TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 428.326 | Formula: C20H22BrN5O
H donors: 2 H acceptors: 3 LogP: 3.61 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CN(CCCC(=O)Nc1ccc2c(c1)c(ncn2)Nc1cccc(c1)Br)C
InChi: 1S/C20H22BrN5O/c1-26(2)10-4-7-19(27)24-16-8-9-18-17(12-16)20(23-13-22-18)25-15-6-3-5-14(21)11-15/h3,5-6,8-9,11-13H,4,7,10H2,1-2H3,(H,24,27)(H,22,23,25)
InChiKey: QKNUBNZRMFTLIJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	erb-b2 receptor tyrosine kinase 4		References
Homo sapiens	erb-b2 receptor tyrosine kinase 3	Starlite/ChEMBL	References
Homo sapiens	erb-b2 receptor tyrosine kinase 2		References
Homo sapiens	epidermal growth factor receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	IPR000494,EGF receptor, L domain,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-2 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis		Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-4 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Brugia malayi	Furin-like cysteine rich region family protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	ko:K05085 receptor tyrosine-protein kinase erbB-4, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Tyrosine-protein kinase transforming protein erbB, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Loa Loa (eye worm)	TK/EGFR protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0022	0.0074	0.0087
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0084	0.0858	0.0414
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0106	0.1148	0.1327
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0074	0.0041
Mycobacterium ulcerans	hypothetical protein	0.0084	0.0858	1
Echinococcus granulosus	epidermal growth factor receptor	0.068	0.849	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0534	0.663	1
Echinococcus granulosus	tar DNA binding protein	0.0277	0.3334	0.391
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0106	0.1148	0.1352
Mycobacterium tuberculosis	Probable lipase LipE	0.0084	0.0858	0.0414
Mycobacterium leprae	Probable lipase LipE	0.0084	0.0858	0.5
Echinococcus granulosus	tumor protein p63	0.0364	0.4446	0.5223
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0022	0.0074	0.0041
Brugia malayi	Bromodomain containing protein	0.0081	0.0829	0.0761
Loa Loa (eye worm)	PHD-finger family protein	0.0022	0.0074	0.0041
Schistosoma mansoni	tyrosine kinase	0.0427	0.525	0.6183
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0022	0.0074	0.0058
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0022	0.0074	0.0058
Toxoplasma gondii	ABC1 family protein	0.0084	0.0858	1
Echinococcus granulosus	geminin	0.0182	0.2124	0.248
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0022	0.0074	0.0087
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.0024	0.0029
Echinococcus multilocularis	geminin	0.0182	0.2124	0.248
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0051	0.0436	0.0513
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0106	0.1148	0.1327
Schistosoma mansoni	hypothetical protein	0.0022	0.0074	0.0087
Loa Loa (eye worm)	TAR-binding protein	0.0277	0.3334	0.3312
Brugia malayi	TAR-binding protein	0.0277	0.3334	0.3285
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0074	0.0041
Echinococcus granulosus	zinc finger protein	0.0021	0.0059	0.0041
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.043	0.5289	0.6219
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0858	0.0828
Mycobacterium ulcerans	beta-lactamase	0.0084	0.0858	1
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0214	0.2527	0.2957
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0858	0.0828
Schistosoma mansoni	thyroid hormone receptor	0.0022	0.0074	0.0087
Schistosoma mansoni	tyrosine kinase	0.0427	0.525	0.6183
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0022	0.0074	0.0058
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0084	0.0858	0.1011
Loa Loa (eye worm)	hypothetical protein	0.0042	0.032	0.0289
Schistosoma mansoni	tar DNA-binding protein	0.0277	0.3334	0.3927
Schistosoma mansoni	aldehyde dehydrogenase	0.0064	0.0609	0.0717
Schistosoma mansoni	hypothetical protein	0.0182	0.2124	0.2501
Echinococcus multilocularis	epidermal growth factor receptor	0.068	0.849	1
Schistosoma mansoni	tyrosine kinase	0.043	0.5289	0.623
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0084	0.0858	0.1011
Mycobacterium tuberculosis	Conserved protein	0.0084	0.0858	0.0414
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0084	0.0858	1
Schistosoma mansoni	tyrosine kinase	0.0214	0.2527	0.2977
Brugia malayi	beta-lactamase family protein	0.0084	0.0858	0.0791
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0084	0.0858	0.0414
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0084	0.0858	0.0414
Schistosoma mansoni	hypothetical protein	0.0182	0.2124	0.2501
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0858	0.0828
Schistosoma mansoni	retinoic acid receptor RXR	0.0022	0.0074	0.0087
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0022	0.0074	0.0058
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0106	0.1148	0.1327
Echinococcus granulosus	epidermal growth factor receptor	0.043	0.5289	0.6219
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0084	0.0858	0.0985
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0277	0.3334	0.3312
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0022	0.0074	0.0058
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0022	0.0074	0.0087
Brugia malayi	Pre-SET motif family protein	0.0032	0.0199	0.0126
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0084	0.0858	0.0828
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0022	0.0074	0.0058
Mycobacterium tuberculosis	Probable esterase LipL	0.0084	0.0858	0.0414
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0051	0.0436	0.0486
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0022	0.0074	0.0041
Echinococcus multilocularis	FTZ F1 alpha	0.0022	0.0074	0.0058
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0022	0.0074	0.0058
Schistosoma mansoni	bromodomain containing protein	0.0069	0.0666	0.0785
Mycobacterium leprae	conserved hypothetical protein	0.0084	0.0858	0.5
Echinococcus granulosus	FTZ F1 alpha	0.0022	0.0074	0.0058
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0039	0.0287	0.031
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0065	0.0617	0.07
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0106	0.1148	0.1352
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.0074	0.0058
Trypanosoma cruzi	hypothetical protein, conserved	0.0084	0.0858	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.0074	0.0058
Mycobacterium tuberculosis	Probable hydrolase	0.0084	0.0858	0.0414
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0065	0.0617	0.07
Leishmania major	hypothetical protein, conserved	0.0084	0.0858	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0224	0.2657	0.2633
Schistosoma mansoni	tyrosine kinase	0.0214	0.2527	0.2977
Echinococcus multilocularis	ecdysone induced protein 78C	0.0022	0.0074	0.0058
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0199	0.0234
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0858	0.0828
Schistosoma mansoni	coup transcription factor	0.0022	0.0074	0.0087
Brugia malayi	beta-lactamase	0.0084	0.0858	0.0791
Schistosoma mansoni	tyrosine kinase	0.068	0.849	1
Mycobacterium tuberculosis	Conserved protein	0.0084	0.0858	0.0414
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0106	0.1148	0.1119
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0106	0.1148	0.1082
Schistosoma mansoni	RAR-like nuclear receptor	0.0022	0.0074	0.0087
Schistosoma mansoni	tyrosine kinase	0.0427	0.525	0.6183
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0084	0.0858	0.0791
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0064	0.0609	0.7094
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0074	0.0041
Schistosoma mansoni	tyrosine kinase	0.043	0.5289	0.623
Brugia malayi	RNA recognition motif domain containing protein	0.0277	0.3334	0.3285
Schistosoma mansoni	tar DNA-binding protein	0.0277	0.3334	0.3927
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.0074	0.0058
Loa Loa (eye worm)	RNA binding protein	0.0277	0.3334	0.3312
Onchocerca volvulus		0.0255	0.3053	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0022	0.0074	0.0041
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0022	0.0074	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0074	0.0041
Onchocerca volvulus		0.0084	0.0858	0.2634
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0469	0.0438
Mycobacterium tuberculosis	Conserved protein	0.0084	0.0858	0.0414
Echinococcus multilocularis	tar DNA binding protein	0.0277	0.3334	0.391
Brugia malayi	Bromodomain containing protein	0.0042	0.0319	0.0248
Schistosoma mansoni	nuclear hormone receptor	0.0022	0.0074	0.0087
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0032	0.0199	0.0206
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0031	0.0184	0.0188
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0032	0.0199	0.0234
Mycobacterium ulcerans	lipase LipD	0.0084	0.0858	1
Mycobacterium tuberculosis	Probable lipase LipD	0.0084	0.0858	0.0414
Onchocerca volvulus		0.0084	0.0858	0.2634
Mycobacterium ulcerans	esterase/lipase LipP	0.0084	0.0858	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0084	0.0858	0.0985
Trichomonas vaginalis	set domain proteins, putative	0.0255	0.3053	1
Onchocerca volvulus		0.0032	0.0199	0.0421
Echinococcus multilocularis	epidermal growth factor receptor	0.043	0.5289	0.6219
Loa Loa (eye worm)	TK/INSR protein kinase	0.0214	0.2527	0.2503
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0022	0.0074	0.0041
Echinococcus multilocularis		0.0307	0.3713	0.4357
Echinococcus granulosus	insulin receptor	0.0214	0.2527	0.2957
Brugia malayi	Furin-like cysteine rich region family protein	0.068	0.849	0.8479
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0064	0.0609	0.0691
Echinococcus granulosus	ecdysone induced protein 78C	0.0022	0.0074	0.0058
Loa Loa (eye worm)	beta-lactamase	0.0084	0.0858	0.0828
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0074	0.0041
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0022	0.0074	0.0058
Loa Loa (eye worm)	TK/EGFR protein kinase	0.068	0.849	0.8485
Brugia malayi	PHD-finger family protein	0.0027	0.0134	0.006
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0022	0.0074	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0858	0.0828
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0106	0.1148	0.1327
Trypanosoma brucei	hypothetical protein, conserved	0.0084	0.0858	1
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0064	0.0609	0.0691
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0022	0.0074	0.0041
Loa Loa (eye worm)	steroid hormone receptor	0.0022	0.0074	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0074	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0074	0.0041
Echinococcus multilocularis	tumor protein p63	0.0364	0.4446	0.5223
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.0024	0.0029
Brugia malayi	Protein kinase domain containing protein	0.0214	0.2527	0.2472
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0022	0.0074	0.0087
Brugia malayi	Pre-SET motif family protein	0.0224	0.2657	0.2602
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0436	0.0404
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0022	0.0074	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0077	0.077	0.0739
Echinococcus multilocularis	zinc finger protein	0.0021	0.0059	0.0041
Schistosoma mansoni	tar DNA-binding protein	0.0277	0.3334	0.3927
Onchocerca volvulus		0.0084	0.0858	0.2634
Brugia malayi	beta-lactamase family protein	0.0084	0.0858	0.0791
Trypanosoma cruzi	hypothetical protein, conserved	0.0084	0.0858	1
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0858	0.0828
Plasmodium vivax	hypothetical protein, conserved	0.0084	0.0858	1
Echinococcus granulosus	fetal alzheimer antigen falz	0.0024	0.0101	0.009
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0022	0.0074	0.0087
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0022	0.0074	0.0087
Schistosoma mansoni	thyroid hormone receptor	0.0022	0.0074	0.0087
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0051	0.0436	0.0513
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0074	0.0041
Schistosoma mansoni	cellular tumor antigen P53	0.0053	0.0469	0.0553
Schistosoma mansoni	tar DNA-binding protein	0.0277	0.3334	0.3927
Schistosoma mansoni	aldehyde dehydrogenase	0.0064	0.0609	0.0717
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0353	0.0322
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0214	0.2527	0.2957
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0022	0.0074	0.0041
Brugia malayi	RNA binding protein	0.0277	0.3334	0.3285
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0024	0.0101	0.0119
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0022	0.0074	0.0058
Schistosoma mansoni	tar DNA-binding protein	0.0277	0.3334	0.3927
Echinococcus multilocularis	insulin receptor	0.0214	0.2527	0.2957
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0039	0.0287	0.031
Echinococcus granulosus	histone lysine methyltransferase setb	0.0051	0.0436	0.0486
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0798	1	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.0074	0.0058
Onchocerca volvulus		0.0053	0.0469	0.1328
Schistosoma mansoni	zinc finger protein	0.0021	0.0059	0.007
Toxoplasma gondii	aldehyde dehydrogenase	0.0064	0.0609	0.6217
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0106	0.1148	0.1352
Loa Loa (eye worm)	hypothetical protein	0.0046	0.038	0.0348
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0024	0.0101	0.009

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)	= -12 %	Inhibition of HER4 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 3 %	Inhibition of Lck at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 7 %	Inhibition of YES1 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 10 %	Inhibition of RIPK2 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 12 %	Inhibition of PIM1 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 14 %	Inhibition of MNK2 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 17 %	Inhibition of EPH-B3 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 18 %	Inhibition of PKD1 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 18 %	Inhibition of SmMLCK at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 21 %	Inhibition of Aurora B at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 27 %	Inhibition of DYRK3 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 29 %	Inhibition of BRSK2 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 29 %	Inhibition of MKK1 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 32 %	Inhibition of PIM3 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 35 %	Inhibition of MINK1 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 37 %	Inhibition of FGF-R1 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 37 %	Inhibition of PRK2 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 38 %	Inhibition of CHK2 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 39 %	Inhibition of NUAK1 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 44 %	Inhibition of Src at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 48 %	Inhibition of GCK at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 49 %	Inhibition of MELK at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 51 %	Inhibition of DYRK2 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 52 %	Inhibition of BRSK1 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 53 %	Inhibition of EPHA2 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 57 %	Inhibition of CAMK1 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 62 %	Inhibition of PIM2 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 63 %	Inhibition of p38alpha at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 63 %	Inhibition of CSK at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 64 %	Inhibition of PAK5 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 65 %	Inhibition of MLK3 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 65 %	Inhibition of DYRK1A at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 66 %	Inhibition of CK1 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 66 %	Inhibition of CAMKKbeta at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 66 %	Inhibition of Aurora A at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 67 %	Inhibition of SYK at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 70 %	Inhibition of IRR at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 72 %	Inhibition of JNK3 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 72 %	Inhibition of SGK1 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 72 %	Inhibition of RSK1 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 74 %	Inhibition of MARK4 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 75 %	Inhibition of PAK2 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 75 %	Inhibition of PBK1 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 75 %	Inhibition of S6K1 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 76 %	Inhibition of JNK1 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 77 %	Inhibition of JNK2 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 77 %	Inhibition of NEK6 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 78 %	Inhibition of RSK2 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 78 %	Inhibition of PKCalpha at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 78 %	Inhibition of ERK8 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 79 %	Inhibition of BTK at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 79 %	Inhibition of p38delta at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 79 %	Inhibition of CHK1 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 79 %	Inhibition of His-IR at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 80 %	Inhibition of PKBbeta at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 81 %	Inhibition of p38beta at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 81 %	Inhibition of IRAK4 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 81 %	Inhibition of MAPKAPK-3 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 82 %	Inhibition of MARK2 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 83 %	Inhibition of PAK4 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 83 %	Inhibition of ERK1 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 85 %	Inhibition of p38-gamma at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 86 %	Inhibition of TTK at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 86 %	Inhibition of PKCzeta at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 86 %	Inhibition of MARK3 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 87 %	Inhibition of SRPK1 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 87 %	Inhibition of MLK1 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 88 %	Inhibition of PDK1 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 88 %	Inhibition of MST4 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 88 %	Inhibition of ERK2 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 89 %	Inhibition of PRAK at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 89 %	Inhibition of IKKepsilon at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 90 %	Inhibition of IKK-beta at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 90 %	Inhibition of MST2 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 90 %	Inhibition of MAPKAP-K2 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 91 %	Inhibition of EF2K at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 93 %	Inhibition of PAK6 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 93 %	Inhibition of CDK2/Cyclin A at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 93 %	Inhibition of MSK1 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 95 %	Inhibition of ROCK2 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 95 %	Inhibition of PLK1 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 96 %	Inhibition of GSK3-beta at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 96 %	Inhibition of NEK2a at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 97 %	Inhibition of HIPK2 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 103 %	Inhibition of LKB1 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 103 %	Inhibition of PKBalpha at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 105 %	Inhibition of IGF-1R at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 106 %	Inhibition of HIPK3 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
Activity (binding)	= 126 %	Inhibition of HIPK1 at 10 uM assessed as residual activity by [33P]ATP radioactive filter binding assay relative to control	ChEMBL.	20222733
IC50 (binding)	< 1 nM	Inhibition of EGFR Leu858Arg mutant by HTRF assay	ChEMBL.	20222733
IC50 (binding)	< 1 nM	Inhibition of wild type EGFR by HTRF assay	ChEMBL.	20222733
IC50 (binding)	= 190 nM	Inhibition of EGFR Leu858Arg and Thr790Met mutant by HTRF assay	ChEMBL.	20222733

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1088901

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1118148