Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | LCK proto-oncogene, Src family tyrosine kinase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.001 | 0.0013 | 0.0013 |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.001 | 0.0013 | 0.0012 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.3617 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.001 | 0.0013 | 0.0012 |
Leishmania major | 0.3617 | 1 | 0.5 | |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.3617 | 1 | 1 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.3617 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.001 | 0.0013 | 0.0012 |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.3617 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.001 | 0.0013 | 0.0012 |
Echinococcus multilocularis | c src tyrosine kinase | 0.001 | 0.0013 | 0.0012 |
Brugia malayi | Sex muscle abnormal protein 5 | 0.0009 | 0.0009 | 0.0009 |
Loa Loa (eye worm) | SRC-1 | 0.001 | 0.0013 | 0.0012 |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Loa Loa (eye worm) | sex muscle abnormal protein 5 | 0.0009 | 0.0009 | 0.0009 |
Brugia malayi | Variant SH3 domain containing protein | 0.0009 | 0.0009 | 0.0009 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.001 | 0.0013 | 0.0012 |
Echinococcus granulosus | NCK adaptor protein | 0.0009 | 0.0009 | 0.0009 |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Schistosoma mansoni | tyrosine kinase | 0.001 | 0.0013 | 0.0013 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.3617 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.001 | 0.0013 | 0.0012 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.001 | 0.0013 | 0.0012 |
Brugia malayi | Variant SH3 domain containing protein | 0.0009 | 0.0009 | 0.0009 |
Schistosoma mansoni | tyrosine kinase | 0.001 | 0.0013 | 0.0013 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.001 | 0.0013 | 0.0012 |
Schistosoma mansoni | nck2/grb4 | 0.0009 | 0.0009 | 0.0009 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.001 | 0.0013 | 0.0012 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0009 | 0.0009 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.001 | 0.0013 | 0.0012 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.001 | 0.0013 | 0.0012 |
Brugia malayi | SRC-1 | 0.001 | 0.0013 | 0.0012 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.001 | 0.0013 | 0.0012 |
Schistosoma mansoni | adapter molecule crk | 0.0009 | 0.0009 | 0.0009 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.001 | 0.0013 | 0.0012 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0009 | 0.0009 | 0.0009 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.001 | 0.0013 | 0.0012 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0009 | 0.0009 | 0.0009 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.001 | 0.0013 | 0.0012 |
Echinococcus multilocularis | NCK adaptor protein | 0.0009 | 0.0009 | 0.0009 |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.001 | 0.0013 | 0.0012 |
Echinococcus granulosus | growth factor receptor bound protein 2 | 0.0009 | 0.0009 | 0.0009 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.3617 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.001 | 0.0013 | 0.0012 |
Echinococcus granulosus | c src tyrosine kinase | 0.001 | 0.0013 | 0.0012 |
Schistosoma mansoni | tyrosine kinase | 0.001 | 0.0013 | 0.0013 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.001 | 0.0013 | 0.0012 |
Echinococcus multilocularis | growth factor receptor bound protein 2 | 0.0009 | 0.0009 | 0.0009 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0006 | 0 | 0.5 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.3617 | 1 | 1 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.001 | 0.0013 | 0.0012 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase abl1 | 0.0009 | 0.0009 | 0.0009 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.001 | 0.0013 | 0.0012 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0009 | 0.0009 | 0.0009 |
Schistosoma mansoni | tyrosine kinase | 0.001 | 0.0013 | 0.0013 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.001 | 0.0013 | 0.0012 |
Toxoplasma gondii | fructose-bisphospatase II | 0.3617 | 1 | 1 |
Onchocerca volvulus | 0.0006 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.