Detailed information for compound 1115218

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 465.504 | Formula: C24H23F4NO2S
  • H donors: 3 H acceptors: 2 LogP: 4.79 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC(CCc1ccc(cc1)c1ccc(cc1F)Sc1ccc(cc1)C(F)(F)F)(CO)N
  • InChi: 1S/C24H23F4NO2S/c25-22-13-20(32-19-7-5-18(6-8-19)24(26,27)28)9-10-21(22)17-3-1-16(2-4-17)11-12-23(29,14-30)15-31/h1-10,13,30-31H,11-12,14-15,29H2
  • InChiKey: KCNVWEJOMWMFMO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis ecdysone induced protein 78C 0.0019 0.0136 0.0126
Onchocerca volvulus 0.0024 0.0256 0.0241
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0156 0.3086 0.3045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0019 0.0136 0.0292
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0789 0.0779
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0019 0.0136 0.0287
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0427 0.037
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.2704 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0256 0.054
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0041 0.0086
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0489 0.103
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0064 0.0135
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.012 0.2318 0.9632
Plasmodium vivax JmjC domain containing protein 0.0035 0.0489 0.0996
Echinococcus granulosus lysine specific demethylase 6a 0.0035 0.0489 0.0479
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1171 0.1119
Schistosoma mansoni hypothetical protein 0.0133 0.2589 0.2545
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0136 0.0246
Trypanosoma cruzi cysteine peptidase, putative 0.0138 0.2704 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0019 0.0136 0.0126
Brugia malayi nuclear hormone receptor 0.0019 0.0136 0.0246
Trichomonas vaginalis set domain proteins, putative 0.0251 0.5121 1
Leishmania major cathepsin L-like protease 0.0036 0.0514 0.1721
Loa Loa (eye worm) cytochrome P450 family protein 0.0098 0.1841 0.3878
Schistosoma mansoni intermediate filament proteins 0.0027 0.0306 0.0249
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0136 0.0246
Leishmania major cysteine peptidase A (CPA) 0.0036 0.0514 0.1721
Brugia malayi Bromodomain containing protein 0.0042 0.0627 0.1284
Loa Loa (eye worm) hypothetical protein 0.0035 0.0489 0.103
Echinococcus granulosus muscleblind protein 0.0147 0.2901 0.2893
Trypanosoma cruzi cysteine protease, putative 0.0019 0.0136 0.0292
Loa Loa (eye worm) hypothetical protein 0.0028 0.0334 0.0703
Schistosoma mansoni bromodomain containing protein 0.0068 0.1198 0.1146
Brugia malayi Papain family cysteine protease containing protein 0.0036 0.0514 0.1045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0019 0.0136 0.0287
Echinococcus multilocularis muscleblind protein 1 0.0147 0.2901 0.2893
Schistosoma mansoni cpg binding protein 0.0037 0.0537 0.0481
Brugia malayi ecdysteroid receptor 0.0019 0.0136 0.0246
Loa Loa (eye worm) TAR-binding protein 0.0067 0.1171 0.2467
Echinococcus granulosus peptidase Clp S14 family 0.012 0.2318 0.231
Loa Loa (eye worm) hypothetical protein 0.0024 0.0256 0.054
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0489 0.103
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0036 0.0514 0.0504
Loa Loa (eye worm) hypothetical protein 0.0019 0.0136 0.0287
Onchocerca volvulus Cathepsin F homolog 0.0036 0.0514 0.0758
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0624 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0019 0.0136 0.0126
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.2404 0.6479
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0019 0.0136 0.0078
Loa Loa (eye worm) CXXC zinc finger family protein 0.0034 0.0455 0.0959
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0514 0.0758
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0035 0.0489 0.0432
Schistosoma mansoni jumonji/arid domain-containing protein 0.0135 0.2644 0.2601
Brugia malayi cathepsin L-like precursor 0.0024 0.0256 0.05
Loa Loa (eye worm) hypothetical protein 0.0036 0.0514 0.1083
Leishmania major cytochrome p450-like protein 0.0015 0.0064 0.002
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0019 0.0136 0.0126
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0039 0.057 0.056
Echinococcus granulosus cysteine protease 0.0019 0.0136 0.0126
Plasmodium falciparum cysteine proteinase falcipain 3 0.0036 0.0514 0.1068
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0041 0.0044
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0183 0.3676 0.367
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1171 0.1119
Echinococcus granulosus cathepsin l cysteine peptidase 0.0036 0.0514 0.0504
Echinococcus granulosus histone acetyltransferase KAT2B 0.0048 0.0756 0.0746
Entamoeba histolytica cysteine proteinase, putative 0.0036 0.0514 0.774
Loa Loa (eye worm) inositol-1 0.0036 0.0517 0.109
Schistosoma mansoni retinoic acid receptor RXR 0.0019 0.0136 0.0078
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0015 0.0064 0.002
Brugia malayi jmjC domain containing protein 0.0035 0.0489 0.0991
Loa Loa (eye worm) hypothetical protein 0.0019 0.0136 0.0287
Brugia malayi Bromodomain containing protein 0.008 0.1446 0.3017
Echinococcus multilocularis phd:f box containing protein 0.0035 0.0489 0.0479
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.2704 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0096 0.0037
Brugia malayi hypothetical protein 0.0233 0.4747 1
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0183 0.3676 0.367
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0019 0.0136 0.0292
Brugia malayi Cathepsin L-like precursor 0.0024 0.0256 0.05
Loa Loa (eye worm) fibroinase 0.0036 0.0514 0.1083
Schistosoma mansoni cpg binding protein 0.0037 0.0537 0.0481
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.2704 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0427 0.1005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0514 0.0758
Echinococcus multilocularis peptidase Clp (S14 family) 0.012 0.2318 0.231
Schistosoma mansoni phosphatidylserine receptor 0.0035 0.0489 0.0432
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.019 0.04
Loa Loa (eye worm) hypothetical protein 0.0019 0.0136 0.0287
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0517 0.0765
Echinococcus granulosus lysine specific demethylase 5A 0.0135 0.2644 0.2636
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0019 0.0136 0.0078
Loa Loa (eye worm) hypothetical protein 0.0019 0.0136 0.0287
Entamoeba histolytica cysteine protease, putative 0.0036 0.0514 0.774
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0514 0.0758
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.022 0.4469 0.9415
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.2404 0.6479
Onchocerca volvulus Protein cycle homolog 0.002 0.0154 0.0035
Onchocerca volvulus Cathepsin L homolog 0.0036 0.0514 0.0758
Echinococcus granulosus cathepsin L 0.0019 0.0136 0.0126
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0035 0.0489 0.1625
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0183 0.3676 1
Plasmodium vivax vivapain-2 0.0036 0.0514 0.1068
Trypanosoma cruzi cysteine peptidase, putative 0.0138 0.2704 1
Trypanosoma cruzi cysteine proteinase, putative 0.0019 0.0136 0.0292
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.2704 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0883 0.0873
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0172 0.0362
Echinococcus granulosus jumonji domain containing 1A 0.0035 0.0489 0.0479
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0022
Loa Loa (eye worm) ctsf protein 0.0036 0.0514 0.1083
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.1122 0.1113
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0064 0.002
Loa Loa (eye worm) hypothetical protein 0.0035 0.0489 0.103
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.0064 0.002
Brugia malayi Cytochrome P450 family protein 0.0015 0.0064 0.0093
Echinococcus granulosus lamin 0.0027 0.0306 0.0296
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0036 0.0514 0.1083
Schistosoma mansoni hypothetical protein 0.0048 0.0757 0.0702
Echinococcus multilocularis cathepsin L 0.0019 0.0136 0.0126
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0133 0.2589 0.2581
Onchocerca volvulus 0.0028 0.0334 0.0396
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0126 0.2447 0.9026
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0019 0.0136 0.0126
Loa Loa (eye worm) hypothetical protein 0.0027 0.0306 0.0645
Echinococcus multilocularis lysine specific demethylase 6a 0.0035 0.0489 0.0479
Brugia malayi Inositol-1 0.0036 0.0517 0.1052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0514 0.0758
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0064 0.0135
Brugia malayi acetyltransferase, GNAT family protein 0.0156 0.3086 0.6486
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0514 0.0758
Echinococcus multilocularis FTZ F1 alpha 0.0019 0.0136 0.0126
Brugia malayi jmjC domain containing protein 0.0035 0.0489 0.0991
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0063 0.1093 0.2702
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0514 0.0758
Echinococcus granulosus histone acetyltransferase KAT2B 0.0149 0.2943 0.2936
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0517 0.0765
Schistosoma mansoni lamin 0.0027 0.0306 0.0249
Echinococcus multilocularis tar DNA binding protein 0.0067 0.1171 0.1162
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0048 0.0756 0.1914
Plasmodium vivax SET domain protein, putative 0.0032 0.0427 0.0822
Loa Loa (eye worm) cytochrome P450 0.0015 0.0064 0.0135
Schistosoma mansoni survival motor neuron protein 0.0048 0.0757 0.0702
Echinococcus multilocularis JmjC domain containing protein 4 0.0035 0.0489 0.0479
Loa Loa (eye worm) CYP4Cod1 0.0015 0.0064 0.0135
Brugia malayi hypothetical protein 0.0028 0.0334 0.0664
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0514 0.0758
Echinococcus multilocularis dnaJ subfamily B 0.0478 1 1
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0035 0.0489 0.1175
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0883 0.1825
Toxoplasma gondii cathepsin CPL 0.0036 0.0514 0.1246
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0256 0.0241
Trypanosoma cruzi cysteine proteinase, putative 0.0019 0.0136 0.0292
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0019 0.0136 0.0246
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0183 0.3676 1
Brugia malayi jmjC domain containing protein 0.0035 0.0489 0.0991
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0254 0.0196
Brugia malayi RNA binding protein 0.0067 0.1171 0.2435
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0883 0.0829
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0096 0.0086
Schistosoma mansoni thyroid hormone receptor 0.0152 0.2991 0.2949
Trichomonas vaginalis bromodomain-containing protein, putative 0.0048 0.0756 0.1242
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0028 0.0334 0.0703
Brugia malayi Cytochrome P450 family protein 0.0015 0.0064 0.0093
Brugia malayi nuclear receptor NHR-88 0.0019 0.0136 0.0246
Echinococcus granulosus ecdysone induced protein 78C 0.0019 0.0136 0.0126
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0514 0.0758
Loa Loa (eye worm) hypothetical protein 0.0183 0.3676 0.7745
Brugia malayi Cathepsin L-like precursor 0.0036 0.0514 0.1045
Leishmania major cathepsin L-like protease 0.0036 0.0514 0.1721
Brugia malayi aryl hydrocarbon receptor AHR-1 0.002 0.0154 0.0283
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0435 0.1028
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0063 0.1093 0.2702
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0072 0.1288 0.1237
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.1171 0.2467
Entamoeba histolytica cysteine proteinase, putative 0.0024 0.0256 0.2463
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0136 0.0246
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.0064 0.002
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0096 0.0086
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0427 0.037
Echinococcus multilocularis jumonji domain containing 1A 0.0035 0.0489 0.0479
Echinococcus multilocularis cpg binding protein 0.0037 0.0537 0.0527
Echinococcus multilocularis 0.0015 0.0064 0.0054
Onchocerca volvulus 0.0036 0.0514 0.0758
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0019 0.0136 0.0287
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0183 0.3676 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0514 0.0758
Brugia malayi Cathepsin L-like precursor 0.0036 0.0514 0.1045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0019 0.0136 0.0287
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.2404 0.6479
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0514 0.0758
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0514 0.0758
Leishmania major cytochrome p450-like protein 0.0015 0.0064 0.002
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0183 0.3676 1
Loa Loa (eye worm) acetyltransferase 0.0156 0.3086 0.6501
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0183 0.3676 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0296 0.0623
Onchocerca volvulus 0.0027 0.0306 0.0341
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0019 0.0136 0.0126
Echinococcus multilocularis cysteine protease 0.0036 0.0514 0.0504
Loa Loa (eye worm) hypothetical protein 0.0044 0.0679 0.143
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0517 0.0508
Loa Loa (eye worm) hypothetical protein 0.0233 0.4747 1
Schistosoma mansoni cathepsin F (C01 family) 0.0036 0.0514 0.0458
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0124 0.2404 0.2397
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0514 0.0758
Leishmania major cathepsin L-like protease 0.0138 0.2704 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0514 0.0758
Brugia malayi Pre-SET motif family protein 0.0032 0.0427 0.0861
Onchocerca volvulus 0.0036 0.0514 0.0758
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0514 0.0758
Echinococcus granulosus cathepsin L cysteine protease 0.0019 0.0136 0.0126
Onchocerca volvulus 0.0036 0.0514 0.0758
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0019 0.0136 0.0246
Schistosoma mansoni cytochrome P450 0.0015 0.0064 0.0005
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0064 0.002
Loa Loa (eye worm) hypothetical protein 0.007 0.1234 0.2599
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0517 0.0508
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0019 0.0136 0.0078
Echinococcus granulosus cathepsin l1 0.0036 0.0514 0.0504
Brugia malayi jmjC domain containing protein 0.0132 0.2563 0.5379
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0757 0.1559
Onchocerca volvulus 0.0036 0.0514 0.0758
Onchocerca volvulus 0.0251 0.5121 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0254 0.0243
Echinococcus multilocularis thyroid hormone receptor alpha 0.0152 0.2991 0.2983
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0789 0.0734
Loa Loa (eye worm) hypothetical protein 0.0147 0.2901 0.6111
Leishmania major cathepsin L-like protease 0.0036 0.0514 0.1721
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0019 0.0136 0.0287
Schistosoma mansoni inositol monophosphatase 0.0036 0.0517 0.0461
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.1122 0.1113
Brugia malayi Cathepsin L-like precursor 0.0024 0.0256 0.05
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0124 0.2404 0.8866
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.002 0.0154 0.0283
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0496 0.0486
Echinococcus granulosus phd:f box containing protein 0.0035 0.0489 0.0479
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0789 0.0779
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0124 0.2404 0.2397
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0496 0.0486
Schistosoma mansoni aldehyde dehydrogenase 0.0124 0.2404 0.2359
Brugia malayi jmjC domain containing protein 0.0135 0.2644 0.5552
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0306 0.0605
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0156 0.3086 0.3079
Loa Loa (eye worm) hypothetical protein 0.002 0.0154 0.0324
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0883 0.0873
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0048 0.0756 0.175
Schistosoma mansoni hypothetical protein 0.002 0.0172 0.0114
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.4747 0.4741
Toxoplasma gondii histone lysine methyltransferase SET1 0.0071 0.1256 0.33
Brugia malayi Cathepsin L-like cysteine proteinase 0.0024 0.0256 0.05
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0514 0.0758
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0514 0.0758
Echinococcus multilocularis cysteine protease 0.0036 0.0514 0.0504
Schistosoma mansoni hypothetical protein 0.0015 0.0064 0.0005
Onchocerca volvulus 0.0027 0.0306 0.0341
Loa Loa (eye worm) hypothetical protein 0.0019 0.0136 0.0287
Echinococcus granulosus cytochrome P450 2K1 0.0015 0.0064 0.0054
Echinococcus multilocularis musashi 0.0027 0.0306 0.0296
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0514 0.0758
Brugia malayi PHD-finger family protein 0.003 0.0385 0.0771
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0036 0.0514 0.0504
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0435 0.1587
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0624 0.5
Toxoplasma gondii aldehyde dehydrogenase 0.0124 0.2404 0.6479
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1171 0.1119
Schistosoma mansoni RAR-like nuclear receptor 0.0019 0.0136 0.0078
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0019 0.0136 0.0287
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.2704 1
Schistosoma mansoni inositol monophosphatase 0.0036 0.0517 0.0461
Echinococcus multilocularis lysine specific demethylase 5A 0.0132 0.2563 0.2555
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0489 0.103
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0019 0.0136 0.0078
Brugia malayi Cathepsin L-like precursor 0.0036 0.0514 0.1045
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0035 0.0489 0.1625
Brugia malayi photoreceptor-specific nuclear receptor 0.0019 0.0136 0.0246
Schistosoma mansoni protein phosphatase 2C 0.0035 0.0489 0.0432
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.2704 1
Brugia malayi Pre-SET motif family protein 0.022 0.4469 0.9413
Loa Loa (eye worm) hypothetical protein 0.0019 0.0136 0.0287
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0789 0.0734
Trypanosoma brucei cytochrome P450, putative 0.0015 0.0064 0.002
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0124 0.2404 1
Onchocerca volvulus 0.0032 0.0427 0.0583
Leishmania major cathepsin L-like protease 0.0138 0.2704 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0514 0.0758
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0019 0.0136 0.0078
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.2704 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0883 0.0873
Echinococcus granulosus tar DNA binding protein 0.0067 0.1171 0.1162
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0019 0.0136 0.0246
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0514 0.0758
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0048 0.0756 0.1242
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1171 0.1119
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0517 0.1733
Loa Loa (eye worm) hypothetical protein 0.0024 0.0256 0.054
Toxoplasma gondii hypothetical protein 0.0063 0.1093 0.2847
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0019 0.0136 0.0246
Loa Loa (eye worm) hypothetical protein 0.0035 0.0489 0.103
Schistosoma mansoni cpg binding protein 0.0034 0.0455 0.0399
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0019 0.0136 0.0078
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0019 0.0136 0.0126
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.012 0.2318 0.624
Echinococcus granulosus FTZ F1 alpha 0.0019 0.0136 0.0126
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0133 0.2589 0.2581
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.2704 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0019 0.0136 0.0246
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0624 0.1379
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0514 0.0758
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0514 0.0758
Brugia malayi Cathepsin L-like precursor 0.0036 0.0514 0.1045
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0136 0.0126
Schistosoma mansoni peptidase Clp (S14 family) 0.0183 0.3676 0.3639
Echinococcus granulosus lamin dm0 0.0027 0.0306 0.0296
Schistosoma mansoni aldehyde dehydrogenase 0.0124 0.2404 0.2359
Loa Loa (eye worm) hypothetical protein 0.002 0.0154 0.0324
Brugia malayi cytochrome P450 0.0015 0.0064 0.0093
Loa Loa (eye worm) hypothetical protein 0.0019 0.0136 0.0287
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0136 0.0246
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0019 0.0136 0.0126
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0136 0.0126
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0136 0.0078
Schistosoma mansoni hypothetical protein 0.0478 1 1
Brugia malayi Cathepsin L-like precursor 0.0036 0.0514 0.1045
Leishmania major cathepsin L-like protease 0.0138 0.2704 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0514 0.0758
Brugia malayi Cytochrome P450 family protein 0.0098 0.1841 0.3852
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0883 0.1859
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0387 0.0376
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0015 0.0064 0.002
Brugia malayi Probable ClpP-like protease 0.0183 0.3676 0.7736
Loa Loa (eye worm) RNA binding protein 0.0067 0.1171 0.2467
Loa Loa (eye worm) hypothetical protein 0.0048 0.0761 0.1602
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0136 0.0246
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0183 0.3676 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0036 0.0514 0.0504
Loa Loa (eye worm) hypothetical protein 0.0147 0.2901 0.6111
Schistosoma mansoni cathepsin F (C01 family) 0.0024 0.0256 0.0199
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0132 0.2563 0.2555
Echinococcus granulosus aryl hydrocarbon receptor 0.0028 0.0334 0.0324
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0019 0.0136 0.0246
Echinococcus multilocularis lamin 0.0027 0.0306 0.0296
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0019 0.0136 0.0126
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.002 0.0154 0.0324
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0517 0.1733
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0136 0.0292
Schistosoma mansoni coup transcription factor 0.0019 0.0136 0.0078
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0183 0.3676 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.0036 0.0514 0.1721
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0254 0.0243
Schistosoma mansoni jumonji domain containing protein 0.0035 0.0489 0.0432
Loa Loa (eye worm) hypothetical protein 0.0019 0.0136 0.0287
Onchocerca volvulus Cathepsin L homolog 0.0036 0.0514 0.0758
Brugia malayi jmjC domain containing protein 0.0035 0.0489 0.0991
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0136 0.0246
Entamoeba histolytica cysteine proteinase, putative 0.0036 0.0514 0.774
Schistosoma mansoni lamin 0.0027 0.0306 0.0249
Echinococcus multilocularis zinc finger protein 0.0025 0.0272 0.0261
Brugia malayi Cathepsin L-like precursor 0.0036 0.0514 0.1045
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0136 0.0126
Brugia malayi Steroid receptor seven-up type 2 0.0019 0.0136 0.0246
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0514 0.0758
Loa Loa (eye worm) hypothetical protein 0.0038 0.0548 0.1154
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0883 0.0829
Brugia malayi Cytochrome P450 family protein 0.0015 0.0064 0.0093
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0036 0.0514 0.1068
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0048 0.0756 0.1914
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0019 0.0136 0.0078
Onchocerca volvulus 0.0048 0.0757 0.1245
Leishmania major cytochrome p450-like protein 0.0015 0.0064 0.002
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0036 0.0514 0.0758
Loa Loa (eye worm) jmjC domain-containing protein 0.0135 0.2644 0.557
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.002 0.0154 0.0096
Trypanosoma cruzi major cysteine proteinase, putative 0.0109 0.2069 0.7597
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0306 0.0645
Schistosoma mansoni jumonji domain containing protein 0.0132 0.2563 0.2518
Leishmania major cathepsin L-like protease 0.0036 0.0514 0.1721
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1171 0.1119
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0427 0.0417
Brugia malayi intermediate filament protein 0.0027 0.0306 0.0605
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0019 0.0136 0.0078
Brugia malayi hypothetical protein 0.002 0.0154 0.0283
Schistosoma mansoni cathepsin F (C01 family) 0.0036 0.0514 0.0458
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.2704 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0883 0.0873
Loa Loa (eye worm) steroid hormone receptor 0.0019 0.0136 0.0287
Echinococcus granulosus cathepsin l1 0.0024 0.0256 0.0246
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0063 0.1093 0.2847
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0136 0.0245
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0883 0.0829
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0306 0.0645
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0136 0.0245
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.002 0.0154 0.0283
Leishmania major cathepsin L-like protease 0.0036 0.0514 0.1721
Echinococcus multilocularis muscleblind protein 0.0147 0.2901 0.2893
Schistosoma mansoni zinc finger protein 0.0025 0.0272 0.0214
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0517 0.1733
Brugia malayi Muscleblind-like protein 0.0147 0.2901 0.6095
Echinococcus multilocularis cathepsin L cysteine protease 0.0036 0.0514 0.0504
Onchocerca volvulus 0.0036 0.0514 0.0758
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0035 0.0489 0.1625
Echinococcus granulosus zinc finger protein 0.0025 0.0272 0.0261
Loa Loa (eye worm) hypothetical protein 0.002 0.0154 0.0324
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0035 0.0489 0.1175
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0036 0.0514 0.1083
Echinococcus granulosus JmjC domain containing protein 4 0.0035 0.0489 0.0479
Schistosoma mansoni phd/f-box containing protein 0.0035 0.0489 0.0432
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0517 0.0765
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0019 0.0136 0.0287
Echinococcus multilocularis cathepsin L cysteine protease 0.0036 0.0514 0.0504
Schistosoma mansoni thyroid hormone receptor 0.0152 0.2991 0.2949
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0136 0.0246
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0183 0.3676 0.5
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0517 0.7809
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0256 0.0241
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.1171 0.2435
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0036 0.0514 0.1068
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0136 0.0126
Echinococcus granulosus cpg binding protein 0.0037 0.0537 0.0527
Brugia malayi hypothetical protein 0.002 0.0154 0.0283
Echinococcus granulosus intermediate filament protein 0.0027 0.0306 0.0296
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0019 0.0136 0.0292
Plasmodium falciparum JmjC domain-containing protein, putative 0.0035 0.0489 0.0996
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0136 0.0078
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.012 0.2318 0.9632
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.2704 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0517 0.1255
Schistosoma mansoni steroid hormone receptor ad4bp 0.0019 0.0136 0.0078
Trypanosoma cruzi cysteine peptidase, putative 0.0138 0.2704 1
Brugia malayi CXXC zinc finger family protein 0.0034 0.0455 0.0921
Loa Loa (eye worm) cysteine protease 0.0036 0.0514 0.1083
Onchocerca volvulus 0.0034 0.0455 0.064
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0183 0.3676 1
Brugia malayi steroid hormone receptor 0.0019 0.0136 0.0246
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0019 0.0136 0.0246
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.2704 1
Brugia malayi TAR-binding protein 0.0067 0.1171 0.2435
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0517 0.1733
Echinococcus multilocularis aryl hydrocarbon receptor 0.0028 0.0334 0.0324
Onchocerca volvulus 0.0036 0.0514 0.0758
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0132 0.2563 0.2555
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0036 0.0514 0.0758
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0517 0.1255
Trypanosoma cruzi cruzipain precursor, putative 0.0138 0.2704 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0183 0.3676 1
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.4747 0.4741
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0183 0.3676 1
Onchocerca volvulus 0.0036 0.0514 0.0758
Loa Loa (eye worm) hypothetical protein 0.002 0.0154 0.0324
Echinococcus multilocularis lamin dm0 0.0027 0.0306 0.0296
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0096 0.0037
Plasmodium vivax vivapain-2 0.0036 0.0514 0.1068
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0019 0.0136 0.0126
Leishmania major hypothetical protein, conserved 0.0035 0.0489 0.1625
Schistosoma mansoni jumonji/arid domain-containing protein 0.0135 0.2644 0.2601
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0015 0.0064 0.002
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0039 0.057 0.056
Loa Loa (eye worm) hypothetical protein 0.0049 0.0789 0.1661

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 0.34 mg kg-1 Immunomodulatory activity in ip dosed BALB/c mouse assessed as reduction in lymphocyte using FITC-conjugated hamster antimouse CD3e antibody by flow cytometry ChEMBL. 20337461

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.