Detailed information for compound 1117417

Basic information

Technical information
  • TDR Targets ID: 1117417
  • Name: 3-(4-methylphenyl)-5,6-dihydroimidazo[2,1-b][ 1,3]thiazole hydrobromide
  • MW: 297.214 | Formula: C12H13BrN2S
  • H donors: 0 H acceptors: 0 LogP: 3.1 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)c1csc2=NCCn12.Br
  • InChi: 1S/C12H12N2S.BrH/c1-9-2-4-10(5-3-9)11-8-15-12-13-6-7-14(11)12;/h2-5,8H,6-7H2,1H3;1H
  • InChiKey: FWEMSGFRJOTYBU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-(p-tolyl)-5,6-dihydroimidazo[2,1-b]thiazole hydrobromide
  • MLS001180848
  • SMR000476179
  • 3-(4-methylphenyl)-5,6-dihydroimidazo[2,1-b][1,3]thiazole

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0211 0.0262
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0248 0.2963 1
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0192 0.0648
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0211 0.0262
Loa Loa (eye worm) hypothetical protein 0.0035 0.0192 0.0345
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0575 0.1031
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0096 0.0325
Mycobacterium ulcerans hypothetical protein 0.0047 0.0348 0.0563
Loa Loa (eye worm) hypothetical protein 0.0447 0.5571 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.0141 0.0476
Brugia malayi beta-NAC-like protein 0.007 0.0645 0.1157
Entamoeba histolytica transcription factor BTF3, putative 0.007 0.0645 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0141 0.0476
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0248 0.2963 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0211 0.0262
Echinococcus granulosus importin subunit beta 1 0.0028 0.0096 0.0173
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0167 0.0098
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0248 0.2963 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0192 0.0345
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0575 0.1583
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0211 0.0262
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0348 0.1174
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0248 0.2963 0.2963
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0248 0.2963 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0192 0.0345
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0211 0.0211
Mycobacterium tuberculosis Conserved protein 0.0037 0.0211 0.0262
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0192 0.0648
Schistosoma mansoni hypothetical protein 0.0205 0.2402 0.6617
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0348 0.5397
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.035 0.0629
Loa Loa (eye worm) hypothetical protein 0.0047 0.0348 0.0625
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0211 0.0378
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0251 0.045
Echinococcus granulosus transcription factor btf3 0.007 0.0645 0.1157
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0348 0.0563
Trypanosoma cruzi transcription factor btf3, putative 0.007 0.0645 0.2176
Echinococcus granulosus GPCR family 2 0.0047 0.035 0.0629
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0235 0.2793 1
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.004 0.0251 0.0846
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0312 0.056
Loa Loa (eye worm) hypothetical protein 0.0037 0.0211 0.0378
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0251 0.045
Echinococcus multilocularis geminin 0.0205 0.2402 0.2402
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0211 0.0067
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0248 0.2963 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.1069 0.1918
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0251 0.045
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0167 0.0098
Echinococcus multilocularis muscleblind protein 0.0447 0.5571 0.5571
Brugia malayi Calcitonin receptor-like protein seb-1 0.015 0.1688 0.3029
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0248 0.2963 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.0141 0.0476
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0348 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0096 0.0325
Onchocerca volvulus 0.0047 0.0348 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.0141 0.0476
Echinococcus multilocularis transcription factor btf3 0.007 0.0645 0.0645
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0348 0.5397
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0348 0.078
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0211 0.058
Leishmania major hypothetical protein, conserved 0.0037 0.0211 0.071
Schistosoma mansoni hypothetical protein 0.0037 0.021 0.0579
Brugia malayi RNA binding protein 0.0065 0.0575 0.1031
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0211 0.071
Echinococcus granulosus muscleblind protein 0.0447 0.5571 1
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0251 0.0846
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0575 0.1583
Brugia malayi hypothetical protein 0.0036 0.02 0.036
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.1069 0.1918
Brugia malayi beta-lactamase family protein 0.0037 0.0211 0.0378
Entamoeba histolytica hypothetical protein 0.0037 0.021 0.326
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0211 0.071
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.021 0.0377
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0248 0.2963 1
Schistosoma mansoni hypothetical protein 0.0047 0.035 0.0965
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0211 0.071
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0162 0.1842 0.5954
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0348 0.0563
Schistosoma mansoni importin beta-1 0.0028 0.0096 0.0266
Echinococcus granulosus tar DNA binding protein 0.0065 0.0575 0.1031
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0027 0.0092
Toxoplasma gondii ABC1 family protein 0.0037 0.0211 0.071
Echinococcus multilocularis GPCR, family 2 0.0047 0.035 0.035
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0248 0.2963 0.5
Trichomonas vaginalis esterase, putative 0.0037 0.0211 0.071
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0251 0.0251
Loa Loa (eye worm) hypothetical protein 0.0037 0.0211 0.0378
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0211 0.071
Brugia malayi TAR-binding protein 0.0065 0.0575 0.1031
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0141 0.0476
Loa Loa (eye worm) RNA binding protein 0.0065 0.0575 0.1031
Trypanosoma cruzi transcription factor btf3, putative 0.007 0.0645 0.2176
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0348 0.0625
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0027 0.0092
Loa Loa (eye worm) hypothetical protein 0.0035 0.0192 0.0345
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.021 0.021
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0211 0.0378
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0348 0.0625
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0141 0.0476
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0348 0.1174
Plasmodium vivax importin-beta 2, putative 0.0028 0.0096 0.0325
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0312 0.086
Loa Loa (eye worm) beta-lactamase 0.0037 0.0211 0.0378
Loa Loa (eye worm) hypothetical protein 0.015 0.1688 0.3029
Schistosoma mansoni hypothetical protein 0.0205 0.2402 0.6617
Mycobacterium ulcerans lipase LipD 0.0037 0.0211 0.0067
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0251 0.0846
Loa Loa (eye worm) hypothetical protein 0.0035 0.0192 0.0345
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0248 0.2963 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0312 0.086
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0141 0.0141
Echinococcus multilocularis muscleblind protein 1 0.0447 0.5571 0.5571
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0312 0.086
Brugia malayi glucose-6-phosphate dehydrogenase 0.0248 0.2963 0.532
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0027 0.0092
Loa Loa (eye worm) pigment dispersing factor receptor c 0.015 0.1688 0.3029
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0211 0.071
Entamoeba histolytica hypothetical protein 0.0023 0.0027 0.0424
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0645 0.2176
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0348 0.0625
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0312 0.056
Schistosoma mansoni hypothetical protein 0.004 0.0251 0.0691
Brugia malayi beta-lactamase 0.0037 0.0211 0.0378
Schistosoma mansoni hypothetical protein 0.0047 0.035 0.0965
Plasmodium falciparum importin beta, putative 0.0028 0.0096 0.0325
Brugia malayi Muscleblind-like protein 0.0447 0.5571 1
Leishmania major basic transcription factor 3a, putative 0.007 0.0645 0.2176
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.0141 0.0141
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0211 0.071
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0348 0.0563
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.0141 0.0388
Plasmodium vivax basic transcription factor 3b, putative 0.007 0.0645 0.2176
Loa Loa (eye worm) hypothetical protein 0.0037 0.0211 0.0378
Plasmodium falciparum basic transcription factor 3b, putative 0.007 0.0645 0.2176
Echinococcus multilocularis snurportin 1 0.0299 0.3629 0.3629
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0248 0.2963 1
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0248 0.2963 1
Entamoeba histolytica hypothetical protein 0.0037 0.021 0.326
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.0141 0.0253
Loa Loa (eye worm) hypothetical protein 0.0047 0.035 0.0629
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.035 0.0629
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0575 0.0575
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0211 0.071
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0645 0.2176
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0141 0.0476
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0211 0.0262
Brugia malayi hypothetical protein 0.0036 0.02 0.036
Loa Loa (eye worm) hypothetical protein 0.0047 0.0348 0.0625
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0248 0.2963 1
Entamoeba histolytica hypothetical protein 0.0037 0.021 0.326
Brugia malayi hypothetical protein 0.0037 0.021 0.0377
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0096 0.0096
Entamoeba histolytica hypothetical protein 0.007 0.0645 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0141 0.0141
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0211 0.0067
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0312 0.0312
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.008 0.0771 0.2602
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.0141 0.0476
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.0141 0.0141
Entamoeba histolytica hypothetical protein 0.0037 0.021 0.326
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0027 0.0092
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0248 0.2963 0.532
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0248 0.2963 0.8165
Loa Loa (eye worm) ICD-1 protein 0.007 0.0645 0.1157
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.015 0.1688 0.3029
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.0141 0.0253
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0575 0.1583
Brugia malayi beta-lactamase family protein 0.0037 0.0211 0.0378
Echinococcus granulosus snurportin 1 0.0299 0.3629 0.6515
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0575 0.1583
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0312 0.056
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0348 0.0563
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0248 0.2963 0.532
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0348 0.1174
Loa Loa (eye worm) hypothetical protein 0.0037 0.0211 0.0378
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0248 0.2963 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0167 0.0098
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0211 0.0262
Brugia malayi RNA, U transporter 1 0.008 0.077 0.1382
Loa Loa (eye worm) hypothetical protein 0.0447 0.5571 1
Brugia malayi Isocitrate dehydrogenase 0.0031 0.0141 0.0253
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0299 0.3629 0.6515
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.035 0.035
Leishmania major importin beta-1 subunit, putative 0.0023 0.0027 0.0092
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0348 0.0563
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0575 0.1031
Loa Loa (eye worm) hypothetical protein 0.0047 0.0348 0.0625
Loa Loa (eye worm) hypothetical protein 0.0028 0.0096 0.0173
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0082 0.0802 0.2707
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0575 0.1031
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.035 0.0629
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0575 0.1583
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0086 0.0852 0.2683
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0096 0.0325
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0211 0.058
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0192 0.0193
Loa Loa (eye worm) hypothetical protein 0.0037 0.0211 0.0378
Schistosoma mansoni hypothetical protein 0.0299 0.3629 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0348 0.5397
Echinococcus granulosus geminin 0.0205 0.2402 0.4311
Mycobacterium ulcerans beta-lactamase 0.0037 0.0211 0.0067
Mycobacterium tuberculosis Conserved protein 0.0037 0.0211 0.0262
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0312 0.0312
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0141 0.0141
Toxoplasma gondii NAC domain-containing protein 0.007 0.0645 0.2176
Loa Loa (eye worm) hypothetical protein 0.0037 0.0211 0.0378
Brugia malayi Latrophilin receptor protein 2 0.0047 0.035 0.0629
Schistosoma mansoni transcription factor btf3 0.007 0.0645 0.1777
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0211 0.071
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0348 0.0563
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0312 0.056
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.021 0.0579
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0348 0.078
Brugia malayi isocitrate dehydrogenase 0.0031 0.0141 0.0253
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0211 0.0378
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0211 0.0262
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0141 0.0476
Schistosoma mansoni hypothetical protein 0.0047 0.035 0.0965
Schistosoma mansoni hypothetical protein 0.0047 0.035 0.0965
Mycobacterium ulcerans hypothetical protein 0.0037 0.0211 0.0067
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0348 0.0563
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0348 1
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0645 0.2176
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0167 0.0098
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0211 0.071
Trypanosoma brucei transcription factor BTF3, putative 0.007 0.0645 0.2176
Loa Loa (eye worm) hypothetical protein 0.004 0.0251 0.045
Mycobacterium tuberculosis Conserved protein 0.0037 0.0211 0.0262
Schistosoma mansoni hypothetical protein 0.0102 0.1069 0.2944
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.035 0.0629
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.035 0.035
Brugia malayi Importin beta-1 subunit 0.0028 0.0096 0.0173
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0162 0.1842 0.6217

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.3078 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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