Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0068 | 0.6944 | 0.9634 |
Schistosoma mansoni | eyes absent homolog | 0.0091 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.1304 | 0.5 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0068 | 0.6944 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.253 | 0.253 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.1304 | 0.5 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.004 | 0.3101 | 0.4303 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.2793 | 0.3875 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.253 | 0.253 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0068 | 0.6944 | 0.9634 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0068 | 0.6944 | 0.6944 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0068 | 0.6944 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.471 | 0.471 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0068 | 0.6944 | 0.6944 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.471 | 0.471 |
Brugia malayi | hypothetical protein | 0.0026 | 0.1304 | 0.1304 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.2793 | 0.3875 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.2793 | 0.2793 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.471 | 0.471 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.253 | 0.253 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0068 | 0.6944 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.1304 | 0.5 |
Schistosoma mansoni | dual specificity serine/threonine tyrosine kinase | 0.007 | 0.7208 | 0.7208 |
Trichomonas vaginalis | CAMK family protein kinase | 0.007 | 0.7208 | 0.5 |
Echinococcus granulosus | dual specificity serine:threonine tyrosine | 0.007 | 0.7208 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.007 | 0.7208 | 0.5 |
Echinococcus multilocularis | dual specificity serine:threonine tyrosine | 0.007 | 0.7208 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 1 | 1 |
Giardia lamblia | Kinase, TTK | 0.007 | 0.7208 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.1304 | 0.5 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0068 | 0.6944 | 0.6944 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.1304 | 0.1304 |
Onchocerca volvulus | Dual specificity protein kinase TTK homolog | 0.007 | 0.7208 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 1 | 1 |
Echinococcus granulosus | transcription factor Dp 1 | 0.004 | 0.3101 | 0.4303 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0069 | 0.0069 |
Loa Loa (eye worm) | TTK protein kinase | 0.007 | 0.7208 | 0.7208 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.2793 | 0.2793 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0068 | 0.6944 | 1 |
Brugia malayi | hypothetical protein | 0.0037 | 0.2793 | 0.2793 |
Brugia malayi | Protein kinase domain containing protein | 0.007 | 0.7208 | 0.7208 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0068 | 0.6944 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.471 | 0.471 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 15.5 % | Agonist activity at ERbeta expressed in HEK293 cells at 10 uM after 24 hrs by luciferase reporter gene assay relative to 3,17-beta-estradiol | ChEMBL. | 20430632 |
Activity (functional) | = 69.5 % | Agonist activity at ERalpha expressed in HEK293 cells at 10 uM after 24 hrs by luciferase reporter gene assay relative to 3,17-beta-estradiol | ChEMBL. | 20430632 |
RBA (binding) | = 0.02 % | Displacement of [3H]estradiol from human ERbeta expressed in african green monkey COS1 cells assessed as relative binding affinity after 2 hrs by liquid scintillation counting relative to estradiol | ChEMBL. | 20430632 |
RBA (binding) | = 0.03 % | Displacement of [3H]estradiol from human ERalpha expressed in african green monkey COS1 cells assessed as relative binding affinity after 2 hrs by liquid scintillation counting relative to estradiol | ChEMBL. | 20430632 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.