Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | Rho-associated, coiled-coil containing protein kinase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0168 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.02 | 0.3473 | 0.5479 |
Echinococcus granulosus | rho-associated protein kinase 1 | 0.0176 | 0.3012 | 0.4674 |
Loa Loa (eye worm) | AGC/DMPK/ROCK protein kinase | 0.0546 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0554 | 0.0393 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0333 | 0.0168 |
Loa Loa (eye worm) | carboxylesterase | 0.02 | 0.3473 | 0.3362 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0554 | 0.0387 |
Brugia malayi | Carboxylesterase family protein | 0.02 | 0.3473 | 0.3473 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.02 | 0.3473 | 0.5479 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0168 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0333 | 0.0168 |
Echinococcus multilocularis | acetylcholinesterase | 0.02 | 0.3473 | 0.5479 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0168 | 0.5 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0168 | 0.0168 |
Brugia malayi | Carboxylesterase family protein | 0.0034 | 0.0333 | 0.0333 |
Loa Loa (eye worm) | carboxylesterase | 0.0034 | 0.0333 | 0.0168 |
Brugia malayi | hypothetical protein | 0.0034 | 0.0333 | 0.0333 |
Brugia malayi | Muscleblind-like protein | 0.0294 | 0.5246 | 0.5246 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0632 | 0.0472 |
Echinococcus granulosus | muscleblind protein | 0.0294 | 0.5246 | 0.8572 |
Echinococcus multilocularis | geminin | 0.0338 | 0.6064 | 1 |
Mycobacterium tuberculosis | Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) | 0.0324 | 0.581 | 1 |
Mycobacterium ulcerans | epoxide hydrolase EphA | 0.0324 | 0.581 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 0.5246 | 0.5165 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0335 | 0.0004 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0554 | 0.0387 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 0.3473 | 0.3362 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 0.3473 | 0.3362 |
Brugia malayi | Carboxylesterase family protein | 0.0034 | 0.0333 | 0.0333 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0554 | 0.0387 |
Brugia malayi | Carboxylesterase family protein | 0.0034 | 0.0333 | 0.0333 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0632 | 0.0632 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0294 | 0.5246 | 0.8572 |
Onchocerca volvulus | 0.0175 | 0.3005 | 0.9974 | |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0168 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.02 | 0.3473 | 0.5479 |
Echinococcus multilocularis | rho associated protein kinase | 0.0176 | 0.3012 | 0.4674 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0554 | 0.0387 |
Loa Loa (eye worm) | carboxylesterase | 0.0034 | 0.0333 | 0.0168 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0335 | 0.017 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0632 | 0.0472 |
Echinococcus multilocularis | carboxylesterase 5A | 0.02 | 0.3473 | 0.5479 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0034 | 0.0333 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0034 | 0.0333 | 0.5 |
Onchocerca volvulus | 0.0176 | 0.3012 | 1 | |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0168 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.02 | 0.3473 | 0.3362 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0168 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0335 | 0.0335 |
Schistosoma mansoni | hypothetical protein | 0.0338 | 0.6064 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0176 | 0.3012 | 0.4674 |
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 0.5246 | 0.5165 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0632 | 0.0632 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0333 | 0.0168 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0554 | 0.0387 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0554 | 0.0387 |
Echinococcus granulosus | carboxylesterase 5A | 0.02 | 0.3473 | 0.5479 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0168 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.02 | 0.3473 | 0.5479 |
Brugia malayi | Carboxylesterase family protein | 0.02 | 0.3473 | 0.3473 |
Echinococcus multilocularis | muscleblind protein | 0.0294 | 0.5246 | 0.8572 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0333 | 0.0168 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0554 | 0.0554 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0333 | 0.0168 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0333 | 0.0168 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0333 | 0.0168 |
Echinococcus granulosus | geminin | 0.0338 | 0.6064 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0168 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0338 | 0.6064 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0554 | 0.0387 |
Brugia malayi | Carboxylesterase family protein | 0.0034 | 0.0333 | 0.0333 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 10000 nM | Inhibition of ROCK2 | ChEMBL. | 20462760 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.