Detailed information for compound 1116527

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 471.597 | Formula: C27H33N7O
  • H donors: 1 H acceptors: 4 LogP: 5.57 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1Nc1nc(nc2c1n(C)cn2)N1CCC(CC1)Oc1ccncc1)C(C)(C)C
  • InChi: 1S/C27H33N7O/c1-18-6-7-19(27(2,3)4)16-22(18)30-25-23-24(29-17-33(23)5)31-26(32-25)34-14-10-21(11-15-34)35-20-8-12-28-13-9-20/h6-9,12-13,16-17,21H,10-11,14-15H2,1-5H3,(H,30,31,32)
  • InChiKey: VHOLPMHUOZLFLQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi DNA polymerase kappa, putative 0.0121 0.2503 0.3127
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0027 0.0317 0.0396
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0019 0.013 0.0013
Giardia lamblia DINP protein human, muc B family 0.0101 0.2037 0.2437
Schistosoma mansoni hypothetical protein 0.0303 0.6723 0.8402
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0371 0.0413
Treponema pallidum exodeoxyribonuclease (exoA) 0.006 0.1094 0.1221
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0073 0.1377 0.1586
Plasmodium vivax phosphoglycerate kinase, putative 0.0354 0.7901 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0599 0.0599
Echinococcus multilocularis tar DNA binding protein 0.0065 0.1197 0.1496
Trypanosoma brucei metacaspase 0.0028 0.0333 0.0366
Echinococcus multilocularis caspase 0.0028 0.0333 0.0417
Giardia lamblia Kinase, PLK 0.0099 0.1979 0.2362
Schistosoma mansoni zinc finger protein 0.002 0.0146 0.0182
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.222 0.2673
Brugia malayi ImpB/MucB/SamB family protein 0.0175 0.3742 0.3742
Loa Loa (eye worm) hypothetical protein 0.0039 0.0587 0.0587
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0599 0.0582
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0265 0.0187
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0122 0.2511 0.3138
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0374 0.0291
Schistosoma mansoni chromobox protein 0.007 0.1312 0.1639
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.002 0.0148 0.0023
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0044 0.0715 0.0852
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0374 0.0468
Loa Loa (eye worm) hypothetical protein 0.0031 0.0403 0.0403
Chlamydia trachomatis phosphoglycerate kinase 0.0354 0.7901 1
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.002 0.0148 0.0023
Brugia malayi Phosphoglycerate kinase 0.013 0.2704 0.2704
Trypanosoma brucei DNA polymerase kappa, putative 0.0121 0.2503 0.3127
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.002 0.0148 0.0036
Brugia malayi polk-prov protein 0.0056 0.099 0.099
Toxoplasma gondii ABC1 family protein 0.0039 0.06 0.0583
Trypanosoma brucei DNA polymerase IV, putative 0.0121 0.2503 0.3127
Onchocerca volvulus 0.0444 1 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0095 0.1884 0.2354
Echinococcus multilocularis chromobox protein 1 0.007 0.1312 0.1639
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0027 0.0317 0.0396
Brugia malayi mbt repeat family protein 0.0048 0.08 0.08
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0797 0.0996
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1197 0.1496
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0294 0.0316
Echinococcus multilocularis Protein lozenge 0.0056 0.0983 0.1229
Entamoeba histolytica serine/threonine protein kinase, putative 0.0099 0.1979 0.238
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0832 0.104
Echinococcus multilocularis bloom syndrome protein 0.0065 0.1207 0.1508
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.099 0.1201
Leishmania major DNA polymerase eta, putative 0.0109 0.2229 0.2779
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0099 0.1979 0.2474
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0354 0.7901 1
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.5701 0.7163
Brugia malayi serine/threonine-protein kinase plk-2 0.0099 0.1979 0.1979
Schistosoma mansoni hypothetical protein 0.0358 0.8001 1
Trypanosoma brucei DNA polymerase eta, putative 0.0175 0.3742 0.4705
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0028 0.0333 0.0417
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.222 0.2673
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0354 0.7901 1
Plasmodium vivax metacaspase 1, putative 0.0028 0.0333 0.0275
Entamoeba histolytica phosphoglycerate kinase, putative 0.0354 0.7901 1
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0374 0.0314
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.3634 0.4497
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.222 0.269
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.002 0.0148 0.0001
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0029 0.0371 0.0288
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0104 0.2109 0.2556
Echinococcus granulosus zinc finger protein 0.002 0.0146 0.0182
Loa Loa (eye worm) hypothetical protein 0.0148 0.3134 0.3134
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.04 0.0326
Loa Loa (eye worm) pip kinase 2 0.0163 0.3474 0.3474
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.108 0.1349
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0201 0.4349 0.5435
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.3634 0.4497
Trypanosoma cruzi DNA polymerase kappa, putative 0.0121 0.2503 0.3127
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0039 0.0587 0.0734
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0073 0.1377 0.1377
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0027 0.0317 0.0317
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0265 0.0265
Brugia malayi hypothetical protein 0.0158 0.3352 0.3352
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0039 0.0587 0.0587
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0024 0.0249 0.0311
Loa Loa (eye worm) hypothetical protein 0.0444 1 1
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0104 0.2109 0.2529
Trypanosoma brucei metacaspase MCA3 0.0028 0.0333 0.0366
Brugia malayi mbt repeat family protein 0.0048 0.08 0.08
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0104 0.2109 0.2109
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0333 0.0239
Leishmania major metacaspase, putative 0.0028 0.0333 0.0366
Mycobacterium leprae conserved hypothetical protein 0.0039 0.06 0.0438
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0027 0.0317 0.0345
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.006 0.1094 0.1334
Trypanosoma brucei DNA polymerase kappa, putative 0.0101 0.2037 0.2535
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.06 0.0704
Schistosoma mansoni DNA helicase recq1 0.0039 0.0587 0.0734
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0823 0.0871
Onchocerca volvulus 0.0163 0.3474 0.3296
Echinococcus granulosus chromobox protein 1 0.007 0.1312 0.1639
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.017 0.017
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0073 0.1377 0.1586
Brugia malayi Pip kinase protein 2 0.0163 0.3474 0.3474
Brugia malayi TAR-binding protein 0.0065 0.1197 0.1197
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.3847 0.4771
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0278 0.6154 0.769
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.06 0.0583
Trichomonas vaginalis DNA helicase recq1, putative 0.0065 0.1207 0.1366
Onchocerca volvulus 0.0158 0.3352 0.3171
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0026 0.0294 0.019
Trichomonas vaginalis DNA helicase recq, putative 0.0065 0.1207 0.1366
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0374 0.0291
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0333 0.0239
Trypanosoma brucei lanosterol synthase 0.002 0.0148 0.0129
Trypanosoma brucei DNA polymerase kappa, putative 0.0121 0.2503 0.3127
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0024 0.0249 0.0249
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.08 0.055
Mycobacterium tuberculosis Conserved protein 0.0039 0.06 0.0645
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.08 0.1
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.06 0.0617
Trichomonas vaginalis ap endonuclease, putative 0.006 0.1094 0.122
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0333 0.0239
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0201 0.4349 0.5435
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.0797 0.0996
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.3634 0.4497
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0087 0.0109
Onchocerca volvulus 0.0039 0.06 0.0344
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0027 0.0317 0.0345
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0163 0.3474 0.4341
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.222 0.222
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0095 0.1884 0.2354
Loa Loa (eye worm) hypothetical protein 0.0021 0.0175 0.0175
Trichomonas vaginalis esterase, putative 0.0039 0.06 0.0583
Trypanosoma cruzi protein farnesyltransferase, putative 0.0073 0.1377 0.1695
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0333 0.0239
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0954 0.1192
Loa Loa (eye worm) hypothetical protein 0.0158 0.3352 0.3352
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0028 0.0333 0.024
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.002 0.0148 0.0129
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0077 0.1482 0.172
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.006 0.1079 0.1233
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0104 0.2109 0.2556
Brugia malayi 6-phosphofructokinase 0.0109 0.222 0.222
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.5701 0.7163
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.002 0.0148 0.0185
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.002 0.0148 0.0129
Trichomonas vaginalis ap endonuclease, putative 0.006 0.1094 0.122
Brugia malayi Pre-SET motif family protein 0.0031 0.04 0.04
Schistosoma mansoni hypothetical protein 0.0358 0.8001 1
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0073 0.1377 0.1605
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.006 0.1094 0.1334
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0374 0.0291
Echinococcus granulosus transcription factor Dp 1 0.0161 0.3431 0.4288
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0039 0.0587 0.0734
Schistosoma mansoni caspase-7 (C14 family) 0.0028 0.0333 0.0417
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0599 0.0582
Echinococcus multilocularis 6 phosphofructokinase 0.0109 0.222 0.2775
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.002 0.0148 0.0066
Entamoeba histolytica recQ family DNA helicase 0.002 0.0147 0.0022
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0374 0.0327
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0354 0.7901 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.3017 0.3782
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0073 0.1377 0.1586
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0026 0.0294 0.0225
Plasmodium falciparum DNA repair protein REV1, putative 0.0029 0.0371 0.0323
Brugia malayi Bromodomain containing protein 0.0075 0.1436 0.1436
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0278 0.6154 0.7775
Trypanosoma brucei DNA polymerase IV, putative 0.0121 0.2503 0.3127
Loa Loa (eye worm) TAR-binding protein 0.0065 0.1197 0.1197
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0044 0.0715 0.0852
Loa Loa (eye worm) hypothetical protein 0.0018 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0354 0.7901 0.7901
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0073 0.1377 0.1721
Brugia malayi beta-lactamase family protein 0.0039 0.06 0.06
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0265 0.0216
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.3634 0.4497
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0333 0.0239
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0027 0.0317 0.0218
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.1979 0.2474
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.08 0.1
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.002 0.0148 0.0185
Loa Loa (eye worm) hypothetical protein 0.0163 0.3474 0.3474
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.222 0.2768
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0026 0.0294 0.0212
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0374 0.0291
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0668 0.0671
Loa Loa (eye worm) hypothetical protein 0.0054 0.0954 0.0954
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0163 0.3474 0.4341
Loa Loa (eye worm) hypothetical protein 0.0175 0.3742 0.3742
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0333 0.0239
Schistosoma mansoni blooms syndrome DNA helicase 0.0046 0.075 0.0937
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0333 0.0239
Trypanosoma brucei hypothetical protein, conserved 0.0029 0.0371 0.0413
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.06 0.0645
Brugia malayi Heterochromatin protein 1 0.007 0.1312 0.1312
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0027 0.0317 0.0345
Brugia malayi Pre-SET motif family protein 0.0213 0.4641 0.4641
Loa Loa (eye worm) hypothetical protein 0.0018 0.0119 0.0119
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0026 0.0294 0.0368
Giardia lamblia Prenyltransferase 0.0073 0.1377 0.1586
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0333 0.0239
Trypanosoma cruzi DNA polymerase eta, putative 0.0109 0.2229 0.2779
Trypanosoma brucei DNA polymerase kappa, putative 0.0121 0.2503 0.3127
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.1979 0.2461
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0832 0.104
Leishmania major DNA polymerase kappa, putative 0.0029 0.0371 0.0413
Loa Loa (eye worm) hypothetical protein 0.0028 0.0333 0.0333
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0024 0.0249 0.0311
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0278 0.6154 0.7751
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1979 0.2362
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0265 0.0187
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0073 0.1377 0.1586
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0832 0.0832
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0303 0.672 0.8496
Loa Loa (eye worm) hypothetical protein 0.0043 0.0683 0.0683
Echinococcus multilocularis caspase 2 0.0028 0.0333 0.0417
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.06 0.0645
Mycobacterium ulcerans DNA polymerase IV 0.0121 0.2503 0.3063
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0026 0.0294 0.0368
Mycobacterium ulcerans lipase LipD 0.0039 0.06 0.0617
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.0797 0.0996
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0895 0.108
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0668 0.0414
Loa Loa (eye worm) hypothetical protein 0.002 0.0148 0.0148
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.002 0.0148 0.0185
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.06 0.06
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0163 0.3474 0.4341
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.1197 0.1197
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.08 0.1
Trichomonas vaginalis chromobox protein, putative 0.007 0.1312 0.1501
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0028 0.0333 0.0333
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.004 0.0621 0.0612
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0026 0.0294 0.0225
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.1197 0.1197
Echinococcus granulosus CTD small phosphatase protein like 0.0026 0.0294 0.0368
Brugia malayi RNA binding protein 0.0065 0.1197 0.1197
Mycobacterium ulcerans 6-phosphofructokinase 0.0109 0.222 0.27
Leishmania major geranylgeranyltransferase, putative 0.002 0.0148 0.0129
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0371 0.0413
Brugia malayi ImpB/MucB/SamB family protein 0.0095 0.1884 0.1884
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0354 0.7901 1
Trypanosoma brucei phosphoglycerate kinase 0.0354 0.7901 1
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0027 0.0317 0.0396
Onchocerca volvulus 0.0031 0.0403 0.0142
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0679 0.0805
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.06 0.0749
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0265 0.0187
Trypanosoma brucei phosphoglycerate kinase, putative 0.013 0.2704 0.3384
Loa Loa (eye worm) hypothetical protein 0.0018 0.0119 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0334 0.024
Leishmania major DNA polymerase eta, putative 0.0175 0.3742 0.4705
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0022 0.0212 0.0083
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1197 0.1496
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.222 0.2775
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0278 0.6154 0.7775
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0039 0.0587 0.0567
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0026 0.0294 0.0368
Giardia lamblia Rab geranylgeranyltransferase 0.0104 0.2109 0.2529
Trypanosoma brucei phosphoglycerate kinase 0.0354 0.7901 1
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.002 0.0148 0.0185
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.06 0.0749
Giardia lamblia Phosphoglycerate kinase 0.0354 0.7901 1
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0027 0.0317 0.0396
Giardia lamblia Sgs1 DNA helicase, putative 0.0039 0.0587 0.0567
Trypanosoma cruzi DNA polymerase eta, putative 0.0175 0.3742 0.4705
Trichomonas vaginalis dullard protein, putative 0.0026 0.0294 0.0189
Plasmodium vivax hypothetical protein, conserved 0.0039 0.06 0.0617
Loa Loa (eye worm) runx1 0.0056 0.0983 0.0983
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0374 0.0327
Loa Loa (eye worm) hypothetical protein 0.0018 0.0119 0.0119
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1979 0.2362
Schistosoma mansoni ap endonuclease 0.006 0.1094 0.1367
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.002 0.0148 0.0001
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0374 0.0291
Schistosoma mansoni terminal deoxycytidyl transferase 0.0095 0.1884 0.2354
Echinococcus multilocularis dna polymerase kappa 0.0121 0.2503 0.3128
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0163 0.3474 0.4341
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0526 0.0658
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.006 0.1094 0.1252
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0026 0.0294 0.0189
Trypanosoma cruzi phosphoglycerate kinase, putative 0.013 0.2704 0.3384
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0073 0.1377 0.1377
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0215 0.0269
Trypanosoma brucei DNA polymerase kappa, putative 0.0121 0.2503 0.3127
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0073 0.1377 0.1586
Mycobacterium ulcerans hypothetical protein 0.0025 0.0265 0.0187
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0104 0.2109 0.2635
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.5701 0.7163
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0147 0.0129
Mycobacterium ulcerans hypothetical protein 0.0029 0.0371 0.0323
Onchocerca volvulus Glucosylceramidase homolog 0.017 0.3634 0.3461
Brugia malayi exodeoxyribonuclease III family protein 0.006 0.1094 0.1094
Plasmodium falciparum metacaspase-like protein 0.0028 0.0333 0.0275
Trypanosoma brucei DNA polymerase kappa, putative 0.0121 0.2503 0.3127
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0028 0.0333 0.024
Loa Loa (eye worm) hypothetical protein 0.0444 1 1
Echinococcus granulosus caspase 8 0.0028 0.0333 0.0417
Toxoplasma gondii hypothetical protein 0.0077 0.1482 0.1721
Echinococcus multilocularis transcription factor Dp 1 0.0161 0.3431 0.4288
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0265 0.0265
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0027 0.0317 0.0345
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.06 0.06
Brugia malayi Cell death protein 3 precursor 0.0028 0.0333 0.0333
Trypanosoma cruzi DNA damage repair protein, putative 0.0029 0.0371 0.0413
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.06 0.0645
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0036 0.0525 0.0487
Loa Loa (eye worm) hypothetical protein 0.0039 0.06 0.06
Brugia malayi Phosphoglycerate kinase 0.0354 0.7901 0.7901
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.06 0.0645
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.3634 0.4497
Trypanosoma cruzi lanosterol synthase, putative 0.002 0.0148 0.0129
Onchocerca volvulus 0.0042 0.0666 0.0412
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0039 0.0587 0.0601
Echinococcus multilocularis dna polymerase eta 0.0175 0.3742 0.4677
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0278 0.6154 0.769
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.002 0.0148 0.0036
Trichomonas vaginalis dullard protein, putative 0.0026 0.0294 0.0189
Schistosoma mansoni zinc finger protein 0.0015 0.0046 0.0058
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0039 0.0587 0.0587
Trypanosoma cruzi metacaspase, putative 0.0028 0.0333 0.0366
Leishmania major farnesyltransferase beta subunit 0.0073 0.1377 0.1695
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.06 0.0749
Schistosoma mansoni kinase 0.005 0.0854 0.1067
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0265 0.0278
Onchocerca volvulus 0.0027 0.0317 0.0054
Trypanosoma cruzi metacaspase, putative 0.0028 0.0333 0.0366
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0039 0.0587 0.0587
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0026 0.0294 0.0225
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0042 0.0666 0.0832
Echinococcus granulosus dna polymerase eta 0.0175 0.3742 0.4677
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0954 0.0954
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.06 0.0704
Echinococcus granulosus caspase 0.0028 0.0333 0.0417
Trypanosoma brucei DNA polymerase kappa, putative 0.0121 0.2503 0.3127
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0354 0.7901 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0095 0.1884 0.2257
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0823 0.0871
Trypanosoma cruzi metacaspase, putative 0.0028 0.0333 0.0366
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1979 0.2362
Trypanosoma brucei hypothetical protein, conserved 0.0029 0.0371 0.0413
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0027 0.0317 0.0254
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0333 0.0239
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.3847 0.4771
Loa Loa (eye worm) hypothetical protein 0.0056 0.099 0.099
Echinococcus granulosus bloom syndrome protein 0.0065 0.1207 0.1508
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0374 0.0291
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0954 0.1192
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0333 0.0239
Loa Loa (eye worm) hypothetical protein 0.0104 0.2109 0.2109
Trypanosoma cruzi DNA damage repair protein, putative 0.0029 0.0371 0.0413
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0073 0.1377 0.1721
Toxoplasma gondii exonuclease III APE 0.006 0.1094 0.1221
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0026 0.0294 0.0294
Trypanosoma cruzi DNA polymerase kappa, putative 0.0121 0.2503 0.3127
Trypanosoma brucei metacaspase MCA2 0.0028 0.0333 0.0366
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.0317 0.0345
Onchocerca volvulus Serine\/threonine kinase homolog 0.0099 0.1979 0.1761
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0354 0.7901 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0147 0.0147
Schistosoma mansoni hypothetical protein 0.0015 0.0046 0.0058
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0265 0.0216
Schistosoma mansoni DNA polymerase IV / kappa 0.0029 0.0371 0.0464
Trypanosoma brucei DNA damage repair protein, putative 0.0029 0.0371 0.0413
Leishmania major hypothetical protein, conserved 0.0039 0.06 0.0704
Loa Loa (eye worm) hypothetical protein 0.0039 0.06 0.06
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.06 0.0583
Trypanosoma brucei unspecified product 0.0065 0.1203 0.1473
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0026 0.0294 0.0189
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0148 0.0129
Schistosoma mansoni phosphoglycerate kinase 0.0354 0.7901 0.9875
Trypanosoma brucei DNA polymerase IV, putative 0.0115 0.2349 0.2932
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0374 0.0292
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.013 0.2704 0.3384
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0374 0.0327
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0028 0.0333 0.0417
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0832 0.104
Loa Loa (eye worm) hypothetical protein 0.0039 0.06 0.06
Loa Loa (eye worm) hypothetical protein 0.0025 0.0265 0.0265
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0832 0.104
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0095 0.1884 0.1884
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.222 0.2673
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0073 0.1377 0.1616
Mycobacterium leprae Probable lipase LipE 0.0039 0.06 0.0438
Loa Loa (eye worm) beta-lactamase 0.0039 0.06 0.06
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0073 0.1377 0.1695
Schistosoma mansoni hypothetical protein 0.0021 0.017 0.0213
Loa Loa (eye worm) hypothetical protein 0.0025 0.0265 0.0265
Leishmania major phosphoglycerate kinase C, glycosomal 0.0354 0.7901 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0099 0.1979 0.2461
Brugia malayi Bloom's syndrome protein homolog 0.0065 0.1207 0.1207
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0109 0.222 0.2722
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.08 0.08
Mycobacterium ulcerans hypothetical protein 0.016 0.3393 0.4207
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0121 0.2503 0.3037
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.006 0.1094 0.1252
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.04 0.05
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0024 0.0249 0.0249
Giardia lamblia DNA damage repair protein 0.0029 0.0371 0.0288
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.006 0.1094 0.1334
Leishmania major hypothetical protein, conserved 0.0026 0.0294 0.0316
Trichomonas vaginalis DNA polymerase eta, putative 0.0121 0.2503 0.3037
Plasmodium vivax geranylgeranyltransferase, putative 0.002 0.0148 0.0036
Echinococcus granulosus dna polymerase kappa 0.0121 0.2503 0.3128
Loa Loa (eye worm) MBCTL1 0.0054 0.0954 0.0954
Leishmania major phosphoglycerate kinase B, cytosolic 0.0354 0.7901 1
Entamoeba histolytica recQ family helicase, putative 0.0044 0.0715 0.0753
Echinococcus multilocularis chromobox protein 1 0.007 0.1312 0.1639
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.013 0.2704 0.3384
Echinococcus granulosus phosphoglycerate kinase 1 0.0354 0.7901 0.9875
Trypanosoma brucei DNA polymerase kappa, putative 0.0121 0.2503 0.3127
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0303 0.672 0.8496
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0679 0.0805
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.108 0.1349
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.3634 0.4497
Loa Loa (eye worm) hypothetical protein 0.0048 0.0797 0.0797
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0374 0.0327
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0374 0.0291
Trypanosoma cruzi DNA polymerase kappa, putative 0.0121 0.2503 0.3127
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.06 0.0704
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0101 0.2037 0.2535
Schistosoma mansoni DNA polymerase eta 0.0175 0.3742 0.4677
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1979 0.2362
Leishmania major DNA polymerase kappa, putative 0.0101 0.2037 0.2535
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0104 0.2109 0.2546
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0022 0.0212 0.0083
Onchocerca volvulus 0.0039 0.06 0.0344
Trypanosoma cruzi metacaspase 5, putative 0.0028 0.0333 0.0366
Echinococcus multilocularis geminin 0.0358 0.8001 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0265 0.0265
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0333 0.0239
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.002 0.0148 0.0185
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0087 0.0109
Echinococcus granulosus caspase 2 0.0028 0.0333 0.0417
Mycobacterium ulcerans phosphoglycerate kinase 0.0354 0.7901 1
Brugia malayi beta-lactamase 0.0039 0.06 0.06
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.5701 0.7163
Trypanosoma brucei DNA damage repair protein, putative 0.0029 0.0371 0.0413
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.006 0.1094 0.1278
Trypanosoma brucei unspecified product 0.0065 0.1203 0.1473
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0104 0.2109 0.2635
Brugia malayi chromobox protein homolog 3 0.0039 0.0599 0.0599
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0087 0.0109
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0374 0.0327
Loa Loa (eye worm) hypothetical protein 0.0018 0.0119 0.0119
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0104 0.2109 0.2635
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0374 0.0292
Trypanosoma brucei chrX additional, unordered contigs 0.0029 0.0371 0.0413
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0101 0.2037 0.2487
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.002 0.0148 0.0148
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0334 0.024
Leishmania major ATP-dependent phosphofructokinase 0.0109 0.222 0.2768
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0333 0.0239
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.013 0.2704 0.3384
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0087 0.0109
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.08 0.1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0039 0.0587 0.0734
Schistosoma mansoni caspase-7 (C14 family) 0.0028 0.0333 0.0417
Echinococcus granulosus tar DNA binding protein 0.0065 0.1197 0.1496
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0526 0.0658
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.06 0.0645
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0278 0.6154 0.769
Loa Loa (eye worm) phosphofructokinase 0.0109 0.222 0.222
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1197 0.1496
Leishmania major mitochondrial DNA polymerase beta 0.0303 0.672 0.8496
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.08 0.1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0374 0.0292
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0333 0.0239
Echinococcus multilocularis caspase 8 0.0028 0.0333 0.0417
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0026 0.0294 0.0189
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0259 0.5701 0.5701
Loa Loa (eye worm) hypothetical protein 0.0039 0.06 0.06
Toxoplasma gondii hypothetical protein 0.0027 0.0317 0.0219
Trypanosoma brucei Metacaspase-4 0.0028 0.0333 0.0366
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0354 0.7901 1
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0104 0.2109 0.2109
Mycobacterium ulcerans beta-lactamase 0.0039 0.06 0.0617
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0026 0.0294 0.0368
Plasmodium falciparum metacaspase 1 0.0028 0.0333 0.0275
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0027 0.0317 0.0345
Trichomonas vaginalis chromobox protein, putative 0.007 0.1312 0.1501
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.06 0.0583
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0109 0.2229 0.2685
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0215 0.0269
Loa Loa (eye worm) hypothetical protein 0.002 0.0148 0.0148
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0265 0.0187
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0099 0.1979 0.1979
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.06 0.0583
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0265 0.0278
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.5701 0.7163
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0026 0.0294 0.0189
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0679 0.0805
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0104 0.2109 0.2529
Trypanosoma cruzi metacaspase, putative 0.0028 0.0333 0.0366
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0028 0.0333 0.024
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0668 0.0671
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.006 0.1094 0.1367
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.06 0.0749
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.4641 0.4641
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0354 0.7901 1
Loa Loa (eye worm) RecQ helicase 0.0065 0.1207 0.1207
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0333 0.0275
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0039 0.0587 0.0567
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.08 0.1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0832 0.104
Trypanosoma cruzi lanosterol synthase, putative 0.002 0.0148 0.0129
Schistosoma mansoni lozenge 0.0056 0.0983 0.1229
Echinococcus granulosus chromobox protein 1 0.007 0.1312 0.1639
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.3017 0.3782
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0215 0.0269
Plasmodium vivax SET domain protein, putative 0.0031 0.04 0.0361
Trypanosoma brucei unspecified product 0.0115 0.2349 0.2932
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0109 0.222 0.2561
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.06 0.0583
Schistosoma mansoni chromobox protein 0.007 0.1312 0.1639
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.06 0.0645
Schistosoma mansoni voltage-gated potassium channel 0.0026 0.03 0.0375
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0832 0.104
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0147 0.0184
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0317 0.0345
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.006 0.1094 0.1094
Echinococcus granulosus 6 phosphofructokinase 0.0109 0.222 0.2775
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0265 0.0187
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0832 0.104
Brugia malayi PHD-finger family protein 0.0025 0.027 0.027
Schistosoma mansoni hypothetical protein 0.0026 0.0287 0.0359
Mycobacterium ulcerans DNA polymerase IV 0.0121 0.2503 0.3063
Trypanosoma brucei DNA polymerase kappa, putative 0.0072 0.1357 0.1668
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0265 0.0173
Trypanosoma brucei DNA polymerase kappa, putative 0.0072 0.1357 0.1668
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0278 0.6154 0.6154
Trypanosoma brucei DNA polymerase kappa, putative 0.0121 0.2503 0.3127
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0039 0.0587 0.0734
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.002 0.0148 0.0148
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.222 0.222
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.5701 0.7163
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0073 0.1377 0.1586
Echinococcus multilocularis 0.0026 0.0294 0.0368
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0027 0.0317 0.0345
Loa Loa (eye worm) hypothetical protein 0.0041 0.0638 0.0638
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.04 0.05
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.1979 0.2461
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0354 0.7901 1
Giardia lamblia Rab geranylgeranyltransferase 0.0027 0.0317 0.0218
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0041 0.0639 0.0668
Trypanosoma cruzi phosphoglycerate kinase, putative 0.013 0.2704 0.3384
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1979 0.2362
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0099 0.1979 0.2474
Plasmodium falciparum geranylgeranyltransferase, putative 0.002 0.0148 0.0036
Treponema pallidum phosphoglycerate kinase 0.0354 0.7901 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0265 0.0187
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0044 0.0715 0.0852
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.006 0.1094 0.122
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0374 0.0291
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0104 0.2109 0.2529
Schistosoma mansoni bromodomain containing protein 0.0063 0.1163 0.1454
Onchocerca volvulus 0.0243 0.5325 0.5198
Trypanosoma brucei DNA polymerase kappa, putative 0.0121 0.2503 0.3127
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0265 0.0173
Schistosoma mansoni caspase-3 (C14 family) 0.0028 0.0333 0.0417
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0028 0.0333 0.0417
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0278 0.6154 0.6154
Brugia malayi phosphofructokinase 0.0109 0.222 0.222
Echinococcus multilocularis zinc finger protein 0.002 0.0146 0.0182
Trypanosoma brucei polo-like protein kinase 0.0099 0.1979 0.2461
Echinococcus granulosus geminin 0.0358 0.8001 1
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0073 0.1377 0.1721
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.06 0.0617
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0027 0.0317 0.0345
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0954 0.1192
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0259 0.5701 0.5701
Onchocerca volvulus 0.0039 0.06 0.0344
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0147 0.0129
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0954 0.1192
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0026 0.0294 0.0316
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0265 0.0278
Schistosoma mansoni ap endonuclease 0.006 0.1094 0.1367
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0027 0.0317 0.0254
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.006 0.1094 0.1252
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0027 0.0317 0.0241
Schistosoma mansoni voltage-gated potassium channel 0.0026 0.03 0.0375
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.006 0.1094 0.1334
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.006 0.1094 0.1367
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0278 0.6154 0.7775
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.002 0.0148 0.0148
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.06 0.0645
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0073 0.1377 0.1586
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0278 0.6154 0.7775
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.3634 0.4497
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0143 0.3017 0.3782
Trypanosoma brucei DNA polymerase kappa, putative 0.0072 0.1357 0.1668
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1197 0.1496
Mycobacterium ulcerans hypothetical protein 0.0039 0.06 0.0617
Toxoplasma gondii hypothetical protein 0.0049 0.0824 0.0873
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1979 0.2362
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.222 0.2673
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0797 0.0996
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.222 0.2768
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.222 0.269
Schistosoma mansoni phosphoglycerate kinase 0.0354 0.7901 0.9875
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0679 0.0805
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0027 0.0317 0.0317
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0148 0.0129
Mycobacterium tuberculosis Conserved hypothetical protein 0.016 0.3393 0.4224
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0374 0.0292
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0832 0.0832
Trypanosoma cruzi metacaspase 5, putative 0.0028 0.0333 0.0366
Brugia malayi Bromodomain containing protein 0.0038 0.0582 0.0582
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1197 0.1496
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0265 0.0173
Mycobacterium tuberculosis Conserved protein 0.0039 0.06 0.0645
Mycobacterium tuberculosis Conserved protein 0.0039 0.06 0.0645
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0026 0.0294 0.0189
Trypanosoma brucei phosphoglycerate kinase 0.013 0.2704 0.3384
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.08 0.1
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.002 0.0148 0.0185
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.222 0.2775
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0333 0.0239
Onchocerca volvulus Cell death protein 3 homolog 0.0028 0.0333 0.0071
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0317 0.0345
Loa Loa (eye worm) hypothetical protein 0.0038 0.0583 0.0583
Mycobacterium tuberculosis Possible penicillin-binding protein 0.025 0.55 0.6924
Loa Loa (eye worm) hypothetical protein 0.0039 0.06 0.06
Trypanosoma cruzi protein farnesyltransferase, putative 0.0073 0.1377 0.1695
Trichomonas vaginalis set domain proteins, putative 0.0243 0.5325 0.6678
Loa Loa (eye worm) hypothetical protein 0.0026 0.0294 0.0294
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0599 0.0344
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0374 0.0327
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.1312 0.1312
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0053 0.092 0.1028
Mycobacterium tuberculosis Conserved hypothetical protein 0.0095 0.1884 0.2291
Brugia malayi 6-phosphofructokinase 0.0109 0.222 0.222
Loa Loa (eye worm) hypothetical protein 0.0028 0.0333 0.0333
Trichomonas vaginalis dullard protein, putative 0.0026 0.0294 0.0189
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1979 0.2362
Loa Loa (eye worm) hypothetical protein 0.0039 0.06 0.06
Onchocerca volvulus 0.0048 0.08 0.055
Entamoeba histolytica exodeoxyribonuclease III, putative 0.006 0.1094 0.124
Loa Loa (eye worm) RNA binding protein 0.0065 0.1197 0.1197
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.222 0.269
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0073 0.1377 0.1616
Brugia malayi beta-lactamase family protein 0.0039 0.06 0.06
Trichomonas vaginalis DNA helicase recq, putative 0.0044 0.0715 0.0732
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0333 0.0239
Plasmodium falciparum phosphoglycerate kinase 0.0354 0.7901 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.1336 0.1336
Loa Loa (eye worm) hypothetical protein 0.0048 0.08 0.08
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0119 0.003
Leishmania major DNA damage repair protein, putative 0.0029 0.0371 0.0413
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0303 0.672 0.8496
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0954 0.1192
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0265 0.0187
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.013 0.2704 0.3384
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.099 0.1201
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0026 0.0287 0.0287
Plasmodium vivax DNA repair protein REV1, putative 0.0029 0.0371 0.0323
Trypanosoma brucei metacaspase 5, putative 0.0028 0.0333 0.0366
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0101 0.0101
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0109 0.222 0.2673
Schistosoma mansoni DNA helicase recq5 0.0039 0.0587 0.0734
Echinococcus multilocularis phosphoglycerate kinase 1 0.0354 0.7901 0.9875

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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