Detailed information for compound 1117538

Basic information

Technical information
  • TDR Targets ID: 1117538
  • Name: 2-morpholin-4-yl-N-[3-(trifluoromethyl)phenyl ]acetamide
  • MW: 288.266 | Formula: C13H15F3N2O2
  • H donors: 1 H acceptors: 1 LogP: 1.68 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cccc(c1)C(F)(F)F)CN1CCOCC1
  • InChi: 1S/C13H15F3N2O2/c14-13(15,16)10-2-1-3-11(8-10)17-12(19)9-18-4-6-20-7-5-18/h1-3,8H,4-7,9H2,(H,17,19)
  • InChiKey: SRKFVTCSBWDXPH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-morpholino-N-[3-(trifluoromethyl)phenyl]acetamide
  • 2-morpholin-4-yl-N-[3-(trifluoromethyl)phenyl]ethanamide
  • 1828-48-4
  • BAS 00622667
  • 4-Morpholineacetanilide, 3'-(trifluoromethyl)-
  • Acetamide, 2-(4-morpholyl)-N-(3-trifluorophenyl)-
  • 2-Morpholin-4-yl-N-(3-trifluoromethyl-phenyl)-acetamide
  • IVK/4040970
  • NSC157347
  • MLS001143901
  • SMR000473340

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glutaminase Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0082 0.1313 0.1313
Echinococcus multilocularis inositol monophosphatase 1 0.0076 0.1186 0.1186
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0043 0.0465 0.0684
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0043 0.0465 0.0465
Trypanosoma brucei polo-like protein kinase 0.0093 0.157 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0198 0.0198
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0799 0.0799
Schistosoma mansoni hypothetical protein 0.0097 0.1654 0.2434
Loa Loa (eye worm) nuclear hormone receptor 0.0038 0.0363 0.0217
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0082 0.1313 0.1268
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.1593 0.1593
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0082 0.1313 0.1313
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0324 0.0477
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0038 0.0363 0.0363
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0283 0.0283
Schistosoma mansoni retinoic acid receptor RXR 0.0082 0.1313 0.1932
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0082 0.1313 0.1181
Schistosoma mansoni inositol monophosphatase 0.0076 0.1186 0.1745
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.1584 0.1541
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.157 0.1527
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0082 0.1313 0.2403
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0198 0.0198
Schistosoma mansoni hypothetical protein 0.0031 0.0198 0.0292
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0082 0.1313 0.1181
Loa Loa (eye worm) hypothetical protein 0.0038 0.0363 0.0217
Loa Loa (eye worm) hypothetical protein 0.0082 0.1313 0.1181
Echinococcus multilocularis nuclear receptor nhr 48 0.0038 0.0363 0.0363
Brugia malayi glutaminase DH11.1 0.033 0.6794 0.6777
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.1593 0.1593
Brugia malayi Nuclear hormone receptor-like 1 0.0082 0.1313 0.1268
Schistosoma mansoni lipoxygenase 0.0117 0.2087 0.3073
Schistosoma mansoni hypothetical protein 0.0031 0.0198 0.0292
Brugia malayi RNA binding protein 0.0197 0.3855 0.3823
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0149 0.022
Loa Loa (eye worm) hypothetical protein 0.0049 0.0603 0.046
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0038 0.0363 0.0363
Schistosoma mansoni hypothetical protein 0.0031 0.0198 0.0292
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1584 0.2332
Loa Loa (eye worm) hypothetical protein 0.0082 0.1313 0.1181
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.157 0.1658
Loa Loa (eye worm) hypothetical protein 0.0038 0.0363 0.0217
Loa Loa (eye worm) hypothetical protein 0.0069 0.1037 0.0901
Loa Loa (eye worm) hypothetical protein 0.0037 0.0341 0.0194
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0082 0.1313 0.1181
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0082 0.1313 0.1313
Trichomonas vaginalis glutaminase, putative 0.033 0.6794 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0391 0.0246
Brugia malayi hypothetical protein 0.0038 0.0363 0.0314
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.157 0.1658
Schistosoma mansoni tar DNA-binding protein 0.0197 0.3855 0.5674
Loa Loa (eye worm) glutaminase 0.033 0.6794 0.6745
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.157 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0198 0.0148
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0825 0.0686
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1584 0.1584
Schistosoma mansoni inositol monophosphatase 0.0076 0.1186 0.1745
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0363 0.0363
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0082 0.1313 0.1932
Loa Loa (eye worm) hypothetical protein 0.0082 0.1313 0.1181
Loa Loa (eye worm) hypothetical protein 0.0043 0.0465 0.032
Schistosoma mansoni tar DNA-binding protein 0.0197 0.3855 0.5674
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0038 0.0363 0.0363
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0076 0.1186 0.5
Onchocerca volvulus Bile acid receptor homolog 0.0082 0.1313 0.2403
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0149 0.5
Schistosoma mansoni kinase 0.0047 0.056 0.0824
Brugia malayi orphan nuclear receptor NR2E1 0.0038 0.0363 0.0314
Echinococcus multilocularis tar DNA binding protein 0.0197 0.3855 0.3855
Onchocerca volvulus 0.0038 0.0363 0.0441
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0082 0.1313 0.1932
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.1675 0.1632
Schistosoma mansoni steroid hormone receptor ad4bp 0.0082 0.1313 0.1932
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0082 0.1313 0.1268
Loa Loa (eye worm) hypothetical protein 0.0038 0.0363 0.0217
Brugia malayi nuclear receptor NHR-67 0.0038 0.0363 0.0314
Brugia malayi jmjC domain containing protein 0.0037 0.0324 0.0274
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0082 0.1313 0.1268
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0082 0.1313 0.1313
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0082 0.1313 0.1268
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0398 0.0398
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0324 0.0477
Brugia malayi RNA recognition motif domain containing protein 0.0197 0.3855 0.3823
Loa Loa (eye worm) hypothetical protein 0.0038 0.0363 0.0217
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0288 0.0288
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0082 0.1313 0.1313
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0038 0.0363 0.0363
Echinococcus multilocularis survival motor neuron protein 1 0.0476 1 1
Echinococcus granulosus peregrin 0.0031 0.02 0.02
Echinococcus granulosus jumonji domain containing protein 0.004 0.0398 0.0398
Echinococcus granulosus tar DNA binding protein 0.0197 0.3855 0.3855
Loa Loa (eye worm) hypothetical protein 0.0043 0.0465 0.032
Schistosoma mansoni nuclear receptor 0.0038 0.0363 0.0534
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0198 0.005
Loa Loa (eye worm) hypothetical protein 0.0098 0.1675 0.1549
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0043 0.0465 0.0684
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0082 0.1313 0.1313
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0043 0.0465 0.032
Echinococcus granulosus GPCR family 2 0.0031 0.0198 0.0198
Loa Loa (eye worm) hypothetical protein 0.0082 0.1313 0.1181
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0082 0.1313 0.1268
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.157 0.157
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0082 0.1313 0.1268
Schistosoma mansoni hypothetical protein 0.0029 0.0149 0.022
Loa Loa (eye worm) steroid hormone receptor 0.0082 0.1313 0.1181
Loa Loa (eye worm) nuclear receptor NHR-67 0.0038 0.0363 0.0217
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0082 0.1313 0.1268
Loa Loa (eye worm) hypothetical protein 0.0038 0.0363 0.0217
Schistosoma mansoni survival motor neuron protein 0.0097 0.1654 0.2434
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.1675 0.1549
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0082 0.1313 0.1313
Echinococcus granulosus FTZ F1 alpha 0.0082 0.1313 0.1313
Echinococcus multilocularis ecdysone induced protein 78C 0.0082 0.1313 0.1313
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0117 0.2087 0.2087
Brugia malayi PHD-finger family protein 0.0029 0.0149 0.0099
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.157 0.157
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0082 0.1313 0.1932
Schistosoma mansoni lipoxygenase 0.0082 0.1313 0.1933
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0149 0.0149
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0082 0.1313 0.1181
Loa Loa (eye worm) hypothetical protein 0.0043 0.0465 0.032
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0799 0.0799
Loa Loa (eye worm) hypothetical protein 0.0043 0.0465 0.032
Loa Loa (eye worm) DR-78 0.0038 0.0363 0.0217
Brugia malayi nuclear receptor RXR 0.0043 0.0465 0.0416
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0082 0.1313 0.1268
Loa Loa (eye worm) hypothetical protein 0.0476 1 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.157 1
Brugia malayi hypothetical protein 0.0043 0.0465 0.0416
Loa Loa (eye worm) hypothetical protein 0.0043 0.0465 0.032
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0082 0.1313 0.1313
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0117 0.2087 0.2087
Loa Loa (eye worm) hypothetical protein 0.0248 0.4992 0.4916
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0991 0.0945
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0082 0.1313 0.1313
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0363 0.0534
Schistosoma mansoni tar DNA-binding protein 0.0197 0.3855 0.5674
Loa Loa (eye worm) hypothetical protein 0.0067 0.0991 0.0855
Loa Loa (eye worm) hypothetical protein 0.0038 0.0363 0.0217
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.157 0.1658
Brugia malayi hypothetical protein 0.0038 0.0363 0.0314
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0082 0.1313 0.1313
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0038 0.0363 0.0534
Schistosoma mansoni glutaminase 0.033 0.6794 1
Brugia malayi Steroid receptor seven-up type 2 0.0082 0.1313 0.1268
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0038 0.0363 0.0441
Brugia malayi nuclear receptor NHR-88 0.0038 0.0363 0.0314
Brugia malayi hypothetical protein 0.0248 0.4992 0.4966
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0082 0.1313 0.1181
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0082 0.1313 0.1268
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0082 0.1313 0.1181
Loa Loa (eye worm) inositol-1 0.0076 0.1186 0.1052
Schistosoma mansoni bromodomain containing protein 0.0062 0.0877 0.129
Loa Loa (eye worm) hypothetical protein 0.0031 0.0198 0.005
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0082 0.1313 0.1268
Loa Loa (eye worm) hypothetical protein 0.0038 0.0363 0.0217
Schistosoma mansoni RAR-like nuclear receptor 0.0082 0.1313 0.1932
Brugia malayi tailless protein 0.0038 0.0363 0.0314
Brugia malayi photoreceptor-specific nuclear receptor 0.0082 0.1313 0.1268
Schistosoma mansoni nuclear hormone receptor 0.0082 0.1313 0.1932
Brugia malayi nuclear receptor NHR-88 0.0082 0.1313 0.1268
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0288 0.0288
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0082 0.1313 0.1932
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0082 0.1313 0.1268
Schistosoma mansoni thyroid hormone receptor 0.0082 0.1313 0.1932
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.157 0.1658
Brugia malayi Nuclear hormone receptor-like 1 0.0043 0.0465 0.0416
Giardia lamblia Kinase, PLK 0.0093 0.157 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0363 0.0217
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0324 0.0177
Loa Loa (eye worm) hypothetical protein 0.0038 0.0363 0.0217
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.1584 0.1457
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.157 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0082 0.1313 0.1313
Loa Loa (eye worm) hypothetical protein 0.0082 0.1313 0.1181
Onchocerca volvulus Huntingtin homolog 0.0248 0.4992 1
Brugia malayi jmjC domain containing protein 0.0094 0.1593 0.155
Plasmodium falciparum phd finger protein, putative 0.0029 0.0149 0.5
Schistosoma mansoni hypothetical protein 0.0031 0.0198 0.0292
Brugia malayi nuclear hormone receptor family member nhr-6 0.0038 0.0363 0.0314
Brugia malayi Bromodomain containing protein 0.0073 0.1129 0.1083
Brugia malayi Inositol-1 0.0076 0.1186 0.1141
Onchocerca volvulus Protein ultraspiracle homolog 0.0082 0.1313 0.2403
Mycobacterium ulcerans glutaminase 0.033 0.6794 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0076 0.1186 0.1043
Loa Loa (eye worm) hypothetical protein 0.0038 0.0363 0.0217
Loa Loa (eye worm) hypothetical protein 0.0042 0.0433 0.0288
Brugia malayi TAR-binding protein 0.0197 0.3855 0.3823
Echinococcus granulosus Nuclear hormone receptor HR96 0.0038 0.0363 0.0363
Brugia malayi ecdysone receptor 0.0038 0.0363 0.0314
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0149 0.0149
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0198 0.0148
Schistosoma mansoni jumonji domain containing protein 0.0075 0.1166 0.1716
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0038 0.0363 0.0534
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0038 0.0363 0.0441
Loa Loa (eye worm) hypothetical protein 0.0248 0.4992 0.4916
Loa Loa (eye worm) hypothetical protein 0.0082 0.1313 0.1181
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0082 0.1313 0.1313
Schistosoma mansoni tar DNA-binding protein 0.0197 0.3855 0.5674
Brugia malayi steroid hormone receptor 0.0082 0.1313 0.1268
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0082 0.1313 0.1932
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0097 0.1654 0.1611
Brugia malayi ecdysteroid receptor 0.0082 0.1313 0.1268
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0038 0.0363 0.0314
Echinococcus granulosus survival motor neuron protein 1 0.0476 1 1
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0363 0.0534
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.157 0.2311
Brugia malayi nuclear hormone receptor 0.0038 0.0363 0.0314
Brugia malayi nuclear receptor RXR 0.0038 0.0363 0.0314
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0076 0.1186 0.1043
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1584 0.1584
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.157 0.2935
Schistosoma mansoni thyroid hormone receptor 0.0082 0.1313 0.1932
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0197 0.3855 0.3761
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0363 0.0363
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0068 0.1011 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1584 0.1584
Brugia malayi Nuclear hormone receptor-like 1 0.0043 0.0465 0.0416
Echinococcus granulosus Nuclear hormone receptor HR96 0.0038 0.0363 0.0363
Echinococcus multilocularis GPCR, family 2 0.0031 0.0198 0.0198
Echinococcus multilocularis thyroid hormone receptor alpha 0.0082 0.1313 0.1313
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0082 0.1313 0.1268
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1584 0.2332
Schistosoma mansoni zinc finger protein 0.0038 0.0363 0.0534
Onchocerca volvulus 0.0097 0.1654 0.3106
Loa Loa (eye worm) hypothetical protein 0.0038 0.0363 0.0217
Loa Loa (eye worm) hypothetical protein 0.0082 0.1313 0.1181
Onchocerca volvulus 0.0082 0.1313 0.2403
Schistosoma mansoni nuclear receptor 0.0038 0.0363 0.0534
Schistosoma mansoni coup transcription factor 0.0082 0.1313 0.1932
Loa Loa (eye worm) hypothetical protein 0.0082 0.1313 0.1181
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0082 0.1313 0.1268
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0076 0.1186 1
Onchocerca volvulus 0.0038 0.0363 0.0441
Loa Loa (eye worm) hypothetical protein 0.0038 0.0363 0.0217
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.157 0.1443
Brugia malayi conserved hypotetical protein 0.0038 0.0363 0.0314
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0082 0.1313 0.1313
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0082 0.1313 0.1181
Echinococcus granulosus nuclear receptor nhr 48 0.0038 0.0363 0.0363
Loa Loa (eye worm) hypothetical protein 0.0038 0.0363 0.0217
Brugia malayi Nuclear hormone receptor E75 0.0038 0.0363 0.0314
Loa Loa (eye worm) RNA binding protein 0.0197 0.3855 0.3761
Loa Loa (eye worm) glutaminase 2 0.033 0.6794 0.6745
Schistosoma mansoni hypothetical protein 0.0067 0.0991 0.1459
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1584 0.1584
Onchocerca volvulus Huntingtin homolog 0.0248 0.4992 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0038 0.0363 0.0217
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0076 0.1186 0.1043
Echinococcus multilocularis FTZ F1 alpha 0.0082 0.1313 0.1313
Echinococcus multilocularis peregrin 0.0031 0.02 0.02
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.157 0.1658
Loa Loa (eye worm) TAR-binding protein 0.0197 0.3855 0.3761
Brugia malayi hypothetical protein 0.0043 0.0465 0.0416
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1584 0.2332
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.157 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0068 0.1011 0.5
Brugia malayi Bromodomain containing protein 0.0037 0.0339 0.029
Echinococcus granulosus ecdysone induced protein 78C 0.0082 0.1313 0.1313
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.157 0.1658
Echinococcus granulosus thyroid hormone receptor alpha 0.0038 0.0363 0.0363
Brugia malayi nuclear hormone receptor 0.0082 0.1313 0.1268
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0038 0.0363 0.0363
Schistosoma mansoni tar DNA-binding protein 0.0197 0.3855 0.5674
Schistosoma mansoni nuclear receptor nhr-48 0.0038 0.0363 0.0534
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.157 0.1658
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0082 0.1313 0.1932
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0324 0.0324
Echinococcus granulosus inositol monophosphatase 1 0.0076 0.1186 0.1186
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0198 0.0198
Brugia malayi Bromodomain containing protein 0.0031 0.02 0.015
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0043 0.0465 0.0465
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0198 0.0198
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.1675 0.1632
Brugia malayi nuclear hormone receptor family member odr-7 0.0038 0.0363 0.0314
Brugia malayi Nuclear hormone receptor E75 0.0038 0.0363 0.0314

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.6234 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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