.0088 0.0286 0.0694
Schistosoma mansoni nAChR subunit 0.0177 0.0635 0.1555
Trichomonas vaginalis conserved hypothetical protein 0.002 0.002 0.002
Plasmodium vivax aspartyl protease, putative 0.0054 0.0152 0.034
Loa Loa (eye worm) hypothetical protein 0.0095 0.0315 0.0306
Loa Loa (eye worm) hypothetical protein 0.0104 0.0348 0.0339
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0081 0.0261 0.0631
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0208 0.0758 0.1861
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0028 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.001
Schistosoma mansoni nuclear hormone receptor 0.0104 0.0348 0.0846
Brugia malayi Niemann-Pick C1 protein precursor 0.0205 0.0746 0.0737
Loa Loa (eye worm) hypothetical protein 0.0095 0.0315 0.0306
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.001
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0015 0.0007
Echinococcus granulosus expressed protein 0.0017 0.0009 0.0009
Brugia malayi nuclear receptor NHR-88 0.0104 0.0348 0.0339
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0044 0.0035
Onchocerca volvulus 0.0054 0.0153 0.0329
Entamoeba histolytica hypothetical protein 0.0021 0.0024 0.0017
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0069 0.0211 0.0474
Echinococcus granulosus chromobox protein 1 0.0123 0.0423 0.103
Brugia malayi Nuclear hormone receptor E75 0.0104 0.0348 0.0339
Loa Loa (eye worm) hypothetical protein 0.0081 0.0261 0.0252
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0177 0.0635 0.1555
Brugia malayi Bromodomain containing protein 0.0069 0.0214 0.0204
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0177 0.0635 0.1555
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0054 0.0152 0.0361
Schistosoma mansoni ap endonuclease 0.0019 0.0015 0.0022
Loa Loa (eye worm) hypothetical protein 0.0116 0.0397 0.0388
Loa Loa (eye worm) hypothetical protein 0.0081 0.0261 0.0252
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0177 0.0635 0.1555
Echinococcus multilocularis bromodomain containing 2 0.0069 0.0214 0.0514
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0123 0.0424 0.1035
Trichomonas vaginalis bromodomain containing protein, putative 0.0043 0.011 0.011
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0104 0.0348 0.0846
Brugia malayi nuclear hormone receptor 0.022 0.0804 0.0795
Loa Loa (eye worm) hypothetical protein 0.256 1 1
Onchocerca volvulus 0.0104 0.0348 0.0814
Toxoplasma gondii histone lysine methyltransferase SET1 0.013 0.0453 0.0446
Trichomonas vaginalis bromodomain-containing protein, putative 0.0031 0.0062 0.0062
Schistosoma mansoni transcription factor LCR-F1 0.0021 0.0024 0.0046
Onchocerca volvulus Protein ultraspiracle homolog 0.022 0.0804 0.1945
Loa Loa (eye worm) hypothetical protein 0.0177 0.0635 0.0626
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0177 0.0635 0.1555
Entamoeba histolytica hypothetical protein 0.0095 0.0315 0.0307
Toxoplasma gondii aspartyl protease ASP1 0.0123 0.0424 0.0417
Trichomonas vaginalis bromodomain-containing protein, putative 0.0031 0.0062 0.0062
Echinococcus granulosus glycine receptor subunit beta 0.0177 0.0635 0.1555
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0177 0.0635 0.1555
Giardia lamblia Synaptic glycoprotein SC2 0.1046 0.4051 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.002 0.002
Brugia malayi hypothetical protein 0.0116 0.0397 0.0388
Brugia malayi hypothetical protein 0.0081 0.0261 0.0252
Plasmodium vivax polyprenol reductase, putative 0.1046 0.4051 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0031 0.0062 0.0062
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.002 0.002 0.0012
Schistosoma mansoni nuclear receptor 0.0104 0.0348 0.0846
Plasmodium falciparum plasmepsin VII 0.0054 0.0152 0.034
Echinococcus multilocularis lamin 0.0026 0.0044 0.0095
Loa Loa (eye worm) hypothetical protein 0.0177 0.0635 0.0626
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0177 0.0635 0.1555
Schistosoma mansoni cpg binding protein 0.0066 0.0202 0.0484
Loa Loa (eye worm) hypothetical protein 0.0081 0.0261 0.0252
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0104 0.0348 0.0846
Loa Loa (eye worm) hypothetical protein 0.0081 0.0261 0.0252
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0177 0.0635 0.1555
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0107 0.0361 0.0878
Schistosoma mansoni steroid hormone receptor ad4bp 0.022 0.0804 0.1973
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0015 0.0007
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.022 0.0804 0.1973
Schistosoma mansoni synaptic glycoprotein sc2 related 0.1046 0.4051 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0177 0.0635 0.0626
Entamoeba histolytica hypothetical protein 0.0021 0.0024 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-25 0.022 0.0804 0.0795
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0051 0.0051
Schistosoma mansoni chromobox protein 0.0123 0.0423 0.103
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.1046 0.4051 0.4046
Echinococcus multilocularis sterol regulatory element binding protein 0.0088 0.0286 0.0694
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.022 0.0804 0.1973
Onchocerca volvulus 0.0177 0.0635 0.1526
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.256 1 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0069 0.0214 0.0214
Loa Loa (eye worm) hypothetical protein 0.0026 0.0044 0.0035
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.256 1 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0348 0.0339
Schistosoma mansoni nuclear receptor 0.0104 0.0348 0.0846
Loa Loa (eye worm) hypothetical protein 0.0104 0.0348 0.0339
Plasmodium falciparum plasmepsin III 0.0054 0.0152 0.034
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0095 0.0315 0.0764
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0177 0.0635 0.0626
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.256 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.022 0.0804 0.0795
Schistosoma mansoni hypothetical protein 0.0945 0.3655 0.9021
Echinococcus granulosus nuclear receptor 2DBD gamma 0.022 0.0804 0.1973
Echinococcus multilocularis chromobox protein 2 0.002 0.002 0.0035
Plasmodium vivax plasmepsin IV, putative 0.0123 0.0424 0.1015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.022 0.0804 0.0795
Schistosoma mansoni hypothetical protein 0.0085 0.0274 0.0663
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0081 0.0261 0.0252
Brugia malayi excitatory GABA receptor EXP-1A 0.0177 0.0635 0.0626
Loa Loa (eye worm) hypothetical protein 0.1046 0.4051 0.4045
Brugia malayi ecdysone receptor 0.0104 0.0348 0.0339
Echinococcus multilocularis Bromodomain containing protein 0.0031 0.0062 0.014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0107 0.0361 0.0878
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0035 0.0079 0.0079
Echinococcus multilocularis nAChR subunit 0.0177 0.0635 0.1555
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0123 0.0424 0.1035
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0009 0.0009
Echinococcus granulosus bromodomain containing 2 0.0069 0.0214 0.0514
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.022 0.0804 0.1973
Echinococcus multilocularis dnaJ subfamily B 0.0945 0.3655 0.9021
Loa Loa (eye worm) hypothetical protein 0.0177 0.0635 0.0626
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0015 0.0015
Brugia malayi chromobox protein homolog 3 0.0069 0.0211 0.0202
Brugia malayi hypothetical protein 0.0116 0.0397 0.0388
Loa Loa (eye worm) ACC-1 protein 0.0177 0.0635 0.0626
Loa Loa (eye worm) hypothetical protein 0.0345 0.1296 0.1288
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0123 0.0424 0.0424
Loa Loa (eye worm) hypothetical protein 0.0104 0.0348 0.0339
Trichomonas vaginalis bromodomain-containing protein, putative 0.0031 0.0062 0.0062
Brugia malayi Synaptic glycoprotein SC2 0.1046 0.4051 0.4045
Schistosoma mansoni retinoic acid receptor RXR 0.022 0.0804 0.1973
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0177 0.0635 0.0626
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0095 0.0315 0.0306
Loa Loa (eye worm) hypothetical protein 0.0177 0.0635 0.0626
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.1046 0.4051 0.4051
Entamoeba histolytica hypothetical protein 0.1046 0.4051 0.4046
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0132 0.0132
Brugia malayi Cation transporter family protein 0.0177 0.0635 0.0626
Onchocerca volvulus 0.0177 0.0635 0.1526
Echinococcus granulosus nuclear receptor 2DBD gamma 0.022 0.0804 0.1973
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0211 0.0211
Schistosoma mansoni hypothetical protein 0.0085 0.0274 0.0663
Loa Loa (eye worm) GABA receptor subunit 0.0095 0.0315 0.0306
Trichomonas vaginalis bromodomain-containing protein, putative 0.0031 0.0062 0.0062
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0095 0.0315 0.0306
Loa Loa (eye worm) hypothetical protein 0.0177 0.0635 0.0626
Loa Loa (eye worm) ACC-1 protein 0.0177 0.0635 0.0626
Loa Loa (eye worm) hypothetical protein 0.0095 0.0315 0.0306
Brugia malayi hypothetical protein 0.0021 0.0024 0.0015
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.002 0.002 0.0012
Plasmodium vivax aspartyl proteinase, putative 0.0054 0.0152 0.034
Loa Loa (eye worm) helicase 0.002 0.002 0.001
Trichomonas vaginalis Heterochromatin protein, putative 0.002 0.002 0.002
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0123 0.0424 0.1035
Brugia malayi Steroid receptor seven-up type 2 0.022 0.0804 0.0795
Schistosoma mansoni chromobox protein 0.0123 0.0423 0.103
Entamoeba histolytica hypothetical protein 0.002 0.002 0.0012
Loa Loa (eye worm) nuclear hormone receptor 0.0104 0.0348 0.0339
Trichomonas vaginalis conserved hypothetical protein 0.002 0.002 0.002
Echinococcus multilocularis synaptic glycoprotein sc2 0.1046 0.4051 1
Onchocerca volvulus 0.0095 0.0315 0.0732
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.011 0.011
Schistosoma mansoni lamin 0.0026 0.0044 0.0095
Loa Loa (eye worm) hypothetical protein 0.0081 0.0261 0.0252
Loa Loa (eye worm) bromodomain containing protein 0.0031 0.0062 0.0053
Schistosoma mansoni ap endonuclease 0.0019 0.0015 0.0022
Echinococcus multilocularis nAChR subunit 0.0095 0.0315 0.0764
Brugia malayi hypothetical protein 0.002 0.002 0.001
Schistosoma mansoni chromobox protein 0.002 0.002 0.0035
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.1046 0.4051 0.4051
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0081 0.0261 0.0631
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0231 0.0231
Echinococcus multilocularis expressed conserved protein 0.0192 0.0697 0.171
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0095 0.0315 0.0306
Onchocerca volvulus 0.0022 0.0025 0.0014
Loa Loa (eye worm) hypothetical protein 0.0177 0.0635 0.0626
Echinococcus multilocularis protein dispatched 1 0.01 0.0335 0.0815
Loa Loa (eye worm) hypothetical protein 0.0177 0.0635 0.0626
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.022 0.0804 0.0795
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.022 0.0804 0.1945
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.1046 0.4051 0.4051
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0107 0.0361 0.0878
Echinococcus granulosus Chromo domain 0.002 0.002 0.0035
Echinococcus granulosus dnaJ subfamily B 0.0945 0.3655 0.9021
Loa Loa (eye worm) hypothetical protein 0.0104 0.0348 0.0339
Schistosoma mansoni neurotransmitter gated ion channel 0.0081 0.0261 0.0631
Brugia malayi Bromodomain containing protein 0.0069 0.0214 0.0204
Loa Loa (eye worm) hypothetical protein 0.0081 0.0261 0.0252
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0031 0.0062 0.0062
Echinococcus multilocularis Niemann Pick C1 protein 0.0205 0.0746 0.183
Trichomonas vaginalis rotamase, putative 0.0017 0.0008 0.0008
Loa Loa (eye worm) acetylcholine receptor protein 0.0081 0.0261 0.0252
Loa Loa (eye worm) hypothetical protein 0.0026 0.0042 0.0033
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0021 0.0011
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0015 0.0005
Echinococcus multilocularis FTZ F1 alpha 0.022 0.0804 0.1973
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0177 0.0635 0.1555
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0044 0.0035
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.002 0.002 0.0035
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.1046 0.4051 0.4046
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0081 0.0261 0.0252
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0177 0.0635 0.0626
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0092 0.0092
Brugia malayi hypothetical protein 0.0081 0.0261 0.0252
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0022 0.0039
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0177 0.0635 0.0626
Trichomonas vaginalis conserved hypothetical protein 0.002 0.002 0.002
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.1046 0.4051 0.4046
Onchocerca volvulus 0.0081 0.0261 0.0599
Loa Loa (eye worm) hypothetical protein 0.0177 0.0635 0.0626
Brugia malayi hypothetical protein 0.0104 0.0348 0.0339
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0177 0.0635 0.0626
Trichomonas vaginalis bromodomain containing protein, putative 0.0031 0.0062 0.0062
Plasmodium falciparum plasmepsin X 0.0054 0.0152 0.034
Plasmodium falciparum polyprenol reductase, putative 0.1046 0.4051 1
Brugia malayi hypothetical protein 0.0026 0.0044 0.0035
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0104 0.0348 0.0846
Loa Loa (eye worm) hypothetical protein 0.0108 0.0364 0.0355
Toxoplasma gondii aspartyl protease ASP3 0.0054 0.0152 0.0144
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0177 0.0635 0.0626
Echinococcus multilocularis Niemann Pick C1 protein 0.0293 0.1092 0.2684
Brugia malayi nuclear hormone receptor family member odr-7 0.0104 0.0348 0.0339
Loa Loa (eye worm) hypothetical protein 0.0177 0.0635 0.0626
Schistosoma mansoni cathepsin D (A01 family) 0.03 0.112 0.2755
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0177 0.0635 0.0626
Loa Loa (eye worm) hypothetical protein 0.0177 0.0635 0.0626
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0177 0.0635 0.0626
Onchocerca volvulus 0.0177 0.0635 0.1526
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0022 0.0025 0.0049
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0177 0.0635 0.1555
Trichomonas vaginalis bromodomain-containing protein, putative 0.0031 0.0062 0.0062
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.002 0.002 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0062 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.1046 0.4051 0.4051
Brugia malayi nuclear receptor RXR 0.0104 0.0348 0.0339
Plasmodium vivax hypothetical protein, conserved 0.002 0.002 0.0013
Echinococcus granulosus geminin 0.0112 0.038 0.0925
Echinococcus granulosus Nuclear hormone receptor HR96 0.0104 0.0348 0.0846
Onchocerca volvulus Putative nachr subunit 0.0177 0.0635 0.1526
Loa Loa (eye worm) hypothetical protein 0.0205 0.0746 0.0737
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0116 0.0397 0.0967
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.002 0.002 0.0035
Brugia malayi Associated with TFs and helicases family protein 0.002 0.002 0.001
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0177 0.0635 0.1555
Brugia malayi MH2 domain containing protein 0.0062 0.0185 0.0176
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0015 0.5
Onchocerca volvulus 0.0054 0.0152 0.0328
Schistosoma mansoni nuclear receptor nhr-48 0.0104 0.0348 0.0846
Loa Loa (eye worm) nuclear receptor NHR-67 0.0104 0.0348 0.0339
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0286 0.0286
Loa Loa (eye worm) hypothetical protein 0.0054 0.0153 0.0143
Loa Loa (eye worm) hypothetical protein 0.0263 0.0976 0.0968
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0116 0.0397 0.0388
Loa Loa (eye worm) heterochromatin protein 1 0.0123 0.0423 0.0414
Loa Loa (eye worm) MH2 domain-containing protein 0.0062 0.0185 0.0176
Schistosoma mansoni acetylcholine receptor subunit beta 0.0081 0.0261 0.0631
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0015 0.0022
Brugia malayi intermediate filament protein 0.0026 0.0044 0.0035
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.1046 0.4051 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0261 0.0252
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.002 0.002 0.0035
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.256 1 1
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0054 0.0152 0.0144
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.001
Echinococcus multilocularis protein patched 0.0088 0.0286 0.0694
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0116 0.0397 0.0967
Brugia malayi Heterochromatin protein 1 0.0123 0.0423 0.0414
Brugia malayi hypothetical protein 0.0104 0.0348 0.0339
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0081 0.0261 0.0252
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0104 0.0348 0.0814
Trichomonas vaginalis bromodomain-containing protein, putative 0.0031 0.0062 0.0062
Echinococcus granulosus lamin dm0 0.0026 0.0044 0.0095

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 17 uM Antituberculosis activity against Mycobacterium tuberculosis H37Rv after 7 days by resazurin microtiter assay ChEMBL. 20138519

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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