Detailed information for compound 1117108

Basic information

Technical information
  • TDR Targets ID: 1117108
  • Name: 2-amino-4,6-dimethyl-5-(pyridin-3-ylmethylide ne)cyclopenta[e]pyridine-3,7-dicarbonitrile
  • MW: 299.329 | Formula: C18H13N5
  • H donors: 1 H acceptors: 4 LogP: 1.85 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC1=C(C)/C(=C\c2cccnc2)/c2c1nc(N)c(c2C)C#N
  • InChi: 1S/C18H13N5/c1-10-13(6-12-4-3-5-22-9-12)16-11(2)15(8-20)18(21)23-17(16)14(10)7-19/h3-6,9H,1-2H3,(H2,21,23)/b13-6+
  • InChiKey: LARXYNLRIYUAHH-AWNIVKPZSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (5E)-2-amino-4,6-dimethyl-5-(pyridin-3-ylmethylidene)cyclopenta[e]pyridine-3,7-dicarbonitrile
  • 2-amino-4,6-dimethyl-5-(3-pyridylmethylene)cyclopenta[e]pyridine-3,7-dicarbonitrile
  • (5E)-2-amino-4,6-dimethyl-5-(3-pyridylmethylene)cyclopenta[e]pyridine-3,7-dicarbonitrile
  • 2-amino-4,6-dimethyl-5-(3-pyridylmethylene)-1-pyrindine-3,7-dicarbonitrile
  • (5E)-2-amino-4,6-dimethyl-5-(3-pyridylmethylene)-1-pyrindine-3,7-dicarbonitrile
  • Oprea1_196446
  • STK177096

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0208 0.0208
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0079 0.0116
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0024 0.0079 0.0086
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0133 0.1536 0.4506
Trichomonas vaginalis ran, putative 0.0024 0.0074 0.0224
Loa Loa (eye worm) hypothetical protein 0.0032 0.018 0.0235
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0074 0.0074
Schistosoma mansoni tar DNA-binding protein 0.0277 0.3448 0.3448
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0433 0.1313
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0157 0.0475
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0024 0.0079 0.0923
Loa Loa (eye worm) intermediate filament protein 0.0032 0.0188 0.0247
Entamoeba histolytica hypothetical protein 0.0041 0.0305 0.2965
Loa Loa (eye worm) hypothetical protein 0.0053 0.0458 0.0645
Echinococcus granulosus inositol monophosphatase 1 0.0044 0.0348 0.0348
Plasmodium vivax SET domain protein, putative 0.0033 0.0203 0.3519
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0133 0.1536 0.4506
Echinococcus multilocularis ecdysone induced protein 78C 0.0034 0.0208 0.0208
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0051 0.0433 0.0433
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0012 0.0012
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0021 0.0034 0.01
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0034 0.0208 0.04
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0036 0.0231 0.0231
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0028 0.0137 0.0398
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.012 0.1358 0.8774
Echinococcus granulosus geminin 0.0396 0.5032 0.5032
Schistosoma mansoni hypothetical protein 0.0041 0.0305 0.0305
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0079 0.0923
Schistosoma mansoni ferritin light chain 0.0028 0.0137 0.0137
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.0188 0.0247
Loa Loa (eye worm) hypothetical protein 0.0528 0.6794 1
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0024 0.0079 0.0923
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0012 0.0012
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0274 0.341 1
Schistosoma mansoni intermediate filament proteins 0.0032 0.0188 0.0188
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0141 0.1638 0.1638
Leishmania major acetyl-CoA synthetase, putative 0.0024 0.0079 0.0923
Brugia malayi Latrophilin receptor protein 2 0.0036 0.0231 0.034
Trypanosoma cruzi target of rapamycin kinase 3 0.004 0.0295 0.5552
Schistosoma mansoni lamin 0.0032 0.0188 0.0188
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0051 0.0433 0.8145
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0024 0.0079 0.1484
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0044 0.0348 0.4071
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0074 0.1281
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0024 0.0079 0.1368
Schistosoma mansoni inositol monophosphatase 0.0044 0.0348 0.0348
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0024 0.0079 0.0923
Echinococcus multilocularis thioredoxin glutathione reductase 0.0053 0.0459 0.0459
Schistosoma mansoni bromodomain containing protein 0.0071 0.0702 0.0702
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0079 0.0923
Onchocerca volvulus Bile acid receptor homolog 0.0034 0.0208 0.04
Schistosoma mansoni ferritin 0.0028 0.0137 0.0137
Trichomonas vaginalis antibiotic synthetase, putative 0.0024 0.0079 0.0239
Trypanosoma brucei target of rapamycin kinase 3, putative 0.004 0.0295 0.5552
Entamoeba histolytica hypothetical protein 0.0026 0.0106 0.0414
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0188 0.3531
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0305 0.0305
Loa Loa (eye worm) glutathione reductase 0.0053 0.0459 0.0647
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0161 0.1907 0.2785
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0233 0.2866 0.4201
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0161 0.0487
Loa Loa (eye worm) hypothetical protein 0.0034 0.0208 0.0276
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0034 0.0208 0.0306
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0329 0.0329
Leishmania major trypanothione reductase 0.0053 0.0459 0.5373
Loa Loa (eye worm) hypothetical protein 0.0043 0.0329 0.0454
Brugia malayi PHD-finger family protein 0.0028 0.0129 0.019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0122 0.0369
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0329 0.0454
Brugia malayi RNA binding protein 0.0277 0.3448 0.5075
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0329 0.0964
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0259 0.0787
Plasmodium falciparum glutathione reductase 0.0053 0.0459 0.7958
Echinococcus multilocularis FTZ F1 alpha 0.0034 0.0208 0.0208
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0061 0.0576 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0082 0.0854 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0026 0.0104 0.0104
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0034 0.0208 0.0208
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0036 0.0231 0.0311
Trypanosoma brucei PAB1-binding protein , putative 0.0058 0.0531 1
Schistosoma mansoni cellular tumor antigen P53 0.0055 0.0491 0.0491
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0034 0.0208 0.0276
Schistosoma mansoni tar DNA-binding protein 0.0277 0.3448 0.3448
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0034 0.0208 0.0208
Trichomonas vaginalis esterase, putative 0.0043 0.0329 0.0997
Loa Loa (eye worm) hypothetical protein 0.0061 0.0576 0.082
Trypanosoma cruzi PAB1-binding protein , putative 0.0058 0.0531 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0237 0.2924 0.4286
Brugia malayi Pre-SET motif family protein 0.0233 0.2866 0.4219
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0208 0.0306
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0036 0.0231 0.0231
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0082 0.0854 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0034 0.0208 0.0306
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0024 0.0079 0.0079
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0074 0.139
Loa Loa (eye worm) hypothetical protein 0.0055 0.0491 0.0694
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0188 0.0188
Onchocerca volvulus 0.0108 0.1192 0.3461
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0348 0.6541
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0348 0.6541
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0348 0.4071
Giardia lamblia GTOR 0.0051 0.0433 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0024 0.0079 0.1484
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0034 0.0208 0.0276
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0044 0.0348 0.6541
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0079 0.0231
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0074 0.0109
Loa Loa (eye worm) hypothetical protein 0.0112 0.1256 0.1824
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0034 0.0208 0.0208
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0074 0.1281
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0294 0.0893
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0208 0.0208
Loa Loa (eye worm) hypothetical protein 0.0046 0.0365 0.0509
Echinococcus granulosus zinc finger protein 0.0022 0.0049 0.0049
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0074 0.139
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0329 0.5701
Loa Loa (eye worm) latrophilin receptor protein 2 0.0036 0.0231 0.0311
Onchocerca volvulus 0.0055 0.0491 0.1281
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0079 0.0923
Schistosoma mansoni tar DNA-binding protein 0.0277 0.3448 0.3448
Mycobacterium tuberculosis Conserved protein 0.0043 0.0329 0.0964
Toxoplasma gondii propionate-CoA ligase 0.0024 0.0079 0.1484
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0161 0.0487
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0074 0.139
Schistosoma mansoni apoferritin-2 0.0028 0.0137 0.0137
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.0188 0.0277
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.0294 0.0294
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0277 0.3448 0.506
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0024 0.0079 0.1484
Plasmodium vivax thioredoxin reductase, putative 0.0053 0.0459 0.7958
Loa Loa (eye worm) hypothetical protein 0.0061 0.0576 0.082
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0024 0.0079 0.0231
Schistosoma mansoni ran 0.0024 0.0074 0.0074
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0329 0.3849
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.012 0.1358 0.3982
Echinococcus multilocularis lamin 0.0032 0.0188 0.0188
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0079 0.0116
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0329 0.0997
Loa Loa (eye worm) steroid hormone receptor 0.0034 0.0208 0.0276
Schistosoma mansoni acetyl-CoA synthetase 0.0024 0.0079 0.0079
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0329 0.6185
Plasmodium vivax glutathione reductase, putative 0.0053 0.0459 0.7958
Loa Loa (eye worm) inositol-1 0.0044 0.0348 0.0482
Mycobacterium ulcerans bacterioferritin BfrA 0.0028 0.0137 0.1603
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0034 0.0208 0.0208
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.0294 0.0294
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0051 0.0433 0.5069
Schistosoma mansoni hypothetical protein 0.0036 0.0231 0.0231
Loa Loa (eye worm) hypothetical protein 0.0043 0.0329 0.0454
Echinococcus granulosus lamin 0.0032 0.0188 0.0188
Echinococcus granulosus ecdysone induced protein 78C 0.0034 0.0208 0.0208
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0079 0.0923
Loa Loa (eye worm) TAR-binding protein 0.0277 0.3448 0.506
Loa Loa (eye worm) hypothetical protein 0.0043 0.033 0.0457
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0034 0.0208 0.0208
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0024 0.0079 0.1484
Schistosoma mansoni thyroid hormone receptor 0.0175 0.2089 0.2089
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0034 0.0208 0.0276
Plasmodium falciparum acyl-CoA synthetase 0.0061 0.0576 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0208 0.0276
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0024 0.0079 0.0086
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0024 0.0079 0.0923
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0121 0.0368
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.0458 0.0458
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0345 0.4356 0.64
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0036 0.0231 0.0231
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0259 0.0787
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0161 0.1907 0.1907
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0203 0.0203
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0161 0.1907 0.1907
Loa Loa (eye worm) beta-lactamase 0.0043 0.0329 0.0454
Loa Loa (eye worm) hypothetical protein 0.0082 0.0854 0.123
Loa Loa (eye worm) hypothetical protein 0.0079 0.0813 0.117
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0329 0.3849
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0305 0.0305
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0121 0.0368
Loa Loa (eye worm) hypothetical protein 0.0034 0.0208 0.0276
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0044 0.0348 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.0458 0.0458
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0034 0.0208 0.0208
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0433 0.1313
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0051 0.0433 0.0433
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0208 0.0306
Echinococcus multilocularis geminin 0.0396 0.5032 0.5032
Loa Loa (eye worm) hypothetical protein 0.0082 0.0854 0.123
Plasmodium vivax acetyl-CoA synthetase, putative 0.0024 0.0079 0.1368
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0034 0.0208 0.0276
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0024 0.0079 0.0923
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0106 0.1998
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0294 0.0893
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0203 0.3817
Onchocerca volvulus 0.0032 0.0188 0.034
Schistosoma mansoni hypothetical protein 0.0077 0.0782 0.0782
Onchocerca volvulus Protein ultraspiracle homolog 0.0034 0.0208 0.04
Trypanosoma cruzi trypanothione reductase, putative 0.0053 0.0459 0.8634
Loa Loa (eye worm) hypothetical protein 0.0024 0.0079 0.0086
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0079 0.0116
Schistosoma mansoni hypothetical protein 0.0026 0.0104 0.0104
Mycobacterium tuberculosis Probable dehydrogenase 0.012 0.1358 0.3982
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0122 0.0369
Plasmodium falciparum thioredoxin reductase 0.0053 0.0459 0.7958
Mycobacterium tuberculosis Probable oxidoreductase 0.0133 0.1536 0.4506
Brugia malayi beta-lactamase family protein 0.0043 0.0329 0.0484
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0203 0.0203
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0106 0.0322
Brugia malayi TAR-binding protein 0.0277 0.3448 0.5075
Mycobacterium tuberculosis Conserved protein 0.0043 0.0329 0.0964
Schistosoma mansoni retinoic acid receptor RXR 0.0034 0.0208 0.0208
Plasmodium vivax acyl-CoA synthetase, putative 0.0061 0.0576 1
Onchocerca volvulus 0.0043 0.0329 0.0776
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0329 0.0329
Trichomonas vaginalis set domain proteins, putative 0.0265 0.3296 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0034 0.0208 0.0208
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0259 0.0787
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0024 0.0079 0.0231
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0051 0.0433 0.5069
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.012 0.1358 0.3982
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0259 0.0787
Leishmania major hypothetical protein, conserved 0.0058 0.0531 0.6223
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0079 0.0116
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0024 0.0079 0.0116
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0051 0.0433 0.8145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0334 0.1013
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0161 0.1907 0.1907
Brugia malayi hypothetical protein 0.0528 0.6794 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0329 0.0454
Onchocerca volvulus 0.0032 0.0188 0.034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0034 0.0208 0.0276
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0203 0.0203
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.012 0.1358 0.3982
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0208 0.0306
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0036 0.0231 0.0231
Echinococcus granulosus GPCR family 2 0.0036 0.0231 0.0231
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0208 0.0306
Schistosoma mansoni steroid hormone receptor ad4bp 0.0034 0.0208 0.0208
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.021 0.0638
Mycobacterium leprae Probable lipase LipE 0.0043 0.0329 0.1713
Brugia malayi latrophilin 2 splice variant baaae 0.0077 0.0782 0.1151
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0053 0.0459 0.1345
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0094 0.0094
Toxoplasma gondii thioredoxin reductase 0.0053 0.0459 0.8634
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0188 0.3531
Brugia malayi beta-lactamase 0.0043 0.0329 0.0484
Brugia malayi Pre-SET motif family protein 0.0033 0.0203 0.0298
Loa Loa (eye worm) hypothetical protein 0.0034 0.0208 0.0276
Toxoplasma gondii target of rapamycin (TOR), putative 0.0038 0.0259 0.4884
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0051 0.0433 0.0433
Onchocerca volvulus 0.0034 0.0208 0.04
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0058 0.0532 0.1559
Mycobacterium ulcerans hypothetical protein 0.0043 0.0329 0.3849
Mycobacterium ulcerans beta-lactamase 0.0043 0.0329 0.3849
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0161 0.1907 0.1907
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0061 0.0576 0.6752
Schistosoma mansoni apoferritin-2 0.0028 0.0137 0.0137
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0329 0.0329
Brugia malayi steroid hormone receptor 0.0034 0.0208 0.0306
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0051 0.0433 0.8145
Echinococcus granulosus thioredoxin glutathione reductase 0.0053 0.0459 0.0459
Schistosoma mansoni hypothetical protein 0.0141 0.1638 0.1638
Brugia malayi hypothetical protein 0.0037 0.0257 0.0378
Leishmania major importin beta-1 subunit, putative 0.0026 0.0106 0.1243
Schistosoma mansoni hypothetical protein 0.0396 0.5032 0.5032
Loa Loa (eye worm) hypothetical protein 0.0043 0.0329 0.0454
Schistosoma mansoni hypothetical protein 0.0036 0.0231 0.0231
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0074 0.0078
Mycobacterium ulcerans bacterioferritin BfrB 0.0028 0.0137 0.1603
Leishmania major 4-coumarate:coa ligase-like protein 0.0082 0.0854 1
Schistosoma mansoni ran 0.0024 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0032 0.0188 0.0247
Echinococcus granulosus histone lysine methyltransferase setb 0.0053 0.0458 0.0458
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0024 0.0079 0.0231
Loa Loa (eye worm) hypothetical protein 0.0077 0.0782 0.1124
Echinococcus multilocularis snurportin 1 0.0345 0.4356 0.4356
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0329 0.1713
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0024 0.0079 0.1484
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0329 0.0329
Plasmodium vivax ataxin-2 like protein, putative 0.0058 0.0531 0.9217
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0161 0.1907 0.2807
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.004 0.0295 0.3455
Brugia malayi nuclear receptor NHR-88 0.0034 0.0208 0.0306
Echinococcus granulosus tar DNA binding protein 0.0277 0.3448 0.3448
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0329 0.0964
Echinococcus granulosus lamin dm0 0.0032 0.0188 0.0188
Brugia malayi AMP-binding enzyme family protein 0.0082 0.0854 0.1256
Brugia malayi Inositol-1 0.0044 0.0348 0.0511
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0034 0.0208 0.0208
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0082 0.0854 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0051 0.0433 0.8145
Schistosoma mansoni ferritin 0.0028 0.0137 0.0137
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0121 0.0368
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0034 0.0208 0.0306
Entamoeba histolytica acyl-coA synthetase, putative 0.0082 0.0854 1
Brugia malayi beta-lactamase family protein 0.0043 0.0329 0.0484
Brugia malayi Bromodomain containing protein 0.0043 0.0329 0.0484
Onchocerca volvulus 0.0082 0.0854 0.2408
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0294 0.0893
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0112 0.1256 0.1849
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0161 0.1907 0.1907
Brugia malayi intermediate filament protein 0.0032 0.0188 0.0277
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0259 0.0787
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0082 0.0854 0.5315
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0286 0.0838
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0079 0.0231
Schistosoma mansoni hypothetical protein 0.0023 0.0065 0.0065
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0058 0.0532 0.1559
Loa Loa (eye worm) hypothetical protein 0.0032 0.0188 0.0246
Brugia malayi photoreceptor-specific nuclear receptor 0.0034 0.0208 0.0306
Echinococcus granulosus FTZ F1 alpha 0.0034 0.0208 0.0208
Echinococcus multilocularis ferritin 0.0028 0.0137 0.0137
Schistosoma mansoni hypothetical protein 0.0036 0.0231 0.0231
Mycobacterium ulcerans acetyl-CoA synthetase 0.0024 0.0079 0.0923
Brugia malayi Calcitonin receptor-like protein seb-1 0.0112 0.1256 0.1849
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0208 0.0208
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0082 0.0854 0.2503
Schistosoma mansoni importin beta-1 0.0032 0.0188 0.0188
Mycobacterium ulcerans acyl-CoA synthetase 0.0082 0.0854 1
Brugia malayi glutathione reductase 0.0053 0.0459 0.0675
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0329 0.0964
Loa Loa (eye worm) hypothetical protein 0.0043 0.0329 0.0454
Echinococcus multilocularis expressed protein 0.0028 0.0137 0.0137
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0079 0.0923
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0024 0.0079 0.0923
Loa Loa (eye worm) hypothetical protein 0.0082 0.0854 0.123
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0034 0.0208 0.0208
Mycobacterium tuberculosis Conserved protein 0.0043 0.0329 0.0964
Echinococcus granulosus snurportin 1 0.0345 0.4356 0.4356
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0141 0.1638 0.1638
Onchocerca volvulus 0.0043 0.0329 0.0776
Entamoeba histolytica acyl-CoA synthetase, putative 0.0082 0.0854 1
Echinococcus granulosus survival motor neuron protein 1 0.0528 0.6794 0.6794
Loa Loa (eye worm) hypothetical protein 0.0024 0.0079 0.0086
Schistosoma mansoni tar DNA-binding protein 0.0277 0.3448 0.3448
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0079 0.0923
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0051 0.0433 0.4602
Echinococcus multilocularis tumor protein p63 0.0376 0.4772 0.4772
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0079 0.0231
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0082 0.0854 0.2503
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0051 0.0433 0.4602
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0024 0.0079 0.0231
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0433 0.1313
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0082 0.0854 0.5315
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0106 0.0322
Mycobacterium ulcerans acyl-CoA synthetase 0.0082 0.0854 1
Brugia malayi AMP-binding enzyme family protein 0.0082 0.0854 0.1256
Echinococcus multilocularis GPCR, family 2 0.0036 0.0231 0.0231
Mycobacterium tuberculosis Putative ferredoxin reductase 0.012 0.1358 0.3982
Plasmodium falciparum ataxin-2 like protein, putative 0.0058 0.0531 0.9217
Trichomonas vaginalis ferritin, putative 0.0028 0.0137 0.0415
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0329 0.6185
Leishmania major 4-coumarate:coa ligase-like protein 0.0082 0.0854 1
Echinococcus granulosus expressed protein 0.0028 0.0137 0.0137
Echinococcus multilocularis survival motor neuron protein 1 0.0528 0.6794 0.6794
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0044 0.0348 0.1054
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0024 0.0076 0.1439
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0208 0.0306
Trichomonas vaginalis antibiotic synthetase, putative 0.0024 0.0079 0.0239
Loa Loa (eye worm) hypothetical protein 0.0048 0.0394 0.0551
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0024 0.0079 0.0079
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0157 0.0475
Trichomonas vaginalis inositol monophosphatase, putative 0.0044 0.0348 0.1054
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0208 0.0208
Loa Loa (eye worm) hypothetical protein 0.0061 0.0576 0.082
Schistosoma mansoni inositol monophosphatase 0.0044 0.0348 0.0348
Brugia malayi follicle stimulating hormone receptor 0.0237 0.2924 0.4304
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0024 0.0079 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0259 0.0787
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0329 0.6185
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0286 0.1419
Plasmodium falciparum importin beta, putative 0.0032 0.0188 0.3255
Brugia malayi RNA recognition motif domain containing protein 0.0277 0.3448 0.5075
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0074 0.1707
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0079 0.0116
Echinococcus multilocularis inositol monophosphatase 1 0.0044 0.0348 0.0348
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0053 0.0458 0.0458
Brugia malayi Bromodomain containing protein 0.0084 0.0877 0.1291
Echinococcus granulosus intermediate filament protein 0.0032 0.0188 0.0188
Brugia malayi Importin beta-1 subunit 0.0032 0.0188 0.0276
Loa Loa (eye worm) hypothetical protein 0.0061 0.0576 0.082
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0024 0.0079 0.0231
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0329 0.0484
Brugia malayi nuclear hormone receptor 0.0034 0.0208 0.0306
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0024 0.0079 0.1484
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0094 0.0094
Onchocerca volvulus 0.0265 0.3296 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0061 0.0576 0.169
Trypanosoma cruzi PAB1-binding protein , putative 0.0058 0.0531 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0208 0.0276
Treponema pallidum bacterioferrin (TpF1) 0.0028 0.0137 1
Schistosoma mansoni microtubule-associated protein tau 0.0768 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0531 0.0754
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0329 0.0964
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0208 0.0208
Entamoeba histolytica hypothetical protein 0.0041 0.0305 0.2965
Brugia malayi hypothetical protein 0.0041 0.0305 0.0449
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0034 0.0208 0.0208
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0034 0.0208 0.0306
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0348 0.6541
Loa Loa (eye worm) hypothetical protein 0.0034 0.0208 0.0276
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0305 0.0305
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0034 0.0208 0.0276
Loa Loa (eye worm) thioredoxin reductase 0.0053 0.0459 0.0647
Echinococcus multilocularis microtubule associated protein 2 0.0768 1 1
Loa Loa (eye worm) oxidoreductase 0.0024 0.0079 0.0086
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0329 0.0997
Brugia malayi AMP-binding enzyme family protein 0.0082 0.0854 0.1256
Schistosoma mansoni ferritin 0.0028 0.0137 0.0137
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0024 0.0079 0.1484
Echinococcus multilocularis musashi 0.0032 0.0188 0.0188
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0026 0.0104 0.0104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0122 0.0369
Loa Loa (eye worm) RNA binding protein 0.0277 0.3448 0.506
Plasmodium vivax importin-beta 2, putative 0.0032 0.0188 0.3255
Mycobacterium ulcerans acyl-CoA synthetase 0.0082 0.0854 1
Schistosoma mansoni coup transcription factor 0.0034 0.0208 0.0208
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0112 0.1256 0.1824
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0188 0.3531
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0161 0.1907 0.1907
Schistosoma mansoni ferritin 0.0028 0.0137 0.0137
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0329 0.0997
Schistosoma mansoni ferritin light chain 0.0028 0.0137 0.0137
Brugia malayi Steroid receptor seven-up type 2 0.0034 0.0208 0.0306
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0021 0.0038 0.0706
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0161 0.0487
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0208 0.0208
Schistosoma mansoni hypothetical protein 0.0108 0.1192 0.1192
Echinococcus granulosus ferritin 0.0028 0.0137 0.0137
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0034 0.0208 0.0276
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0012 0.0012
Brugia malayi hypothetical protein 0.0058 0.0531 0.0782
Schistosoma mansoni tar DNA-binding protein 0.0277 0.3448 0.3448
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0329 0.0964
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0028 0.0137 0.0401
Schistosoma mansoni hypothetical protein 0.0396 0.5032 0.5032
Echinococcus multilocularis lamin dm0 0.0032 0.0188 0.0188
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0108 0.1192 0.1755
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0186 0.0186
Schistosoma mansoni RAR-like nuclear receptor 0.0034 0.0208 0.0208
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0024 0.0079 0.1484
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0036 0.0231 0.034
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0329 0.0997
Leishmania major acetyl-CoA synthetase, putative 0.0024 0.0079 0.0923
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0329 0.0997
Loa Loa (eye worm) hypothetical protein 0.0061 0.0576 0.082
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0082 0.0854 1
Schistosoma mansoni hypothetical protein 0.0036 0.0231 0.0231
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0106 0.0322
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0067 0.0649 0.0649
Onchocerca volvulus 0.0043 0.0329 0.0776
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0058 0.0532 0.1559
Toxoplasma gondii ABC1 family protein 0.0043 0.0329 0.6185
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0044 0.0348 0.1054
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0133 0.1536 1
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0024 0.0079 0.0231
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0034 0.0208 0.0208
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0024 0.0079 0.0923
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0082 0.0854 1
Echinococcus multilocularis zinc finger protein 0.0022 0.0049 0.0049
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0058 0.0532 0.1559
Loa Loa (eye worm) hypothetical protein 0.0034 0.0208 0.0276
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0034 0.0208 0.0208
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0294 0.0893
Entamoeba histolytica acyl-CoA synthetase, putative 0.0082 0.0854 1
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0028 0.0137 0.3937
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0034 0.0208 0.0306
Leishmania major hypothetical protein, conserved 0.0043 0.0329 0.3849
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0012 0.0012
Onchocerca volvulus 0.0033 0.0203 0.0385
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0294 0.0893
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0259 0.0787
Trypanosoma brucei trypanothione reductase 0.0053 0.0459 0.8634
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0024 0.0079 0.0231
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0329 0.0964
Echinococcus granulosus tumor protein p63 0.0376 0.4772 0.4772
Echinococcus multilocularis tar DNA binding protein 0.0277 0.3448 0.3448
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0094 0.0094
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0034 0.0208 0.0306
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0122 0.0369
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0067 0.0649 0.0649
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0079 0.0923
Schistosoma mansoni survival motor neuron protein 0.0108 0.1192 0.1192
Entamoeba histolytica hypothetical protein 0.0041 0.0305 0.2965
Loa Loa (eye worm) phosphatidylinositol 3 0.0051 0.0433 0.0608
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0161 0.1907 0.1907
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0028 0.0137 0.0401
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0051 0.0433 0.0637
Schistosoma mansoni hypothetical protein 0.0345 0.4356 0.4356
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0034 0.0208 0.0208
Leishmania major GTP-binding protein, putative 0.0024 0.0074 0.0865
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0208 0.0306
Mycobacterium ulcerans hypothetical protein 0.0082 0.0854 1
Brugia malayi RNA, U transporter 1 0.0092 0.0982 0.1445
Schistosoma mansoni zinc finger protein 0.0022 0.0049 0.0049
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0034 0.0208 0.0208
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0079 0.0923
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0079 0.0231
Schistosoma mansoni lamin 0.0032 0.0188 0.0188
Entamoeba histolytica hypothetical protein 0.0041 0.0305 0.2965
Mycobacterium tuberculosis Probable reductase 0.012 0.1358 0.3982
Loa Loa (eye worm) hypothetical protein 0.0043 0.0329 0.0454
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0065 0.0065
Brugia malayi Thioredoxin reductase 0.0053 0.0459 0.0675
Toxoplasma gondii LsmAD domain-containing protein 0.0058 0.0531 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0329 0.0964
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0208 0.0306
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0074 0.139
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0024 0.0079 0.0923
Schistosoma mansoni thyroid hormone receptor 0.0175 0.2089 0.2089
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0044 0.0348 0.3509
Mycobacterium ulcerans lipase LipD 0.0043 0.0329 0.3849
Loa Loa (eye worm) hypothetical protein 0.0034 0.0208 0.0276
Echinococcus multilocularis thyroid hormone receptor alpha 0.0175 0.2089 0.2089
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0196 0.0593
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0034 0.0208 0.0306
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0079 0.0923
Plasmodium falciparum ataxin-2 like protein, putative 0.0058 0.0531 0.9217
Echinococcus granulosus importin subunit beta 1 0.0032 0.0188 0.0188
Brugia malayi ecdysteroid receptor 0.0034 0.0208 0.0306

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Inhibition of recombinant MBP tagged CDC25B assessed as substrate 3-O-methylfluorescein fluorescent emission after 4 hrs ChEMBL. 19969400
IC50 (functional) = 12.2 uM Cytotoxicity against human A2058 cells assessed as inhibition of formazan formation at day 5 by measuring absorbance at 430 nm ChEMBL. 19969400
IC50 (functional) = 13.2 uM Cytotoxicity against human HeLa cells assessed as inhibition of formazan formation at day 6 by measuring absorbance at 430 nm ChEMBL. 19969400

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 19969400

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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