Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0698 | 0.0699 |
Loa Loa (eye worm) | steroid hormone receptor | 0.014 | 0.1645 | 0.1646 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.0696 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.1645 | 0.1646 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0064 | 0.0564 | 0.0565 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.014 | 0.1645 | 0.1646 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0066 | 0.0585 | 0.0418 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.014 | 0.1645 | 0.1646 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.014 | 0.1645 | 0.1951 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.049 | 1 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0064 | 0.0564 | 0.0565 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0064 | 0.0564 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0698 | 0.0699 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0066 | 0.0585 | 0.0585 |
Onchocerca volvulus | Bile acid receptor homolog | 0.014 | 0.1645 | 0.2402 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.014 | 0.1645 | 0.1646 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0059 | 0.049 | 0.5 |
Brugia malayi | follicle stimulating hormone receptor | 0.072 | 0.9989 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.0696 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.049 | 0.0257 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.014 | 0.1645 | 0.1646 |
Schistosoma mansoni | nuclear hormone receptor | 0.014 | 0.1645 | 0.1951 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0074 | 0.0698 | 0.0699 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0585 | 0.0585 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0066 | 0.0585 | 0.0418 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.2015 | 0.2495 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0066 | 0.0585 | 0.0396 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.014 | 0.1645 | 0.1496 |
Schistosoma mansoni | zinc finger protein | 0.0066 | 0.0585 | 0.0396 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0066 | 0.0585 | 0.0396 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.1645 | 0.1646 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0054 | 0.0413 | 0.0243 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.014 | 0.1645 | 0.1951 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0066 | 0.0585 | 0.0585 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0236 | 0.3027 | 0.398 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.049 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0066 | 0.0585 | 0.0585 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.014 | 0.1645 | 0.1646 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0585 | 0.0585 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.014 | 0.1645 | 0.1646 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0054 | 0.0413 | 0.0243 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0066 | 0.0585 | 0.0487 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0066 | 0.0585 | 0.0418 |
Schistosoma mansoni | nuclear hormone receptor | 0.0066 | 0.0585 | 0.0396 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.014 | 0.1645 | 0.1496 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.014 | 0.1645 | 0.1951 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.014 | 0.1645 | 0.1496 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.014 | 0.1645 | 0.1951 |
Schistosoma mansoni | hypothetical protein | 0.0074 | 0.0696 | 0.0559 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0585 | 0.0585 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0074 | 0.0698 | 0.0563 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.014 | 0.1645 | 0.1646 |
Schistosoma mansoni | nuclear receptor | 0.0066 | 0.0585 | 0.0396 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.014 | 0.1645 | 0.1496 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.014 | 0.1645 | 0.1646 |
Brugia malayi | hypothetical protein | 0.0066 | 0.0585 | 0.0585 |
Brugia malayi | nuclear receptor RXR | 0.0074 | 0.0698 | 0.0699 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.014 | 0.1645 | 0.1646 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.014 | 0.1645 | 0.1951 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0698 | 0.0699 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0066 | 0.0585 | 0.0418 |
Brugia malayi | tailless protein | 0.0066 | 0.0585 | 0.0585 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0585 | 0.0585 |
Brugia malayi | hypothetical protein | 0.0432 | 0.585 | 0.5857 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0074 | 0.0696 | 0.0559 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0066 | 0.0585 | 0.0487 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.014 | 0.1645 | 0.1646 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0066 | 0.0585 | 0.0418 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0059 | 0.049 | 0.0321 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0059 | 0.049 | 0.5 |
Schistosoma mansoni | lozenge | 0.0054 | 0.0418 | 0.0151 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0066 | 0.0585 | 0.0585 |
Brugia malayi | nuclear receptor NHR-67 | 0.0066 | 0.0585 | 0.0585 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.014 | 0.1645 | 0.1496 |
Brugia malayi | hypothetical protein | 0.0074 | 0.0696 | 0.0696 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.0696 | 1 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0064 | 0.0564 | 0.0366 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0105 | 0.1155 | 0.1233 |
Brugia malayi | hypothetical protein | 0.0074 | 0.0698 | 0.0699 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.014 | 0.1645 | 0.1646 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.0696 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0074 | 0.0698 | 0.0533 |
Schistosoma mansoni | nuclear receptor | 0.0066 | 0.0585 | 0.0396 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0074 | 0.0698 | 0.0563 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0066 | 0.0585 | 0.0585 |
Echinococcus multilocularis | tumor protein p63 | 0.0721 | 1 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0059 | 0.049 | 0.0321 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0585 | 0.0585 |
Brugia malayi | ecdysteroid receptor | 0.014 | 0.1645 | 0.1646 |
Brugia malayi | steroid hormone receptor | 0.014 | 0.1645 | 0.1646 |
Brugia malayi | hypothetical protein | 0.0066 | 0.0585 | 0.0585 |
Schistosoma mansoni | coup transcription factor | 0.014 | 0.1645 | 0.1951 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.014 | 0.1645 | 0.1646 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0585 | 0.0585 |
Brugia malayi | hypothetical protein | 0.0231 | 0.2955 | 0.2958 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.014 | 0.1645 | 0.1646 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0064 | 0.0564 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0231 | 0.2955 | 0.283 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.014 | 0.1645 | 0.1496 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0066 | 0.0585 | 0.0585 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.1645 | 0.1646 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.014 | 0.1645 | 0.1496 |
Brugia malayi | conserved hypotetical protein | 0.0066 | 0.0585 | 0.0585 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.072 | 0.9989 | 1 |
Onchocerca volvulus | 0.0432 | 0.585 | 1 | |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.014 | 0.1645 | 0.1496 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.014 | 0.1645 | 0.1496 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.014 | 0.1645 | 0.1496 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0066 | 0.0585 | 0.0585 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0231 | 0.2955 | 0.283 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.014 | 0.1645 | 0.1496 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0585 | 0.0585 |
Onchocerca volvulus | 0.0066 | 0.0585 | 0.0487 | |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0074 | 0.0696 | 0.0531 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0236 | 0.3027 | 0.2903 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0381 | 0.5123 | 0.5037 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.014 | 0.1645 | 0.1496 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.1645 | 0.1646 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.014 | 0.1645 | 0.1496 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0585 | 0.0585 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0521 | 0.7129 | 0.7078 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.1645 | 0.1646 |
Echinococcus granulosus | FTZ F1 alpha | 0.014 | 0.1645 | 0.1496 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0066 | 0.0585 | 0.0585 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.1645 | 0.1646 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0585 | 0.0585 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0059 | 0.049 | 0.8685 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.1155 | 0.1156 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0585 | 0.0585 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0066 | 0.0585 | 0.0418 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.1645 | 0.1646 |
Brugia malayi | nuclear receptor NHR-88 | 0.0066 | 0.0585 | 0.0585 |
Loa Loa (eye worm) | DR-78 | 0.0066 | 0.0585 | 0.0585 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.014 | 0.1645 | 0.1646 |
Schistosoma mansoni | hypothetical protein | 0.0381 | 0.5123 | 0.7056 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0066 | 0.0585 | 0.0396 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0066 | 0.0585 | 0.0418 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0066 | 0.0585 | 0.0585 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.014 | 0.1645 | 0.1646 |
Loa Loa (eye worm) | runx1 | 0.0054 | 0.0418 | 0.0418 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.014 | 0.1645 | 0.1951 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.1645 | 0.1646 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.2955 | 0.2958 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0064 | 0.0564 | 0.0397 |
Onchocerca volvulus | 0.014 | 0.1645 | 0.2402 | |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0698 | 0.0699 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.014 | 0.1645 | 0.1646 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.014 | 0.1645 | 0.1951 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.014 | 0.1645 | 0.1646 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.014 | 0.1645 | 0.1646 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0064 | 0.0564 | 0.0397 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.014 | 0.1645 | 0.1496 |
Brugia malayi | nuclear receptor NHR-88 | 0.014 | 0.1645 | 0.1646 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.014 | 0.1645 | 0.2402 |
Brugia malayi | nuclear hormone receptor | 0.014 | 0.1645 | 0.1646 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0698 | 0.0699 |
Brugia malayi | ecdysone receptor | 0.0066 | 0.0585 | 0.0585 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.014 | 0.1645 | 0.1646 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.049 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0381 | 0.5123 | 0.5037 |
Onchocerca volvulus | 0.0105 | 0.1155 | 0.1518 | |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.014 | 0.1645 | 0.1646 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0064 | 0.0564 | 1 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0066 | 0.0585 | 0.0418 |
Loa Loa (eye worm) | hypothetical protein | 0.0432 | 0.585 | 0.5857 |
Loa Loa (eye worm) | hypothetical protein | 0.0432 | 0.585 | 0.5857 |
Schistosoma mansoni | thyroid hormone receptor | 0.0521 | 0.7129 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0521 | 0.7129 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.0315 | 0.0315 |
Schistosoma mansoni | lipoxygenase | 0.0054 | 0.0413 | 0.0144 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.014 | 0.1645 | 0.2402 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0074 | 0.0698 | 0.0533 |
Brugia malayi | hypothetical protein | 0.0074 | 0.0698 | 0.0699 |
Echinococcus multilocularis | Protein lozenge | 0.0054 | 0.0418 | 0.0248 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0074 | 0.0696 | 0.0531 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.2015 | 0.2495 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0585 | 0.0585 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0064 | 0.0564 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0066 | 0.0585 | 0.0418 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.014 | 0.1645 | 0.1646 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.049 | 0.0257 |
Brugia malayi | nuclear hormone receptor | 0.0066 | 0.0585 | 0.0585 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0074 | 0.0698 | 0.0699 |
Echinococcus multilocularis | FTZ F1 alpha | 0.014 | 0.1645 | 0.1496 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0585 | 0.0585 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0066 | 0.0585 | 0.0418 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0585 | 0.0585 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0162 | 0.1967 | 0.1825 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.014 | 0.1645 | 0.1951 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.014 | 0.1645 | 0.1646 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0066 | 0.0585 | 0.0418 |
Echinococcus granulosus | geminin | 0.0165 | 0.2015 | 0.1873 |
Onchocerca volvulus | 0.0066 | 0.0585 | 0.0487 | |
Echinococcus multilocularis | geminin | 0.0165 | 0.2015 | 0.1873 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0074 | 0.0698 | 0.0699 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.014 | 0.1645 | 0.1646 |
Brugia malayi | nuclear receptor RXR | 0.0066 | 0.0585 | 0.0585 |
Schistosoma mansoni | nuclear hormone receptor | 0.0066 | 0.0585 | 0.0396 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 0.03 uM | Growth inhibition of human RFX393 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 0.48 uM | Growth inhibition of human SF295 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 0.69 uM | Growth inhibition of human CCRF-CEM cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 0.78 uM | Growth inhibition of human NCI-H460 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 0.82 uM | Growth inhibition of human SNB75 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 0.92 uM | Growth inhibition of human IGROV1 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 1.14 uM | Growth inhibition of human BT549 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 1.42 uM | Growth inhibition of human RPMI8226 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 1.44 uM | Growth inhibition of human HCT15 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 1.45 uM | Growth inhibition of human TK10 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 1.6 uM | Growth inhibition of human NCI/ADR-RES cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 1.72 uM | Growth inhibition of human K562 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 1.72 uM | Growth inhibition of human OVCAR-3 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 1.88 uM | Growth inhibition of human OVCAR8 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 1.97 uM | Growth inhibition of human MDA-MB-435 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 1.98 uM | Growth inhibition of human HOP62 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 1.99 uM | Growth inhibition of human EKVX cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 2 uM | Growth inhibition of human HCT116 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 2.16 uM | Growth inhibition of human UACC62 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 2.37 uM | Growth inhibition of human LOXIMVI cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 2.42 uM | Growth inhibition of human HL-60(TB) cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 2.43 uM | Growth inhibition of human OVCAR4 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 2.43 uM | Growth inhibition of human Caki1 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 2.49 uM | Growth inhibition of human SK-MEL-5 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 2.53 uM | Growth inhibition of human ACHN cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 2.55 uM | Growth inhibition of human MOLT4 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 2.6 uM | Growth inhibition of human OVCAR5 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 2.67 uM | Growth inhibition of human NCI-H522 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 2.67 uM | Growth inhibition of human UACC257 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 2.71 uM | Growth inhibition of human NCI-H226 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 2.81 uM | Growth inhibition of human SF539 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 2.97 uM | Growth inhibition of human COLO205 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 3.51 uM | Growth inhibition of human MCF7 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 3.55 uM | Growth inhibition of human SKOV3 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 3.63 uM | Growth inhibition of human SF268 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 3.82 uM | Growth inhibition of human SK-MEL-2 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 3.84 uM | Growth inhibition of human UO31 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 4.16 uM | Growth inhibition of human T47D cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 4.28 uM | Growth inhibition of human M14 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 4.37 uM | Growth inhibition of human SNB19 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 4.56 uM | Growth inhibition of human HT-29 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 4.66 uM | Growth inhibition of human MDA-MB-468 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 4.75 uM | Growth inhibition of human SW620 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 4.9 uM | Growth inhibition of human HOP92 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 5.18 uM | Growth inhibition of human SN12C cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 5.59 uM | Growth inhibition of human NCI-H23 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 5.86 uM | Growth inhibition of human U251 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 5.88 uM | Growth inhibition of human KM12 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 6.6 uM | Growth inhibition of human 786-0 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 7.23 uM | Growth inhibition of human A549 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 8.71 uM | Growth inhibition of human A498 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 9.22 uM | Growth inhibition of human SK-MEL-28 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 10.5 uM | Growth inhibition of human HCC2998 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 10.5 uM | Growth inhibition of human DU145 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
GI50 (functional) | = 26.3 uM | Growth inhibition of human PC3 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 20207545 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.