TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 217.06 | Formula: C8H9BrO2
H donors: 1 H acceptors: 2 LogP: 1.52 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: BrCC1=CCC(C=C1)C(=O)O
InChi: 1S/C8H9BrO2/c9-5-6-1-3-7(4-2-6)8(10)11/h1-3,7H,4-5H2,(H,10,11)
InChiKey: BZRNNESIJWWEOJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	nuclear receptor nhr 48	0.0029	0.02	0.02
Plasmodium falciparum	aldo-keto reductase, putative	0.0356	0.2868	1
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0356	0.2868	0.2868
Echinococcus granulosus	thyroid hormone receptor alpha	0.0029	0.02	0.02
Trypanosoma cruzi	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.001	0.0038	0.0031
Schistosoma mansoni	DNA ligase IV	0.001	0.0038	0.0038
Schistosoma mansoni	protein tyrosine phosphatase	0.0006	0.0007	0.0007
Brugia malayi	Common central domain of tyrosinase family protein	0.0089	0.0686	0.0686
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0229	0.0229
Leishmania major	hypothetical protein, conserved	0.0012	0.0058	0.0051
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0062	0.0468	0.0468
Trichomonas vaginalis	nuclear lim interactor-interacting factor, putative	0.0012	0.0058	0.0051
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.1231	1	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0006	0.0007	0.0007
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0006	0.0007	0.0007
Echinococcus granulosus	ecdysone induced protein 78C	0.0062	0.0468	0.0468
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0085	0.0085
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0029	0.02	0.02
Brugia malayi	Nuclear hormone receptor E75	0.0029	0.02	0.02
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0006	0.0007	0.0007
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0062	0.0468	0.0468
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0062	0.0468	0.0468
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0089	0.0686	0.0686
Brugia malayi	steroid hormone receptor	0.0062	0.0468	0.0468
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0062	0.0468	0.0468
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0086	0.0664	0.0657
Brugia malayi	ATP dependent DNA ligase C terminal region family protein	0.001	0.0038	0.0038
Giardia lamblia	Replication factor C, subunit 1	0.001	0.0038	0.0031
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0114	0.0892	0.0892
Echinococcus multilocularis	aldo keto reductase	0.1231	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0062	0.0468	0.0468
Loa Loa (eye worm)	hypothetical protein	0.0017	0.01	0.01
Trichomonas vaginalis	aldo-keto reductase, putative	0.0356	0.2868	0.2863
Schistosoma mansoni	hypothetical protein	0.0059	0.0443	0.0443
Trichomonas vaginalis	aldo-keto reductase, putative	0.1231	1	1
Entamoeba histolytica	aldose reductase, putative	0.1231	1	1
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0136	0.1071	0.1071
Loa Loa (eye worm)	hypothetical protein	0.0029	0.02	0.02
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0147	0.0132
Schistosoma mansoni	aldo-keto reductase	0.1231	1	1
Toxoplasma gondii	LsmAD domain-containing protein	0.0024	0.0159	0.0144
Brugia malayi	ecdysone receptor	0.0029	0.02	0.02
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0114	0.0892	0.0892
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0006	0.0007	0.0007
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0006	0.0007	0.0007
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.014	0.1103	0.1103
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0147	0.0147
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0029	0.02	0.02
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.1231	1	1
Wolbachia endosymbiont of Brugia malayi	NAD-dependent DNA ligase, Lig	0.001	0.0038	0.5
Entamoeba histolytica	acetyltransferase, GNAT family	0.0038	0.0268	0.0268
Schistosoma mansoni	retinoic acid receptor RXR	0.0062	0.0468	0.0468
Onchocerca volvulus		0.0006	0.0007	0.0007
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0029	0.02	0.02
Plasmodium falciparum	replication factor C subunit 1, putative	0.001	0.0038	0.008
Schistosoma mansoni	acetyl-CoA synthetase	0.0007	0.0015	0.0015
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0006	0.0007	0.0007
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0006	0.0007	0.0007
Loa Loa (eye worm)	nuclear hormone receptor	0.0029	0.02	0.02
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.1231	1	1
Onchocerca volvulus		0.0029	0.02	0.02
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0007	0.0015	0.0008
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0062	0.0468	0.0468
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.0038	0.0031
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0114	0.0892	0.0892
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.001	0.0039	0.0032
Echinococcus multilocularis	voltage gated potassium channel subunit	0.0356	0.2868	0.2868
Trypanosoma brucei	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.001	0.0038	0.0031
Trichomonas vaginalis	antibiotic synthetase, putative	0.0007	0.0015	0.0008
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0017	0.01	1
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0041	0.0296	0.0296
Onchocerca volvulus		0.0006	0.0007	0.0007
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0006	0.0007	0.0007
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.1231	1	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0114	0.0892	0.0892
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0006	0.0007	0.0007
Onchocerca volvulus		0.0006	0.0007	0.0007
Onchocerca volvulus		0.0007	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0007	0.0007
Brugia malayi	Protein-tyrosine phosphatase	0.0006	0.0007	0.0007
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0062	0.0468	0.0468
Onchocerca volvulus		0.1231	1	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0038	0.0038
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0006	0.0007	0.0007
Schistosoma mansoni	hypothetical protein	0.0015	0.0085	0.0085
Trichomonas vaginalis	dullard protein, putative	0.0012	0.0058	0.0051
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0038	0.0031
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0062	0.0468	0.0468
Loa Loa (eye worm)	hypothetical protein	0.0029	0.02	0.02
Brugia malayi	DnaJ domain containing protein	0.0059	0.0443	0.0443
Loa Loa (eye worm)	hypothetical protein	0.0017	0.01	0.01
Loa Loa (eye worm)	tyrosinase 1	0.0089	0.0686	0.0686
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0007	0.0007
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0006	0.0007	0.0007
Brugia malayi	Protein-tyrosine phosphatase	0.0006	0.0007	0.0007
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0062	0.0468	0.0468
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0006	0.0007	0.0007
Schistosoma mansoni	hypothetical protein	0.0015	0.0085	0.0085
Onchocerca volvulus	Protein ultraspiracle homolog	0.0062	0.0468	0.0468
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0006	0.0007	0.0007
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0006	0.0007	0.0007
Leishmania major	acetyl-CoA synthetase, putative	0.0007	0.0015	0.0008
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0006	0.0007	0.0007
Trichomonas vaginalis	antibiotic synthetase, putative	0.0007	0.0015	0.0008
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.1231	1	1
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0007	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.001	0.0038	0.0038
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0006	0.0007	0.0007
Schistosoma mansoni	hypothetical protein	0.0015	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.1231	1	1
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0015	0.0015
Leishmania major	hypothetical protein, conserved	0.0024	0.0159	0.0152
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0041	0.0296	0.0282
Leishmania major	acetyl-CoA synthetase, putative	0.0007	0.0015	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0057	0.0057
Plasmodium vivax	NLI interacting factor-like phosphatase, putative	0.0012	0.0058	0.015
Onchocerca volvulus		0.1231	1	1
Echinococcus granulosus	aldo keto reductase	0.1231	1	1
Onchocerca volvulus		0.0006	0.0007	0.0007
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0006	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0468	0.0468
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0006	0.0007	0.0007
Brugia malayi	Nuclear hormone receptor-like 1	0.0033	0.0228	0.0228
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0147	0.014
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0147	0.0147
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0006	0.0007	0.0007
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.1231	1	1
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0147	0.0147
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0006	0.0007	0.0007
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0085	0.0085
Trichomonas vaginalis	aldo-keto reductase, putative	0.1231	1	1
Echinococcus granulosus	replication factor c subunit 1	0.001	0.0038	0.0038
Echinococcus multilocularis	aldo keto reductase	0.1231	1	1
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0029	0.02	0.02
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0007	0.0007
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0006	0.0007	0.0007
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0006	0.0007	0.0007
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0006	0.0007	0.0007
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0007	0.0015	0.0015
Schistosoma mansoni	protein tyrosine phosphatase	0.0006	0.0007	0.0007
Onchocerca volvulus		0.0006	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0017	0.01	0.01
Loa Loa (eye worm)	oxidoreductase	0.1231	1	1
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0017	0.01	0.0092
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0041	0.0296	0.0282
Entamoeba histolytica	aldose reductase, putative	0.1231	1	1
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0089	0.0686	0.0686
Trichomonas vaginalis	aldo-keto reductase, putative	0.1231	1	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0029	0.02	0.02
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0007	0.0015	0.0008
Brugia malayi	Protein-tyrosine phosphatase 1	0.0006	0.0007	0.0007
Loa Loa (eye worm)	glutamate-cysteine ligase modifier subunit	0.0356	0.2868	0.2868
Plasmodium falciparum	NLI interacting factor-like phosphatase, putative	0.0012	0.0058	0.015
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0007	0.0015	0.0015
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.001	0.0038	0.0023
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0041	0.0296	0.0985
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0062	0.0468	0.0468
Onchocerca volvulus		0.0007	0.0015	0.0015
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0006	0.0007	0.0007
Loa Loa (eye worm)	ShTK domain-containing protein	0.0089	0.0686	0.0686
Giardia lamblia	Histone acetyltransferase GCN5	0.0038	0.0268	0.0261
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0085	0.0085
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0006	0.0007	0.0007
Brugia malayi	hypothetical protein	0.001	0.0038	0.0038
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0006	0.0007	0.0007
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.0086	0.0664	0.0657
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0038	0.0031
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.001	0.0038	0.0038
Echinococcus multilocularis	FTZ F1 alpha	0.0062	0.0468	0.0468
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0147	0.0132
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0033	0.0228	0.0228
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0062	0.0468	0.0468
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0038	0.0031
Brugia malayi	nuclear hormone receptor	0.0062	0.0468	0.0468
Brugia malayi	nuclear receptor NHR-88	0.0062	0.0468	0.0468
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0006	0.0007	0.0007
Trichomonas vaginalis	aldo-keto reductase, putative	0.1231	1	1
Brugia malayi	hypothetical protein	0.0006	0.0007	0.0007
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0062	0.0468	0.0468
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.1231	1	1
Trypanosoma cruzi	hypothetical protein, conserved	0.001	0.0038	0.0031
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0147	0.014
Onchocerca volvulus		0.0006	0.0007	0.0007
Mycobacterium ulcerans	hypothetical protein	0.0356	0.2868	0.2858
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0006	0.0007	0.0007
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0086	0.0664	0.0664
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0062	0.0468	0.0468
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0006	0.0007	0.0007
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0006	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0007	0.0007
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.1231	1	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0147	0.0147
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0006	0.0007	0.0007
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0006	0.0007	0.0007
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0006	0.0007	0.0007
Echinococcus multilocularis	nuclear receptor nhr 48	0.0029	0.02	0.02
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0006	0.0007	0.0007
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0006	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0029	0.02	0.02
Onchocerca volvulus		0.0006	0.0007	0.0007
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.1231	1	1
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0147	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0029	0.02	0.02
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0007	0.0015	0.0015
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.1231	1	1
Schistosoma mansoni	pcd6 interacting protein-related	0.0006	0.0007	0.0007
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0086	0.0664	0.0657
Trichomonas vaginalis	aldo-keto reductase, putative	0.1231	1	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0062	0.0468	0.0468
Echinococcus granulosus	GPCR family 2	0.0015	0.0085	0.0085
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0062	0.0468	0.0468
Loa Loa (eye worm)	hypothetical protein	0.0029	0.02	0.02
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0006	0.0007	0.0007
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0033	0.0228	0.0228
Toxoplasma gondii	aldose reductase, putative	0.1231	1	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0114	0.0892	0.0892
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0006	0.0007	0.0007
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0007	0.0015	0.0008
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0147	0.0147
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0092	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0468	0.0468
Brugia malayi	hypothetical protein	0.0029	0.02	0.02
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0006	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0007	0.0007
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0006	0.0007	0.0007
Schistosoma mansoni	tyrosinase precursor	0.0089	0.0686	0.0686
Onchocerca volvulus		0.0089	0.0686	0.0686
Loa Loa (eye worm)	hypothetical protein	0.001	0.0038	0.0038
Brugia malayi	tailless protein	0.0029	0.02	0.02
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0029	0.02	0.02
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0006	0.0007	0.0007
Mycobacterium tuberculosis	Conserved protein	0.0356	0.2868	0.2863
Brugia malayi	Steroid receptor seven-up type 2	0.0062	0.0468	0.0468
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0159	0.0504
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0006	0.0007	0.0007
Echinococcus multilocularis	aldo keto reductase	0.1231	1	1
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0468	0.0468
Trichomonas vaginalis	aldo-keto reductase, putative	0.0356	0.2868	0.2863
Trichomonas vaginalis	dullard protein, putative	0.0012	0.0058	0.0051
Loa Loa (eye worm)	acetyltransferase	0.014	0.1103	0.1103
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0062	0.0468	0.0468
Schistosoma mansoni	protein tyrosine phosphatase	0.0006	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0086	0.066	0.066
Schistosoma mansoni	nuclear receptor	0.0029	0.02	0.02
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0006	0.0007	0.0007
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0006	0.0007	0.0007
Onchocerca volvulus		0.0006	0.0007	0.0007
Brugia malayi	hypothetical protein	0.0033	0.0228	0.0228
Onchocerca volvulus		0.0006	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0007	0.0007
Loa Loa (eye worm)	steroid hormone receptor	0.0062	0.0468	0.0468
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0089	0.0686	0.0686
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0062	0.0468	0.0468
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0015	0.0008
Trichomonas vaginalis	nuclear lim interactor-interacting factor, putative	0.0012	0.0058	0.0051
Echinococcus multilocularis	dnaJ subfamily C 6	0.0059	0.0443	0.0443
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0029	0.02	0.02
Plasmodium vivax	acyl-CoA synthetase, putative	0.0017	0.01	0.0297
Treponema pallidum	DNA ligase (lig)	0.001	0.0038	0.5
Onchocerca volvulus		0.1231	1	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0062	0.0468	0.0468
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0006	0.0007	0.0007
Trypanosoma cruzi	aldo/keto reductase, putative	0.0356	0.2868	0.2863
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0007	0.0015	0.0008
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0039	0.0032
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0006	0.0007	0.0007
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0006	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0029	0.02	0.02
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0006	0.0007	0.0007
Loa Loa (eye worm)	oxidoreductase	0.1231	1	1
Onchocerca volvulus		0.0089	0.0686	0.0686
Brugia malayi	Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1	0.0012	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0029	0.02	0.02
Trichomonas vaginalis	aldo-keto reductase, putative	0.1231	1	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0007	0.0007
Echinococcus granulosus	nibrin	0.001	0.0038	0.0038
Brugia malayi	hypothetical protein	0.0006	0.0007	0.0007
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0029	0.02	0.02
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0159	0.0152
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0092	0.0085
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.1231	1	1
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.0007	0.0015	0.0008
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0062	0.0468	0.0468
Brugia malayi	Nuclear hormone receptor-like 1	0.0033	0.0228	0.0228
Entamoeba histolytica	protein kinase, putative	0.0086	0.0664	0.0664
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0228	0.0228
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0159	0.0504
Brugia malayi	photoreceptor-specific nuclear receptor	0.0062	0.0468	0.0468
Entamoeba histolytica	protein kinase domain containing protein	0.0086	0.0664	0.0664
Schistosoma mansoni	serine/threonine protein kinase	0.0086	0.0664	0.0664
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0029	0.02	0.02
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0356	0.2868	0.2868
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0007	0.0007
Onchocerca volvulus		0.0006	0.0007	0.0007
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.1231	1	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0147	0.014
Brugia malayi	hypothetical protein	0.0029	0.02	0.02
Onchocerca volvulus		0.001	0.0038	0.0038
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0007	0.0015	0.0008
Schistosoma mansoni	thyroid hormone receptor	0.0062	0.0468	0.0468
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0029	0.02	0.02
Echinococcus multilocularis		0.0012	0.0058	0.0058
Brugia malayi	ShTK domain containing protein	0.0089	0.0686	0.0686
Echinococcus multilocularis	ecdysone induced protein 78C	0.0062	0.0468	0.0468
Entamoeba histolytica	aldose reductase, putative	0.1231	1	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0147	0.0132
Toxoplasma gondii	aldo/keto reductase family oxidoreductase	0.0356	0.2868	0.2858
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.1231	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0062	0.0468	0.0468
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0353	0.0353
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0033	0.0228	0.0228
Brugia malayi	nuclear receptor RXR	0.0033	0.0228	0.0228
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0007	0.0007
Trichomonas vaginalis	aldo/keto reductase, putative	0.1231	1	1
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0011	0.005	0.005
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0007	0.0007
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0007	0.0015	0.0008
Onchocerca volvulus		0.0007	0.0015	0.0015
Onchocerca volvulus		0.0006	0.0007	0.0007
Mycobacterium tuberculosis	Probable oxidoreductase	0.1231	1	1
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0011	0.005	0.005
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0006	0.0007	0.0007
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0092	0.0085
Schistosoma mansoni	nuclear receptor nhr-48	0.0029	0.02	0.02
Leishmania major	aldo/keto reductase, putative,aldo/keto reductase family-like protein	0.0356	0.2868	0.2863
Onchocerca volvulus		0.0089	0.0686	0.0686
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0006	0.0007	0.0007
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0041	0.0296	0.0289
Loa Loa (eye worm)	hypothetical protein	0.001	0.0038	0.0038
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0006	0.0007	0.0007
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0147	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0007	0.0007
Schistosoma mansoni	potassium channel beta	0.0356	0.2868	0.2868
Loa Loa (eye worm)	hypothetical protein	0.001	0.0039	0.0039
Echinococcus multilocularis	hypothetical protein	0.0006	0.0007	0.0007
Entamoeba histolytica	hypothetical protein	0.001	0.0038	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0086	0.066	0.066
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0015	0.0008
Trichomonas vaginalis	aldo-keto reductase, putative	0.1231	1	1
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0007	0.0015	0.0015
Echinococcus granulosus	dual specificity	0.0086	0.0664	0.0664
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.1231	1	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0006	0.0007	0.0007
Schistosoma mansoni	topbp1	0.001	0.0038	0.0038
Brugia malayi	Protein kinase domain containing protein	0.0086	0.0664	0.0664
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.1231	1	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0062	0.0468	0.0468
Trypanosoma cruzi	aldo/keto reductase, putative	0.1231	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.1231	1	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.1231	1	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.1231	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0062	0.0468	0.0468
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0085	0.0085
Brugia malayi	nuclear receptor NHR-67	0.0029	0.02	0.02
Onchocerca volvulus	Bile acid receptor homolog	0.0062	0.0468	0.0468
Onchocerca volvulus		0.0006	0.0007	0.0007
Echinococcus granulosus	aldo keto reductase family 1, member B4	0.0356	0.2868	0.2868
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0006	0.0007	0.0007
Echinococcus granulosus	CTD small phosphatase protein like	0.0012	0.0058	0.0058
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0007	0.0015	0.0008
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0029	0.02	0.02
Loa Loa (eye worm)	oxidoreductase	0.1231	1	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0062	0.0468	0.0468
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0015	0.0008
Leishmania major	long-chain-fatty-acid-CoA ligase, putative	0.0007	0.0015	0.0008
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0062	0.0468	0.0468
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0062	0.0468	0.0468
Entamoeba histolytica	NLI interacting factor-like phosphatase domain-containing protein	0.0012	0.0058	0.0058
Onchocerca volvulus	4.1 G protein, putative homolog	0.0006	0.0007	0.0007
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0006	0.0007	0.0007
Onchocerca volvulus		0.1231	1	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0228	0.0228
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.1231	1	1
Echinococcus multilocularis	aldehyde reductase	0.0874	0.7092	0.7092
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0114	0.0892	0.0892
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0006	0.0007	0.0007
Trichomonas vaginalis	aldo-keto reductase, putative	0.0356	0.2868	0.2863
Echinococcus multilocularis	replication factor c subunit 1	0.001	0.0038	0.0038
Onchocerca volvulus		0.0089	0.0686	0.0686
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0007	0.0007
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0085	0.0085
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.1231	1	1
Plasmodium falciparum	acyl-CoA synthetase	0.0017	0.01	0.0297
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0468	0.0468
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0033	0.0228	0.0228
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0015	0.0015
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0007	0.0015	0.0008
Schistosoma mansoni	hypothetical protein	0.0033	0.0229	0.0229
Trichomonas vaginalis	aldo-keto reductase, putative	0.1231	1	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0085	0.0085
Schistosoma mansoni	RAR-like nuclear receptor	0.0062	0.0468	0.0468
Onchocerca volvulus		0.0356	0.2868	0.2868
Brugia malayi	hypothetical protein	0.0006	0.0007	0.0007
Onchocerca volvulus		0.0006	0.0007	0.0007
Onchocerca volvulus		0.001	0.0046	0.0046
Trichomonas vaginalis	aldo-keto reductase, putative	0.1231	1	1
Schistosoma mansoni	thyroid hormone receptor	0.0062	0.0468	0.0468
Loa Loa (eye worm)	hypothetical protein	0.0029	0.02	0.02
Onchocerca volvulus		0.0029	0.02	0.02
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0062	0.0468	0.0468
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0029	0.02	0.02
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0353	0.0353
Brugia malayi	Hypothetical tyrosinase-like protein F21C3.2 in chromosome I	0.0089	0.0686	0.0686
Trichomonas vaginalis	nuclear lim interactor-interacting factor, putative	0.0012	0.0058	0.0051
Loa Loa (eye worm)	DnaJ domain-containing protein	0.0059	0.0443	0.0443
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0006	0.0007	0.0007
Brugia malayi	nuclear receptor RXR	0.0029	0.02	0.02
Onchocerca volvulus		0.0062	0.0468	0.0468
Echinococcus granulosus	muscleblind protein	0.0144	0.1138	0.1138
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.1231	1	1
Schistosoma mansoni	nuclear hormone receptor	0.0029	0.02	0.02
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0353	0.0353
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0006	0.0007	0.0007
Trichomonas vaginalis	aldo/keto reductase, putative	0.1231	1	1
Trypanosoma cruzi	hypothetical protein, conserved	0.001	0.0038	0.0031
Brugia malayi	DKFZp564C0469 protein	0.001	0.0038	0.0038
Brugia malayi	Muscleblind-like protein	0.0144	0.1138	0.1138
Trichomonas vaginalis	alcohol dehydrogenase, putative	0.0356	0.2868	0.2863
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0007	0.0007
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0006	0.0007	0.0007
Brugia malayi	nuclear receptor NHR-88	0.0029	0.02	0.02
Trichomonas vaginalis	protein kinase inhibitor, putative	0.0059	0.0443	0.0436
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0007	0.0007
Trypanosoma brucei	PAB1-binding protein , putative	0.0024	0.0159	0.0152
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0007	0.0015	0.0015
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0017	0.01	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0007	0.0007
Schistosoma mansoni	tyrosinase precursor	0.0089	0.0686	0.0686
Mycobacterium ulcerans	oxidoreductase	0.1231	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0038	0.0031
Trichomonas vaginalis	conserved hypothetical protein	0.0356	0.2868	0.2863
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0062	0.0468	0.0468
Brugia malayi	NADH-dependent xylose reductase	0.0356	0.2868	0.2868
Trypanosoma brucei	Mitochondrial import inner membrane translocase subunit TIM50	0.0012	0.0058	0.0051
Loa Loa (eye worm)	hypothetical protein	0.001	0.0038	0.0038
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0029	0.02	0.02
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0006	0.0007	0.0007
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0006	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0229	0.0229
Toxoplasma gondii	ATPase, AAA family protein	0.001	0.0038	0.0023
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.1231	1	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0062	0.0468	0.0468
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0006	0.0007	0.0007
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.0086	0.0664	0.0657
Brugia malayi	conserved hypotetical protein	0.0029	0.02	0.02
Trypanosoma brucei	prostaglandin f synthase	0.1231	1	1
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0686	0.0686
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0159	0.0159
Mycobacterium leprae	Conserved hypothetical protein	0.0874	0.7092	0.7088
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0006	0.0007	0.0007
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0006	0.0007	0.0007
Entamoeba histolytica	protein kinase, putative	0.0086	0.0664	0.0664
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0062	0.0468	0.0468
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0006	0.0007	0.0007
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0085	0.0085
Echinococcus multilocularis		0.0006	0.0007	0.0007
Trypanosoma cruzi	aldo-keto reductase	0.1231	1	1
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0468	0.0468
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0006	0.0007	0.0007
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0005	0.0004	0.0004
Plasmodium vivax	ataxin-2 like protein, putative	0.0024	0.0159	0.0504
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0006	0.0007	0.0007
Trichomonas vaginalis	aldo-keto reductase, putative	0.1231	1	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0062	0.0468	0.0468
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0006	0.0007	0.0007
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0062	0.0468	0.0468
Schistosoma mansoni	chromosome transmission fidelity factor	0.001	0.0038	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0228	0.0228
Echinococcus multilocularis	muscleblind protein 1	0.0144	0.1138	0.1138
Giardia lamblia	Aldose reductase	0.1231	1	1
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.014	0.1103	0.1103
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0006	0.0007	0.0007
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0006	0.0007	0.0007
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0147	0.0132
Schistosoma mansoni	nuclear hormone receptor	0.0029	0.02	0.02
Brugia malayi	nuclear hormone receptor	0.0029	0.02	0.02
Schistosoma mansoni	nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if)	0.0012	0.0058	0.0058
Trypanosoma cruzi	FHA domain containing protein, putative	0.001	0.0038	0.0031
Brugia malayi	hypothetical protein	0.0006	0.0007	0.0007
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0033	0.0228	0.0228
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0007	0.0015	0.0008
Entamoeba histolytica	protein kinase, putative	0.0005	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0228	0.0228
Echinococcus granulosus	aldehyde reductase	0.0874	0.7092	0.7092
Trichomonas vaginalis	aldo-keto reductase, putative	0.1231	1	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.01	0.01
Schistosoma mansoni	aldo-keto reductase	0.1231	1	1
Plasmodium vivax	aldehyde reductase, putative	0.0356	0.2868	1
Brugia malayi	hypothetical protein	0.0033	0.0228	0.0228
Plasmodium vivax	NLI interacting factor-like phosphatase, putative	0.0012	0.0058	0.015
Trypanosoma cruzi	hypothetical protein, conserved	0.0012	0.0058	0.0051
Schistosoma mansoni	nuclear hormone receptor	0.0062	0.0468	0.0468
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0006	0.0007	0.0007
Brugia malayi	orphan nuclear receptor NR2E1	0.0029	0.02	0.02
Mycobacterium leprae	Possible oxidoreductase	0.0356	0.2868	0.2858
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0062	0.0468	0.0468
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0006	0.0007	0.0007
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.0007	0.0015	0.0008
Toxoplasma gondii	Dullard family phosphatase domain-containing protein	0.0012	0.0058	0.0043
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0062	0.0468	0.0468
Loa Loa (eye worm)	oxidoreductase	0.0007	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0029	0.02	0.02
Plasmodium vivax	oxidoreductase, aldo/keto reductase domain containing protein	0.0356	0.2868	1
Trichomonas vaginalis	pps1 dual specificty phosphatase, putative	0.056	0.453	0.4526
Echinococcus multilocularis	dual specificity	0.0086	0.0664	0.0664
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0062	0.0468	0.0468
Leishmania major	aldo-keto reductase-like protein	0.1231	1	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0092	0.0085
Onchocerca volvulus		0.0006	0.0007	0.0007
Brugia malayi	hypothetical protein	0.0006	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0029	0.02	0.02
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0007	0.0015	0.0008
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0029	0.02	0.02
Onchocerca volvulus		0.1231	1	1
Plasmodium falciparum	histone acetyltransferase GCN5	0.0038	0.0268	0.0887
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0228	0.0228
Onchocerca volvulus		0.0006	0.0007	0.0007
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0006	0.0007	0.0007
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0006	0.0007	0.0007
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0147	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0007	0.0007
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0062	0.0468	0.0468
Schistosoma mansoni	nuclear receptor	0.0029	0.02	0.02
Loa Loa (eye worm)	hypothetical protein	0.0029	0.02	0.02
Onchocerca volvulus		0.0023	0.0147	0.0147
Entamoeba histolytica	dual specificity protein phosphatase, putative	0.056	0.453	0.453
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0041	0.0296	0.0289
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0006	0.0007	0.0007
Echinococcus multilocularis	Carboxy terminal domain RNA polymerase II	0.0012	0.0058	0.0058
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0006	0.0007	0.0007
Trichomonas vaginalis	aldo/keto reductase, putative	0.1231	1	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0006	0.0007	0.0007
Trichomonas vaginalis	nuclear lim interactor-interacting factor, putative	0.0012	0.0058	0.0051
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.1231	1	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0062	0.0468	0.0468
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0006	0.0007	0.0007
Trypanosoma brucei	aldo/keto reductase, putative	0.0356	0.2868	0.2863
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0058	0.0058
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0006	0.0007	0.0007
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0007	0.0015	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0007	0.0007
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.1231	1	1
Entamoeba histolytica	hypothetical protein	0.0086	0.0664	0.0664
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0353	0.0353
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0006	0.0007	0.0007
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0062	0.0468	0.0468
Loa Loa (eye worm)	oxidoreductase	0.1231	1	1
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0006	0.0007	0.0007
Trypanosoma brucei	aldo-keto reductase, putative	0.1231	1	1
Mycobacterium leprae	PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+])	0.001	0.0038	0.0023
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0147	0.0132
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0006	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0686	0.0686
Plasmodium vivax	replication factor C subunit 1, putative	0.001	0.0038	0.008
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	0.0007	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0144	0.1138	0.1138
Loa Loa (eye worm)	ShTK domain-containing protein	0.0089	0.0686	0.0686
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0062	0.0468	0.0468
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.0038	0.0031
Echinococcus granulosus	dnaJ subfamily C 6	0.0059	0.0443	0.0443
Brugia malayi	hypothetical protein	0.0016	0.0089	0.0089
Onchocerca volvulus		0.1231	1	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0006	0.0007	0.0007
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0062	0.0468	0.0468
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0006	0.0007	0.0007
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0006	0.0007	0.0007
Onchocerca volvulus		0.0006	0.0007	0.0007
Echinococcus granulosus	hypothetical protein	0.1231	1	1
Brugia malayi	glutamate-cysteine ligase modifier subunit	0.0356	0.2868	0.2868
Brugia malayi	hypothetical protein	0.0024	0.0159	0.0159
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0015	0.0015
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0147	0.0147
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.001	0.0039	0.0032
Brugia malayi	Nuclear hormone receptor E75	0.0029	0.02	0.02
Loa Loa (eye worm)	hypothetical protein	0.0144	0.1138	0.1138
Onchocerca volvulus		0.0006	0.0007	0.0007
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0085	0.0085
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0159	0.0152
Brugia malayi	nuclear hormone receptor family member odr-7	0.0029	0.02	0.02
Echinococcus granulosus	aldo keto reductase	0.1231	1	1
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0015	0.0015
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0147	0.014
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0147	0.014
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0468	0.0468
Giardia lamblia	Aldose reductase	0.1231	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0062	0.0468	0.0468
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0006	0.0007	0.0007
Schistosoma mansoni	zinc finger protein	0.0029	0.02	0.02
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0015	0.0008
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0006	0.0007	0.0007
Brugia malayi	topoisomerase	0.001	0.0038	0.0038
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.1231	1	1
Schistosoma mansoni	pol-related	0.1231	1	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.01	0.01
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0006	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0007	0.0007
Entamoeba histolytica	acyl-coA synthetase, putative	0.0023	0.0147	0.0147
Loa Loa (eye worm)	oxidoreductase	0.1231	1	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0147	0.0147
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.1231	1	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0006	0.0007	0.0007
Echinococcus granulosus	Carboxy terminal domain RNA polymerase II	0.0012	0.0058	0.0058
Onchocerca volvulus		0.0006	0.0007	0.0007
Brugia malayi	Pax transcription activation domain interacting protein	0.001	0.0038	0.0038
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0147	0.0132
Onchocerca volvulus		0.0006	0.0007	0.0007
Schistosoma mansoni	hypothetical protein	0.0011	0.005	0.005
Echinococcus multilocularis	nibrin	0.001	0.0038	0.0038
Trichomonas vaginalis	aldo-keto reductase, putative	0.1231	1	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0062	0.0468	0.0468
Echinococcus granulosus	voltage gated potassium channel subunit	0.0356	0.2868	0.2868
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0015	0.0015
Onchocerca volvulus		0.0006	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0007	0.0007
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.1231	1	1
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0005	0.0004	0.0004
Echinococcus multilocularis	muscleblind protein	0.0144	0.1138	0.1138
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0062	0.0468	0.0468
Leishmania major	prostaglandin f synthase, putative	0.1231	1	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.02	0.02
Schistosoma mansoni	nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if)	0.0012	0.0058	0.0058
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0006	0.0007	0.0007
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0006	0.0007	0.0007
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0085	0.0085
Onchocerca volvulus		0.0006	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0147	0.0147
Onchocerca volvulus		0.0006	0.0007	0.0007
Giardia lamblia	Nuclear LIM interactor-interacting factor 1	0.0012	0.0058	0.0051
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0006	0.0007	0.0007
Schistosoma mansoni	hypothetical protein	0.0012	0.0057	0.0057
Brugia malayi	ecdysteroid receptor	0.0062	0.0468	0.0468
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0029	0.02	0.02
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0006	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0007	0.0007
Trichomonas vaginalis	replication factor C large subunit, putative	0.001	0.0038	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0468	0.0468
Loa Loa (eye worm)	hypothetical protein	0.0029	0.02	0.02
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0007	0.0007
Schistosoma mansoni	topbp1	0.001	0.0038	0.0038
Schistosoma mansoni	coup transcription factor	0.0062	0.0468	0.0468
Loa Loa (eye worm)	DR-78	0.0029	0.02	0.02
Echinococcus multilocularis	aldo keto reductase	0.1231	1	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0147	0.0132
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0006	0.0007	0.0007
Schistosoma mansoni	hypothetical protein	0.0015	0.0085	0.0085
Trichomonas vaginalis	dullard protein, putative	0.0012	0.0058	0.0051
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0006	0.0007	0.0007
Echinococcus granulosus	aldo keto reductase	0.1231	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.1231	1	1
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0015	0.0015
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0029	0.02	0.02
Mycobacterium ulcerans	NAD-dependent DNA ligase LigA	0.001	0.0038	0.0023
Onchocerca volvulus		0.0006	0.0007	0.0007
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0114	0.0892	0.0892
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0062	0.0468	0.0468
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0007	0.0007
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.1231	1	1
Echinococcus granulosus	FTZ F1 alpha	0.0062	0.0468	0.0468
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0006	0.0007	0.0007
Plasmodium falciparum	aldehyde reductase, putative	0.0356	0.2868	1
Brugia malayi	acetyltransferase, GNAT family protein	0.014	0.1103	0.1103
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0006	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0468	0.0468
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0006	0.0007	0.0007
Toxoplasma gondii	oxidoreductase, aldo/keto reductase family protein	0.0356	0.2868	0.2858
Toxoplasma gondii	aldo-keto reductase	0.0356	0.2868	0.2858
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0006	0.0007	0.0007
Brugia malayi	hypothetical protein	0.001	0.0038	0.0038
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0029	0.02	0.02

Activities

Activity type	Activity value	Assay description	Source	Reference
Hammett constant (ADMET)	= 0.14	Hammett constant was evaluated	ChEMBL.	8667357

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 206918

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 111790