Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | geminin | 0.0185 | 0.5205 | 0.8674 |
Brugia malayi | beta-lactamase family protein | 0.0039 | 0.0001 | 0.0002 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0319 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0319 | 1 | 1 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0084 | 0.1602 | 0.267 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0055 | 0.0564 | 0.094 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0178 | 0.495 | 0.8249 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0039 | 0.0001 | 0.0002 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0084 | 0.1602 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0207 | 0.6 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0039 | 0.0001 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0039 | 0.0001 | 0.0001 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0039 | 0.0001 | 0.0001 |
Schistosoma mansoni | hypothetical protein | 0.0185 | 0.5205 | 0.8674 |
Schistosoma mansoni | tar DNA-binding protein | 0.0207 | 0.6 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0252 | 0.7613 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0084 | 0.1602 | 0.3847 |
Schistosoma mansoni | alpha-glucosidase | 0.0153 | 0.4064 | 0.6773 |
Brugia malayi | Probable ClpP-like protease | 0.0084 | 0.1602 | 0.267 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0084 | 0.1602 | 0.5 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0039 | 0.0001 | 0.0002 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0319 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0319 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0001 | 0.0002 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.0001 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0084 | 0.1602 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.1602 | 0.267 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0084 | 0.1602 | 0.3847 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0207 | 0.6 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0084 | 0.1602 | 0.5 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0084 | 0.1602 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0039 | 0.0001 | 0.0001 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0207 | 0.6 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0178 | 0.495 | 0.8249 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0178 | 0.495 | 0.8249 |
Schistosoma mansoni | tar DNA-binding protein | 0.0207 | 0.6 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0039 | 0.0001 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0055 | 0.0564 | 0.1352 |
Schistosoma mansoni | hypothetical protein | 0.0185 | 0.5205 | 0.8674 |
Onchocerca volvulus | 0.0103 | 0.2268 | 1 | |
Toxoplasma gondii | ABC1 family protein | 0.0039 | 0.0001 | 0.0006 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0055 | 0.0564 | 0.0739 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0156 | 0.4163 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0207 | 0.6 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0084 | 0.1602 | 0.3847 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0055 | 0.0564 | 0.0739 |
Echinococcus multilocularis | geminin | 0.0185 | 0.5205 | 0.8674 |
Schistosoma mansoni | tar DNA-binding protein | 0.0207 | 0.6 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0001 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0001 | 0.0002 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0084 | 0.1602 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0039 | 0.0001 | 0.0002 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0039 | 0.0001 | 0.0001 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0039 | 0.0001 | 0.0001 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0039 | 0.0001 | 0.0002 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0084 | 0.1602 | 0.267 |
Brugia malayi | beta-lactamase | 0.0039 | 0.0001 | 0.0002 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0084 | 0.1602 | 0.267 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0319 | 1 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0178 | 0.495 | 0.8249 |
Brugia malayi | beta-lactamase family protein | 0.0039 | 0.0001 | 0.0002 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0319 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0319 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0319 | 1 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0319 | 1 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0319 | 1 | 1 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0055 | 0.0564 | 0.094 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0039 | 0.0001 | 0.0002 |
Brugia malayi | RNA binding protein | 0.0207 | 0.6 | 1 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0156 | 0.4163 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0039 | 0.0001 | 0.0002 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.0001 | 1 |
Brugia malayi | TAR-binding protein | 0.0207 | 0.6 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0178 | 0.495 | 0.8249 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0319 | 1 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0039 | 0.0001 | 0.0001 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0001 | 0.0002 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0156 | 0.4163 | 0.5468 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0084 | 0.1602 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0153 | 0.4064 | 0.6773 |
Echinococcus granulosus | tar DNA binding protein | 0.0207 | 0.6 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0207 | 0.6 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0207 | 0.6 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0039 | 0.0001 | 0.0002 |
Echinococcus multilocularis | tar DNA binding protein | 0.0207 | 0.6 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0001 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0001 | 0.0002 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 37 % | Antiinflammatory activity in LPS-stimulated human THP1 cells assessed as inhibition of TNFalpha formation at 10 uM pretreated 30 mins before LPS challenge measured after 24 hrs by ELISA | ChEMBL. | 20207143 |
Activity (functional) | = 41 % | Antiinflammatory activity in LPS-stimulated human THP1 cells assessed as inhibition of IL6 formation at 1 uM pretreated 30 mins before LPS challenge measured after 24 hrs by ELISA | ChEMBL. | 20207143 |
Activity (functional) | = 81 % | Antiinflammatory activity in LPS-stimulated human THP1 cells assessed as inhibition of IL6 formation at 10 uM pretreated 30 mins before LPS challenge measured after 24 hrs by ELISA | ChEMBL. | 20207143 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.