Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0083 | 0.4997 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0053 | 0.3027 | 0.6057 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0053 | 0.3027 | 0.3027 |
Giardia lamblia | Cathepsin B precursor | 0.0053 | 0.3027 | 0.6057 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0083 | 0.4997 | 0.4997 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0083 | 0.4997 | 1 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0083 | 0.4997 | 0.4997 |
Echinococcus granulosus | cathepsin b | 0.016 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent protease peptidase subunit | 0.0006 | 0 | 0.5 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0083 | 0.4997 | 0.4997 |
Onchocerca volvulus | Notchless protein homolog | 0.0006 | 0 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.0053 | 0.3027 | 0.6057 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0083 | 0.4997 | 0.4997 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0053 | 0.3027 | 0.6057 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0083 | 0.4997 | 1 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0083 | 0.4997 | 0.4997 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0083 | 0.4997 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0053 | 0.3027 | 0.6057 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0083 | 0.4997 | 1 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0083 | 0.4997 | 1 |
Echinococcus multilocularis | cathepsin b | 0.016 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.016 | 1 | 1 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0083 | 0.4997 | 1 |
Mycobacterium ulcerans | proteasome PrcB | 0.0083 | 0.4997 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0053 | 0.3027 | 0.6057 |
Loa Loa (eye worm) | cathepsin B | 0.0053 | 0.3027 | 0.3027 |
Echinococcus granulosus | proteasome prosome macropain | 0.0083 | 0.4997 | 0.4997 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0083 | 0.4997 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0083 | 0.4997 | 0.4997 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0083 | 0.4997 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.016 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0053 | 0.3027 | 0.3027 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.016 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.016 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.016 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.016 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.016 | 1 | 1 |
Toxoplasma gondii | cathepsin B | 0.0053 | 0.3027 | 0.6057 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0083 | 0.4997 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Survival (functional) | = 67 % | Histamine induced lethality, at 30-min pretreatment time when 30 mg/kg compound was administered intra peritonially in guinea pigs | ChEMBL. | 2570152 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.