Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | NADH-ubiquinone oxidoreductase 51 kDa subunit | 0.0078 | 0.0129 | 0.0498 |
Brugia malayi | bHLH-PAS transcription factor | 0.007 | 0.01 | 0.0242 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0095 | 0.0188 | 0.0115 |
Brugia malayi | NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial precursor | 0.0078 | 0.0129 | 0.0498 |
Brugia malayi | hypoxia-induced factor 1 | 0.0293 | 0.0893 | 0.7327 |
Schistosoma mansoni | NADH-ubiquinone oxidoreductase | 0.0078 | 0.0129 | 0.0056 |
Mycobacterium tuberculosis | Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. | 0.1598 | 0.5534 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0317 | 0.098 | 0.8109 |
Onchocerca volvulus | 0.0062 | 0.0073 | 0.7295 | |
Onchocerca volvulus | 0.007 | 0.01 | 1 | |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0062 | 0.0073 | 0.7295 |
Onchocerca volvulus | 0.0062 | 0.0073 | 0.7295 | |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0293 | 0.0893 | 0.7327 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0377 | 0.1192 | 1 |
Onchocerca volvulus | 0.0062 | 0.0073 | 0.7295 | |
Trichomonas vaginalis | NADH-ubiquinone oxidoreductase flavoprotein, putative | 0.0078 | 0.0129 | 0.5 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0062 | 0.0073 | 0.7295 |
Onchocerca volvulus | 0.0062 | 0.0073 | 0.7295 | |
Brugia malayi | hypothetical protein | 0.0317 | 0.098 | 0.8109 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0377 | 0.1192 | 0.1127 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0377 | 0.1192 | 1 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0377 | 0.1192 | 1 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0377 | 0.1192 | 1 |
Onchocerca volvulus | 0.0062 | 0.0073 | 0.7295 | |
Onchocerca volvulus | 0.0062 | 0.0073 | 0.7295 | |
Mycobacterium leprae | probable proteasome (alpha subunit) PrcA | 0.1598 | 0.5534 | 0.5 |
Onchocerca volvulus | 0.0062 | 0.0073 | 0.7295 | |
Onchocerca volvulus | 0.0062 | 0.0073 | 0.7295 | |
Schistosoma mansoni | single-minded | 0.0095 | 0.0188 | 0.0115 |
Trypanosoma cruzi | NADH-ubiquinone oxidoreductase, mitochondrial, putative | 0.0078 | 0.0129 | 0.5 |
Onchocerca volvulus | 0.0062 | 0.0073 | 0.7295 | |
Echinococcus granulosus | single minded 2 | 0.007 | 0.01 | 0.0242 |
Echinococcus multilocularis | transfer RNA-Lys | 0.007 | 0.01 | 0.0242 |
Onchocerca volvulus | 0.0062 | 0.0073 | 0.7295 | |
Trypanosoma cruzi | NADH-ubiquinone oxidoreductase, mitochondrial, putative | 0.0078 | 0.0129 | 0.5 |
Onchocerca volvulus | 0.0062 | 0.0073 | 0.7295 | |
Leishmania major | NADH-ubiquinone oxidoreductase, mitochondrial, putative | 0.0078 | 0.0129 | 0.5 |
Onchocerca volvulus | 0.0062 | 0.0073 | 0.7295 | |
Mycobacterium ulcerans | NADH dehydrogenase I subunit F | 0.0078 | 0.0129 | 0.0053 |
Echinococcus multilocularis | NADH dehydrogenase (ubiquinone) flavoprotein 1 | 0.0078 | 0.0129 | 0.0498 |
Trypanosoma brucei | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial, putative | 0.0078 | 0.0129 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | NADH dehydrogenase I subunit F | 0.0078 | 0.0129 | 0.5 |
Trichomonas vaginalis | NADH-ubiquinone oxidoreductase flavoprotein, putative | 0.0078 | 0.0129 | 0.5 |
Onchocerca volvulus | 0.0062 | 0.0073 | 0.7295 | |
Mycobacterium ulcerans | proteasome PrcA | 0.1598 | 0.5534 | 1 |
Brugia malayi | PAS domain containing protein | 0.0095 | 0.0188 | 0.1024 |
Onchocerca volvulus | 0.0062 | 0.0073 | 0.7295 | |
Trypanosoma brucei | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | 0.0078 | 0.0129 | 0.5 |
Onchocerca volvulus | 0.0062 | 0.0073 | 0.7295 | |
Echinococcus granulosus | NADH dehydrogenase ubiquinone flavoprotein 1 | 0.0078 | 0.0129 | 0.0498 |
Onchocerca volvulus | 0.0062 | 0.0073 | 0.7295 | |
Onchocerca volvulus | 0.0062 | 0.0073 | 0.7295 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | > 0.00001 M | Effective dose for differentiation -inducing activity against human promyelotic leukemia cells | ChEMBL. | 3184125 |
ED50 (functional) | > 0.00001 M | Effective dose for differentiation -inducing activity against human promyelotic leukemia cells | ChEMBL. | 3184125 |
Ratio (functional) | < 0.001 | Ratio of the ED50 of compound to that of ED50 of retinoic acid, expressed as relative activity | ChEMBL. | 3184125 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.