Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | Get druggable targets OG5_146698 | All targets in OG5_146698 |
Mycobacterium ulcerans | bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase | Get druggable targets OG5_146698 | All targets in OG5_146698 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 565 aa | 475 aa | 27.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | rotamase | 0.0035 | 0.0228 | 0.0555 |
Echinococcus multilocularis | expressed protein | 0.0035 | 0.0228 | 0.0228 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0034 | 0.0218 | 0.5 |
Brugia malayi | hypothetical protein | 0.0074 | 0.0706 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0074 | 0.0706 | 0.0706 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0415 | 0.9663 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0074 | 0.0706 | 0.172 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0035 | 0.0228 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0355 | 0.4105 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.043 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0415 | 0.9663 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.0706 | 1 |
Loa Loa (eye worm) | Pin1-type peptidyl-prolyl cis-trans isomerase | 0.0035 | 0.0228 | 0.5302 |
Echinococcus granulosus | expressed protein | 0.0035 | 0.0228 | 0.0555 |
Echinococcus multilocularis | tumor protein p63 | 0.0351 | 0.4055 | 0.4055 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0415 | 0.5878 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0034 | 0.0218 | 0.5 |
Trichomonas vaginalis | rotamase, putative | 0.0035 | 0.0228 | 1 |
Mycobacterium ulcerans | bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase | 0.0675 | 0.7978 | 0.5 |
Brugia malayi | Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 | 0.0035 | 0.0228 | 0.3225 |
Schistosoma mansoni | hypothetical protein | 0.0355 | 0.4105 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0415 | 0.5878 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase/rotamase, putative | 0.0034 | 0.0218 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0223 | 0.519 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.0675 | 0.7978 | 0.5 |
Echinococcus granulosus | tumor protein p63 | 0.0351 | 0.4055 | 0.9879 |
Echinococcus multilocularis | geminin | 0.0355 | 0.4105 | 0.4105 |
Echinococcus granulosus | geminin | 0.0355 | 0.4105 | 1 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0051 | 0.043 | 0.1046 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0074 | 0.0706 | 0.172 |
Onchocerca volvulus | 0.0051 | 0.043 | 0.5 | |
Toxoplasma gondii | peptidylprolyl isomerase | 0.0034 | 0.0218 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.0706 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.0706 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0223 | 0.3157 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0223 | 0.0543 |
Leishmania major | peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative | 0.0034 | 0.0218 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0074 | 0.0706 | 0.172 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.0706 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 2.05 10'3nM | Inhibition of Mycobacterium tuberculosis recombinant MbtA expressed in Escherichia coli by ATP-PPi exchange assay | ChEMBL. | 18690677 |
MIC99 (functional) | > 50 uM | Antitubercular activity against Mycobacterium tuberculosis H37Rv in iron-deficient GAST medium after 10 to 14 days by broth dilution method | ChEMBL. | 18690677 |
MIC99 (functional) | > 50 uM | Antitubercular activity against Mycobacterium tuberculosis H37Rv in iron-replete GAST medium after 10 to 14 days by broth dilution method | ChEMBL. | 18690677 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.