Detailed information for compound 1117264

Basic information

Technical information
  • TDR Targets ID: 1117264
  • Name: (2E,6E)-2,6-bis[(2,4-dichlorophenyl)methylide ne]cyclohexan-1-one
  • MW: 412.137 | Formula: C20H14Cl4O
  • H donors: 0 H acceptors: 1 LogP: 7.57 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(c(c1)Cl)/C=C/1\CCC/C(=C\c2ccc(cc2Cl)Cl)/C1=O
  • InChi: 1S/C20H14Cl4O/c21-16-6-4-12(18(23)10-16)8-14-2-1-3-15(20(14)25)9-13-5-7-17(22)11-19(13)24/h4-11H,1-3H2/b14-8+,15-9+
  • InChiKey: KZJYHNUZXHLSFI-VOMDNODZSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2,6-bis[(2,4-dichlorophenyl)methylidene]cyclohexan-1-one
  • (2E,6E)-2,6-bis[(2,4-dichlorophenyl)methylene]cyclohexan-1-one
  • 2,6-bis[(2,4-dichlorophenyl)methylene]cyclohexan-1-one
  • (2E,6E)-2,6-bis[(2,4-dichlorophenyl)methylene]-1-cyclohexanone
  • 2,6-bis[(2,4-dichlorophenyl)methylene]-1-cyclohexanone
  • (2E,6E)-2,6-bis(2,4-dichlorobenzylidene)cyclohexan-1-one
  • 2,6-bis(2,4-dichlorobenzylidene)cyclohexan-1-one
  • 18989-83-8
  • A1737/0073815
  • ZINC04482195
  • NSC148599

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0096 0.175 0.5901
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0007 0.0037 0.0065
Loa Loa (eye worm) hypothetical protein 0.0024 0.0367 0.0569
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0025 0.039 0.089
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0388 0.0885
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0025 0.039 0.089
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0022 0.0316 0.0311
Brugia malayi CXXC zinc finger family protein 0.0029 0.0458 0.1531
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.1844 0.2897
Toxoplasma gondii ABC1 family protein 0.0061 0.1077 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.1077 0.1688
Loa Loa (eye worm) hypothetical protein 0.0046 0.0785 0.1229
Echinococcus granulosus RUN 0.002 0.0283 0.0277
Echinococcus multilocularis isocitrate dehydrogenase 0.0024 0.037 0.0364
Loa Loa (eye worm) hypothetical protein 0.0032 0.0513 0.08
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0227 0.2016
Entamoeba histolytica Ran family GTPase 0.0023 0.0343 0.727
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0013 0.0145 0.014
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0022 0.0316 0.0311
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0046 0.0785 0.2638
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0046 0.0785 0.2638
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0333 0.6352 1
Echinococcus multilocularis pyruvate kinase 0.0022 0.0327 0.0322
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0145 0.1303
Trypanosoma brucei hypothetical protein, conserved 0.0061 0.1077 0.2492
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0025 0.0178
Trypanosoma brucei pyruvate kinase 1, putative 0.0022 0.0327 0.0737
Loa Loa (eye worm) hypothetical protein 0.001 0.0087 0.0128
Brugia malayi intermediate filament protein 0.002 0.0289 0.096
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0383 0.3521
Trypanosoma cruzi hypothetical protein, conserved 0.0061 0.1077 0.2497
Schistosoma mansoni ran 0.0023 0.0343 0.0343
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0025 0.0178
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0046 0.0785 0.1229
Brugia malayi Nuclear hormone receptor E75 0.0022 0.0316 0.1051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0145 0.1303
Brugia malayi hypothetical protein 0.002 0.0283 0.0938
Loa Loa (eye worm) hypothetical protein 0.0069 0.1228 0.1926
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0013 0.0145 0.0472
Loa Loa (eye worm) hypothetical protein 0.0016 0.0203 0.0311
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0158 0.3345
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0283 0.0277
Echinococcus multilocularis pyruvate kinase 0.0011 0.0118 0.0112
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.1228 0.4136
Schistosoma mansoni hypothetical protein 0.003 0.0471 0.0471
Loa Loa (eye worm) hypothetical protein 0.0022 0.0316 0.049
Entamoeba histolytica hypothetical protein 0.0018 0.0238 0.5044
Trichomonas vaginalis rotamase, putative 0.0024 0.0371 0.3415
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0025 0.039 0.828
Schistosoma mansoni RAR-like nuclear receptor 0.0046 0.0785 0.0785
Echinococcus granulosus cpg binding protein 0.0031 0.049 0.0485
Mycobacterium ulcerans acyl-CoA synthetase 0.0016 0.0203 0.037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0145 0.1303
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0513 0.0508
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0325 0.639
Plasmodium falciparum importin beta, putative 0.0031 0.0502 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0316 0.049
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0024 0.037 0.0364
Brugia malayi exodeoxyribonuclease III family protein 0.0025 0.039 0.1301
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0046 0.0785 0.078
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0015 0.019 0.0422
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0135 0.2517 0.3958
Echinococcus multilocularis expressed protein 0.0025 0.0383 0.0378
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0022 0.0316 0.0316
Giardia lamblia Pyruvate kinase 0.0022 0.0327 0.7833
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0024 0.037 0.0364
Echinococcus multilocularis pyruvate kinase 0.0011 0.0118 0.0112
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0343 0.0337
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0025 0.0178
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0107 0.1975 0.4592
Echinococcus granulosus serine protein kinase ATM 0.0018 0.0238 0.0232
Schistosoma mansoni importin-beta 2 0.0006 0.0012 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0007 0.0037 0.0296
Loa Loa (eye worm) steroid hormone receptor 0.0046 0.0785 0.1229
Brugia malayi Doublecortin family protein 0.002 0.0283 0.0938
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0227 0.4286 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0061 0.1077 0.1317
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0024 0.0371 0.0846
Loa Loa (eye worm) hypothetical protein 0.0009 0.008 0.0117
Plasmodium falciparum acyl-CoA synthetase 0.0012 0.0126 0.2318
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0016 0.0203 0.037
Echinococcus multilocularis lamin 0.002 0.0289 0.0284
Loa Loa (eye worm) hypothetical protein 0.0022 0.0316 0.049
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0025 0.0178
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0024 0.0367 0.0367
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0388 0.3568
Trichomonas vaginalis penicillin-binding protein, putative 0.0061 0.1077 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0343 0.0531
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0008 0.0045 0.0083
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0283 0.2543
Schistosoma mansoni retinoic acid receptor RXR 0.0046 0.0785 0.0785
Schistosoma mansoni coup transcription factor 0.0046 0.0785 0.0785
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0025 0.0178
Trichomonas vaginalis rotamase, putative 0.0025 0.0383 0.3521
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0316 0.0316
Onchocerca volvulus Pyruvate kinase homolog 0.0022 0.0327 0.045
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0343 0.114
Echinococcus granulosus pyruvate kinase 0.0011 0.0118 0.0112
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0145 0.1303
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0024 0.0371 0.0846
Echinococcus granulosus pyruvate kinase 0.0011 0.0118 0.0112
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0011 0.0108 0.0161
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0099 0.0915
Brugia malayi nuclear hormone receptor 0.0046 0.0785 0.2638
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0343 0.0779
Trichomonas vaginalis ap endonuclease, putative 0.0025 0.039 0.3589
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0046 0.0785 0.0785
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0046 0.0785 0.2638
Brugia malayi Pyruvate kinase, muscle isozyme 0.0022 0.0327 0.1087
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0099 0.0915
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0384 0.3535
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.175 0.175
Brugia malayi RNA, U transporter 1 0.0089 0.1617 0.5452
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0145 0.1303
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.003 0.0471 0.0466
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0145 0.1303
Loa Loa (eye worm) hypothetical protein 0.0022 0.0316 0.049
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0007 0.0037 0.0107
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0046 0.0785 0.0785
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0145 0.1303
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0022 0.0327 0.0292
Loa Loa (eye worm) hypothetical protein 0.0061 0.1077 0.1688
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0283 0.5526
Brugia malayi RNA binding protein 0.0135 0.2517 0.8498
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0032 0.0515 0.1181
Loa Loa (eye worm) hypothetical protein 0.0126 0.2348 0.369
Schistosoma mansoni DNA helicase recq1 0.001 0.0099 0.0099
Echinococcus multilocularis GPCR, family 2 0.0032 0.0513 0.0508
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0007 0.0037 0.079
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0513 0.1718
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0384 0.0379
Toxoplasma gondii FATC domain-containing protein 0.0018 0.0238 0.2207
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0046 0.0785 0.078
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0316 0.0311
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0046 0.0785 0.0785
Mycobacterium ulcerans acyl-CoA synthetase 0.0016 0.0203 0.037
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0099 0.0093
Brugia malayi beta-lactamase family protein 0.0061 0.1077 0.3625
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0025 0.039 1
Entamoeba histolytica hypothetical protein 0.003 0.0471 1
Brugia malayi nuclear receptor RXR 0.0022 0.0316 0.1051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0145 0.1303
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0024 0.037 0.0364
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0013 0.0145 0.0312
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0046 0.0785 0.2638
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0513 0.08
Loa Loa (eye worm) hypothetical protein 0.01 0.1844 0.2897
Loa Loa (eye worm) hypothetical protein 0.0008 0.0053 0.0075
Schistosoma mansoni hypothetical protein 0.0333 0.6352 0.6352
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0007 0.0037 0.0032
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0024 0.037 0.0842
Loa Loa (eye worm) hypothetical protein 0.0022 0.0316 0.049
Schistosoma mansoni hypothetical protein 0.0069 0.1228 0.1228
Loa Loa (eye worm) hypothetical protein 0.0009 0.008 0.0117
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0024 0.037 0.035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0145 0.1303
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0024 0.0367 0.0361
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0013 0.0145 0.014
Plasmodium falciparum pyruvate kinase 2 0.0011 0.0118 0.2163
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0012 0.0126 0.0017
Brugia malayi nuclear hormone receptor 0.0022 0.0316 0.1051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0145 0.1303
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0389 0.7434 1
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0008 0.0045 0.0419
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0099 0.0146
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0013 0.0145 0.0317
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0158 0.0346
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0025 0.0178
Echinococcus multilocularis transportin 1 0.0006 0.0012 0.0006
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.175 0.1745
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0238 0.2166
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0367 0.1221
Echinococcus granulosus tar DNA binding protein 0.0135 0.2517 0.2513
Brugia malayi nuclear receptor NHR-88 0.0022 0.0316 0.1051
Echinococcus multilocularis FTZ F1 alpha 0.0046 0.0785 0.078
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0223 0.2068
Schistosoma mansoni loxhd1 0.002 0.0283 0.0283
Leishmania major importin beta-1 subunit, putative 0.0025 0.0388 0.0885
Toxoplasma gondii HEAT repeat-containing protein 0.0006 0.0012 0.0111
Toxoplasma gondii HEAT repeat-containing protein 0.0006 0.0012 0.0111
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0022 0.0316 0.1051
Loa Loa (eye worm) hypothetical protein 0.0016 0.0203 0.0311
Brugia malayi ecdysteroid receptor 0.0046 0.0785 0.2638
Leishmania major phosphatidylinositol 3-kinase, putative 0.0013 0.0145 0.0317
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0025 0.0178
Echinococcus granulosus FTZ F1 alpha 0.0046 0.0785 0.078
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0046 0.0785 0.2638
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0203 0.0667
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0384 0.3535
Brugia malayi hypothetical protein 0.002 0.0283 0.0938
Echinococcus granulosus importin 5 0.0006 0.0012 0.0006
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0013 0.0145 0.0317
Trichomonas vaginalis penicillin-binding protein, putative 0.0061 0.1077 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0316 0.049
Brugia malayi tailless protein 0.0022 0.0316 0.1051
Schistosoma mansoni lipoxygenase 0.0119 0.2202 0.2202
Mycobacterium ulcerans pyruvate kinase 0.0022 0.0327 0.0966
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0107 0.1975 0.4595
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0025 0.039 0.0385
Loa Loa (eye worm) hypothetical protein 0.0046 0.0785 0.1229
Loa Loa (eye worm) hypothetical protein 0.0022 0.0316 0.049
Brugia malayi Nuclear hormone receptor E75 0.0022 0.0316 0.1051
Loa Loa (eye worm) phosphatidylinositol 3 0.0013 0.0145 0.022
Entamoeba histolytica acyl-coA synthetase, putative 0.0016 0.0203 0.4303
Loa Loa (eye worm) TAR-binding protein 0.0135 0.2517 0.3958
Loa Loa (eye worm) hypothetical protein 0.0016 0.0203 0.0311
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0013 0.0145 0.0312
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0016 0.0203 0.037
Schistosoma mansoni lipoxygenase 0.0083 0.1509 0.1509
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0013 0.0145 0.014
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0013 0.0145 0.0317
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0145 0.1303
Onchocerca volvulus 0.0046 0.0785 0.2112
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0022 0.0316 0.0311
Loa Loa (eye worm) hypothetical protein 0.0012 0.0126 0.0189
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0008 0.0045 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0025 0.0178
Echinococcus multilocularis translational activator gcn1 0.0006 0.0012 0.0006
Toxoplasma gondii hypothetical protein 0.0037 0.0605 0.562
Loa Loa (eye worm) hypothetical protein 0.001 0.0099 0.0146
Trypanosoma cruzi pyruvate kinase 2, putative 0.0022 0.0327 0.0742
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0025 0.039 0.0378
Schistosoma mansoni nuclear hormone receptor 0.0046 0.0785 0.0785
Schistosoma mansoni pyruvate kinase 0.0011 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0022 0.0327 0.0506
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.001 0.0099 0.1766
Chlamydia trachomatis pyruvate kinase 0.0022 0.0327 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0096 0.175 0.2748
Loa Loa (eye worm) importin-beta domain-containing protein 0.0006 0.0012 0.001
Mycobacterium leprae Probable pyruvate kinase PykA 0.0022 0.0327 0.1421
Toxoplasma gondii isocitrate dehydrogenase 0.0024 0.037 0.3432
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0046 0.0785 0.2112
Leishmania major phosphatidylinositol kinase related protein, putative 0.0013 0.0146 0.0318
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0013 0.0145 0.0317
Schistosoma mansoni hypothetical protein 0.0281 0.5346 0.5346
Loa Loa (eye worm) intermediate filament protein 0.002 0.0289 0.0447
Mycobacterium leprae Probable lipase LipE 0.0061 0.1077 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0016 0.0203 0.037
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0316 0.0316
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0388 0.3568
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0513 0.0508
Echinococcus granulosus intermediate filament protein 0.002 0.0289 0.0284
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0013 0.0145 0.0317
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0024 0.0367 0.0361
Loa Loa (eye worm) kap beta 3 protein 0.0006 0.0012 0.001
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0061 0.1077 0.3625
Loa Loa (eye worm) hypothetical protein 0.0024 0.0367 0.0569
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0145 0.1303
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0013 0.0145 0.0312
Brugia malayi nuclear receptor RXR 0.0024 0.0367 0.1221
Trypanosoma cruzi target of rapamycin kinase 3 0.0013 0.0145 0.0317
Echinococcus multilocularis thyroid hormone receptor alpha 0.0046 0.0785 0.078
Onchocerca volvulus 0.002 0.0283 0.029
Treponema pallidum exodeoxyribonuclease (exoA) 0.0025 0.039 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0283 0.0437
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0024 0.037 0.0842
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0502 0.1147
Brugia malayi TAR-binding protein 0.0135 0.2517 0.8498
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0032 0.0515 0.1181
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0007 0.0028 0.0074
Entamoeba histolytica HEAT repeat domain containing protein 0.0006 0.0012 0.0253
Echinococcus granulosus lamin dm0 0.002 0.0289 0.0284
Brugia malayi nuclear receptor NHR-67 0.0022 0.0316 0.1051
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.001 0.0087 0.0081
Schistosoma mansoni nuclear receptor nhr-48 0.0022 0.0316 0.0316
Echinococcus multilocularis pyruvate kinase 0.0017 0.0237 0.0231
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0013 0.0145 0.0145
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0046 0.0785 0.0785
Mycobacterium ulcerans hypothetical protein 0.0016 0.0203 0.037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0145 0.1303
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0037 0.0031
Loa Loa (eye worm) RNA binding protein 0.0135 0.2517 0.3958
Onchocerca volvulus Pyruvate kinase homolog 0.0022 0.0327 0.045
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0025 0.039 0.7715
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0013 0.0145 0.3081
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0282 0.0282
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0016 0.0203 0.0122
Schistosoma mansoni thyroid hormone receptor 0.0046 0.0785 0.0785
Echinococcus multilocularis musashi 0.002 0.0289 0.0284
Trichomonas vaginalis D-aminoacylase, putative 0.0061 0.1077 1
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0502 0.4662
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0046 0.0785 0.078
Schistosoma mansoni cpg binding protein 0.0029 0.0458 0.0458
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0022 0.0316 0.0316
Trichomonas vaginalis ran, putative 0.0023 0.0343 0.3145
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0099 0.0314
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0343 0.8369
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0099 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0008 0.0053 0.0445
Schistosoma mansoni tar DNA-binding protein 0.0135 0.2517 0.2517
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0513 0.1718
Brugia malayi conserved hypotetical protein 0.0022 0.0316 0.1051
Echinococcus multilocularis lamin dm0 0.002 0.0289 0.0284
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0458 0.0713
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0025 0.039 0.3551
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0046 0.0785 0.078
Schistosoma mansoni polycystin 1-related 0.002 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0024 0.0367 0.0569
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0071 0.0066
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0283 0.0277
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0343 0.0337
Leishmania major hypothetical protein, conserved 0.0061 0.1077 0.2497
Echinococcus granulosus ecdysone induced protein 78C 0.0046 0.0785 0.078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0007 0.0037 0.0296
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0046 0.0785 0.0785
Loa Loa (eye worm) hypothetical protein 0.0012 0.0126 0.0189
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0046 0.0785 0.1229
Echinococcus multilocularis tar DNA binding protein 0.0135 0.2517 0.2513
Loa Loa (eye worm) hypothetical protein 0.0024 0.0367 0.0569
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0022 0.0316 0.049
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0367 0.0367
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0022 0.0316 0.0412
Loa Loa (eye worm) isocitrate dehydrogenase 0.0024 0.037 0.0574
Onchocerca volvulus 0.0061 0.1077 0.317
Loa Loa (eye worm) hypothetical protein 0.0022 0.0316 0.049
Schistosoma mansoni ap endonuclease 0.0025 0.039 0.039
Loa Loa (eye worm) hypothetical protein 0.0046 0.0785 0.1229
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0119 0.2202 0.2198
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0046 0.0785 0.1229
Mycobacterium tuberculosis Conserved hypothetical protein 0.0119 0.2209 0.2863
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0046 0.0785 0.1229
Echinococcus multilocularis nuclear receptor nhr 48 0.0022 0.0316 0.0311
Brugia malayi steroid hormone receptor 0.0046 0.0785 0.2638
Brugia malayi beta-lactamase 0.0061 0.1077 0.3625
Onchocerca volvulus 0.002 0.0283 0.029
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0283 0.0277
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0046 0.0785 0.2638
Onchocerca volvulus Protein ultraspiracle homolog 0.0046 0.0785 0.2112
Schistosoma mansoni hypothetical protein 0.0032 0.0513 0.0513
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0145 0.1303
Echinococcus multilocularis dnaJ subfamily B 0.0281 0.5346 0.5343
Echinococcus granulosus pyruvate kinase 0.0022 0.0327 0.0322
Schistosoma mansoni nuclear receptor 0.0022 0.0316 0.0316
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0022 0.0316 0.0311
Mycobacterium ulcerans lipase LipD 0.0061 0.1077 0.4567
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0145 0.1303
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0032 0.0515 0.1176
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0024 0.037 0.0837
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0024 0.0371 0.7884
Schistosoma mansoni lamin 0.002 0.0289 0.0289
Echinococcus multilocularis importin 5 0.0006 0.0012 0.0006
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0283 0.0277
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0502 0.0497
Trichomonas vaginalis PIKK family atypical protein kinase 0.0007 0.0037 0.0296
Echinococcus granulosus beta LACTamase domain containing family member 0.0061 0.1077 0.1072
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0024 0.037 0.0837
Trichomonas vaginalis hypothetical protein 0.0006 0.0012 0.006
Brugia malayi Intermediate filament tail domain containing protein 0.002 0.0289 0.096
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0046 0.0785 0.078
Entamoeba histolytica hypothetical protein 0.003 0.0471 1
Toxoplasma gondii pyruvate kinase PyKII 0.0011 0.0118 0.1095
Trichomonas vaginalis D-aminoacylase, putative 0.0061 0.1077 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0012 0.0126 0.1067
Plasmodium vivax importin-beta 2, putative 0.0031 0.0502 0.4603
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0008 0.0053 0.0494
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0046 0.0785 0.1229
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0046 0.0785 0.078
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.175 0.1745
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0025 0.0178
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0283 0.0277
Mycobacterium ulcerans esterase/lipase LipP 0.0061 0.1077 0.4567
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0013 0.0145 0.0472
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0024 0.037 0.3359
Schistosoma mansoni thyroid hormone receptor 0.0046 0.0785 0.0785
Toxoplasma gondii target of rapamycin (TOR), putative 0.0013 0.0145 0.1348
Leishmania major 4-coumarate:coa ligase-like protein 0.0016 0.0203 0.0452
Schistosoma mansoni cpg binding protein 0.0031 0.049 0.049
Mycobacterium tuberculosis Conserved protein 0.0061 0.1077 0.1317
Schistosoma mansoni hypothetical protein 0.0521 1 1
Echinococcus granulosus lamin 0.002 0.0289 0.0284
Loa Loa (eye worm) hypothetical protein 0.002 0.0282 0.0436
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0099 0.0314
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0145 0.1303
Schistosoma mansoni nuclear receptor 0.0022 0.0316 0.0316
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0145 0.1303
Onchocerca volvulus 0.0022 0.0316 0.0412
Schistosoma mansoni rab6-interacting 0.002 0.0283 0.0283
Brugia malayi beta-lactamase family protein 0.0061 0.1077 0.3625
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0025 0.0178
Loa Loa (eye worm) hypothetical protein 0.0022 0.0316 0.049
Brugia malayi hypothetical protein 0.0158 0.2961 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0316 0.049
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0037 0.0031
Loa Loa (eye worm) hypothetical protein 0.0012 0.0126 0.0189
Mycobacterium ulcerans beta-lactamase 0.0061 0.1077 0.4567
Brugia malayi nuclear hormone receptor family member nhr-6 0.0022 0.0316 0.1051
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.175 0.175
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0024 0.037 0.0364
Echinococcus granulosus cytoplasmic intermediate filament protein 0.001 0.0087 0.0081
Trypanosoma brucei pyruvate kinase 1 0.0022 0.0327 0.0737
Echinococcus granulosus translational activator gcn1 0.0006 0.0012 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0145 0.1303
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0025 0.039 0.0385
Brugia malayi hypothetical protein 0.0022 0.0316 0.1051
Loa Loa (eye worm) phosphatidylinositol 3 0.0013 0.0145 0.022
Brugia malayi ecdysone receptor 0.0022 0.0316 0.1051
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0013 0.0145 0.0145
Loa Loa (eye worm) nuclear receptor NHR-67 0.0022 0.0316 0.049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0145 0.1303
Plasmodium vivax pyruvate kinase, putative 0.0022 0.0327 0.2957
Loa Loa (eye worm) hypothetical protein 0.0024 0.0367 0.0569
Loa Loa (eye worm) hypothetical protein 0.0061 0.1077 0.1688
Schistosoma mansoni hypothetical protein 0.0032 0.0513 0.0513
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0013 0.0146 0.0318
Brugia malayi Steroid receptor seven-up type 2 0.0046 0.0785 0.2638
Schistosoma mansoni tar DNA-binding protein 0.0135 0.2517 0.2517
Echinococcus granulosus transportin 1 0.0006 0.0012 0.0006
Echinococcus multilocularis serine protein kinase ATM 0.0018 0.0238 0.0232
Loa Loa (eye worm) pyruvate kinase 0.0022 0.0327 0.0506
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0024 0.0371 0.0846
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0158 0.0341
Mycobacterium tuberculosis Conserved protein 0.0061 0.1077 0.1317
Loa Loa (eye worm) hypothetical protein 0.0061 0.1077 0.1688
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0013 0.0145 0.0317
Loa Loa (eye worm) pyruvate kinase 0.0022 0.0327 0.0506
Mycobacterium leprae conserved hypothetical protein 0.0061 0.1077 1
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0158 0.1419
Brugia malayi kap beta 3 protein 0.0006 0.0012 0.0022
Schistosoma mansoni importin beta-1 0.0031 0.0502 0.0502
Loa Loa (eye worm) hypothetical protein 0.0012 0.0126 0.0189
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0018 0.0238 0.0528
Echinococcus granulosus bloom syndrome protein 0.0025 0.0384 0.0379
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0316 0.0311
Schistosoma mansoni steroid hormone receptor ad4bp 0.0046 0.0785 0.0785
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0046 0.0785 0.2638
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0032 0.0515 0.1181
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0013 0.0145 0.0317
Loa Loa (eye worm) hypothetical protein 0.0015 0.019 0.0291
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0071 0.0066
Leishmania major 4-coumarate:coa ligase-like protein 0.0016 0.0203 0.0452
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0343 0.318
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0039 0.065 0.1497
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0107 0.1975 0.4595
Giardia lamblia Pyruvate kinase 0.0011 0.0118 0.0667
Onchocerca volvulus 0.0029 0.0458 0.0926
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0119 0.2202 0.2198
Loa Loa (eye worm) hypothetical protein 0.0022 0.0316 0.049
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0022 0.0316 0.0412
Entamoeba histolytica pyruvate kinase, putative 0.0015 0.0197 0.4182
Toxoplasma gondii isocitrate dehydrogenase 0.0024 0.037 0.3432
Toxoplasma gondii pyruvate kinase PyK1 0.0022 0.0327 0.3035
Loa Loa (eye worm) DR-78 0.0022 0.0316 0.049
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0046 0.0785 0.2638
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0145 0.1303
Trichomonas vaginalis PIKK family atypical protein kinase 0.0007 0.0037 0.0296
Echinococcus granulosus expressed protein 0.0025 0.0383 0.0378
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0025 0.0178
Brugia malayi orphan nuclear receptor NR2E1 0.0022 0.0316 0.1051
Echinococcus multilocularis beta LACTamase domain containing family member 0.0061 0.1077 0.1072
Toxoplasma gondii peptidylprolyl isomerase 0.0024 0.0371 0.3449
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0022 0.0316 0.0311
Schistosoma mansoni hypothetical protein 0.0006 0.0006 0.0006
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0343 0.0774
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0025 0.039 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0158 0.0346
Loa Loa (eye worm) hypothetical protein 0.0022 0.0316 0.049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0145 0.1303
Giardia lamblia GTOR 0.0013 0.0145 0.1601
Loa Loa (eye worm) RecQ helicase 0.0025 0.0384 0.0597
Schistosoma mansoni rotamase 0.0025 0.0383 0.0383
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0046 0.0785 0.078
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0037 0.0037
Onchocerca volvulus 0.002 0.0289 0.0314
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.002 0.0289 0.0447
Trichomonas vaginalis pyruvate kinase, putative 0.0022 0.0327 0.2999
Loa Loa (eye worm) hypothetical protein 0.0031 0.0502 0.0783
Leishmania major mitochondrial DNA polymerase beta 0.0227 0.4286 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0145 0.1303
Onchocerca volvulus 0.0158 0.2961 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0061 0.1077 0.1077
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0025 0.039 0.127
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0008 0.0045 0.0083
Brugia malayi photoreceptor-specific nuclear receptor 0.0046 0.0785 0.2638
Schistosoma mansoni DNA helicase recq5 0.001 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.002 0.0289 0.0447
Onchocerca volvulus 0.0061 0.1077 0.317
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0025 0.0178
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0013 0.0145 0.014
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0046 0.0785 0.078
Loa Loa (eye worm) hypothetical protein 0.0158 0.2961 0.4657
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0025 0.0178
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.1844 0.622
Brugia malayi Pyruvate kinase, M2 isozyme 0.0022 0.0327 0.1087
Loa Loa (eye worm) hypothetical protein 0.0012 0.0126 0.0189
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0024 0.037 0.7297
Mycobacterium tuberculosis Probable lipase LipD 0.0061 0.1077 0.1317
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0025 0.039 0.0606
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0008 0.0045 0.0078
Brugia malayi hypothetical protein 0.003 0.0471 0.1575
Echinococcus granulosus nuclear receptor nhr 48 0.0022 0.0316 0.0311
Schistosoma mansoni hypothetical protein 0.002 0.0283 0.0283
Trypanosoma cruzi hypothetical protein, conserved 0.0061 0.1077 0.2497
Echinococcus granulosus Nuclear hormone receptor HR96 0.0022 0.0316 0.0311
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.1844 0.622
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0384 0.1281
Loa Loa (eye worm) beta-lactamase 0.0061 0.1077 0.1688
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0061 0.1077 0.1317
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0025 0.039 0.089
Brugia malayi cytoplasmic intermediate filament protein 0.0011 0.0108 0.0345
Toxoplasma gondii exonuclease III APE 0.0025 0.039 0.3622
Schistosoma mansoni intermediate filament proteins 0.002 0.0289 0.0289
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0013 0.0145 0.0317
Leishmania major GTP-binding protein, putative 0.0023 0.0343 0.0779
Plasmodium falciparum pyruvate kinase 0.0022 0.0327 0.6425
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0008 0.0053 0.0097
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0069 0.0214
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0046 0.0785 0.0785
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0343 0.6744
Onchocerca volvulus Pyruvate kinase homolog 0.0022 0.0327 0.045
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0013 0.0145 0.0312
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0061 0.1077 0.1688
Schistosoma mansoni ran 0.0023 0.0343 0.0343
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0024 0.037 0.0364
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.1087 0.1087
Leishmania major hypothetical protein, conserved 0.0006 0.0012 0.0006
Leishmania major pyruvate kinase 0.0022 0.0327 0.0742
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0145 0.1303
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0513 0.0508
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0061 0.1077 0.1317
Onchocerca volvulus Bile acid receptor homolog 0.0046 0.0785 0.2112
Schistosoma mansoni transcription factor LCR-F1 0.003 0.0471 0.0471
Schistosoma mansoni pyruvate kinase 0.0022 0.0327 0.0327
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0013 0.0145 0.0312
Loa Loa (eye worm) pyruvate kinase-PB 0.0015 0.0197 0.0302
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0024 0.037 0.0842
Onchocerca volvulus 0.0061 0.1077 0.317
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0053 0.0445
Brugia malayi isocitrate dehydrogenase 0.0024 0.037 0.1232
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0046 0.0785 0.2638
Loa Loa (eye worm) hypothetical protein 0.0046 0.0785 0.1229
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.175 0.1745
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0025 0.0178
Schistosoma mansoni cpg binding protein 0.0031 0.049 0.049
Echinococcus granulosus snurportin 1 0.0333 0.6352 0.635
Schistosoma mansoni lamin 0.002 0.0289 0.0289
Trichomonas vaginalis PIKK family atypical protein kinase 0.0007 0.0037 0.0296
Trichomonas vaginalis PIKK family atypical protein kinase 0.0007 0.0037 0.0296
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0024 0.0371 0.0841
Brugia malayi Isocitrate dehydrogenase 0.0024 0.037 0.1232
Loa Loa (eye worm) hypothetical protein 0.002 0.0283 0.0437
Mycobacterium tuberculosis Probable hydrolase 0.0061 0.1077 0.1317
Schistosoma mansoni pyruvate kinase 0.0022 0.0327 0.0327
Brugia malayi Importin beta-1 subunit 0.0031 0.0502 0.168
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0046 0.0785 0.078
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0025 0.0178
Schistosoma mansoni fkbp-rapamycin associated protein 0.0007 0.0037 0.0037
Trichomonas vaginalis D-aminoacylase, putative 0.0061 0.1077 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0238 0.0534
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0227 0.4286 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0016 0.0203 0.0452
Echinococcus granulosus Nuclear hormone receptor HR96 0.0022 0.0316 0.0311
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0238 0.0785
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0502 0.1147
Brugia malayi Nuclear hormone receptor-like 1 0.0046 0.0785 0.2638
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.175 0.175
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0025 0.0383 0.0595
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.003 0.0471 0.0466
Plasmodium vivax pyruvate kinase 2, putative 0.0011 0.0118 0.0995
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0037 0.0031
Schistosoma mansoni tar DNA-binding protein 0.0135 0.2517 0.2517
Loa Loa (eye worm) nuclear hormone receptor 0.0022 0.0316 0.049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0145 0.1303
Loa Loa (eye worm) hypothetical protein 0.0061 0.1077 0.1688
Echinococcus granulosus GPCR family 2 0.0032 0.0513 0.0508
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0145 0.1303
Echinococcus multilocularis cpg binding protein 0.0031 0.049 0.0485
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0099 0.0093
Brugia malayi nuclear hormone receptor family member odr-7 0.0022 0.0316 0.1051
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0046 0.0785 0.2638
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0145 0.1303
Loa Loa (eye worm) pyruvate kinase 0.0022 0.0327 0.0506
Mycobacterium tuberculosis Probable lipase LipE 0.0061 0.1077 0.1317
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0025 0.0178
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0046 0.0785 0.2638
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0018 0.0238 0.0238
Mycobacterium ulcerans hypothetical protein 0.0119 0.2209 1
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0007 0.0037 0.0032
Loa Loa (eye worm) hypothetical protein 0.0046 0.0785 0.1229
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0145 0.1303
Brugia malayi RNA recognition motif domain containing protein 0.0135 0.2517 0.8498
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0025 0.0383 0.1277
Schistosoma mansoni zinc finger protein 0.0022 0.0316 0.0316
Entamoeba histolytica acyl-CoA synthetase, putative 0.0016 0.0203 0.4303
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0203 0.0667
Echinococcus multilocularis ecdysone induced protein 78C 0.0046 0.0785 0.078
Schistosoma mansoni ap endonuclease 0.0025 0.039 0.039
Entamoeba histolytica hypothetical protein 0.003 0.0471 1
Plasmodium vivax hypothetical protein, conserved 0.0061 0.1077 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0022 0.0327 0.0742
Trichomonas vaginalis pyruvate kinase, putative 0.0022 0.0327 0.2999
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0025 0.0178
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0046 0.0785 0.1229
Onchocerca volvulus 0.002 0.0289 0.0314
Echinococcus granulosus pyruvate kinase 0.0011 0.0118 0.0112
Loa Loa (eye worm) hypothetical protein 0.0046 0.0785 0.1229
Loa Loa (eye worm) hypothetical protein 0.0022 0.0316 0.049
Entamoeba histolytica hypothetical protein 0.0025 0.0388 0.8231
Entamoeba histolytica protein kinase rad3, putative 0.0007 0.0037 0.079
Trichomonas vaginalis helicase, putative 0.0007 0.0025 0.0178
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0024 0.037 0.037
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0203 0.0667
Echinococcus multilocularis RUN 0.002 0.0283 0.0277
Schistosoma mansoni tar DNA-binding protein 0.0135 0.2517 0.2517
Loa Loa (eye worm) hypothetical protein 0.0007 0.0037 0.005
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.096 0.891
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0046 0.0785 0.078
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0388 0.3568
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0343 0.0779
Echinococcus multilocularis pyruvate kinase 0.0011 0.0118 0.0112
Echinococcus granulosus pyruvate kinase 0.0022 0.0327 0.0322
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0046 0.0785 0.1229
Echinococcus granulosus importin subunit beta 1 0.0031 0.0502 0.0497
Echinococcus multilocularis geminin 0.0521 1 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0025 0.039 0.0885
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0145 0.1303
Onchocerca volvulus 0.0022 0.0316 0.0412
Trichomonas vaginalis ap endonuclease, putative 0.0025 0.039 0.3589
Brugia malayi hypothetical protein 0.0024 0.0367 0.1221
Loa Loa (eye worm) hypothetical protein 0.0046 0.0785 0.1229
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0024 0.0367 0.0569
Schistosoma mansoni hypothetical protein 0.0032 0.0513 0.0513
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0343 0.3104
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.175 0.1745
Schistosoma mansoni hypothetical protein 0.0032 0.0513 0.0513
Mycobacterium ulcerans hypothetical protein 0.0061 0.1077 0.4567
Echinococcus multilocularis snurportin 1 0.0333 0.6352 0.635
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0513 0.0508
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0227 0.4286 1
Schistosoma mansoni rab6-interacting 0.002 0.0283 0.0283
Echinococcus granulosus dnaJ subfamily B 0.0281 0.5346 0.5343
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0061 0.1077 0.4567
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0046 0.0785 0.2638
Entamoeba histolytica acyl-CoA synthetase, putative 0.0016 0.0203 0.4303
Schistosoma mansoni tar DNA-binding protein 0.0135 0.2517 0.2517
Loa Loa (eye worm) hypothetical protein 0.0015 0.0197 0.0302
Brugia malayi nuclear receptor NHR-88 0.0046 0.0785 0.2638
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0037 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0046 0.0785 0.2638
Loa Loa (eye worm) doublecortin family protein 0.002 0.0283 0.0437
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0283 0.0277
Trichomonas vaginalis PIKK family atypical protein kinase 0.0007 0.0037 0.0296
Mycobacterium tuberculosis Conserved protein 0.0061 0.1077 0.1317
Trichomonas vaginalis esterase, putative 0.0061 0.1077 1
Brugia malayi hypothetical protein 0.0024 0.0367 0.1221
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0061 0.1077 0.1077
Loa Loa (eye worm) hypothetical protein 0.0061 0.1077 0.1688
Loa Loa (eye worm) hypothetical protein 0.0046 0.0785 0.1229
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0099 0.0093
Brugia malayi hypothetical protein 0.0022 0.0316 0.1051
Entamoeba histolytica hypothetical protein 0.003 0.0471 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0145 0.1303
Schistosoma mansoni hypothetical protein 0.0521 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0046 0.0785 0.078
Echinococcus multilocularis pyruvate kinase 0.0022 0.0327 0.0322
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0016 0.0203 0.037
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0046 0.0785 0.078
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0016 0.0203 0.037
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0203 0.0122
Mycobacterium tuberculosis Probable esterase LipL 0.0061 0.1077 0.1317
Leishmania major pyruvate kinase 0.0022 0.0327 0.0742
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0071 0.0103
Echinococcus granulosus thyroid hormone receptor alpha 0.0022 0.0316 0.0311
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0013 0.0145 0.3081
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0046 0.0785 0.078
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0367 0.1221

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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