Detailed information for compound 1118345

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 334.346 | Formula: C12H18N2O7S
  • H donors: 6 H acceptors: 6 LogP: -1.66 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC[C@H]1O[C@@H](Nc2ccc(cc2)S(=O)(=O)N)[C@@H]([C@H]([C@H]1O)O)O
  • InChi: 1S/C12H18N2O7S/c13-22(19,20)7-3-1-6(2-4-7)14-12-11(18)10(17)9(16)8(5-15)21-12/h1-4,8-12,14-18H,5H2,(H2,13,19,20)/t8-,9+,10+,11-,12-/m1/s1
  • InChiKey: RMCYKIOWPVOBJX-YBXAARCKSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens carbonic anhydrase II Starlite/ChEMBL References
Homo sapiens carbonic anhydrase I Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Putative carbonic anhydrase 5 precursor Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) Get druggable targets OG5_127628 All targets in OG5_127628
Echinococcus multilocularis carbonic anhydrase II Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania donovani carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Loa Loa (eye worm) carbonic anhydrase 3 Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma japonicum ko:K01672 carbonic anhydrase [EC4.2.1.1], putative Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma congolense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania braziliensis carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania infantum carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma cruzi carbonic anhydrase-like protein, putative Get druggable targets OG5_127628 All targets in OG5_127628
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase Get druggable targets OG5_127628 All targets in OG5_127628
Brugia malayi Eukaryotic-type carbonic anhydrase family protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma congolense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma cruzi carbonic anhydrase-like protein, putative Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania mexicana carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Echinococcus granulosus carbonic anhydrase II Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania major carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma brucei carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma brucei gambiense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei carbonic anhydrase-like protein carbonic anhydrase I 261 aa 281 aa 25.3 %
Brugia malayi Carbonic anhydrase like protein 2 precursor carbonic anhydrase II 260 aa 259 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0109 0.0159
Echinococcus multilocularis carbonic anhydrase II 0.0181 0.0647 0.0647
Echinococcus granulosus carbonic anhydrase 0.0067 0.0192 0.0489
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.0021 0.0031
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0207 0.0751 0.1909
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0192
Brugia malayi Nuclear hormone receptor-like 1 0.0207 0.0751 0.1094
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.0551 0.1483
Schistosoma mansoni hypothetical protein 0.0049 0.0121 0.032
Loa Loa (eye worm) hypothetical protein 0.0148 0.0517 0.0753
Loa Loa (eye worm) hypothetical protein 0.006 0.0163 0.0238
Loa Loa (eye worm) inositol-1 0.0036 0.0069 0.01
Loa Loa (eye worm) hypothetical protein 0.039 0.1486 0.2163
Echinococcus multilocularis carbonic anhydrase 0.0067 0.0192 0.0192
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0148 0.0517 0.4252
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0154 0.0407
Loa Loa (eye worm) hypothetical protein 0.0147 0.0512 0.0745
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.1114 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0207 0.0751 0.0751
Echinococcus multilocularis dna polymerase eta 0.0044 0.01 0.01
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0148 0.0517 0.0753
Entamoeba histolytica hypothetical protein 0.0024 0.0021 0.0345
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0008 0.0068
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0193 0.0696 0.0696
Loa Loa (eye worm) hypothetical protein 0.0571 0.2209 0.3215
Schistosoma mansoni nuclear hormone receptor 0.0207 0.0751 0.1983
Onchocerca volvulus 0.0058 0.0157 0.0146
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.006 0.0163 0.0163
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0137 0.1392
Brugia malayi hypothetical protein 0.006 0.0163 0.0238
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0207 0.0751 0.1094
Echinococcus granulosus mitogen activated protein kinase 11 0.0127 0.0434 0.1102
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.016 0.1619
Mycobacterium ulcerans beta-lactamase 0.0148 0.0517 0.4252
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0966 0.3788 0.5515
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0059 0.016 0.154
Loa Loa (eye worm) hypothetical protein 0.0027 0.0032 0.0047
Loa Loa (eye worm) hypothetical protein 0.0027 0.0032 0.0047
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0127 0.0434 0.3894
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0623 0.6322
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0426 0.1123
Echinococcus multilocularis thyroid hormone receptor alpha 0.0296 0.1109 0.1109
Trichomonas vaginalis hypothetical protein 0.0184 0.0659 0.6691
Trypanosoma brucei hypothetical protein, conserved 0.0148 0.0517 0.4643
Brugia malayi Peroxidasin 0.0052 0.0132 0.0192
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.006 0.0163 0.0238
Echinococcus granulosus beta LACTamase domain containing family member 0.0148 0.0517 0.1314
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.0137 0.0971
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0207 0.0751 0.1983
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.0393 0.1059
Leishmania major DNA polymerase eta, putative 0.0031 0.0048 0.0394
Mycobacterium ulcerans esterase/lipase LipP 0.0148 0.0517 0.4252
Echinococcus multilocularis ecdysone induced protein 78C 0.0207 0.0751 0.0751
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0181 0.0647 0.5805
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0207 0.0751 0.1094
Schistosoma mansoni hypothetical protein 0.0049 0.0121 0.032
Brugia malayi nuclear receptor RXR 0.006 0.0163 0.0238
Onchocerca volvulus Peroxidase homolog 0.0052 0.0132 0.0109
Echinococcus multilocularis jun protein 0.0083 0.0256 0.0256
Echinococcus multilocularis survival motor neuron protein 1 0.0239 0.0879 0.0879
Brugia malayi TAR-binding protein 0.0125 0.0426 0.062
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0083 0.0256 0.0651
Echinococcus granulosus Nuclear hormone receptor HR96 0.006 0.0163 0.0415
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0048 0.043
Onchocerca volvulus 0.0207 0.0751 0.1018
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0081 0.0247 0.036
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0184 0.0468
Brugia malayi exodeoxyribonuclease III family protein 0.0059 0.016 0.0232
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0091 0.0819
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0147 0.0512 0.0512
Schistosoma mansoni peroxidasin 0.0052 0.0132 0.0348
Loa Loa (eye worm) hypothetical protein 0.006 0.0163 0.0238
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.1114 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0233 0.0857 0.1247
Schistosoma mansoni RAR-like nuclear receptor 0.0207 0.0751 0.1983
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0147 0.0512 0.1351
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0147 0.0512 0.0745
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0207 0.0751 0.1094
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0049 0.0071
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0148 0.0517 0.1393
Loa Loa (eye worm) hypothetical protein 0.0207 0.0751 0.1094
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.0346 0.4832
Mycobacterium tuberculosis Conserved protein 0.0148 0.0517 0.1393
Echinococcus granulosus Nuclear hormone receptor HR96 0.006 0.0163 0.0415
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.006 0.0163 0.0155
Schistosoma mansoni nuclear receptor 0.006 0.0163 0.0432
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0426 0.1123
Onchocerca volvulus Glucosylceramidase homolog 0.0166 0.0587 0.0777
Echinococcus granulosus peroxidasin 0.0052 0.0132 0.0335
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.0137 0.1128
Toxoplasma gondii poly(ADP-ribose) glycohydrolase 0.0077 0.0231 0.1758
Onchocerca volvulus Bile acid receptor homolog 0.1737 0.687 1
Echinococcus granulosus polyADP ribose glycohydrolase 0.0173 0.0614 0.156
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.0137 0.8603
Trypanosoma cruzi poly(ADP-ribose) glycohydrolase, putative 0.0173 0.0614 0.5512
Brugia malayi MAP kinase sur-1 0.0053 0.0137 0.02
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0207 0.0751 0.1094
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0058 0.0152
Schistosoma mansoni nuclear hormone receptor 0.006 0.0163 0.0432
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0069 0.0615
Echinococcus multilocularis beta LACTamase domain containing family member 0.0148 0.0517 0.0517
Loa Loa (eye worm) hypothetical protein 0.006 0.0163 0.0238
Echinococcus granulosus GPCR family 2 0.0049 0.0121 0.0308
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0127 0.0434 0.3894
Brugia malayi hypothetical protein 0.0239 0.0879 0.1279
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0207 0.0751 0.1094
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0207 0.0751 0.1909
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0207 0.0751 0.0751
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0059 0.016 0.2598
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0207 0.0751 0.1094
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.0154 0.0154
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0623 0.6322
Echinococcus multilocularis microtubule associated protein 2 0.0965 0.3785 0.3785
Brugia malayi intermediate filament protein 0.0058 0.0157 0.0229
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0181 0.0647 0.0942
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0207 0.0751 0.1094
Trypanosoma brucei protein kinase, putative 0.0053 0.0137 0.1232
Loa Loa (eye worm) carbonic anhydrase 3 0.0181 0.0647 0.0942
Loa Loa (eye worm) hypothetical protein 0.0458 0.1756 0.2556
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.0137 0.02
Onchocerca volvulus 0.0265 0.0986 0.1362
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0966 0.3788 0.9624
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0207 0.0751 0.1909
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.015 0.0525 0.0525
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.015 0.0525 0.1335
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0948 0.3715 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.0393 0.1059
Loa Loa (eye worm) hypothetical protein 0.0147 0.0511 0.0744
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0193 0.0696 0.1013
Loa Loa (eye worm) RNA binding protein 0.0125 0.0426 0.062
Echinococcus multilocularis muscleblind protein 1 0.0103 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.0156 0.0547 0.0797
Brugia malayi bZIP transcription factor family protein 0.0083 0.0256 0.0373
Trichomonas vaginalis D-aminoacylase, putative 0.0148 0.0517 0.5249
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.01 0.0146
Echinococcus granulosus thyroid hormone receptor alpha 0.006 0.0163 0.0415
Toxoplasma gondii ABC1 family protein 0.0148 0.0517 0.415
Loa Loa (eye worm) hypothetical protein 0.0081 0.0247 0.036
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0121 0.0176
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0207 0.0751 0.1018
Brugia malayi ecdysteroid receptor 0.1737 0.687 1
Brugia malayi beta-lactamase family protein 0.0148 0.0517 0.0753
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.0393 0.5609
Echinococcus granulosus geminin 0.0367 0.1391 0.3533
Treponema pallidum exodeoxyribonuclease (exoA) 0.0059 0.016 0.5
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0154 0.0392
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0207 0.0751 0.1094
Echinococcus granulosus serine protein kinase ATM 0.0024 0.0021 0.0054
Brugia malayi Steroid receptor seven-up type 2 0.0207 0.0751 0.1094
Echinococcus multilocularis carbonic anhydrase 0.0067 0.0192 0.0192
Mycobacterium tuberculosis Conserved protein 0.0148 0.0517 0.1393
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0021 0.019
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0059 0.016 0.1311
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0069 0.0695
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0207 0.0751 0.1094
Loa Loa (eye worm) hypothetical protein 0.006 0.0163 0.0238
Echinococcus granulosus FTZ F1 alpha 0.0207 0.0751 0.1909
Brugia malayi conserved hypotetical protein 0.006 0.0163 0.0238
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0193 0.0696 0.1837
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.0137 0.0349
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0137 0.1392
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0147 0.0512 0.13
Loa Loa (eye worm) hypothetical protein 0.039 0.1486 0.2163
Brugia malayi nuclear hormone receptor family member odr-7 0.006 0.0163 0.0238
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0587 0.5959
Loa Loa (eye worm) hypothetical protein 0.0148 0.0517 0.0753
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0487 0.4004
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0323 0.1217 0.3275
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0154 0.0224
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0587 0.5959
Loa Loa (eye worm) hypothetical protein 0.0207 0.0751 0.1094
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0119 0.0173
Trypanosoma cruzi hypothetical protein, conserved 0.0148 0.0517 0.4643
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0192
Brugia malayi hypothetical protein 0.0458 0.1756 0.2556
Echinococcus multilocularis FTZ F1 alpha 0.0207 0.0751 0.0751
Brugia malayi MH2 domain containing protein 0.0116 0.0388 0.0565
Loa Loa (eye worm) hypothetical protein 0.006 0.0163 0.0238
Brugia malayi steroid hormone receptor 0.0207 0.0751 0.1094
Brugia malayi ecdysone receptor 0.006 0.0163 0.0238
Brugia malayi Thioredoxin reductase 0.0046 0.0109 0.0159
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0192
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0067 0.0192 0.028
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0121 0.0308
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.0346 0.0932
Brugia malayi Inositol-1 0.0036 0.0069 0.01
Loa Loa (eye worm) blistered cuticle protein 3 0.0052 0.0132 0.0192
Loa Loa (eye worm) hypothetical protein 0.006 0.0163 0.0238
Onchocerca volvulus 0.006 0.0163 0.0155
Loa Loa (eye worm) hypothetical protein 0.0148 0.0517 0.0753
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.01 0.0901
Schistosoma mansoni thyroid hormone receptor 0.0296 0.1109 0.2926
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0207 0.0751 0.1094
Loa Loa (eye worm) nuclear receptor NHR-67 0.006 0.0163 0.0238
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0067 0.0192 0.028
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0207 0.0751 0.0751
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0184 0.2998
Echinococcus multilocularis neuropeptide receptor A26 0.0498 0.1917 0.1917
Loa Loa (eye worm) nuclear receptor nhr-7B 0.006 0.0163 0.0238
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0059 0.016 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0192
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.006 0.0163 0.0432
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0069 0.0396
Brugia malayi hypothetical protein 0.0065 0.0185 0.0269
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.0154 0.0154
Loa Loa (eye worm) animal heme peroxidase 0.0052 0.0132 0.0192
Mycobacterium tuberculosis Conserved protein 0.0148 0.0517 0.1393
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0207 0.0751 0.1909
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.0137 0.0349
Loa Loa (eye worm) hypothetical protein 0.1737 0.687 1
Echinococcus multilocularis peroxidasin 0.0052 0.0132 0.0132
Brugia malayi RNA binding protein 0.0125 0.0426 0.062
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0207 0.0751 0.1909
Schistosoma mansoni ap endonuclease 0.0059 0.016 0.0421
Brugia malayi photoreceptor-specific nuclear receptor 0.0207 0.0751 0.1094
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0192
Trypanosoma brucei poly(ADP-ribose) glycohydrolase, putative 0.0173 0.0614 0.5512
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.0935 0.9487
Leishmania major hypothetical protein, conserved 0.0148 0.0517 0.4252
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0075 0.0189
Mycobacterium tuberculosis Probable hydrolase 0.0148 0.0517 0.1393
Loa Loa (eye worm) glutathione reductase 0.0046 0.0109 0.0159
Loa Loa (eye worm) hypothetical protein 0.0207 0.0751 0.1094
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0207 0.0751 0.1094
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0058 0.0152
Echinococcus granulosus ecdysone induced protein 78C 0.0207 0.0751 0.1909
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.016 0.0917
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0127 0.0434 0.3565
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0207 0.0751 0.1983
Loa Loa (eye worm) hypothetical protein 0.0058 0.0157 0.0229
Brugia malayi beta-lactamase family protein 0.0148 0.0517 0.0753
Schistosoma mansoni transcription factor LCR-F1 0.015 0.0525 0.1387
Echinococcus multilocularis tar DNA binding protein 0.0125 0.0426 0.0426
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0426 0.1123
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0059 0.016 0.0405
Echinococcus multilocularis Nuclear hormone receptor HR96 0.006 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0207 0.0751 0.1094
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0184 0.1513
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0109 0.0277
Brugia malayi map kinase activated protein kinase protein 2 0.0966 0.3788 0.5515
Echinococcus multilocularis GPCR, family 2 0.0049 0.0121 0.0121
Brugia malayi nuclear hormone receptor 0.006 0.0163 0.0238
Brugia malayi small heat shock protein 0.0571 0.2209 0.3215
Loa Loa (eye worm) Poly(ADP-ribose) glycohydrolase 0.0173 0.0614 0.0894
Mycobacterium ulcerans aldehyde dehydrogenase 0.0323 0.1217 1
Loa Loa (eye worm) nuclear hormone receptor 0.006 0.0163 0.0238
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0109 0.0294
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0207 0.0751 0.1094
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0181 0.0647 0.1707
Trichomonas vaginalis D-aminoacylase, putative 0.0148 0.0517 0.5249
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0048 0.0224
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0207 0.0751 0.1909
Brugia malayi nuclear hormone receptor family member nhr-6 0.006 0.0163 0.0238
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0069 0.1116
Brugia malayi hypothetical protein 0.0052 0.0132 0.0192
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0059 0.016 0.1432
Schistosoma mansoni hypothetical protein 0.0067 0.0192 0.0508
Mycobacterium ulcerans lipase LipD 0.0148 0.0517 0.4252
Echinococcus multilocularis neuropeptide s receptor 0.0498 0.1917 0.1917
Onchocerca volvulus 0.0049 0.0119 0.0089
Schistosoma mansoni microtubule-associated protein tau 0.0965 0.3785 0.9991
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0184 0.0659 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.016 0.1692
Loa Loa (eye worm) hypothetical protein 0.0147 0.0512 0.0745
Loa Loa (eye worm) hypothetical protein 0.0049 0.0121 0.0176
Onchocerca volvulus 0.0147 0.0511 0.0666
Loa Loa (eye worm) animal heme peroxidase 0.0052 0.0132 0.0192
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0109 0.0979
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0184 0.0268
Mycobacterium leprae conserved hypothetical protein 0.0148 0.0517 0.7656
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0081 0.0247 0.4027
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0207 0.0751 0.1094
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.006 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0147 0.0512 0.0745
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0021 0.0215
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.0346 0.0932
Echinococcus granulosus carbonic anhydrase 0.0067 0.0192 0.0489
Brugia malayi nuclear receptor NHR-88 0.006 0.0163 0.0238
Schistosoma mansoni hypothetical protein 0.0068 0.0194 0.0512
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0207 0.0751 0.0751
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0121 0.0308
Toxoplasma gondii aldehyde dehydrogenase 0.0323 0.1217 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0184 0.0486
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0067 0.0192 0.028
Brugia malayi Blistered cuticle protein 3 0.0052 0.0132 0.0192
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.0346 0.0932
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0587 0.5959
Schistosoma mansoni aldehyde dehydrogenase 0.0323 0.1217 0.3212
Loa Loa (eye worm) hypothetical protein 0.0148 0.0517 0.0753
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0075 0.0075
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.0137 0.1232
Onchocerca volvulus Peroxidase homolog 0.0052 0.0132 0.0109
Brugia malayi Pre-SET motif family protein 0.0033 0.0058 0.0084
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0089 0.0281 0.0281
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0207 0.0751 0.1094
Plasmodium falciparum enoyl-acyl carrier reductase 0.0184 0.0659 1
Entamoeba histolytica hypothetical protein 0.015 0.0525 0.8557
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0132 0.0192
Echinococcus granulosus survival motor neuron protein 1 0.0239 0.0879 0.2232
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0121 0.0176
Leishmania major DNA polymerase eta, putative 0.0044 0.01 0.0825
Mycobacterium leprae Probable lipase LipE 0.0148 0.0517 0.7656
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0154 0.0407
Trichomonas vaginalis penicillin-binding protein, putative 0.0148 0.0517 0.5249
Brugia malayi Nuclear hormone receptor E75 0.006 0.0163 0.0238
Onchocerca volvulus Peroxidasin homolog 0.0052 0.0132 0.0109
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0192
Loa Loa (eye worm) hypothetical protein 0.0207 0.0751 0.1094
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0207 0.0751 0.0751
Schistosoma mansoni carbonic anhydrase-related 0.0067 0.0192 0.0508
Echinococcus granulosus lamin 0.0058 0.0157 0.04
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0067 0.0192 0.028
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0388 0.0565
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0137 0.1232
Loa Loa (eye worm) hypothetical protein 0.006 0.0163 0.0238
Loa Loa (eye worm) hypothetical protein 0.0147 0.0512 0.0745
Schistosoma mansoni serine/threonine protein kinase 0.0966 0.3788 1
Echinococcus granulosus nuclear receptor nhr 48 0.006 0.0163 0.0415
Loa Loa (eye worm) hypothetical protein 0.0239 0.0879 0.1279
Echinococcus multilocularis mitogen activated protein kinase 14 0.0127 0.0434 0.0434
Plasmodium falciparum carbonic anhydrase 0.0067 0.0192 0.1514
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0192
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0192
Trypanosoma cruzi poly(ADP-ribose) glycohydrolase, putative 0.0173 0.0614 0.5512
Echinococcus granulosus carbonic anhydrase 0.0067 0.0192 0.0489
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.01 0.0901
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0184 0.0184
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0069 0.0563
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.0935 0.9487
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0053 0.0134
Loa Loa (eye worm) hypothetical protein 0.0033 0.0058 0.0084
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0587 0.5959
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0148 0.0517 0.1366
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.006 0.0163 0.0432
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0184 0.0659 0.5419
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0192
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0132 0.0192
Loa Loa (eye worm) hypothetical protein 0.006 0.0163 0.0238
Entamoeba histolytica poly(ADP-ribose) glycohydrolase, putative 0.0173 0.0614 1
Plasmodium vivax glutathione reductase, putative 0.0046 0.0109 0.0853
Loa Loa (eye worm) hypothetical protein 0.006 0.0163 0.0238
Loa Loa (eye worm) animal heme peroxidase 0.0052 0.0132 0.0192
Onchocerca volvulus 0.0458 0.1756 0.2493
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0137 0.1392
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0253 0.0935 0.1361
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0137 0.1232
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0109 0.0853
Echinococcus granulosus intermediate filament protein 0.0058 0.0157 0.04
Onchocerca volvulus Chorion peroxidase homolog 0.0052 0.0132 0.0109
Toxoplasma gondii hypothetical protein 0.0067 0.0192 0.1432
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0323 0.1217 0.3091
Loa Loa (eye worm) hypothetical protein 0.006 0.0163 0.0238
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0184 0.0659 0.1775
Mycobacterium ulcerans aldehyde dehydrogenase 0.0323 0.1217 1
Brugia malayi Nuclear hormone receptor-like 1 0.0147 0.0512 0.0745
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.0137 0.1232
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.016 0.1619
Schistosoma mansoni cellular tumor antigen P53 0.0147 0.0511 0.1349
Entamoeba histolytica hypothetical protein 0.0077 0.0231 0.3768
Loa Loa (eye worm) steroid hormone receptor 0.0207 0.0751 0.1094
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0132 0.0192
Echinococcus granulosus nuclear receptor 2DBD gamma 0.006 0.0163 0.0415
Onchocerca volvulus 0.0052 0.0132 0.0109
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0184 0.0659 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0587 0.5959
Echinococcus multilocularis lamin 0.0058 0.0157 0.0157
Brugia malayi jmjC domain containing protein 0.0058 0.0154 0.0224
Brugia malayi Poly 0.0173 0.0614 0.0894
Brugia malayi Nuclear hormone receptor-like 1 0.0147 0.0512 0.0745
Toxoplasma gondii poly(ADP-ribose) glycohydrolase 0.0173 0.0614 0.4959
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.006 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0057 0.0153 0.0223
Echinococcus multilocularis musashi 0.0058 0.0157 0.0157
Trichomonas vaginalis set domain proteins, putative 0.0265 0.0986 1
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0426 0.1123
Echinococcus multilocularis Nuclear hormone receptor HR96 0.006 0.0163 0.0163
Schistosoma mansoni hypothetical protein 0.0367 0.1391 0.3671
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0192
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0024 0.0021 0.0056
Schistosoma mansoni inositol monophosphatase 0.0036 0.0069 0.0181
Onchocerca volvulus 0.0052 0.0132 0.0109
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0192
Schistosoma mansoni zinc finger protein 0.006 0.0163 0.0432
Echinococcus multilocularis tumor protein p63 0.1003 0.3936 0.3936
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0053 0.0144
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0587 0.5959
Echinococcus multilocularis poly(ADP ribose) glycohydrolase 0.0173 0.0614 0.0614
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0156 0.0547 0.0797
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0207 0.0751 0.0751
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0207 0.0751 0.1983
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0587 0.5959
Loa Loa (eye worm) hypothetical protein 0.006 0.0163 0.0238
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0059 0.016 0.1432
Schistosoma mansoni intermediate filament proteins 0.0058 0.0157 0.0415
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0127 0.0434 0.3894
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0067 0.0192 0.028
Loa Loa (eye worm) hypothetical protein 0.0067 0.0192 0.028
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0207 0.0751 0.1909
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0207 0.0751 0.1983
Trichomonas vaginalis penicillin-binding protein, putative 0.0148 0.0517 0.5249
Schistosoma mansoni aldehyde dehydrogenase 0.0323 0.1217 0.3212
Onchocerca volvulus Protein ultraspiracle homolog 0.0207 0.0751 0.1018
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0323 0.1217 1
Brugia malayi nuclear receptor NHR-88 0.0207 0.0751 0.1094
Echinococcus granulosus dna polymerase eta 0.0044 0.01 0.0255
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0207 0.0751 0.1094
Loa Loa (eye worm) hypothetical protein 0.0067 0.0192 0.028
Schistosoma mansoni hypothetical protein 0.0367 0.1391 0.3671
Loa Loa (eye worm) hypothetical protein 0.0107 0.035 0.051
Echinococcus multilocularis mitogen activated protein kinase 11 0.0127 0.0434 0.0434
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0125 0.0426 0.062
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0059 0.016 0.1311
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0058 0.0058
Loa Loa (eye worm) intermediate filament protein 0.0058 0.0157 0.0229
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0083 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0207 0.0751 0.1094
Schistosoma mansoni retinoic acid receptor RXR 0.0207 0.0751 0.1983
Trypanosoma brucei carbonic anhydrase-like protein 0.0181 0.0647 0.5805
Brugia malayi hypothetical protein 0.0147 0.0512 0.0745
Onchocerca volvulus Huntingtin homolog 0.039 0.1486 0.2096
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0049 0.0071
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0069 0.0069
Entamoeba histolytica hypothetical protein 0.015 0.0525 0.8557
Schistosoma mansoni nuclear hormone receptor 0.006 0.0163 0.0432
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0148 0.0517 0.1393
Brugia malayi orphan nuclear receptor NR2E1 0.006 0.0163 0.0238
Onchocerca volvulus 0.0148 0.0517 0.0675
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0148 0.0517 0.1366
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0184 0.0659 0.5338
Schistosoma mansoni nuclear receptor 0.006 0.0163 0.0432
Loa Loa (eye worm) hypothetical protein 0.0103 0.0336 0.0489
Brugia malayi Muscleblind-like protein 0.0103 0.0336 0.0489
Schistosoma mansoni inositol monophosphatase 0.0036 0.0069 0.0181
Echinococcus multilocularis lamin dm0 0.0058 0.0157 0.0157
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0137 0.0362
Schistosoma mansoni lamin 0.0058 0.0157 0.0415
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0193 0.0696 0.1768
Schistosoma mansoni coup transcription factor 0.0207 0.0751 0.1983
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0037 0.0037
Echinococcus granulosus neuropeptide receptor A26 0.0498 0.1917 0.4869
Loa Loa (eye worm) hypothetical protein 0.006 0.0163 0.0238
Brugia malayi hypothetical protein 0.0147 0.0512 0.0745
Brugia malayi glutathione reductase 0.0046 0.0109 0.0159
Loa Loa (eye worm) hypothetical protein 0.0028 0.0037 0.0053
Echinococcus granulosus neuropeptide s receptor 0.0498 0.1917 0.4869
Entamoeba histolytica hypothetical protein 0.015 0.0525 0.8557
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0058 0.0157 0.0229
Brugia malayi nuclear receptor NHR-67 0.006 0.0163 0.0238
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0069 0.0174
Brugia malayi jmjC domain containing protein 0.0058 0.0154 0.0224
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.006 0.0163 0.0415
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0193 0.0696 0.1013
Leishmania major trypanothione reductase 0.0046 0.0109 0.0896
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0121 0.0176
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.0137 0.0137
Brugia malayi RNA recognition motif domain containing protein 0.0125 0.0426 0.062
Loa Loa (eye worm) hypothetical protein 0.0148 0.0517 0.0753
Schistosoma mansoni poly(ADP-ribose) glycohydrolase 0.0173 0.0614 0.1621
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0192
Schistosoma mansoni hypothetical protein 0.0107 0.035 0.0924
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0059 0.016 0.016
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0059 0.016 0.1432
Loa Loa (eye worm) hypothetical protein 0.0147 0.0512 0.0745
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.0393 0.1059
Brugia malayi Pre-SET motif family protein 0.0233 0.0857 0.1247
Onchocerca volvulus 0.0052 0.0132 0.0109
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0192
Brugia malayi Calcitonin receptor-like protein seb-1 0.0156 0.0547 0.0797
Echinococcus granulosus lamin dm0 0.0058 0.0157 0.04
Echinococcus multilocularis muscleblind protein 0.0103 0.0336 0.0336
Onchocerca volvulus Peroxidasin homolog 0.0052 0.0132 0.0109
Echinococcus granulosus microtubule associated protein 2 0.0965 0.3785 0.9615
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0193 0.0696 0.1837
Loa Loa (eye worm) DR-78 0.006 0.0163 0.0238
Loa Loa (eye worm) hypothetical protein 0.0207 0.0751 0.1094
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0137 0.1392
Brugia malayi Intermediate filament tail domain containing protein 0.0058 0.0157 0.0229
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0109 0.0109
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0426 0.1123
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0058 0.0306
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0069 0.0615
Brugia malayi latrophilin 2 splice variant baaae 0.0107 0.035 0.051
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0081 0.0247 0.4027
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0323 0.1217 0.1217
Onchocerca volvulus 0.0058 0.0157 0.0146
Onchocerca volvulus Huntingtin homolog 0.039 0.1486 0.2096
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0132 0.0192
Trichomonas vaginalis D-aminoacylase, putative 0.0148 0.0517 0.5249
Echinococcus multilocularis carbonic anhydrase 0.0067 0.0192 0.0192
Echinococcus multilocularis nuclear receptor nhr 48 0.006 0.0163 0.0163
Brugia malayi beta-lactamase 0.0148 0.0517 0.0753
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0181 0.0647 0.1707
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0147 0.0512 0.1351
Echinococcus multilocularis mitogen activated protein kinase 11 0.0127 0.0434 0.0434
Schistosoma mansoni jun-related protein 0.0068 0.0194 0.0512
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0156 0.0547 0.0797
Schistosoma mansoni survival motor neuron protein 0.0049 0.0119 0.0313
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.0137 0.0137
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0184 0.0659 1
Trichomonas vaginalis esterase, putative 0.0148 0.0517 0.5249
Brugia malayi tailless protein 0.006 0.0163 0.0238
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.0346 0.0932
Mycobacterium ulcerans hypothetical protein 0.0148 0.0517 0.4252
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0184 0.0268
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0154 0.0407
Schistosoma mansoni DNA polymerase eta 0.0044 0.01 0.0265
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0148 0.0517 0.0753
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.0935 0.9487
Brugia malayi hypothetical protein 0.006 0.0163 0.0238
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0253 0.0935 0.1361
Toxoplasma gondii exonuclease III APE 0.0059 0.016 0.1157
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.0137 0.1128
Schistosoma mansoni peroxidasin 0.0052 0.0132 0.0348
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0192
Echinococcus granulosus jun protein 0.0083 0.0256 0.0651
Schistosoma mansoni steroid hormone receptor ad4bp 0.0207 0.0751 0.1983
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0024 0.0021 0.019
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0193 0.0696 0.1837
Trypanosoma brucei trypanothione reductase 0.0046 0.0109 0.0979
Loa Loa (eye worm) hypothetical protein 0.006 0.0163 0.0238
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0184 0.1652
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0069 0.0615
Brugia malayi nuclear receptor RXR 0.0147 0.0512 0.0745
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0059 0.016 0.0429
Echinococcus granulosus muscleblind protein 0.0103 0.0336 0.0853
Schistosoma mansoni lamin 0.0058 0.0157 0.0415
Onchocerca volvulus Dual oxidase homolog 0.0052 0.0132 0.0109
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0181 0.0647 0.5805
Leishmania major carbonic anhydrase-like protein 0.0181 0.0647 0.5316
Entamoeba histolytica poly(ADP-ribose) glycohydrolase, putative 0.0077 0.0231 0.3768
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0207 0.0751 0.1094
Schistosoma mansoni carbonic anhydrase 0.0067 0.0192 0.0508
Loa Loa (eye worm) animal heme peroxidase 0.0052 0.0132 0.0192
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0966 0.3788 0.3788
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0184 0.0659 1
Mycobacterium ulcerans hypothetical protein 0.0157 0.0551 0.4527
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.0346 0.0932
Onchocerca volvulus 0.006 0.0163 0.0155
Loa Loa (eye worm) hypothetical protein 0.0148 0.0517 0.0753
Mycobacterium tuberculosis Probable lipase LipD 0.0148 0.0517 0.1393
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0298 0.1114 1
Trypanosoma cruzi hypothetical protein, conserved 0.0148 0.0517 0.4643
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0184 0.1652
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0207 0.0751 0.1983
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0207 0.0751 0.1094
Leishmania major mitochondrial DNA polymerase beta 0.0298 0.1114 0.9156
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0127 0.0434 0.0632
Brugia malayi P38 map kinase family protein 2 0.0127 0.0434 0.0632
Schistosoma mansoni hypothetical protein 0.0049 0.0121 0.032
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0058 0.0152
Echinococcus granulosus mitogen activated protein kinase 14 0.0127 0.0434 0.1102
Loa Loa (eye worm) hypothetical protein 0.0044 0.01 0.0146
Echinococcus granulosus tar DNA binding protein 0.0125 0.0426 0.1081
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0128 0.1148
Toxoplasma gondii thioredoxin reductase 0.0046 0.0109 0.0735
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0388 0.0565
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0184 0.1652
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.0935 0.9487
Schistosoma mansoni nuclear receptor nhr-48 0.006 0.0163 0.0432
Onchocerca volvulus 0.0148 0.0517 0.0675
Mycobacterium tuberculosis Probable reductase 0.0106 0.0346 0.0932
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0121 0.0121
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0132 0.0192
Echinococcus granulosus tumor protein p63 0.1003 0.3936 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0323 0.1217 1
Echinococcus granulosus carbonic anhydrase II 0.0181 0.0647 0.1643
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0037 0.0093
Loa Loa (eye worm) beta-lactamase 0.0148 0.0517 0.0753
Brugia malayi nuclear hormone receptor 0.0207 0.0751 0.1094
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.0137 0.1232
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0069 0.0695
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.0487 0.4373
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.0935 0.9487
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0487 0.4373
Echinococcus granulosus lysine specific demethylase 5A 0.0058 0.0154 0.0392
Entamoeba histolytica hypothetical protein 0.0173 0.0614 1
Schistosoma mansoni carbonic anhydrase-related 0.0067 0.0192 0.0508
Echinococcus multilocularis geminin 0.0367 0.1391 0.1391
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0058 0.0147
Entamoeba histolytica hypothetical protein 0.015 0.0525 0.8557
Echinococcus multilocularis serine protein kinase ATM 0.0024 0.0021 0.0021
Schistosoma mansoni hypothetical protein 0.015 0.0525 0.1387
Schistosoma mansoni carbonic anhydrase-related 0.0067 0.0192 0.0508
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0121 0.0121
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0207 0.0751 0.1094
Brugia malayi hypothetical protein 0.039 0.1486 0.2163
Brugia malayi hypothetical protein 0.015 0.0525 0.0765
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0059 0.016 0.0232
Toxoplasma gondii hypothetical protein 0.0048 0.0116 0.0792
Mycobacterium tuberculosis Probable esterase LipL 0.0148 0.0517 0.1393
Schistosoma mansoni hypothetical protein 0.0049 0.0121 0.032
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.0935 0.9487
Loa Loa (eye worm) hypothetical protein 0.0067 0.0192 0.028
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0181 0.0647 0.0942
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0207 0.0751 0.1094
Brugia malayi Nuclear hormone receptor E75 0.006 0.0163 0.0238
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0069 0.0695
Schistosoma mansoni thyroid hormone receptor 0.0296 0.1109 0.2926
Mycobacterium tuberculosis Probable lipase LipE 0.0148 0.0517 0.1393
Onchocerca volvulus 0.0148 0.0517 0.0675
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0207 0.0751 0.1094
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0091 0.0819
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0091 0.0819
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0069 0.0563
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0181 0.0647 0.0942
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0089 0.0281 0.0715
Echinococcus multilocularis mitogen activated protein kinase 14 0.0127 0.0434 0.0434
Schistosoma mansoni hypothetical protein 0.0049 0.0119 0.0313
Onchocerca volvulus 0.0065 0.0185 0.0187
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.006 0.0163 0.0155
Plasmodium vivax hypothetical protein, conserved 0.0148 0.0517 0.7639
Schistosoma mansoni hypothetical protein 0.0089 0.0281 0.0742
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0091 0.0819
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0058 0.0152
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0193 0.0696 0.0696
Schistosoma mansoni ap endonuclease 0.0059 0.016 0.0421
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0193 0.0696 0.1768
Loa Loa (eye worm) TAR-binding protein 0.0125 0.0426 0.062
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0207 0.0751 0.1983
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0148 0.0517 0.1393
Loa Loa (eye worm) hypothetical protein 0.0103 0.0336 0.0489
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0067 0.0192 0.028

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 25 nM Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by stopped flow carbon dioxide hydrase assay method ChEMBL. 20211561
Ki (binding) = 25 nM Inhibition of human carbonic anhydrase II by spectrophotometry at pH 7.5 ChEMBL. 21251841
Ki (binding) = 1000 nM Inhibition of human recombinant carbonic anhydrase1 after 15 mins by stopped flow carbon dioxide hydrase assay method ChEMBL. 20211561
Ki (binding) = 1000 nM Inhibition of human carbonic anhydrase I by spectrophotometry at pH 7.5 ChEMBL. 21251841

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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