Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.4084 | 0.7867 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0054 | 0.235 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0083 | 0.4954 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.4084 | 0.7867 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.4084 | 0.7867 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0039 | 0.0966 | 0.0227 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0039 | 0.0966 | 0.0227 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0073 | 0.4084 | 0.3451 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0039 | 0.0966 | 0.1949 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0083 | 0.4954 | 1 |
Brugia malayi | RNA binding protein | 0.0073 | 0.4084 | 0.3518 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0039 | 0.0966 | 0.5 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0083 | 0.4954 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0073 | 0.4084 | 0.7867 |
Loa Loa (eye worm) | TAR-binding protein | 0.0073 | 0.4084 | 0.3451 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0054 | 0.235 | 1 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0035 | 0.0592 | 0.1194 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0073 | 0.4084 | 0.3518 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.4084 | 0.7867 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.0966 | 0.5 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0054 | 0.235 | 0.3619 |
Schistosoma mansoni | inositol monophosphatase | 0.0039 | 0.0966 | 0.0227 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0039 | 0.0966 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0073 | 0.4084 | 0.3451 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0138 | 1 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0083 | 0.4954 | 1 |
Brugia malayi | Probable ClpP-like protease | 0.0083 | 0.4954 | 0.4472 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.4084 | 0.7867 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0083 | 0.4954 | 1 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0054 | 0.235 | 0.3619 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0083 | 0.4954 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0054 | 0.235 | 0.4744 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.0966 | 0.5 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0039 | 0.0966 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.4954 | 0.4415 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.0966 | 0.5 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0083 | 0.4954 | 1 |
Brugia malayi | TAR-binding protein | 0.0073 | 0.4084 | 0.3518 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0083 | 0.4954 | 1 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.0966 | 0.5 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0039 | 0.0966 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0073 | 0.4084 | 0.7867 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0083 | 0.4954 | 1 |
Brugia malayi | Inositol-1 | 0.0039 | 0.0966 | 0.0101 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0138 | 1 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0083 | 0.4954 | 0.5 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0083 | 0.4954 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0039 | 0.0966 | 0.0227 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0083 | 0.4954 | 1 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0083 | 0.4954 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0083 | 0.4954 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 8 ug ml-1 | Antifungal activity against Candida albicans after 48 to 72 hrs by broth microdilution method | ChEMBL. | 20047777 |
MIC (functional) | > 500 ug ml-1 | Antibacterial activity against Escherichia coli MTCC 1089 after 18 hrs by broth microdilution method | ChEMBL. | 20047777 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.