Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A3 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2b receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2a receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | adenosine A2a receptor | 412 aa | 336 aa | 22.3 % |
Brugia malayi | hypothetical protein | adenosine A1 receptor | 326 aa | 305 aa | 21.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Latrophilin receptor protein 2 | 0.0017 | 0.0485 | 0.0485 |
Schistosoma mansoni | lamin | 0.0028 | 0.3397 | 0.5697 |
Echinococcus granulosus | lamin | 0.0028 | 0.3397 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.3397 | 0.3397 |
Schistosoma mansoni | lamin | 0.0028 | 0.3397 | 0.5697 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.3397 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.5596 | 0.5596 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0017 | 0.0485 | 0.0485 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.3397 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 1 | 1 |
Echinococcus multilocularis | musashi | 0.0028 | 0.3397 | 1 |
Onchocerca volvulus | 0.0028 | 0.3397 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.5596 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.3263 | 0.3263 |
Schistosoma mansoni | intermediate filament proteins | 0.0028 | 0.3397 | 0.5697 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.5596 | 0.5596 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.3397 | 0.3397 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.3397 | 0.3397 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0017 | 0.0485 | 0.0485 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0485 | 0.0485 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.3397 | 0.3397 |
Brugia malayi | intermediate filament protein | 0.0028 | 0.3397 | 0.3397 |
Onchocerca volvulus | 0.0028 | 0.3397 | 0.5 | |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.3397 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 1 | 1 |
Echinococcus multilocularis | lamin | 0.0028 | 0.3397 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 72.4 nM | Displacement of [3H]NECA from human cloned adenosine A3 receptor expressed in CHO cells | ChEMBL. | 20307065 |
Ki (binding) | = 2020 nM | Displacement of [3H]NECA from human cloned adenosine A2a receptor expressed in CHO cells | ChEMBL. | 20307065 |
Ki (binding) | = 4860 nM | Displacement of [3H]CCPA from human cloned adenosine A1 receptor expressed in CHO cells | ChEMBL. | 20307065 |
Ki (functional) | > 10000 nM | Antagonist activity at human cloned adenosine A2b receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP accumulation | ChEMBL. | 20307065 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.