TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 447.566 | Formula: C23H30FN3O3S
H donors: 2 H acceptors: 2 LogP: 4.71 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: CCCCOc1ccc(cc1)S(=O)(=O)N(CC1=CNC(N1)C)CCc1ccc(cc1)F
InChi: 1S/C23H30FN3O3S/c1-3-4-15-30-22-9-11-23(12-10-22)31(28,29)27(17-21-16-25-18(2)26-21)14-13-19-5-7-20(24)8-6-19/h5-12,16,18,25-26H,3-4,13-15,17H2,1-2H3
InChiKey: BALXNULBGVGZCO-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Giardia lamblia	Grp94/Hsp90	0.0028	0.0333	0.2738
Echinococcus multilocularis	heat shock protein	0.0035	0.047	0.047
Leishmania major	heat shock protein 83-1	0.0035	0.047	0.0665
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0252	0.1788
Leishmania major	heat shock protein 83-1	0.0035	0.047	0.0665
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0304	0.0386
Brugia malayi	orphan nuclear receptor NR2E1	0.0026	0.0304	0.0386
Trypanosoma brucei	heat shock protein, putative	0.0035	0.047	0.0665
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0017	0.0116	0.0116
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0543	0.1168
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0056	0.0875	0.0875
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0304	0.0386
Onchocerca volvulus		0.0026	0.0304	0.0577
Schistosoma mansoni	zinc finger protein	0.0026	0.0304	0.0304
Trypanosoma cruzi	Heat shock protein 83, putative	0.0035	0.047	0.0665
Brugia malayi	Pre-SET motif family protein	0.0029	0.0348	0.0458
Brugia malayi	beta-NAC-like protein	0.0066	0.1082	0.1676
Schistosoma mansoni	tar DNA-binding protein	0.0195	0.3576	0.3576
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0252	0.1788
Echinococcus multilocularis	ecdysone induced protein 78C	0.0056	0.0875	0.0875
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0056	0.0875	0.0875
Echinococcus granulosus	FTZ F1 alpha	0.0056	0.0875	0.0875
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0056	0.0875	0.1332
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0153	0.2764	0.449
Echinococcus multilocularis	transient receptor potential ion channel A	0.0088	0.1497	0.1497
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0365	0.0487
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0055	0.0853	0.1296
Trypanosoma brucei	heat shock protein, putative	0.0035	0.047	0.0665
Schistosoma mansoni	transient receptor potential channel	0.006	0.096	0.096
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0543	0.0781
Echinococcus granulosus	transcription factor btf3	0.0066	0.1082	0.1082
Brugia malayi	nuclear receptor NHR-67	0.0026	0.0304	0.0386
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0026	0.0304	0.0304
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.0028	0.0333	0.0333
Brugia malayi	MAP kinase sur-1	0.0055	0.0853	0.1296
Plasmodium falciparum	basic transcription factor 3b, putative	0.0066	0.1082	1
Brugia malayi	CXXC zinc finger family protein	0.0027	0.0316	0.0405
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0348	0.0458
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0056	0.0875	0.1332
Schistosoma mansoni	high-affinity choline transporter	0.0326	0.6103	0.6103
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0039	0.0543	0.0781
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0055	0.0853	0.1304
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0195	0.3576	0.5811
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0018	0.0136	0.0108
Echinococcus multilocularis	FTZ F1 alpha	0.0056	0.0875	0.0875
Echinococcus granulosus	heat shock protein 75 kDa mitochondrial	0.0014	0.0072	0.0072
Brugia malayi	Transient-receptor-potential like protein	0.0034	0.045	0.0627
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0171	0.3099	0.6679
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0348	0.2735
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0304	0.0386
Echinococcus multilocularis	smad	0.0017	0.0116	0.0116
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0543	0.0786
Echinococcus granulosus	sodium coupled monocarboxylate transporter 1	0.0036	0.0491	0.0491
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0543	0.1168
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0055	0.0853	0.1304
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0017	0.0116	0.0116
Brugia malayi	hypothetical protein	0.0026	0.0304	0.0386
Echinococcus granulosus	dnaJ subfamily B	0.0383	0.7217	0.7217
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0055	0.0853	0.1304
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0875	0.1332
Toxoplasma gondii	heat shock protein 90, putative	0.0035	0.047	0.3942
Echinococcus granulosus	tar DNA binding protein	0.0195	0.3576	0.3576
Loa Loa (eye worm)	endoplasmin	0.0035	0.047	0.0661
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0056	0.0875	0.1332
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0153	0.2764	0.449
Trypanosoma cruzi	transcription factor btf3, putative	0.0066	0.1082	0.1686
Loa Loa (eye worm)	RNA binding protein	0.0195	0.3576	0.5811
Toxoplasma gondii	hypothetical protein	0.0052	0.0807	0.7273
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0056	0.0875	0.0875
Echinococcus multilocularis	short transient receptor potential channel 6	0.006	0.096	0.096
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0056	0.0875	0.0875
Schistosoma mansoni	serine/threonine protein kinase	0.0055	0.0853	0.0853
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0304	0.0386
Leishmania major	heat shock protein 83-1	0.0035	0.047	0.0665
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0055	0.087	0.1331
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0304	0.0386
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0543	0.1168
Brugia malayi	nuclear hormone receptor	0.0056	0.0875	0.1332
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0875	0.1332
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0056	0.0875	0.0875
Loa Loa (eye worm)	MH2 domain-containing protein	0.0243	0.4505	0.7351
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0056	0.0875	0.1332
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0543	0.0916
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0039	0.0543	0.0543
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0543	0.0781
Brugia malayi	hypothetical protein	0.0024	0.0252	0.03
Echinococcus multilocularis	transient receptor potential gamma protein	0.0091	0.1556	0.1556
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0055	0.0853	0.0853
Leishmania major	heat shock protein 83-1	0.0035	0.047	0.0665
Brugia malayi	nuclear receptor NHR-88	0.0056	0.0875	0.1332
Schistosoma mansoni	thyroid hormone receptor	0.0056	0.0875	0.0875
Onchocerca volvulus		0.0026	0.0304	0.0577
Echinococcus multilocularis	endoplasmin	0.0028	0.0333	0.0333
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0056	0.0875	0.0875
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0056	0.0875	0.0875
Echinococcus granulosus	solute carrier family 5	0.0036	0.0491	0.0491
Mycobacterium ulcerans	heat shock protein 90	0.0028	0.0333	0.0663
Brugia malayi	beta-lactamase family protein	0.0039	0.0543	0.0781
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0304	0.0386
Trypanosoma cruzi	heat shock protein 85, putative	0.0035	0.047	0.0665
Brugia malayi	nuclear receptor NHR-88	0.0026	0.0304	0.0386
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0039	0.0543	0.1372
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0136	0.0107
Plasmodium vivax	heat shock protein 86, putative	0.0035	0.047	0.3942
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0056	0.0875	0.1332
Schistosoma mansoni	tar DNA-binding protein	0.0195	0.3576	0.3576
Echinococcus granulosus	mitogen activated protein kinase 3	0.0055	0.0853	0.0853
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0304	0.0386
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0026	0.0304	0.0386
Schistosoma mansoni	cpg binding protein	0.0027	0.0316	0.0316
Entamoeba histolytica	heat shock protein 90, putative	0.0035	0.047	0.3942
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0348	0.0348
Giardia lamblia	Kinase, CMGC MAPK	0.0055	0.0853	1
Onchocerca volvulus		0.0039	0.0543	0.1168
Leishmania major	hypothetical protein, conserved	0.0024	0.0252	0.0301
Leishmania major	heat shock protein 83-1	0.0035	0.047	0.0665
Echinococcus granulosus	transient receptor potential gamma protein	0.0091	0.1556	0.1556
Echinococcus granulosus	smad	0.0017	0.0116	0.0116
Schistosoma mansoni	heat shock protein	0.0035	0.047	0.047
Brugia malayi	MH1 domain containing protein	0.0017	0.0116	0.0073
Schistosoma mansoni	inositol transporter	0.0036	0.0491	0.0491
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0029	0.0365	0.0365
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	0.0028	0.0333	1
Plasmodium vivax	SET domain protein, putative	0.0029	0.0348	0.2735
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0875	0.1332
Echinococcus multilocularis	sodium:glucose cotransporter 2	0.0036	0.0491	0.0491
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0046	0.0677	0.101
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0056	0.0875	0.0875
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0543	0.1168
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0543	0.0781
Echinococcus multilocularis	dnaJ subfamily B	0.0383	0.7217	0.7217
Echinococcus granulosus	nuclear receptor nhr 48	0.0026	0.0304	0.0304
Toxoplasma gondii	ABC1 family protein	0.0039	0.0543	0.4662
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0543	0.0916
Echinococcus granulosus	short transient receptor potential channel 6	0.006	0.096	0.096
Brugia malayi	MH2 domain containing protein	0.0243	0.4505	0.7351
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0028	0.0333	0.2738
Brugia malayi	hypothetical protein	0.0026	0.0304	0.0386
Onchocerca volvulus		0.0029	0.0348	0.0685
Brugia malayi	GH02984p	0.0326	0.6103	1
Mycobacterium tuberculosis	Probable esterase LipL	0.0039	0.0543	0.0916
Schistosoma mansoni	ap endonuclease	0.0018	0.0136	0.0136
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0136	0.0108
Toxoplasma gondii	heat shock protein HSP90	0.0035	0.047	0.3942
Brugia malayi	beta-lactamase family protein	0.0039	0.0543	0.0781
Echinococcus granulosus	mitogen activated protein kinase	0.0055	0.0853	0.0853
Onchocerca volvulus		0.0039	0.0543	0.1168
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0056	0.0875	0.1332
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0056	0.0875	0.0875
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0026	0.0304	0.0577
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0304	0.0386
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0056	0.0875	0.0875
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0136	0.0639
Schistosoma mansoni	retinoic acid receptor RXR	0.0056	0.0875	0.0875
Brugia malayi	Nuclear hormone receptor E75	0.0026	0.0304	0.0386
Echinococcus multilocularis	heat shock protein 90	0.0028	0.0333	0.0333
Brugia malayi	nuclear receptor RXR	0.0026	0.0304	0.0386
Leishmania major	heat shock protein 83-1	0.0035	0.047	0.0665
Loa Loa (eye worm)	nuclear hormone receptor	0.0026	0.0304	0.0386
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0055	0.0853	0.1304
Entamoeba histolytica	transcription factor BTF3, putative	0.0066	0.1082	1
Trichomonas vaginalis	CMGC family protein kinase	0.0055	0.0853	0.1938
Trypanosoma brucei	heat shock protein, putative	0.0035	0.047	0.0665
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0348	0.0348
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0056	0.0875	0.1332
Mycobacterium tuberculosis	Probable hydrolase	0.0039	0.0543	0.0916
Onchocerca volvulus		0.0056	0.0875	0.1992
Echinococcus granulosus	sodium:glucose cotransporter	0.0036	0.0491	0.0491
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0056	0.0875	0.1332
Mycobacterium tuberculosis	Probable lipase LipD	0.0039	0.0543	0.0916
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0543	0.0916
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0196	0.3583	0.5822
Loa Loa (eye worm)	heat shock protein 90	0.0035	0.047	0.0661
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.0136	0.0136
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0026	0.0304	0.0304
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0056	0.0875	0.0875
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0056	0.0875	0.1332
Schistosoma mansoni	hypothetical protein	0.0527	1	1
Brugia malayi	MH2 domain containing protein	0.0017	0.0116	0.0073
Schistosoma mansoni	tar DNA-binding protein	0.0195	0.3576	0.3576
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0324	0.6069	1
Mycobacterium ulcerans	lipase LipD	0.0039	0.0543	0.1372
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0304	0.0386
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0018	0.0136	0.0639
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0543	0.0543
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0039	0.0543	0.0916
Mycobacterium leprae	conserved hypothetical protein	0.0039	0.0543	1
Schistosoma mansoni	nuclear receptor	0.0026	0.0304	0.0304
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0055	0.0853	0.1304
Echinococcus granulosus	heat shock protein 90	0.0028	0.0333	0.0333
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0056	0.0875	0.0875
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0029	0.0365	0.0365
Entamoeba histolytica	hypothetical protein	0.0066	0.1082	1
Trichomonas vaginalis	heat shock protein, putative	0.0021	0.0209	0.0341
Echinococcus granulosus	cpg binding protein	0.0028	0.0346	0.0346
Leishmania major	basic transcription factor 3a, putative	0.0066	0.1082	0.1686
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0056	0.0875	0.1332
Loa Loa (eye worm)	MH1 domain-containing protein	0.0017	0.0116	0.0073
Trypanosoma cruzi	heat shock protein 90, putative	0.0028	0.0333	0.0435
Trichomonas vaginalis	heat shock protein, putative	0.0035	0.047	0.0988
Echinococcus granulosus	high affinity choline transporter 1	0.0326	0.6103	0.6103
Echinococcus granulosus	thyroid hormone receptor alpha	0.0026	0.0304	0.0304
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0324	0.6069	1
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0136	0.0639
Brugia malayi	steroid hormone receptor	0.0056	0.0875	0.1332
Mycobacterium ulcerans	beta-lactamase	0.0039	0.0543	0.1372
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0056	0.0875	0.1332
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0056	0.0875	0.0875
Schistosoma mansoni	hypothetical protein	0.0527	1	1
Brugia malayi	nuclear hormone receptor	0.0026	0.0304	0.0386
Onchocerca volvulus	Protein ultraspiracle homolog	0.0056	0.0875	0.1992
Echinococcus granulosus	beta LACTamase domain containing family member	0.0039	0.0543	0.0543
Brugia malayi	tailless protein	0.0026	0.0304	0.0386
Echinococcus granulosus	Smad4	0.0017	0.0116	0.0116
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0056	0.0875	0.1332
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0324	0.6069	1
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0026	0.0304	0.0577
Schistosoma mansoni	ap endonuclease	0.0018	0.0136	0.0136
Brugia malayi	hypothetical protein	0.0029	0.0365	0.0487
Leishmania major	heat shock protein 83-1	0.0035	0.047	0.0665
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0039	0.0543	0.0781
Trypanosoma cruzi	transcription factor btf3, putative	0.0066	0.1082	0.1686
Leishmania major	heat shock protein 83-1	0.0035	0.047	0.0665
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0017	0.0116	0.0116
Brugia malayi	ecdysone receptor	0.0026	0.0304	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0875	0.1332
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0055	0.0853	0.1304
Schistosoma mansoni	nuclear hormone receptor	0.0056	0.0875	0.0875
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0039	0.0543	0.0916
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0026	0.0304	0.0386
Toxoplasma gondii	NAC domain-containing protein	0.0066	0.1082	1
Toxoplasma gondii	LsmAD domain-containing protein	0.0024	0.0252	0.1788
Schistosoma mansoni	RAR-like nuclear receptor	0.0056	0.0875	0.0875
Plasmodium falciparum	heat shock protein 90	0.0035	0.047	0.3942
Trypanosoma brucei	heat shock protein, putative	0.0035	0.047	0.0665
Onchocerca volvulus		0.0039	0.0543	0.1168
Schistosoma mansoni	smad1 5 8 and	0.0017	0.0116	0.0116
Schistosoma mansoni	heat shock protein	0.0035	0.047	0.047
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0875	0.1332
Leishmania major	heat shock protein 83-1	0.0035	0.047	0.0665
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0056	0.0875	0.0875
Trichomonas vaginalis	CMGC family protein kinase	0.0055	0.0853	0.1938
Schistosoma mansoni	transient receptor potential channel	0.006	0.096	0.096
Schistosoma mansoni	tar DNA-binding protein	0.0195	0.3576	0.3576
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0304	0.0386
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0026	0.0304	0.0304
Echinococcus granulosus	sodium:myo inositol cotransporter	0.0036	0.0491	0.0491
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0056	0.0875	0.1332
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0365	0.0487
Schistosoma mansoni	nuclear receptor	0.0026	0.0304	0.0304
Schistosoma mansoni	endoplasmin	0.0035	0.047	0.047
Trypanosoma brucei	heat shock protein, putative	0.0035	0.047	0.0665
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0304	0.0386
Schistosoma mansoni	transient receptor potential channel 4	0.0091	0.1556	0.1556
Schistosoma mansoni	Smad4	0.0017	0.0116	0.0116
Trichomonas vaginalis	conserved hypothetical protein	0.0066	0.1082	0.2506
Echinococcus multilocularis	solute carrier family 5	0.0036	0.0491	0.0491
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0252	0.03
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0304	0.0386
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0055	0.0853	0.7734
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0056	0.0875	0.0875
Brugia malayi	Endoplasmin precursor	0.0035	0.047	0.0661
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0046	0.0677	0.101
Loa Loa (eye worm)	TAR-binding protein	0.0195	0.3576	0.5811
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0901	0.1376
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0252	0.0301
Brugia malayi	Pre-SET motif family protein	0.0196	0.3583	0.5822
Schistosoma mansoni	cpg binding protein	0.0028	0.0346	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0365	0.0487
Echinococcus multilocularis	heat shock protein 75 kDa, mitochondrial	0.0014	0.0072	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0543	0.0781
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0058	0.092	0.092
Loa Loa (eye worm)	DR-78	0.0026	0.0304	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0326	0.6103	1
Schistosoma mansoni	nuclear hormone receptor	0.0026	0.0304	0.0304
Echinococcus multilocularis	cpg binding protein	0.0028	0.0346	0.0346
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0543	0.1168
Trichomonas vaginalis	CMGC family protein kinase	0.0055	0.0853	0.1938
Schistosoma mansoni	smad1 5 8 and	0.0017	0.0116	0.0116
Brugia malayi	Steroid receptor seven-up type 2	0.0056	0.0875	0.1332
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0056	0.0875	0.0875
Trypanosoma brucei	transcription factor BTF3, putative	0.0066	0.1082	0.1686
Echinococcus multilocularis	Smad4	0.0017	0.0116	0.0116
Echinococcus multilocularis	high affinity choline transporter 1	0.0326	0.6103	0.6103
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0875	0.1332
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0136	0.016
Leishmania major	heat shock protein 83-1	0.0035	0.047	0.0665
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0348	0.0348
Schistosoma mansoni	tar DNA-binding protein	0.0195	0.3576	0.3576
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0026	0.0304	0.0304
Mycobacterium leprae	Probable lipase LipE	0.0039	0.0543	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0247	0.4573	1
Brugia malayi	RNA recognition motif domain containing protein	0.0195	0.3576	0.5811
Loa Loa (eye worm)	Smad1	0.0017	0.0116	0.0073
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	0.0028	0.0333	0.0443
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0026	0.0304	0.0304
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0875	0.1332
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0046	0.0677	0.101
Trypanosoma brucei	heat shock protein, putative	0.0035	0.047	0.0665
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0348	0.0348
Leishmania major	heat shock protein 83-1	0.0035	0.047	0.0665
Trichomonas vaginalis	conserved hypothetical protein	0.0066	0.1082	0.2506
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0026	0.0304	0.0386
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0039	0.0543	0.0916
Trypanosoma cruzi	heat shock protein 85, putative	0.0035	0.047	0.0665
Schistosoma mansoni	sodium/solute symporter	0.0036	0.0491	0.0491
Leishmania major	hypothetical protein, conserved	0.0039	0.0543	0.0786
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0153	0.2764	0.449
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0029	0.0365	0.0365
Echinococcus granulosus	ecdysone induced protein 78C	0.0056	0.0875	0.0875
Brugia malayi	Nuclear hormone receptor-like 1	0.0056	0.0875	0.1332
Onchocerca volvulus	Bile acid receptor homolog	0.0056	0.0875	0.1992
Schistosoma mansoni	transient receptor potential channel	0.0091	0.1556	0.1556
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0026	0.0304	0.0304
Echinococcus granulosus	heat shock protein 90	0.0035	0.047	0.047
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0027	0.0317	0.0317
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0055	0.0853	0.1304
Trypanosoma brucei	heat shock protein, putative	0.0035	0.047	0.0665
Trypanosoma cruzi	heat shock protein 90, putative	0.0035	0.047	0.0665
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0035	0.047	0.4656
Trichomonas vaginalis	endoplasmin, putative	0.0021	0.0209	0.0341
Echinococcus multilocularis	heat shock protein 90	0.0035	0.047	0.047
Leishmania major	heat shock protein 83-1	0.0035	0.047	0.0665
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0056	0.0875	0.1332
Trypanosoma brucei	Heat shock protein 83, putative	0.0035	0.047	0.0665
Plasmodium vivax	hypothetical protein, conserved	0.0039	0.0543	0.4662
Schistosoma mansoni	cpg binding protein	0.0028	0.0346	0.0346
Schistosoma mansoni	hypothetical protein	0.0383	0.7217	0.7217
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0365	0.0487
Brugia malayi	conserved hypotetical protein	0.0026	0.0304	0.0386
Echinococcus multilocularis	sodium:myo inositol cotransporter	0.0036	0.0491	0.0491
Toxoplasma gondii	exonuclease III APE	0.0018	0.0136	0.0639
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0026	0.0304	0.0304
Loa Loa (eye worm)	hypothetical protein	0.0034	0.045	0.0627
Mycobacterium ulcerans	hypothetical protein	0.0039	0.0543	0.1372
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0026	0.0304	0.0304
Plasmodium vivax	basic transcription factor 3b, putative	0.0066	0.1082	1
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.0034	0.045	0.045
Brugia malayi	TAR-binding protein	0.0195	0.3576	0.5811
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0052	0.0802	0.7228
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0056	0.0875	0.0875
Schistosoma mansoni	nuclear receptor nhr-48	0.0026	0.0304	0.0304
Brugia malayi	photoreceptor-specific nuclear receptor	0.0056	0.0875	0.1332
Brugia malayi	Nuclear hormone receptor-like 1	0.0029	0.0365	0.0487
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0056	0.0875	0.0875
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0026	0.0304	0.0304
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0491	0.0695
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0056	0.0875	0.0875
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0026	0.0304	0.0304
Echinococcus granulosus	endoplasmin	0.0028	0.0333	0.0333
Echinococcus multilocularis	transcription factor btf3	0.0066	0.1082	0.1082
Leishmania major	mitochondrial DNA polymerase beta	0.0324	0.6069	1
Onchocerca volvulus		0.0036	0.0491	0.1039
Plasmodium vivax	endoplasmin, putative	0.0035	0.047	0.3942
Schistosoma mansoni	nuclear hormone receptor	0.0026	0.0304	0.0304
Leishmania major	heat shock protein 83-1	0.0035	0.047	0.0665
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.0028	0.0333	0.0435
Echinococcus granulosus	mothers against decapentaplegic 5	0.0017	0.0116	0.0116
Brugia malayi	Nuclear hormone receptor-like 1	0.0029	0.0365	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0391	0.053
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0029	0.0365	0.0487
Trypanosoma brucei	heat shock protein 90, putative	0.0035	0.047	0.0665
Entamoeba histolytica	heat shock protein 90, putative	0.0035	0.047	0.3942
Echinococcus granulosus	transient receptor potential ion channel A	0.0088	0.1497	0.1497
Brugia malayi	Smad1	0.0017	0.0116	0.0073
Echinococcus multilocularis	short transient receptor potential channel 6	0.006	0.096	0.096
Echinococcus multilocularis	nuclear receptor nhr 48	0.0026	0.0304	0.0304
Echinococcus multilocularis	tar DNA binding protein	0.0195	0.3576	0.3576
Echinococcus granulosus	short transient receptor potential channel 6	0.006	0.096	0.096
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0026	0.0304	0.0304
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0056	0.0875	0.1332
Trypanosoma brucei	PAB1-binding protein , putative	0.0024	0.0252	0.0301
Schistosoma mansoni	smad1 5 8 and	0.0017	0.0116	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0875	0.1332
Leishmania major	heat shock protein 83-1	0.0035	0.047	0.0665
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0056	0.0875	0.1332
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0304	0.0386
Leishmania major	heat shock protein 83-1	0.0035	0.047	0.0665
Brugia malayi	beta-lactamase	0.0039	0.0543	0.0781
Loa Loa (eye worm)	transcription factor SMAD2	0.0243	0.4505	0.7351
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0543	0.0786
Loa Loa (eye worm)	steroid hormone receptor	0.0056	0.0875	0.1332
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0056	0.0875	0.1332
Brugia malayi	MH1 domain containing protein	0.0017	0.0116	0.0073
Brugia malayi	nuclear hormone receptor family member odr-7	0.0026	0.0304	0.0386
Trichomonas vaginalis	heat shock protein, putative	0.0028	0.0333	0.0647
Echinococcus granulosus	sodium:glucose cotransporter 2	0.0036	0.0491	0.0491
Echinococcus multilocularis	mitogen activated protein kinase	0.0055	0.0853	0.0853
Mycobacterium tuberculosis	Probable lipase LipE	0.0039	0.0543	0.0916
Schistosoma mansoni	heat shock protein	0.0014	0.0072	0.0072
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0136	0.0107
Schistosoma mansoni	thyroid hormone receptor	0.0056	0.0875	0.0875
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0365	0.0487
Trichomonas vaginalis	set domain proteins, putative	0.0222	0.4105	1
Trypanosoma brucei	heat shock protein 90, putative	0.0035	0.047	0.0665
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0056	0.0875	0.1332
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0136	0.0108
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0056	0.0875	0.0875
Echinococcus granulosus	heat shock protein	0.0035	0.047	0.047
Trichomonas vaginalis	esterase, putative	0.0039	0.0543	0.1168
Plasmodium falciparum	endoplasmin, putative	0.0021	0.0209	0.136
Schistosoma mansoni	transcription factor btf3	0.0066	0.1082	0.1082
Plasmodium vivax	ataxin-2 like protein, putative	0.0024	0.0252	0.1788
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0026	0.0304	0.0386
Leishmania major	heat shock protein 83-1	0.0035	0.047	0.0665
Brugia malayi	RNA binding protein	0.0195	0.3576	0.5811
Trichomonas vaginalis	heat shock protein, putative	0.0028	0.0333	0.0647
Brugia malayi	hypothetical protein	0.0029	0.0365	0.0487
Schistosoma mansoni	coup transcription factor	0.0056	0.0875	0.0875
Mycobacterium ulcerans	esterase/lipase LipP	0.0039	0.0543	0.1372
Brugia malayi	MH2 domain containing protein	0.0017	0.0116	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0543	0.0781
Loa Loa (eye worm)	hypothetical protein	0.0091	0.1556	0.2462
Trichomonas vaginalis	CMGC family protein kinase	0.0055	0.0853	0.1938
Brugia malayi	nuclear receptor RXR	0.0029	0.0365	0.0487
Trypanosoma cruzi	heat shock protein 90, putative	0.0021	0.0193	0.0203
Loa Loa (eye worm)	ICD-1 protein	0.0066	0.1082	0.1676
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0543	0.0543
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0046	0.0677	0.101
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0027	0.0316	0.0405
Schistosoma mansoni	inositol transporter	0.0036	0.0491	0.0491
Onchocerca volvulus		0.0027	0.0316	0.0606
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0252	0.0301
Trypanosoma cruzi	heat shock protein 85, putative	0.0028	0.0333	0.0435
Onchocerca volvulus		0.0222	0.4105	1
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.0136	0.0136
Brugia malayi	hypothetical protein	0.0015	0.009	0.0031
Brugia malayi	heat shock protein 90	0.0035	0.047	0.0661
Echinococcus granulosus	TRP transient receptor potential channel	0.0034	0.045	0.045
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0056	0.0875	0.1332
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0017	0.0116	0.0116
Trypanosoma brucei	hypothetical protein, conserved	0.0039	0.0543	0.0786
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0543	0.0781
Brugia malayi	ecdysteroid receptor	0.0056	0.0875	0.1332
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0029	0.0365	0.0365
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0056	0.0875	0.1332
Trypanosoma brucei	protein kinase, putative	0.0055	0.0853	0.1304
Brugia malayi	Sodium:solute symporter family protein	0.0036	0.0491	0.0695
Loa Loa (eye worm)	beta-lactamase	0.0039	0.0543	0.0781
Brugia malayi	Nuclear hormone receptor E75	0.0026	0.0304	0.0386
Trypanosoma brucei	heat shock protein, putative	0.0035	0.047	0.0665
Trypanosoma cruzi	heat shock protein 85, putative	0.0035	0.047	0.0665
Mycobacterium ulcerans	hypothetical protein	0.0171	0.3099	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0348	0.0348
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0018	0.0136	0.0108
Trichomonas vaginalis	conserved hypothetical protein	0.0066	0.1082	0.2506
Treponema pallidum	heat shock protein 90	0.0028	0.0333	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0348	0.0348
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0056	0.0875	0.1992
Trichomonas vaginalis	heat shock protein, putative	0.0028	0.0333	0.0647
Echinococcus multilocularis	sodium coupled monocarboxylate transporter 1	0.0036	0.0491	0.0491
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0136	0.016
Echinococcus multilocularis	geminin	0.0527	1	1
Schistosoma mansoni	endoplasmin	0.0035	0.047	0.047
Toxoplasma gondii	transporter, solute:sodium symporter (SSS) family protein	0.0036	0.0491	0.4145
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0056	0.0875	0.0875
Schistosoma mansoni	smad	0.0017	0.0116	0.0116
Leishmania major	heat shock protein 83-1	0.0035	0.047	0.0665
Loa Loa (eye worm)	MH2 domain-containing protein	0.0017	0.0116	0.0073
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0348	0.0348

Activities

Activity type	Activity value	Assay description	Source	Reference
pLADm (functional)	= 3.92	Antifungal activity against molds expressed as negative log (pLAD value).	ChEMBL.	11012023
pLADy (functional)	= 3.95	Antifungal activity against yeast expressed as negative log (pLAD value).	ChEMBL.	11012023
pLADy (functional)	= 3.95	Antifungal activity against yeast expressed as negative log (pLAD value).	ChEMBL.	11012023

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL302030

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 111499