Detailed information for compound 111612

Basic information

Technical information
  • TDR Targets ID: 111612
  • Name: (3S)-5-benzylsulfanyl-3-[(5-bromopyridine-3-c arbonyl)amino]-4-oxopentanoic acid
  • MW: 437.308 | Formula: C18H17BrN2O4S
  • H donors: 2 H acceptors: 5 LogP: 2.28 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C[C@@H](C(=O)CSCc1ccccc1)NC(=O)c1cncc(c1)Br
  • InChi: 1S/C18H17BrN2O4S/c19-14-6-13(8-20-9-14)18(25)21-15(7-17(23)24)16(22)11-26-10-12-4-2-1-3-5-12/h1-6,8-9,15H,7,10-11H2,(H,21,25)(H,23,24)/t15-/m0/s1
  • InChiKey: SZRHFBSJKYTCPW-HNNXBMFYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (3S)-5-benzylsulfanyl-3-[(5-bromopyridine-3-carbonyl)amino]-4-oxo-pentanoic acid
  • (3S)-5-(benzylthio)-3-[[(5-bromo-3-pyridyl)-oxomethyl]amino]-4-oxopentanoic acid
  • (3S)-5-benzylsulfanyl-3-[(5-bromopyridin-3-yl)carbonylamino]-4-oxo-pentanoic acid
  • (3S)-5-(benzylthio)-3-[(5-bromonicotinoyl)amino]-4-keto-valeric acid
  • (3S)-3-[(5-bromopyridine-3-carbonyl)amino]-4-oxo-5-(phenylmethylsulfanyl)pentanoic acid
  • (3S)-3-[[(5-bromo-3-pyridyl)-oxomethyl]amino]-4-oxo-5-(phenylmethylthio)pentanoic acid
  • (3S)-5-(benzylthio)-3-[(5-bromopyridine-3-carbonyl)amino]-4-keto-valeric acid
  • (3S)-3-[(5-bromopyridin-3-yl)carbonylamino]-4-oxo-5-(phenylmethylsulfanyl)pentanoic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens caspase 3, apoptosis-related cysteine peptidase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni caspase-7 (C14 family) Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus granulosus caspase Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus multilocularis caspase Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus granulosus caspase 3 Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus multilocularis caspase 3 Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase Get druggable targets OG5_130238 All targets in OG5_130238
Schistosoma mansoni caspase-3 (C14 family) Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase Get druggable targets OG5_130238 All targets in OG5_130238
Schistosoma japonicum ko:K04397 caspase 7, apoptosis-related cysteine protease, putative Get druggable targets OG5_130238 All targets in OG5_130238
Schistosoma japonicum ko:K02187 caspase 3, apoptosis-related cysteine protease, putative Get druggable targets OG5_130238 All targets in OG5_130238
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Cell death protein 3 precursor caspase 3, apoptosis-related cysteine peptidase 277 aa 253 aa 38.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis acetylcholinesterase 0.0752 0.2873 0.287
Giardia lamblia Fructose-bisphosphate aldolase 0.019 0.0664 1
Loa Loa (eye worm) carboxylesterase 0.0127 0.0417 0.0439
Echinococcus multilocularis nAChR subunit 0.0031 0.004 0.0037
Plasmodium vivax ataxin-2 like protein, putative 0.0093 0.0284 0.79
Mycobacterium leprae conserved hypothetical protein 0.0101 0.0314 0.5397
Brugia malayi MH1 domain containing protein 0.0027 0.0023 0.0022
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0027 0.0024 0.0355
Echinococcus granulosus glycine receptor subunit alpha 1 0.0031 0.004 0.0039
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0157 0.0536 0.0565
Brugia malayi Carboxylesterase family protein 0.0127 0.0417 0.0439
Leishmania major hypothetical protein, conserved 0.0112 0.0358 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0027 0.0024 0.1445
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0023 0.0007 0.0193
Echinococcus granulosus TGF beta signal transducer SmadC 0.0049 0.0109 0.0112
Brugia malayi Carboxylesterase family protein 0.0127 0.0417 0.0439
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0031 0.004 0.0039
Brugia malayi Cation transporter family protein 0.0031 0.004 0.0039
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0031 0.004 0.0037
Mycobacterium tuberculosis Conserved protein 0.0112 0.0358 0.1289
Mycobacterium ulcerans putative regulatory protein 0.0034 0.0049 0.1036
Onchocerca volvulus 0.0112 0.0358 0.1357
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.004 0.0039
Mycobacterium ulcerans biphenyl-2,3-diol 1,2-dioxygenase 0.0101 0.0314 0.7488
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0031 0.004 0.0039
Echinococcus granulosus lysine specific demethylase 6a 0.0023 0.0008 0.0005
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0079 0.1192
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0052 0.0122 1
Loa Loa (eye worm) hypothetical protein 0.0109 0.0346 0.0363
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0031 0.004 0.0039
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0185 0.0645 0.0681
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0025 0.0016 0.0013
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0026 0.0021 0.0019
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0041 0.0079 0.2056
Echinococcus granulosus caspase 2 0.0032 0.0044 0.0043
Schistosoma mansoni hypothetical protein 0.0075 0.0211 0.0221
Schistosoma mansoni hypothetical protein 0.0075 0.0211 0.0221
Plasmodium vivax glyoxalase I, putative 0.0101 0.0314 0.8745
Loa Loa (eye worm) hypothetical protein 0.0031 0.004 0.0039
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0052 0.0122 0.1955
Onchocerca volvulus 0.0045 0.0094 0.0348
Brugia malayi jmjC domain containing protein 0.0023 0.0008 0.0005
Toxoplasma gondii LsmAD domain-containing protein 0.0093 0.0284 0.79
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0034 0.0051 0.0163
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0025 0.0016 0.0012
Echinococcus granulosus intermediate filament protein 0.0058 0.0144 0.015
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0127 0.0417 0.0439
Loa Loa (eye worm) hypothetical protein 0.0031 0.004 0.0039
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.004 0.0039
Echinococcus granulosus survival motor neuron protein 1 0.022 0.0783 0.0827
Brugia malayi Carboxylesterase family protein 0.0752 0.2873 0.3043
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0031 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0005
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0026 0.0021 0.0589
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0026 0.0021 0.0019
Loa Loa (eye worm) TAR-binding protein 0.0208 0.0736 0.0778
Onchocerca volvulus 0.0058 0.0144 0.054
Leishmania major alpha glucosidase II subunit, putative 0.0041 0.0079 0.2209
Schistosoma mansoni peptidase Clp (S14 family) 0.0052 0.0122 0.0126
Brugia malayi Carboxylesterase family protein 0.0127 0.0417 0.0439
Leishmania major hypothetical protein, conserved 0.0023 0.0008 0.0208
Brugia malayi hypothetical protein 0.0425 0.1589 0.1682
Schistosoma mansoni acetylcholinesterase 0.0127 0.0417 0.0439
Schistosoma mansoni aryl hydrocarbon receptor 0.0045 0.0096 0.0098
Mycobacterium ulcerans carboxylesterase, LipT 0.0127 0.0417 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0044 0.0043
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0025 0.0016 0.0012
Loa Loa (eye worm) hypothetical protein 0.0112 0.0358 0.0376
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0045 0.0094 0.0097
Loa Loa (eye worm) hypothetical protein 0.0031 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0127 0.0417 0.0439
Echinococcus multilocularis glycine receptor subunit beta 0.0031 0.004 0.0037
Trypanosoma brucei Metacaspase-4 0.0032 0.0044 0.1217
Schistosoma mansoni alpha glucosidase 0.0041 0.0079 0.0081
Loa Loa (eye worm) hypothetical protein 0.0425 0.1589 0.1682
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0031 0.004 0.0039
Trichomonas vaginalis penicillin-binding protein, putative 0.0112 0.0358 0.5392
Giardia lamblia GTOR 0.0026 0.0021 0.0216
Brugia malayi excitatory GABA receptor EXP-1A 0.0031 0.004 0.0039
Loa Loa (eye worm) acetylcholinesterase 1 0.0752 0.2873 0.3043
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0031 0.004 0.0039
Brugia malayi indoleamine 2,3-dioxygenase 0.2421 0.9432 1
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0044 0.0657
Schistosoma mansoni hypothetical protein 0.0051 0.0117 0.012
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0031 0.004 0.0039
Loa Loa (eye worm) inositol-1 0.0027 0.0024 0.0022
Echinococcus multilocularis jumonji domain containing 1A 0.0023 0.0008 0.0004
Brugia malayi beta-lactamase family protein 0.0112 0.0358 0.0376
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0031 0.004 0.0039
Trypanosoma cruzi hypothetical protein, conserved 0.0112 0.0358 1
Mycobacterium ulcerans hypothetical protein 0.0101 0.0314 0.7488
Mycobacterium leprae Probable lipase LipE 0.0112 0.0358 0.6186
Mycobacterium tuberculosis Probable esterase LipL 0.0112 0.0358 0.1289
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0031 0.004 0.0037
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0031 0.004 0.0039
Brugia malayi Carboxylesterase family protein 0.0752 0.2873 0.3043
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0023 0.0008 0.0208
Onchocerca volvulus 0.0031 0.004 0.0141
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0044 0.0657
Brugia malayi hypothetical protein 0.0183 0.0636 0.0671
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0052 0.0122 0.0119
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0093 0.0282 0.6715
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0021 0.0319
Echinococcus multilocularis neutral alpha glucosidase AB 0.0041 0.0079 0.0076
Brugia malayi jmjC domain containing protein 0.0023 0.0008 0.0005
Trypanosoma cruzi metacaspase, putative 0.0032 0.0044 0.1217
Trypanosoma brucei trypanothione reductase 0.0066 0.0175 0.4898
Onchocerca volvulus 0.0112 0.0358 0.1357
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0023 0.0007 0.0193
Loa Loa (eye worm) hypoxia-induced factor 1 0.014 0.0469 0.0494
Echinococcus multilocularis indoleamine 2,3 dioxygenase 2 0.2421 0.9432 0.9432
Mycobacterium tuberculosis Probable lipase LipD 0.0112 0.0358 0.1289
Echinococcus granulosus para nitrobenzyl esterase 0.0127 0.0417 0.0439
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0079 0.1192
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0023 0.0008 0.0015
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0042 0.0082 0.0079
Trypanosoma brucei PAB1-binding protein , putative 0.0093 0.0284 0.794
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0112 0.0358 0.1289
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0034 0.0051 0.0697
Echinococcus granulosus lamin dm0 0.0058 0.0144 0.015
Mycobacterium ulcerans hypothetical protein 0.0101 0.0314 0.7488
Schistosoma mansoni hypothetical protein 0.0075 0.0211 0.0221
Schistosoma mansoni hypothetical protein 0.0045 0.0094 0.0097
Loa Loa (eye worm) hypothetical protein 0.0031 0.004 0.0039
Trichomonas vaginalis sucrase-isomaltase, putative 0.0041 0.0079 0.1192
Brugia malayi hypothetical protein 0.0127 0.0417 0.0439
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0023 0.0007 0.0004
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.015 0.0506 0.183
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0031 0.004 0.0039
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0023 0.0007 0.0193
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0031 0.004 0.0039
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0026 0.0021 0.0589
Echinococcus multilocularis caspase 8 0.0032 0.0044 0.004
Brugia malayi MH1 domain containing protein 0.0027 0.0023 0.0022
Schistosoma mansoni jumonji/arid domain-containing protein 0.0086 0.0255 0.0267
Loa Loa (eye worm) hypothetical protein 0.0054 0.0128 0.0133
Mycobacterium ulcerans glyoxalase GloA 0.0101 0.0314 0.7488
Onchocerca volvulus 0.0058 0.0144 0.054
Echinococcus multilocularis neuroligin 0.0127 0.0417 0.0414
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0112 0.0358 0.1289
Echinococcus granulosus neuroligin 0.0127 0.0417 0.0439
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0031 0.004 0.0039
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0031 0.004 0.0037
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0052 0.0122 0.0126
Onchocerca volvulus 0.0198 0.0694 0.2642
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0112 0.0358 0.0376
Loa Loa (eye worm) hypothetical protein 0.0112 0.0358 0.0376
Trypanosoma brucei metacaspase 5, putative 0.0032 0.0044 0.1217
Trypanosoma brucei metacaspase MCA2 0.0032 0.0044 0.1217
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0026 0.0021 0.0018
Leishmania major hypothetical protein, conserved 0.0093 0.0284 0.794
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0023 0.0007 0.0193
Echinococcus multilocularis Smad4 0.0049 0.0109 0.0106
Schistosoma mansoni intermediate filament proteins 0.0058 0.0144 0.015
Schistosoma mansoni nAChR subunit 0.0031 0.004 0.0039
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0079 0.1192
Mycobacterium tuberculosis Conserved hypothetical protein 0.0101 0.0314 0.1127
Brugia malayi hypothetical protein 0.0054 0.0128 0.0133
Onchocerca volvulus 0.0127 0.0417 0.1583
Echinococcus multilocularis lamin dm0 0.0058 0.0144 0.0141
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0007 0.0193
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0075 0.0211 0.0221
Schistosoma mansoni caspase-3 (C14 family) 0.012 0.0389 0.0409
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0208 0.0736 0.0778
Schistosoma mansoni Smad4 0.0049 0.0109 0.0112
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0079 0.2209
Schistosoma mansoni nAChR subunit 0.0031 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0152 0.0515 0.0543
Leishmania major metacaspase, putative 0.0032 0.0044 0.1217
Mycobacterium ulcerans glyoxalase GloA 0.0101 0.0314 0.7488
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0031 0.004 0.0039
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0032 0.0044 0.1044
Loa Loa (eye worm) hypothetical protein 0.0031 0.004 0.0039
Loa Loa (eye worm) MH2 domain-containing protein 0.0714 0.2725 0.2886
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0157 0.0536 0.0565
Brugia malayi jmjC domain containing protein 0.0023 0.0008 0.0005
Brugia malayi RNA recognition motif domain containing protein 0.0208 0.0736 0.0778
Schistosoma mansoni sodium/solute symporter 0.0025 0.0016 0.0013
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0066 0.0175 0.0618
Mycobacterium ulcerans hypothetical protein 0.0101 0.0314 0.7488
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0086 0.0255 0.0267
Loa Loa (eye worm) hypothetical protein 0.0112 0.0358 0.0376
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0031 0.004 0.0039
Schistosoma mansoni inositol monophosphatase 0.0027 0.0024 0.0022
Loa Loa (eye worm) hypothetical protein 0.0054 0.0128 0.0133
Echinococcus multilocularis mothers against decapentaplegic 5 0.0049 0.0109 0.0106
Loa Loa (eye worm) hypothetical protein 0.0025 0.0016 0.0013
Loa Loa (eye worm) hypothetical protein 0.0101 0.0314 0.033
Onchocerca volvulus Putative protein 0.0687 0.2617 1
Echinococcus multilocularis acetylcholinesterase 0.0752 0.2873 0.287
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0236 0.0846 0.0894
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0079 0.2209
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0025
Onchocerca volvulus 0.0112 0.0358 0.1357
Schistosoma mansoni inositol transporter 0.0025 0.0016 0.0013
Schistosoma mansoni BC026374 protein (S09 family) 0.0127 0.0417 0.0439
Echinococcus granulosus sodium:glucose cotransporter 0.0025 0.0016 0.0013
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0031 0.004 0.0039
Trichomonas vaginalis esterase, putative 0.0112 0.0358 0.5392
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0127 0.0417 0.0439
Brugia malayi Probable ClpP-like protease 0.0052 0.0122 0.0126
Loa Loa (eye worm) indoleamine 2,3-dioxygenase 0.2421 0.9432 1
Mycobacterium tuberculosis Carboxylesterase LipT 0.0127 0.0417 0.1505
Plasmodium vivax glyoxalase I, putative 0.0101 0.0314 0.8745
Loa Loa (eye worm) hypothetical protein 0.0075 0.0211 0.0221
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.0314 0.4729
Echinococcus granulosus peptidase Clp S14 family 0.0034 0.0051 0.0051
Echinococcus multilocularis caspase 3 0.0088 0.0263 0.026
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0031 0.004 0.0039
Brugia malayi hypothetical protein 0.006 0.0154 0.016
Echinococcus granulosus glycine receptor subunit alpha 1 0.0031 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0226 0.0805 0.0851
Loa Loa (eye worm) hypothetical protein 0.0031 0.004 0.0039
Schistosoma mansoni survival motor neuron protein 0.0045 0.0094 0.0097
Mycobacterium tuberculosis Probable reductase 0.015 0.0506 0.183
Schistosoma mansoni caspase-7 (C14 family) 0.0032 0.0044 0.0043
Echinococcus granulosus glycine receptor subunit beta 0.0031 0.004 0.0039
Onchocerca volvulus 0.0025 0.0016 0.0048
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0044 0.1044
Schistosoma mansoni hypothetical protein 0.086 0.3297 0.3493
Brugia malayi MH2 domain containing protein 0.0049 0.0109 0.0112
Schistosoma mansoni nAChR subunit 0.0031 0.004 0.0039
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0127 0.0417 0.1505
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0044 0.0657
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0026 0.0021 0.0589
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0127 0.0417 0.0439
Schistosoma mansoni tar DNA-binding protein 0.0208 0.0736 0.0778
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0023 0.0007 0.0193
Schistosoma mansoni jumonji/arid domain-containing protein 0.0086 0.0255 0.0267
Echinococcus multilocularis transfer RNA-Lys 0.0034 0.0049 0.0046
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0025 0.0016 0.0012
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0079 0.0902
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0157 0.0536 0.0565
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0023 0.0008 0.0005
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0026 0.0021 0.0589
Leishmania major glyoxalase I,trypanothione-dependent glyoxalase I 0.0101 0.0314 0.8769
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0236 0.0846 0.0894
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0021 0.0319
Plasmodium vivax thioredoxin reductase, putative 0.0066 0.0175 0.4797
Loa Loa (eye worm) LGC-31 protein 0.0031 0.004 0.0039
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0039 0.0038
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0044 0.0657
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.004 0.0039
Schistosoma mansoni smad1 5 8 and 0.0049 0.0109 0.0112
Echinococcus granulosus tumor protein p63 0.135 0.522 0.5533
Mycobacterium ulcerans lipase LipD 0.0112 0.0358 0.8562
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.019 0.0664 1
Trichomonas vaginalis glutathione reductase, putative 0.0023 0.0007 0.0105
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0007 0.0193
Brugia malayi bHLH-PAS transcription factor 0.0034 0.0049 0.0049
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0023 0.0008 0.0208
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0052 0.0122 1
Trypanosoma brucei hypothetical protein, conserved 0.0112 0.0358 1
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.0358 0.5392
Brugia malayi hypothetical protein 0.0051 0.0117 0.012
Echinococcus granulosus caspase 8 0.0032 0.0044 0.0043
Brugia malayi jmjC domain containing protein 0.0086 0.0255 0.0267
Echinococcus granulosus lysosomal alpha glucosidase 0.0185 0.0645 0.0681
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0127 0.0417 0.1505
Schistosoma mansoni nAChR subunit 0.0031 0.004 0.0039
Mycobacterium tuberculosis Probable lipase LipE 0.0112 0.0358 0.1289
Echinococcus granulosus caspase 0.012 0.0389 0.0409
Echinococcus granulosus carboxylesterase 5A 0.0752 0.2873 0.3043
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0025 0.0016 0.0245
Echinococcus multilocularis phd:f box containing protein 0.0023 0.0008 0.0004
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0005
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0031 0.004 0.0039
Loa Loa (eye worm) beta-lactamase 0.0112 0.0358 0.0376
Echinococcus multilocularis muscleblind protein 0.0109 0.0346 0.0343
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0052 0.0122 0.3267
Echinococcus multilocularis GPCR, family 2 0.0075 0.0211 0.0208
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0112 0.0358 0.0376
Onchocerca volvulus 0.0127 0.0417 0.1583
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0157 0.0536 0.0565
Loa Loa (eye worm) intermediate filament protein 0.0058 0.0144 0.015
Brugia malayi beta-lactamase 0.0112 0.0358 0.0376
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0112 0.0358 0.1289
Echinococcus granulosus mothers against decapentaplegic 5 0.0049 0.0109 0.0112
Loa Loa (eye worm) hypothetical protein 0.0031 0.004 0.0039
Brugia malayi Glycosyl hydrolases family 31 protein 0.0185 0.0645 0.0681
Echinococcus multilocularis caspase 0.012 0.0389 0.0386
Loa Loa (eye worm) hypothetical protein 0.0031 0.004 0.0039
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0031 0.004 0.0039
Brugia malayi Latrophilin receptor protein 2 0.0075 0.0211 0.0221
Loa Loa (eye worm) hypothetical protein 0.0031 0.004 0.0039
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0051 0.0117 0.0114
Echinococcus granulosus acetylcholinesterase 0.0752 0.2873 0.3043
Echinococcus granulosus BC026374 protein S09 family 0.0127 0.0417 0.0439
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0023 0.0007 0.0004
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0058 0.0144 0.015
Mycobacterium ulcerans esterase/lipase LipP 0.0112 0.0358 0.8562
Loa Loa (eye worm) hypothetical protein 0.0127 0.0417 0.0439
Echinococcus multilocularis JmjC domain containing protein 4 0.0023 0.0008 0.0004
Plasmodium falciparum glutathione reductase 0.0066 0.0175 0.5485
Schistosoma mansoni hypothetical protein 0.2421 0.9432 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0027 0.0024 0.0355
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0044 0.0657
Brugia malayi hypoxia-induced factor 1 0.014 0.0469 0.0494
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0052 0.0122 0.3267
Plasmodium falciparum metacaspase 1 0.0032 0.0044 0.1193
Trypanosoma cruzi lactoylglutathione lyase-like protein, putative 0.0101 0.0314 0.8769
Loa Loa (eye worm) jmjC domain-containing protein 0.0023 0.0008 0.0005
Plasmodium vivax metacaspase 1, putative 0.0032 0.0044 0.1044
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0031 0.004 0.0039
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0023 0.0007 0.0193
Loa Loa (eye worm) hypothetical protein 0.0052 0.0122 0.0126
Plasmodium vivax glutathione reductase, putative 0.0066 0.0175 0.4797
Trypanosoma cruzi trypanothione reductase, putative 0.0066 0.0175 0.4898
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0027 0.0024 0.0656
Plasmodium falciparum glyoxalase I 0.0101 0.0314 1
Echinococcus granulosus phd:f box containing protein 0.0023 0.0008 0.0005
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.0358 0.5392
Brugia malayi Cell death protein 3 precursor 0.0032 0.0044 0.0043
Plasmodium falciparum glyoxalase I 0.0101 0.0314 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.004 0.0039
Trypanosoma cruzi metacaspase, putative 0.0032 0.0044 0.1217
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0052 0.0122 0.1746
Brugia malayi MH1 domain containing protein 0.0049 0.0109 0.0112
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0127 0.0417 0.0439
Schistosoma mansoni hypothetical protein 0.086 0.3297 0.3493
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0031 0.004 0.0037
Echinococcus granulosus high affinity choline transporter 1 0.0226 0.0805 0.0851
Echinococcus granulosus tar DNA binding protein 0.0208 0.0736 0.0778
Loa Loa (eye worm) hypothetical protein 0.0031 0.004 0.0039
Brugia malayi latrophilin 2 splice variant baaae 0.0161 0.0552 0.0582
Brugia malayi MH1 domain containing protein 0.0049 0.0109 0.0112
Loa Loa (eye worm) 4-hydroxyphenylpyruvate dioxygenase 0.0687 0.2617 0.2773
Echinococcus granulosus thioredoxin glutathione reductase 0.0066 0.0175 0.0183
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0031 0.004 0.0039
Brugia malayi intermediate filament protein 0.0058 0.0144 0.015
Echinococcus granulosus lysine specific demethylase 5A 0.0086 0.0255 0.0267
Loa Loa (eye worm) hypothetical protein 0.0031 0.004 0.0039
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0031 0.004 0.0037
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0075 0.0211 0.0208
Echinococcus multilocularis BC026374 protein (S09 family) 0.0127 0.0417 0.0414
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0007 0.0193
Schistosoma mansoni single-minded 0.0045 0.0096 0.0098
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0052 0.0122 0.2798
Toxoplasma gondii ABC1 family protein 0.0112 0.0358 1
Onchocerca volvulus Putative nachr subunit 0.0031 0.004 0.0141
Schistosoma mansoni inositol transporter 0.0025 0.0016 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0044 0.0657
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0027 0.0024
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.019 0.0664 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.004 0.0039
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0086 0.0255 0.0251
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0127 0.0417 0.628
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0296 0.108 0.1142
Loa Loa (eye worm) hypothetical protein 0.0031 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.022 0.0783 0.0827
Mycobacterium ulcerans beta-lactamase 0.0112 0.0358 0.8562
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0027 0.0025
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0023 0.0007 0.0193
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0752 0.2873 0.3043
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.019 0.0664 1
Loa Loa (eye worm) hypothetical protein 0.0127 0.0417 0.0439
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0031 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0031 0.004 0.0039
Echinococcus granulosus acetylcholinesterase 0.0752 0.2873 0.3043
Brugia malayi MH2 domain containing protein 0.0049 0.0109 0.0112
Trypanosoma cruzi PAB1-binding protein , putative 0.0093 0.0284 0.794
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.012 0.0389 0.0409
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0027 0.0024 0.0656
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.015 0.0506 0.8826
Loa Loa (eye worm) hypothetical protein 0.0027 0.0023 0.0022
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0079 0.1192
Loa Loa (eye worm) hypothetical protein 0.0031 0.004 0.0039
Brugia malayi hypothetical protein 0.0152 0.0515 0.0543
Schistosoma mansoni eyes absent homolog 0.0054 0.0128 0.0133
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0024 0.0012 0.002
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.015 0.0506 0.183
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0031 0.004 0.0037
Trypanosoma cruzi trypanothione reductase, putative 0.0023 0.0007 0.0193
Brugia malayi Muscleblind-like protein 0.0109 0.0346 0.0363
Loa Loa (eye worm) hypothetical protein 0.0109 0.0346 0.0363
Loa Loa (eye worm) ACC-1 protein 0.0031 0.004 0.0039
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0166 0.0571 0.2071
Brugia malayi Calcitonin receptor-like protein seb-1 0.0236 0.0846 0.0894
Mycobacterium tuberculosis Conserved protein TB27.3 0.0101 0.0314 0.1127
Loa Loa (eye worm) hypothetical protein 0.0031 0.004 0.0039
Echinococcus granulosus nAChR subunit 0.0031 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0112 0.0358 0.0376
Trichomonas vaginalis spcc417.12 protein, putative 0.0127 0.0417 0.628
Loa Loa (eye worm) MH2 domain-containing protein 0.0049 0.0109 0.0112
Loa Loa (eye worm) nuclear factor I 0.0027 0.0023 0.0022
Schistosoma mansoni smad1 5 8 and 0.0049 0.0109 0.0112
Schistosoma mansoni jumonji domain containing protein 0.0086 0.0255 0.0267
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0079 0.1192
Trypanosoma brucei glucosidase, putative 0.0041 0.0079 0.2209
Schistosoma mansoni gliotactin 0.0127 0.0417 0.0439
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0157 0.0536 0.0533
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0031 0.004 0.0039
Schistosoma mansoni serine/threonine protein kinase 0.0296 0.108 0.1142
Echinococcus multilocularis lysosomal alpha glucosidase 0.0185 0.0645 0.0642
Schistosoma mansoni high-affinity choline transporter 0.0226 0.0805 0.0851
Echinococcus multilocularis lamin 0.0058 0.0144 0.0141
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0023 0.0007 0.0193
Entamoeba histolytica hypothetical protein 0.0051 0.0117 0.1486
Schistosoma mansoni nAChR subunit 0.0031 0.004 0.0039
Onchocerca volvulus 0.0031 0.004 0.0141
Echinococcus multilocularis microtubule associated protein 2 0.0908 0.3485 0.3483
Mycobacterium tuberculosis Probable hydrolase 0.0112 0.0358 0.1289
Onchocerca volvulus 0.0127 0.0417 0.1583
Loa Loa (eye worm) ACC-1 protein 0.0031 0.004 0.0039
Echinococcus multilocularis lysine specific demethylase 5A 0.0086 0.0255 0.0251
Schistosoma mansoni cellular tumor antigen P53 0.0198 0.0694 0.0732
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.012 0.0389 0.0386
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0112 0.0358 0.0376
Echinococcus multilocularis high affinity choline transporter 1 0.0226 0.0805 0.0802
Mycobacterium tuberculosis Conserved protein 0.0101 0.0314 0.1127
Loa Loa (eye worm) hypothetical protein 0.0112 0.0358 0.0376
Onchocerca volvulus 0.0127 0.0417 0.1583
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.019 0.0664 1
Schistosoma mansoni hypothetical protein 0.2421 0.9432 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0044 0.0657
Toxoplasma gondii thioredoxin reductase 0.0066 0.0175 0.4797
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0027 0.0024 0.0404
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0031 0.004 0.0039
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0032 0.0044 0.0043
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0026 0.0021 0.0589
Leishmania major trypanothione reductase 0.0066 0.0175 0.4898
Echinococcus multilocularis inositol monophosphatase 1 0.0027 0.0024 0.002
Brugia malayi Cation transporter family protein 0.0031 0.004 0.0039
Loa Loa (eye worm) jmjC domain-containing protein 0.0086 0.0255 0.0267
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0166 0.0571 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0157 0.0536 0.0565
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0032 0.0044 0.1044
Schistosoma mansoni alpha-glucosidase 0.0159 0.0544 0.0574
Loa Loa (eye worm) hypothetical protein 0.0127 0.0417 0.0439
Loa Loa (eye worm) hypothetical protein 0.0127 0.0417 0.0439
Brugia malayi beta-lactamase family protein 0.0112 0.0358 0.0376
Brugia malayi Carboxylesterase family protein 0.0127 0.0417 0.0439
Brugia malayi Smad1 0.0049 0.0109 0.0112
Loa Loa (eye worm) hypothetical protein 0.0027 0.0023 0.0021
Loa Loa (eye worm) hypothetical protein 0.0027 0.0023 0.0021
Echinococcus multilocularis geminin 0.086 0.3297 0.3295
Trypanosoma cruzi hypothetical protein, conserved 0.0112 0.0358 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0049 0.0109 0.0106
Trypanosoma brucei metacaspase 0.0032 0.0044 0.1217
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0031 0.004 0.0039
Schistosoma mansoni neuroligin 3 (S09 family) 0.0127 0.0417 0.0439
Brugia malayi RNA binding protein 0.0208 0.0736 0.0778
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0052 0.0122 0.3267
Echinococcus multilocularis caspase 2 0.0032 0.0044 0.004
Echinococcus granulosus geminin 0.086 0.3297 0.3493
Echinococcus granulosus microtubule associated protein 2 0.0908 0.3485 0.3692
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0052 0.0122 0.3736
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0157 0.0536 0.0533
Loa Loa (eye worm) hypothetical protein 0.0031 0.004 0.0039
Schistosoma mansoni tar DNA-binding protein 0.0208 0.0736 0.0778
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0044 0.0657
Brugia malayi PAS domain containing protein 0.0045 0.0096 0.0098
Brugia malayi Inositol-1 0.0027 0.0024 0.0022
Schistosoma mansoni hypothetical protein 0.0161 0.0552 0.0582
Mycobacterium tuberculosis Probable oxidoreductase 0.0166 0.0571 0.2071
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0031 0.004 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0021 0.0319
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0027 0.0024 0.0472
Schistosoma mansoni nAChR subunit 0.0031 0.004 0.0039
Entamoeba histolytica hypothetical protein 0.0051 0.0117 0.1486
Toxoplasma gondii glyoxalase I, putative 0.0101 0.0314 0.8745
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0027 0.0024 0.0656
Echinococcus granulosus JmjC domain containing protein 4 0.0023 0.0008 0.0005
Onchocerca volvulus 0.0127 0.0417 0.1583
Trypanosoma cruzi metacaspase 5, putative 0.0032 0.0044 0.1217
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0031 0.004 0.0039
Echinococcus multilocularis beta LACTamase domain containing family member 0.0112 0.0358 0.0355
Brugia malayi MH2 domain containing protein 0.0714 0.2725 0.2886
Loa Loa (eye worm) hypothetical protein 0.0161 0.0552 0.0582
Mycobacterium leprae conserved hypothetical protein 0.0112 0.0358 0.6186
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0112 0.0358 0.8562
Plasmodium falciparum JmjC domain-containing protein, putative 0.0023 0.0008 0.0017
Trichomonas vaginalis penicillin-binding protein, putative 0.0112 0.0358 0.5392
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.004 0.0039
Echinococcus granulosus indoleamine 23 dioxygenase 2 0.2421 0.9432 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0027 0.0024 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0044 0.0657
Echinococcus multilocularis lysine specific demethylase 6a 0.0023 0.0008 0.0004
Onchocerca volvulus 0.0031 0.004 0.0141
Brugia malayi GH02984p 0.0226 0.0805 0.0851
Echinococcus multilocularis lysosomal alpha glucosidase 0.0185 0.0645 0.0642
Loa Loa (eye worm) thioredoxin reductase 0.0066 0.0175 0.0183
Mycobacterium tuberculosis Cadmium inducible protein CadI 0.0101 0.0314 0.1127
Schistosoma mansoni inositol monophosphatase 0.0027 0.0024 0.0022
Mycobacterium tuberculosis Probable dehydrogenase 0.015 0.0506 0.183
Loa Loa (eye worm) hypothetical protein 0.0752 0.2873 0.3043
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0007 0.0193
Schistosoma mansoni phosphatidylserine receptor 0.0023 0.0008 0.0005
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0079 0.1192
Onchocerca volvulus 0.0107 0.0339 0.1283
Echinococcus multilocularis muscleblind protein 1 0.0109 0.0346 0.0343
Schistosoma mansoni microtubule-associated protein tau 0.0908 0.3485 0.3692
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0042 0.0082 0.0084
Plasmodium vivax JmjC domain containing protein 0.0023 0.0008 0.0015
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0041 0.0079 0.0081
Onchocerca volvulus 0.0031 0.004 0.0141
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0007 0.0193
Mycobacterium tuberculosis Putative ferredoxin reductase 0.015 0.0506 0.183
Echinococcus granulosus sodium:myo inositol cotransporter 0.0025 0.0016 0.0013
Schistosoma mansoni jumonji domain containing protein 0.0023 0.0008 0.0005
Echinococcus multilocularis tumor protein p63 0.135 0.522 0.5219
Onchocerca volvulus 0.0183 0.0636 0.2421
Trichomonas vaginalis maltase-glucoamylase, putative 0.0041 0.0079 0.1192
Loa Loa (eye worm) hypothetical protein 0.0112 0.0358 0.0376
Echinococcus granulosus lamin 0.0058 0.0144 0.015
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0027 0.0024 0.0656
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0044 0.0657
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0051 0.0117 0.012
Brugia malayi hypothetical protein 0.022 0.0783 0.0827
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.0358 0.5392
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.019 0.0664 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0075 0.0211 0.0221
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0023 0.0008 0.0005
Brugia malayi Sodium:solute symporter family protein 0.0025 0.0016 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0044 0.0657
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0031 0.004 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0006 0.0091
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0075 0.0211 0.0221
Loa Loa (eye worm) hypothetical protein 0.0127 0.0417 0.0439
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0166 0.0571 0.2071
Trichomonas vaginalis mercuric reductase, putative 0.0023 0.0007 0.0105
Echinococcus granulosus jumonji domain containing 1A 0.0023 0.0008 0.0005
Loa Loa (eye worm) hypothetical protein 0.0058 0.0144 0.015
Brugia malayi Protein kinase domain containing protein 0.0296 0.108 0.1142
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0093 0.0282 0.1011
Plasmodium falciparum ataxin-2 like protein, putative 0.0093 0.0284 0.9033
Schistosoma mansoni protein phosphatase 2C 0.0023 0.0008 0.0005
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0026 0.0021 0.0019
Echinococcus granulosus glycine receptor subunit beta 0.0031 0.004 0.0039
Entamoeba histolytica hypothetical protein 0.0051 0.0117 0.1486
Echinococcus granulosus caspase 3 0.0088 0.0263 0.0275
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0023 0.0007 0.0193
Echinococcus granulosus muscleblind protein 0.0109 0.0346 0.0363
Echinococcus multilocularis para nitrobenzyl esterase 0.0127 0.0417 0.0414
Brugia malayi hypothetical protein 0.0093 0.0284 0.0298
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0039 0.0038
Schistosoma mansoni tar DNA-binding protein 0.0208 0.0736 0.0778
Plasmodium falciparum ataxin-2 like protein, putative 0.0093 0.0284 0.9033
Treponema pallidum fructose-bisphosphate aldolase 0.019 0.0664 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0023 0.0008 0.0005
Loa Loa (eye worm) hypothetical protein 0.0752 0.2873 0.3043
Echinococcus granulosus GPCR family 2 0.0075 0.0211 0.0221
Loa Loa (eye worm) hypothetical protein 0.0183 0.0636 0.0671
Echinococcus granulosus sodium:glucose cotransporter 2 0.0025 0.0016 0.0013
Schistosoma mansoni smad 0.0049 0.0109 0.0112
Brugia malayi lactoylglutathione lyase 0.0101 0.0314 0.033
Echinococcus granulosus Smad4 0.0049 0.0109 0.0112
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0079 0.1192
Schistosoma mansoni alpha-glucosidase 0.0159 0.0544 0.0574
Echinococcus multilocularis glycine receptor subunit beta 0.0031 0.004 0.0037
Mycobacterium tuberculosis Conserved protein 0.0112 0.0358 0.1289
Mycobacterium ulcerans hypothetical protein 0.0112 0.0358 0.8562
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0157 0.0536 0.0565
Trypanosoma cruzi PAB1-binding protein , putative 0.0093 0.0284 0.794
Onchocerca volvulus Lactoylglutathione lyase homolog 0.0101 0.0314 0.1189
Schistosoma mansoni tar DNA-binding protein 0.0208 0.0736 0.0778
Echinococcus granulosus single minded 2 0.0034 0.0049 0.0049
Brugia malayi Cation transporter family protein 0.0031 0.004 0.0039
Schistosoma mansoni nAChR subunit 0.0031 0.004 0.0039
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0075 0.0211 0.0221
Schistosoma mansoni caspase-7 (C14 family) 0.012 0.0389 0.0409
Echinococcus granulosus solute carrier family 5 0.0025 0.0016 0.0013
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0079 0.0902
Schistosoma mansoni hypothetical protein 0.0075 0.0211 0.0221
Echinococcus granulosus smad 0.0049 0.0109 0.0112
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0127 0.0417 0.0414
Brugia malayi jmjC domain containing protein 0.0023 0.0008 0.0005
Loa Loa (eye worm) hypothetical protein 0.0057 0.014 0.0145
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0031 0.004 0.0037
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0023 0.0007 0.0004
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0031 0.004 0.0039
Onchocerca volvulus Cell death protein 3 homolog 0.0032 0.0044 0.0155
Loa Loa (eye worm) carboxylesterase 0.0752 0.2873 0.3043
Loa Loa (eye worm) transcription factor SMAD2 0.0714 0.2725 0.2886
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.019 0.0664 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.019 0.0664 1
Brugia malayi Intermediate filament tail domain containing protein 0.0058 0.0144 0.015
Trypanosoma cruzi metacaspase 5, putative 0.0032 0.0044 0.1217
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0031 0.004 0.0037
Loa Loa (eye worm) jmjC domain-containing protein 0.0023 0.0008 0.0005
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0034 0.0051 0.0163
Brugia malayi TAR-binding protein 0.0208 0.0736 0.0778
Trypanosoma brucei metacaspase MCA3 0.0032 0.0044 0.1217
Toxoplasma gondii glyoxalase family protein 0.0101 0.0314 0.8745
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0031 0.004 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0044 0.0657
Echinococcus granulosus beta LACTamase domain containing family member 0.0112 0.0358 0.0376
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0031 0.004 0.0039
Echinococcus granulosus glycine receptor subunit alpha 1 0.0031 0.004 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.0314 0.4729
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0032 0.0044 0.1044
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0157 0.0536 0.0565
Schistosoma mansoni lamin 0.0058 0.0144 0.015
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0032 0.0044 0.0043
Echinococcus multilocularis musashi 0.0058 0.0144 0.0141
Entamoeba histolytica hypothetical protein 0.0051 0.0117 0.1486
Mycobacterium tuberculosis Conserved protein 0.0101 0.0314 0.1127
Schistosoma mansoni phd/f-box containing protein 0.0023 0.0008 0.0005
Schistosoma mansoni tar DNA-binding protein 0.0208 0.0736 0.0778
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0716 0.2731 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0041 0.0079 0.0081
Loa Loa (eye worm) phosphatidylinositol 3 0.0026 0.0021 0.0019
Loa Loa (eye worm) hypothetical protein 0.0236 0.0846 0.0894
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0044 0.0657
Mycobacterium ulcerans hypothetical protein 0.0101 0.0314 0.7488
Brugia malayi sulfakinin receptor protein 0.0425 0.1589 0.1682
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.004 0.0039
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0075 0.0211 0.0208
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0044 0.0657
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0023 0.0007 0.0004
Onchocerca volvulus 0.0034 0.0049 0.0177
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0052 0.0122 1
Plasmodium falciparum metacaspase-like protein 0.0032 0.0044 0.1193
Mycobacterium tuberculosis Conserved protein 0.0112 0.0358 0.1289
Mycobacterium ulcerans hypothetical protein 0.0101 0.0314 0.7488
Loa Loa (eye worm) hypothetical protein 0.0032 0.0044 0.0043
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0031 0.004 0.0039
Brugia malayi jmjC domain containing protein 0.0086 0.0255 0.0267
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0027 0.0024 0.0355
Trypanosoma cruzi metacaspase, putative 0.0032 0.0044 0.1217
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0093 0.0282 0.483
Loa Loa (eye worm) glutathione reductase 0.0066 0.0175 0.0183
Trypanosoma cruzi lactoylglutathione lyase-like protein, putative 0.0101 0.0314 0.8769
Echinococcus granulosus inositol monophosphatase 1 0.0027 0.0024 0.0022
Echinococcus multilocularis tar DNA binding protein 0.0208 0.0736 0.0734
Echinococcus multilocularis thioredoxin glutathione reductase 0.0066 0.0175 0.0172
Brugia malayi glutathione reductase 0.0066 0.0175 0.0183
Loa Loa (eye worm) hypothetical protein 0.0127 0.0417 0.0439
Plasmodium vivax hypothetical protein, conserved 0.0112 0.0358 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.019 0.0664 1
Echinococcus multilocularis smad 0.0049 0.0109 0.0106
Loa Loa (eye worm) carboxylesterase 0.0127 0.0417 0.0439
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0026 0.0021 0.0589
Loa Loa (eye worm) RNA binding protein 0.0208 0.0736 0.0778
Brugia malayi 4-hydroxyphenylpyruvate dioxygenase family protein 0.0687 0.2617 0.2773
Schistosoma mansoni hypothetical protein 0.0042 0.0082 0.0084
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0023 0.0007 0.0193
Schistosoma mansoni lamin 0.0058 0.0144 0.015
Plasmodium falciparum thioredoxin reductase 0.0066 0.0175 0.5485
Echinococcus granulosus neutral alpha glucosidase AB 0.0041 0.0079 0.0081
Loa Loa (eye worm) hypothetical protein 0.0031 0.004 0.0039
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0049 0.0109 0.0112
Loa Loa (eye worm) hypothetical protein 0.0093 0.0284 0.0298
Schistosoma mansoni smad1 5 8 and 0.0049 0.0109 0.0112
Onchocerca volvulus 0.0031 0.004 0.0141
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0023 0.0008 0.0208
Brugia malayi Thioredoxin reductase 0.0066 0.0175 0.0183
Mycobacterium ulcerans hypothetical protein 0.0101 0.0314 0.7488
Loa Loa (eye worm) MH1 domain-containing protein 0.0049 0.0109 0.0112
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.015 0.0506 0.183
Schistosoma mansoni 4-hydroxyphenylpyruvate dioxygenase 0.0101 0.0314 0.033
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0005
Echinococcus multilocularis survival motor neuron protein 1 0.022 0.0783 0.078
Loa Loa (eye worm) hypothetical protein 0.0031 0.004 0.0039
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0031 0.004 0.0037
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0052 0.0122 0.2798
Trypanosoma cruzi metacaspase, putative 0.0032 0.0044 0.1217
Loa Loa (eye worm) hypothetical protein 0.0198 0.0694 0.0732
Loa Loa (eye worm) Smad1 0.0049 0.0109 0.0112
Schistosoma mansoni gynecophoral canal protein 0.0101 0.0314 0.033
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0112 0.0358 0.0376
Onchocerca volvulus 0.0031 0.004 0.0141
Echinococcus multilocularis solute carrier family 5 0.0025 0.0016 0.0012
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0044 0.0657
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0023 0.0008 0.0015
Echinococcus multilocularis carboxylesterase 5A 0.0752 0.2873 0.287
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0007 0.0193
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.019 0.0664 1
Echinococcus multilocularis peptidase Clp (S14 family) 0.0034 0.0051 0.0048
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0023 0.0008 0.0004
Schistosoma mansoni transcription factor LCR-F1 0.0051 0.0117 0.012
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.019 0.0664 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.1 uM Inhibitory concentration required against human Caspase-3 ChEMBL. 12798321
IC50 (binding) = 1.1 uM Inhibitory concentration required against human Caspase-3 ChEMBL. 12798321

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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