Detailed information for compound 1116724

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 577.797 | Formula: C35H51N3O4
  • H donors: 1 H acceptors: 2 LogP: 6.06 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1cc(ccc1OC)C(C(C)C)(CCCN(CC1=CC(N(C1(C)C)O)(C)C)CCc1ccc(c(c1)OC)C)C#N
  • InChi: 1S/C35H51N3O4/c1-25(2)35(24-36,28-14-15-30(40-8)32(21-28)42-10)17-11-18-37(19-16-27-13-12-26(3)31(20-27)41-9)23-29-22-33(4,5)38(39)34(29,6)7/h12-15,20-22,25,39H,11,16-19,23H2,1-10H3
  • InChiKey: SOPNFKUTUHHEAI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis CMGC family protein kinase 0.0107 0.1384 0.3071
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0053 0.057 0.0834
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0015 0.0009 0.0009
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0035 0.0058
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0009
Echinococcus multilocularis cysteine protease 0.0017 0.0035 0.0058
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0092 0.0184
Echinococcus multilocularis lamin 0.0028 0.0193 0.0409
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0009
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0092 0.0184
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0125 0.1658 0.3683
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0164 0.2241 0.2957
Leishmania major cathepsin L-like protease 0.0017 0.0035 0.0039
Leishmania major cytochrome p450-like protein 0.0245 0.3462 0.5142
Echinococcus multilocularis transfer RNA-Lys 0.015 0.2033 0.4521
Echinococcus granulosus cytochrome P450 2K1 0.0164 0.2241 0.4986
Schistosoma mansoni aryl hydrocarbon receptor 0.0203 0.2825 0.6291
Leishmania major cathepsin L-like protease 0.0017 0.0035 0.0039
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0191 0.2648 0.3929
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0313 0.4485 0.6666
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0035 0.0058
Loa Loa (eye worm) hypothetical protein 0.0191 0.2648 0.2648
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0035 0.0058
Brugia malayi Cathepsin L-like precursor 0.0017 0.0035 0.0035
Trichomonas vaginalis CMGC family protein kinase 0.0107 0.1384 0.3071
Loa Loa (eye worm) hypothetical protein 0.0081 0.0999 0.0999
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0596 0.0596
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0462 0.6723 1
Brugia malayi Cytochrome P450 family protein 0.0245 0.3462 0.3462
Schistosoma mansoni serine/threonine protein kinase 0.0107 0.1384 0.3071
Schistosoma mansoni rab6-interacting 0.0021 0.0092 0.0184
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0759 0.1117
Schistosoma mansoni cytochrome P450 0.0164 0.2241 0.4986
Trichomonas vaginalis guanylate cyclase, putative 0.0053 0.057 0.1252
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0191 0.2648 0.5895
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0009
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0359 0.0781
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0056 0.062 0.0909
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0759 0.1117
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0712 0.0555
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.0759 0.1117
Mycobacterium leprae putative cytochrome p450 0.0164 0.2241 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0009
Brugia malayi Cytochrome P450 family protein 0.0478 0.6967 0.6967
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0125 0.1658 0.3683
Onchocerca volvulus 0.0017 0.0035 0.0128
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.0015 0.0009 0.0009
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0245 0.3462 0.4875
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0035 0.0098
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0107 0.1384 0.2047
Trypanosoma brucei cytochrome P450, putative 0.0245 0.3462 0.5142
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0191 0.2648 1
Schistosoma mansoni serine/threonine protein kinase 0.0313 0.4485 1
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0164 0.2241 0.2957
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0062 0.0717 0.158
Mycobacterium ulcerans putative regulatory protein 0.015 0.2033 0.263
Loa Loa (eye worm) hypothetical protein 0.0027 0.0185 0.0185
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0313 0.4485 1
Onchocerca volvulus 0.0028 0.0193 0.0906
Toxoplasma gondii cytochrome p450 superfamily protein 0.0164 0.2241 0.4986
Echinococcus granulosus mitogen activated protein kinase 0.0107 0.1384 0.3071
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0164 0.2241 0.2957
Leishmania major protein kinase, putative 0.0313 0.4485 0.6666
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0107 0.1384 0.2047
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0015 0.0009 0.0009
Schistosoma mansoni rab6-interacting 0.0021 0.0092 0.0184
Leishmania major cathepsin L-like protease 0.0065 0.0759 0.1117
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0164 0.2241 0.2957
Leishmania major protein kinase, putative 0.0056 0.062 0.0909
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0015 0.0009 0.0009
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0164 0.2241 0.2957
Brugia malayi Cathepsin L-like precursor 0.0017 0.0035 0.0035
Giardia lamblia Kinase, CMGC MAPK 0.0107 0.1384 0.3071
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0164 0.2241 0.2957
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0359 0.052
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0053 0.057 0.1252
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0164 0.2241 0.2957
Trypanosoma cruzi cytochrome P450, putative 0.0245 0.3462 0.5142
Onchocerca volvulus 0.0028 0.0193 0.0906
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0759 0.1117
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0712 0.0555
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0359 0.0781
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0015 0.0009 0.0009
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0359 0.0781
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0035 0.0058
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0164 0.2241 0.2957
Schistosoma mansoni intermediate filament proteins 0.0028 0.0193 0.0409
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0015 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0058
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0062 0.0717 0.158
Brugia malayi hypothetical protein 0.0021 0.0092 0.0092
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0058
Leishmania major cathepsin L-like protease 0.0065 0.0759 0.1117
Echinococcus granulosus intermediate filament protein 0.0028 0.0193 0.0409
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0015 0.0009 0.0009
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0035 0.0058
Loa Loa (eye worm) hypothetical protein 0.0053 0.057 0.057
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0759 0.1117
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0313 0.4485 0.6666
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0164 0.2241 0.2957
Trichomonas vaginalis adenylate cyclase, putative 0.0053 0.057 0.1252
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0712 0.157
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0164 0.2241 0.2957
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0062 0.0717 0.0562
Loa Loa (eye worm) cytochrome P450 family protein 0.0478 0.6967 0.6967
Schistosoma mansoni hypothetical protein 0.0021 0.0092 0.0184
Brugia malayi PAS domain containing protein 0.0203 0.2825 0.2825
Entamoeba histolytica cysteine protease, putative 0.0017 0.0035 0.0098
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0164 0.2241 0.3323
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0359 0.0359
Brugia malayi Cathepsin L-like precursor 0.0017 0.0035 0.0035
Leishmania major cathepsin L-like protease 0.0017 0.0035 0.0039
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0359 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0759 0.1117
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0056 0.062 0.0909
Schistosoma mansoni lipoxygenase 0.0125 0.1658 0.3683
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0164 0.2241 0.2957
Echinococcus granulosus dual specificity protein kinase clk2 0.0313 0.4485 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0058
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0015 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.0164 0.2241 0.4986
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0056 0.062 0.0909
Echinococcus multilocularis aryl hydrocarbon receptor 0.0053 0.057 0.1252
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0359 0.0359
Loa Loa (eye worm) hypothetical protein 0.0021 0.0092 0.0092
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0053 0.057 0.1252
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0015 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0058
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0462 0.6723 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0015 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0028 0.0193 0.0193
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0015 0.0009 0.0009
Brugia malayi Cathepsin L-like precursor 0.0017 0.0035 0.0035
Onchocerca volvulus 0.0017 0.0035 0.0128
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0759 0.1117
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0035 0.0058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0759 0.1117
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0191 0.2648 0.5895
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0164 0.2241 0.2957
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0015 0.0009 0.0009
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0164 0.2241 0.2957
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0712 0.157
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0092 0.0184
Trichomonas vaginalis CMGC family protein kinase 0.0313 0.4485 1
Loa Loa (eye worm) cytochrome P450 0.0164 0.2241 0.2241
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0164 0.2241 0.2957
Loa Loa (eye worm) hypoxia-induced factor 1 0.0627 0.9208 0.9208
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0058
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0164 0.2241 0.2957
Echinococcus multilocularis mitogen activated protein kinase 3 0.0107 0.1384 0.3071
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.057 0.1252
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0107 0.1384 0.2047
Schistosoma mansoni ap endonuclease 0.0039 0.0359 0.0781
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.057 0.1252
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0053 0.057 0.1252
Onchocerca volvulus 0.0053 0.057 0.2768
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0053 0.057 0.0834
Schistosoma mansoni lipoxygenase 0.0087 0.1092 0.2419
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0009
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0313 0.4485 0.6666
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0053 0.057 0.1252
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0462 0.6723 1
Brugia malayi hypothetical protein 0.0015 0.0009 0.0009
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0107 0.1384 0.2047
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0191 0.2648 0.5895
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0035 0.0058
Leishmania major cytochrome p450-like protein 0.0164 0.2241 0.3323
Plasmodium vivax vivapain-2 0.0017 0.0035 0.0058
Brugia malayi hypothetical protein 0.0021 0.0092 0.0092
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0462 0.6723 1
Brugia malayi Protein kinase domain containing protein 0.0313 0.4485 0.4485
Plasmodium vivax vivapain-2 0.0017 0.0035 0.0058
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0164 0.2241 0.2957
Toxoplasma gondii cathepsin CPL 0.0017 0.0035 0.0058
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0191 0.2648 0.5895
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0712 0.0555
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0009
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0164 0.2241 0.2957
Brugia malayi hypoxia-induced factor 1 0.0627 0.9208 0.9208
Onchocerca volvulus 0.015 0.2033 1
Leishmania major cytochrome p450-like protein 0.0164 0.2241 0.3323
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0053 0.057 0.1252
Brugia malayi MAP kinase sur-1 0.0107 0.1384 0.1384
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0015 0.0009 0.0009
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0092 0.0184
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0359 0.0781
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0058
Echinococcus multilocularis mitogen activated protein kinase 0.0107 0.1384 0.3071
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0191 0.2648 0.2648
Schistosoma mansoni polycystin 1-related 0.0021 0.0092 0.0184
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0015 0.0009 0.0009
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0164 0.2241 0.2957
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0313 0.4485 0.6666
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0015 0.0009 0.0009
Schistosoma mansoni loxhd1 0.0021 0.0092 0.0184
Echinococcus multilocularis ubiquitin specific protease 41 0.0191 0.2648 0.5895
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0164 0.2241 0.2957
Leishmania major cathepsin L-like protease 0.0065 0.0759 0.1117
Plasmodium falciparum protein serine/threonine kinase-1 0.0313 0.4485 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0035 0.0058
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0164 0.2241 0.2957
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0107 0.1384 0.3071
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0009
Toxoplasma gondii exonuclease III APE 0.0039 0.0359 0.0781
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0015 0.0009 0.0009
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0191 0.2648 0.5895
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0164 0.2241 0.2957
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0712 0.1047
Schistosoma mansoni peptidase 0.0019 0.0059 0.0112
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0712 0.157
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0164 0.2241 0.2957
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0092 0.0184
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0191 0.2648 0.5895
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0359 0.0781
Onchocerca volvulus 0.0017 0.0035 0.0128
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0759 0.1117
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0164 0.2241 0.2957
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0193 0.0193
Echinococcus multilocularis cysteine protease 0.0017 0.0035 0.0058
Loa Loa (eye worm) cytochrome P450 family protein 0.0245 0.3462 0.3462
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0035 0.0058
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 46 0.0015 0.0009 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0759 0.1117
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0462 0.6723 1
Leishmania major cathepsin L-like protease 0.0017 0.0035 0.0039
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0009
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0056 0.062 0.0909
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0164 0.2241 0.2957
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0035 0.0058
Leishmania major protein kinase, putative 0.0313 0.4485 0.6666
Schistosoma mansoni serine/threonine protein kinase 0.0313 0.4485 1
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0062 0.0717 0.0717
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0164 0.2241 0.2957
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0712 0.0555
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0035 0.0058
Echinococcus multilocularis 0.0164 0.2241 0.4986
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0058
Echinococcus granulosus lamin 0.0028 0.0193 0.0409
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0164 0.2241 0.2957
Brugia malayi follicle stimulating hormone receptor 0.0473 0.6886 0.6886
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0015 0.0009 0.0009
Trichomonas vaginalis guanylate cyclase, putative 0.0053 0.057 0.1252
Leishmania major cathepsin L-like protease 0.0017 0.0035 0.0039
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0313 0.4485 0.6666
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0164 0.2241 0.2957
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0191 0.2648 0.5895
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0193 0.0193
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0035 0.0058
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0092 0.0184
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0191 0.2648 0.5895
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0062 0.0717 0.1053
Brugia malayi ubiquitin carboxyl-terminal hydrolase 46 0.0015 0.0009 0.0009
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0015 0.0009 0.0009
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0035 0.0039
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0062 0.0717 0.0562
Brugia malayi Cytochrome P450 family protein 0.0164 0.2241 0.2241
Loa Loa (eye worm) hypothetical protein 0.0017 0.0035 0.0035
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0359 0.5
Echinococcus granulosus hypothetical protein 0.031 0.4435 0.9888
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0313 0.4485 0.4485
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0035 0.0058
Loa Loa (eye worm) CYP4Cod1 0.0245 0.3462 0.3462
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0107 0.1384 0.2047
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0164 0.2241 0.2957
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0053 0.057 0.1252
Loa Loa (eye worm) cytochrome P450 family protein 0.0245 0.3462 0.3462
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0058
Echinococcus granulosus single minded 2 0.015 0.2033 0.4521
Onchocerca volvulus 0.0021 0.0092 0.0408
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0092 0.0092
Echinococcus granulosus aryl hydrocarbon receptor 0.0053 0.057 0.1252
Trypanosoma brucei protein kinase, putative 0.0107 0.1384 0.2047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0058
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0473 0.6886 0.6886
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0035 0.0058
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0759 0.1117
Schistosoma mansoni lamin 0.0028 0.0193 0.0409
Brugia malayi Doublecortin family protein 0.0021 0.0092 0.0092
Onchocerca volvulus 0.0017 0.0035 0.0128
Schistosoma mansoni lamin 0.0028 0.0193 0.0409
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0164 0.2241 0.2957
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0759 0.1117
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0107 0.1384 0.2047
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0009
Echinococcus granulosus ubiquitin specific protease 41 0.0191 0.2648 0.5895
Loa Loa (eye worm) hypothetical protein 0.031 0.4435 0.4435
Loa Loa (eye worm) ctsf protein 0.0017 0.0035 0.0035
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0035 0.0058
Brugia malayi ubiquitin specific protease 14 0.0015 0.0009 0.0009
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0359 0.052
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0035 0.0058
Onchocerca volvulus 0.0017 0.0035 0.0128
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0712 0.157
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0015 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0021 0.0092 0.0092
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0015 0.0009 0.0009
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0359 0.0781
Echinococcus granulosus cathepsin l1 0.0017 0.0035 0.0058
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0035 0.0035
Echinococcus multilocularis lamin dm0 0.0028 0.0193 0.0409
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0009
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0015 0.0009 0.0009
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0164 0.2241 0.2957
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0359 0.052
Brugia malayi bHLH-PAS transcription factor 0.015 0.2033 0.2033
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0191 0.2648 0.3929
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0462 0.6723 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0058
Schistosoma mansoni single-minded 0.0203 0.2825 0.6291
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0191 0.2648 0.3929
Mycobacterium leprae Conserved hypothetical protein 0.0164 0.2241 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0015 0.0009 0.0009
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0164 0.2241 0.2957
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0015 0.0009 0.0009
Echinococcus multilocularis 0.031 0.4435 0.9888
Onchocerca volvulus 0.0017 0.0035 0.0128
Onchocerca volvulus 0.0021 0.0092 0.0408
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0193 0.0193
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0035 0.0039
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0053 0.057 0.057
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0035 0.0058
Trichomonas vaginalis CMGC family protein kinase 0.0107 0.1384 0.3071
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0058
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0009
Plasmodium vivax serine/threonine kinase-1, putative 0.0313 0.4485 1
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0712 0.157
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0164 0.2241 0.2957
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0164 0.2241 0.2957
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0035 0.0058
Brugia malayi cytochrome P450 0.0164 0.2241 0.2241
Echinococcus multilocularis RUN 0.0021 0.0092 0.0184
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0092 0.0184
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0164 0.2241 0.2957
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0107 0.1384 0.2047
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0053 0.057 0.1252
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0191 0.2648 0.3929
Echinococcus multilocularis musashi 0.0028 0.0193 0.0409
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0062 0.0717 0.0562
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0759 0.1117
Echinococcus granulosus lamin dm0 0.0028 0.0193 0.0409
Echinococcus multilocularis dual specificity protein kinase clk2 0.0313 0.4485 1
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0164 0.2241 0.2957
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0035 0.0058
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0035 0.0058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0058
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0359 0.0781
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0549 0.0804
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0062 0.0717 0.158
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0191 0.2648 0.5895
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0313 0.4485 0.6666
Brugia malayi Cathepsin L-like precursor 0.0017 0.0035 0.0035
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0015 0.0009 0.0009
Onchocerca volvulus 0.0017 0.0035 0.0128
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.006 0.0674 0.099
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0759 0.1117
Brugia malayi Cytochrome P450 family protein 0.0245 0.3462 0.3462
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0164 0.2241 0.2957
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0035 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.057 0.1252
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0359 0.1324
Leishmania major protein kinase, putative 0.0056 0.062 0.0909
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0015 0.0009 0.0009
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0164 0.2241 0.2957
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0759 0.1117
Trypanosoma cruzi cytochrome P450, putative 0.0245 0.3462 0.5142
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0035 0.0128
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0035 0.0128
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0035 0.0058
Giardia lamblia Kinase, CMGC CLK 0.0313 0.4485 1
Brugia malayi Cathepsin L-like precursor 0.0017 0.0035 0.0035
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0053 0.057 0.0834
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0058
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0053 0.057 0.5
Trichomonas vaginalis CMGC family protein kinase 0.0107 0.1384 0.3071
Loa Loa (eye worm) fibroinase 0.0017 0.0035 0.0035
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0107 0.1384 0.1384
Brugia malayi intermediate filament protein 0.0028 0.0193 0.0193
Loa Loa (eye worm) hypothetical protein 0.068 1 1
Echinococcus granulosus RUN 0.0021 0.0092 0.0184
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0092 0.0184
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0035 0.0098
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0359 0.052
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0164 0.2241 0.2957
Trichomonas vaginalis conserved hypothetical protein 0.0191 0.2648 0.5895
Loa Loa (eye worm) cysteine protease 0.0017 0.0035 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0058
Schistosoma mansoni ap endonuclease 0.0039 0.0359 0.0781
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0035 0.0128
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0035 0.0035
Echinococcus granulosus mitogen activated protein kinase 3 0.0107 0.1384 0.3071

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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