Detailed information for compound 1114569

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 327.338 | Formula: C16H17N5O3
  • H donors: 3 H acceptors: 6 LogP: 1.78 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCCNc1nc(nc2c1ncn2C)c1cccc(c1)C(=O)O
  • InChi: 1S/C16H17N5O3/c1-21-9-18-12-14(17-6-3-7-22)19-13(20-15(12)21)10-4-2-5-11(8-10)16(23)24/h2,4-5,8-9,22H,3,6-7H2,1H3,(H,23,24)(H,17,19,20)
  • InChiKey: GZSQGYAUZIKFRU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis geminin 0.0171 0.4107 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0254 0.0254
Schistosoma mansoni inositol monophosphatase 0.0075 0.1585 0.1585
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0271 0.0952
Onchocerca volvulus 0.0026 0.0271 0.0248
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0043 0.072 0.2208
Trypanosoma brucei glucosidase, putative 0.0036 0.0558 0.196
Brugia malayi Glycosyl hydrolases family 31 protein 0.0164 0.3944 0.6784
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.1585 0.4857
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0439 0.0966
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0074 0.002
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.1214 0.2875
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0271 0.1303
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0043 0.072 0.1613
Onchocerca volvulus 0.0095 0.2109 0.3457
Onchocerca volvulus 0.0026 0.0271 0.0248
Schistosoma mansoni hypothetical protein 0.002 0.0129 0.0129
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0271 0.0831
Onchocerca volvulus 0.0036 0.0554 0.0742
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0271 0.0952
Onchocerca volvulus 0.0036 0.0554 0.0742
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0382 0.0382
Schistosoma mansoni alpha-glucosidase 0.0141 0.3338 0.3338
Plasmodium falciparum glutathione reductase 0.0123 0.2848 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0271 0.0341
Schistosoma mansoni alpha glucosidase 0.0036 0.0558 0.0558
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0026 0.0271 0.0341
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0558 0.3203
Echinococcus multilocularis cathepsin b 0.0139 0.3263 0.7921
Brugia malayi Cathepsin L-like cysteine proteinase 0.0026 0.0271 0.0345
Loa Loa (eye worm) hypothetical protein 0.002 0.0129 0.0116
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1214 0.6404
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0439 0.064
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0074 0.0228
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.055 0.1239
Loa Loa (eye worm) hypothetical protein 0.0069 0.1422 0.2377
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0254 0.0779
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0558 0.0837
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0074 0.0261
Loa Loa (eye worm) hypothetical protein 0.0036 0.0554 0.0859
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0043 0.072 0.5
Brugia malayi Cathepsin L-like precursor 0.0026 0.0271 0.0345
Loa Loa (eye worm) hypothetical protein 0.0026 0.0271 0.0364
Mycobacterium tuberculosis Probable dehydrogenase 0.028 0.7018 0.8864
Echinococcus multilocularis inositol monophosphatase 1 0.0075 0.1585 0.3788
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0271 0.0341
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0074 0.0261
Loa Loa (eye worm) doublecortin family protein 0.002 0.0129 0.0116
Loa Loa (eye worm) hypothetical protein 0.0039 0.0615 0.0965
Loa Loa (eye worm) hypothetical protein 0.0071 0.1477 0.2473
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0271 0.0831
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0439 0.064
Leishmania major trypanothione reductase 0.0123 0.2848 1
Brugia malayi Papain family cysteine protease containing protein 0.0026 0.0271 0.0345
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0271 0.0341
Plasmodium falciparum glutathione reductase 0.0043 0.072 0.2174
Onchocerca volvulus Cathepsin L homolog 0.0026 0.0271 0.0248
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.028 0.7018 0.8864
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0047 0.0047
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0271 0.0952
Brugia malayi Bromodomain containing protein 0.0075 0.1591 0.2658
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1214 0.1214
Leishmania major cathepsin L-like protease 0.0026 0.0271 0.0952
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.1585 0.5566
Brugia malayi glutathione reductase 0.0123 0.2848 0.4862
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0271 0.0341
Schistosoma mansoni lipoxygenase 0.0057 0.1096 0.1096
Echinococcus multilocularis cathepsin L cysteine protease 0.0026 0.0271 0.0553
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.1096 0.2584
Loa Loa (eye worm) hypothetical protein 0.0032 0.0439 0.0658
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.1214 0.0905
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0558 0.0837
Leishmania major cathepsin L-like protease 0.0026 0.0271 0.0952
Schistosoma mansoni loxhd1 0.002 0.0129 0.0129
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.2268 0.3846
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0074 0.0228
Schistosoma mansoni cathepsin F (C01 family) 0.0026 0.0271 0.0271
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0074 0.0261
Onchocerca volvulus 0.0026 0.0271 0.0248
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0382 0.1109
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0254 0.0649
Echinococcus granulosus zinc finger protein 0.002 0.0114 0.0166
Onchocerca volvulus 0.0026 0.0271 0.0248
Loa Loa (eye worm) hypothetical protein 0.002 0.0129 0.0116
Trichomonas vaginalis inositol monophosphatase, putative 0.0075 0.1585 0.2612
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0031 0.0421 0.0608
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.5096 0.8806
Echinococcus multilocularis zinc finger protein 0.002 0.0114 0.0166
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0193 0.0193
Loa Loa (eye worm) inositol-1 0.0075 0.1585 0.2662
Echinococcus granulosus cathepsin l1 0.0026 0.0271 0.0553
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0031 0.0421 0.0608
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0558 0.0837
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0043 0.072 0.253
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0271 0.0341
Loa Loa (eye worm) cathepsin B 0.005 0.091 0.1481
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0074 0.0261
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.0836 0.1944
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0554 0.1698
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0067 0.1376 0.1127
Echinococcus granulosus cathepsin l cysteine peptidase 0.0026 0.0271 0.0553
Leishmania major cathepsin L-like protease 0.0026 0.0271 0.0952
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0271 0.0952
Plasmodium vivax glutathione reductase, putative 0.0123 0.2848 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0312 0.7846 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0271 0.0341
Echinococcus granulosus geminin 0.0171 0.4107 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0554 0.1698
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0382 0.0382
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0558 0.196
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0234 0.5779 1
Loa Loa (eye worm) hypothetical protein 0.0139 0.3263 0.5598
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0075 0.023
Schistosoma mansoni hypothetical protein 0.0069 0.1422 0.1422
Onchocerca volvulus Cathepsin F homolog 0.0026 0.0271 0.0248
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.287 0.4912
Schistosoma mansoni bromodomain containing protein 0.0064 0.1278 0.1278
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0043 0.072 0.2208
Mycobacterium tuberculosis Probable reductase 0.028 0.7018 0.8864
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0142 0.0138
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0271 0.0341
Onchocerca volvulus Cathepsin L homolog 0.0026 0.0271 0.0248
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0271 0.0952
Echinococcus multilocularis lysosomal alpha glucosidase 0.0164 0.3944 0.9599
Loa Loa (eye worm) fibroinase 0.0026 0.0271 0.0364
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0075 0.1585 0.2612
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0043 0.072 0.253
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0382 0.0825
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0554 0.083
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.0836 0.1944
Schistosoma mansoni cathepsin F (C01 family) 0.0026 0.0271 0.0271
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0271 0.0341
Loa Loa (eye worm) hypothetical protein 0.0036 0.0554 0.0859
Trichomonas vaginalis mercuric reductase, putative 0.0043 0.072 0.1117
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0043 0.072 0.233
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0271 0.0341
Loa Loa (eye worm) hypothetical protein 0.0047 0.0836 0.1353
Schistosoma mansoni alpha-glucosidase 0.0141 0.3338 0.3338
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.055 0.1239
Trypanosoma cruzi trypanothione reductase, putative 0.0043 0.072 0.2208
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1214 0.1214
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0074 0.0068
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0026 0.0271 0.0831
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.287 0.4912
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0075 0.1585 1
Brugia malayi beta-lactamase family protein 0.0036 0.0554 0.0841
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0075 0.1585 1
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0554 0.1946
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0043 0.072 0.1659
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.2268 0.3846
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.3384 0.8218
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0271 0.0341
Trichomonas vaginalis esterase, putative 0.0036 0.0554 0.083
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.3384 0.3384
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0554 0.1562
Echinococcus multilocularis cathepsin L cysteine protease 0.0026 0.0271 0.0553
Giardia lamblia NADH oxidase lateral transfer candidate 0.0043 0.072 0.7735
Brugia malayi Cathepsin L-like precursor 0.0026 0.0271 0.0345
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0554 0.125
Trichomonas vaginalis set domain proteins, putative 0.0237 0.5857 1
Echinococcus granulosus cathepsin l1 0.0026 0.0271 0.0553
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0271 0.0952
Brugia malayi Cathepsin L-like precursor 0.0026 0.0271 0.0345
Trypanosoma brucei trypanothione reductase 0.0123 0.2848 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0271 0.0341
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0439 0.0966
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0254 0.0893
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0043 0.072 0.253
Treponema pallidum NADH oxidase 0.0043 0.072 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0558 0.171
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0232 0.5736 0.7107
Loa Loa (eye worm) hypothetical protein 0.0026 0.0271 0.0364
Loa Loa (eye worm) beta-lactamase 0.0036 0.0554 0.0859
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0047 0.0047
Plasmodium vivax vivapain-2 0.0026 0.0271 0.0522
Schistosoma mansoni polycystin 1-related 0.002 0.0129 0.0129
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0139 0.3263 0.3263
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0074 0.0228
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0271 0.0341
Toxoplasma gondii cathepsin CPL 0.0026 0.0271 0.071
Schistosoma mansoni hypothetical protein 0.0171 0.4107 0.4107
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0558 0.0866
Toxoplasma gondii ABC1 family protein 0.0036 0.0554 0.173
Echinococcus multilocularis cysteine protease 0.0026 0.0271 0.0553
Onchocerca volvulus 0.0026 0.0271 0.0248
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0271 0.0831
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0558 0.1259
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0554 0.0859
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.3384 0.8218
Echinococcus granulosus GPCR family 2 0.0032 0.0439 0.0966
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0026 0.0271 0.0553
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0312 0.7846 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0074 0.0261
Schistosoma mansoni inositol monophosphatase 0.0075 0.1585 0.1585
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.2268 0.3858
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.005 0.091 0.1445
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0129 0.0204
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0558 0.0848
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0129 0.0204
Schistosoma mansoni hypothetical protein 0.0032 0.0439 0.0439
Brugia malayi Pre-SET motif family protein 0.003 0.0382 0.0539
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0254 0.0511
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0074 0.0074
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0074 0.0261
Schistosoma mansoni lipoxygenase 0.002 0.0129 0.0129
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.3384 0.8218
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0271 0.0952
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0558 0.1259
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0043 0.072 0.1613
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.1585 0.5566
Giardia lamblia Cathepsin B precursor 0.005 0.091 1
Plasmodium falciparum thioredoxin reductase 0.0123 0.2848 1
Brugia malayi MH2 domain containing protein 0.0124 0.287 0.4902
Brugia malayi beta-lactamase family protein 0.0036 0.0554 0.0841
Brugia malayi Cathepsin L-like precursor 0.0026 0.0271 0.0345
Echinococcus granulosus cathepsin L cysteine proteinase 0.0026 0.0271 0.0553
Schistosoma mansoni hypothetical protein 0.0032 0.0439 0.0439
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0129 0.0204
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0043 0.072 0.253
Echinococcus granulosus thioredoxin glutathione reductase 0.0124 0.2874 0.6964
Brugia malayi hypothetical protein 0.002 0.0129 0.0097
Brugia malayi Cathepsin L-like precursor 0.0026 0.0271 0.0345
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0026 0.0271 0.0522
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0043 0.072 0.2208
Schistosoma mansoni rab6-interacting 0.002 0.0129 0.0129
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0271 0.0341
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0554 0.083
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0439 0.0966
Leishmania major cathepsin L-like protease 0.0026 0.0271 0.0952
Leishmania major cathepsin L-like protease 0.0026 0.0271 0.0952
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.005 0.091 0.3194
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0043 0.072 0.2208
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0193 0.036
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0074 0.0261
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0075 0.0264
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0439 0.0658
Plasmodium falciparum cysteine proteinase falcipain 3 0.0026 0.0271 0.0522
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0164 0.3944 0.679
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0271 0.0341
Schistosoma mansoni hypothetical protein 0.0021 0.0142 0.0142
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0271 0.0341
Brugia malayi beta-lactamase 0.0036 0.0554 0.0841
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0554 0.083
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0043 0.072 0.2208
Entamoeba histolytica hypothetical protein 0.0025 0.0254 0.1191
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0554 0.083
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0558 0.0837
Onchocerca volvulus 0.003 0.0382 0.0441
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0026 0.0271 0.0364
Onchocerca volvulus 0.0026 0.0271 0.0248
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0554 0.083
Plasmodium vivax vivapain-2 0.0026 0.0271 0.0522
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0143 0.3384 0.581
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0043 0.072 0.253
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0043 0.072 0.253
Schistosoma mansoni zinc finger protein 0.002 0.0114 0.0114
Loa Loa (eye worm) thioredoxin reductase 0.0123 0.2848 0.4872
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0271 0.0341
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0558 0.0837
Toxoplasma gondii thioredoxin reductase 0.0123 0.2848 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0271 0.0952
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0129 0.0204
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0554 0.0554
Onchocerca volvulus 0.0026 0.0271 0.0248
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0043 0.072 0.253
Loa Loa (eye worm) hypothetical protein 0.0036 0.0554 0.0859
Brugia malayi Bromodomain containing protein 0.0039 0.0613 0.0944
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0043 0.072 0.0228
Giardia lamblia Cathepsin B precursor 0.005 0.091 1
Brugia malayi Doublecortin family protein 0.002 0.0129 0.0097
Brugia malayi PHD-finger family protein 0.0025 0.0256 0.0319
Plasmodium vivax thioredoxin reductase, putative 0.0123 0.2848 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0558 0.0837
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0043 0.072 0.2208
Echinococcus multilocularis thioredoxin glutathione reductase 0.0124 0.2874 0.6964
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0074 0.0068
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0558 0.0837
Echinococcus multilocularis RUN 0.002 0.0129 0.0204
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0074 0.0228
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0129 0.0204
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0271 0.0341
Toxoplasma gondii NADPH-glutathione reductase 0.0043 0.072 0.233
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0026 0.0271 0.0553
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.028 0.7018 0.8864
Brugia malayi cathepsin B-like cysteine proteinase 0.0139 0.3263 0.559
Leishmania major cysteine peptidase A (CPA) 0.0026 0.0271 0.0952
Brugia malayi Pre-SET motif family protein 0.0208 0.5096 0.8804
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.1214 0.4111
Giardia lamblia Cathepsin B precursor 0.005 0.091 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0139 0.3263 0.3263
Loa Loa (eye worm) hypothetical protein 0.0026 0.0271 0.0364
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.3384 0.3384
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0271 0.0952
Mycobacterium tuberculosis Probable oxidoreductase 0.0312 0.7846 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0678 0.1075
Onchocerca volvulus 0.0036 0.0554 0.0742
Loa Loa (eye worm) cysteine protease 0.0026 0.0271 0.0364
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.028 0.7018 0.8864
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0074 0.0068
Trypanosoma cruzi cruzipain precursor, putative 0.0026 0.0271 0.0831
Loa Loa (eye worm) hypothetical protein 0.0036 0.0554 0.0859
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0836 0.0836
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0043 0.072 0.2208
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0043 0.072 0.2174
Loa Loa (eye worm) hypothetical protein 0.0043 0.0729 0.1164
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0554 0.0554
Schistosoma mansoni rab6-interacting 0.002 0.0129 0.0129
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0043 0.072 0.1133
Loa Loa (eye worm) glutathione reductase 0.0123 0.2848 0.4872
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0043 0.072 0.1659
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0558 0.171
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0558 0.0837
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0139 0.3263 0.3263
Echinococcus multilocularis GPCR, family 2 0.0032 0.0439 0.0966
Leishmania major cathepsin L-like protease 0.0026 0.0271 0.0952
Brugia malayi hypothetical protein 0.002 0.0129 0.0097
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0074 0.0261
Plasmodium vivax SET domain protein, putative 0.003 0.0382 0.0929
Echinococcus multilocularis cysteine protease 0.0026 0.0271 0.0553
Mycobacterium tuberculosis Putative ferredoxin reductase 0.028 0.7018 0.8864
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.1183 0.2798
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0139 0.3263 0.3263
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0439 0.0966
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0271 0.0341
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0554 0.125
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0074 0.0261
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0271 0.1303
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0271 0.0952
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0043 0.072 0.072
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0143 0.3384 0.5801
Trypanosoma cruzi trypanothione reductase, putative 0.0123 0.2848 0.8727
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0043 0.072 0.1613
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0043 0.072 0.2174
Schistosoma mansoni hypothetical protein 0.0032 0.0439 0.0439
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0043 0.072 0.2174
Loa Loa (eye worm) hypothetical protein 0.0036 0.0554 0.0859
Brugia malayi Inositol-1 0.0075 0.1585 0.2648
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0271 0.0831
Loa Loa (eye worm) ctsf protein 0.0026 0.0271 0.0364
Echinococcus granulosus cathepsin b 0.0139 0.3263 0.7921
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0074 0.0261
Trypanosoma brucei cysteine peptidase C (CPC) 0.005 0.091 0.3194
Schistosoma mansoni hypothetical protein 0.0032 0.0439 0.0439
Loa Loa (eye worm) hypothetical protein 0.0036 0.0554 0.0859
Brugia malayi Cathepsin L-like precursor 0.0026 0.0271 0.0345
Leishmania major cathepsin L-like protease 0.0026 0.0271 0.0952
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0193 0.036
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0123 0.2848 0.3145
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.1183 0.2798
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0312 0.7846 1
Echinococcus granulosus cathepsin b 0.0139 0.3263 0.7921
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1214 0.6404
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0067 0.1376 0.1127
Echinococcus granulosus inositol monophosphatase 1 0.0075 0.1585 0.3788
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.028 0.7018 0.8864
Schistosoma mansoni cathepsin F (C01 family) 0.0026 0.0271 0.0271
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1214 0.6404
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0836 0.0836
Brugia malayi Cathepsin L-like precursor 0.0026 0.0271 0.0345
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.1422 0.2362
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0271 0.1303
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0043 0.072 0.2174
Brugia malayi Thioredoxin reductase 0.0123 0.2848 0.4862
Loa Loa (eye worm) hypothetical protein 0.0021 0.0162 0.0172
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0271 0.0952
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0075 0.1585 0.5447
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0554 0.0841
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.1214 0.2875
Brugia malayi follicle stimulating hormone receptor 0.0234 0.5779 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0254 0.0315
Echinococcus granulosus RUN 0.002 0.0129 0.0204
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0026 0.0271 0.0522
Onchocerca volvulus 0.0026 0.0271 0.0248
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0271 0.0341
Loa Loa (eye worm) hypothetical protein 0.0026 0.0271 0.0364
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0129 0.0204
Echinococcus multilocularis lysosomal alpha glucosidase 0.0164 0.3944 0.9599
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0043 0.072 0.253
Onchocerca volvulus 0.0237 0.5857 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0026 0.0271 0.0341
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.1096 0.2584
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0043 0.072 0.2208
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0558 0.3203
Echinococcus granulosus lysosomal alpha glucosidase 0.0164 0.3944 0.9599
Loa Loa (eye worm) hypothetical protein 0.0101 0.2268 0.3858
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0074 0.002
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.3384 0.8218
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0271 0.0341
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0558 0.1745
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0075 0.1585 1
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0254 0.0511
Entamoeba histolytica cysteine protease, putative 0.0026 0.0271 0.1303
Leishmania major hypothetical protein, conserved 0.0036 0.0554 0.1946
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.3384 0.3384
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0271 0.0341
Brugia malayi cathepsin L-like precursor 0.0026 0.0271 0.0345
Schistosoma mansoni hypothetical protein 0.0171 0.4107 0.4107
Brugia malayi Cathepsin L-like precursor 0.0026 0.0271 0.0345
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0271 0.0341
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0074 0.0228
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.1214 0.4264
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0075 0.1585 0.2612
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.1585 0.4857
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0558 0.0837
Leishmania major cathepsin L-like protease 0.0026 0.0271 0.0952
Trichomonas vaginalis glutathione reductase, putative 0.0043 0.072 0.1117
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.005 0.091 0.2788
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0271 0.0341
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0026 0.0271 0.0364
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0162 0.0495
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0139 0.3263 1
Echinococcus multilocularis cathepsin b 0.0139 0.3263 0.7921
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.005 0.091 0.091
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0074 0.0068
Plasmodium falciparum thioredoxin reductase 0.0043 0.072 0.2174
Toxoplasma gondii cathepsin B 0.005 0.091 0.3012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0254 0.0311
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0353 0.0754
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0271 0.0341
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0074 0.0074
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0271 0.0341

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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