Detailed information for compound 111872

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 325.445 | Formula: C21H27NO2
  • H donors: 2 H acceptors: 2 LogP: 3.95 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(Cc1ccc(cc1)O)CN1CCC(CC1)Cc1ccccc1
  • InChi: 1S/C21H27NO2/c23-20-8-6-18(7-9-20)15-21(24)16-22-12-10-19(11-13-22)14-17-4-2-1-3-5-17/h1-9,19,21,23-24H,10-16H2
  • InChiKey: LUKRWTWMHQMEIS-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glutamate receptor, ionotropic, N-methyl-D-aspartate 3A Starlite/ChEMBL References
Homo sapiens adrenoceptor alpha 1A Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0042 0.0064
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0156 0.0559
Trichomonas vaginalis endoplasmin, putative 0.0019 0.0073 0.0399
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0029 0.0199
Brugia malayi MH1 domain containing protein 0.0014 0.0029 0.0094
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.0116
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1301 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0099 0.0688 0.0927
Schistosoma mansoni cpg binding protein 0.0035 0.0194 0.0374
Brugia malayi hypothetical protein 0.005 0.0313 0.1133
Brugia malayi hypothetical protein 0.0273 0.2035 0.7424
Echinococcus multilocularis peroxidasin 0.0026 0.0126 0.0204
Brugia malayi MH1 domain containing protein 0.0014 0.0029 0.0094
Onchocerca volvulus 0.0026 0.0126 0.0676
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0156 0.0254
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0027
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0111 0.3045
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0111 0.1383
Leishmania major heat shock protein 83-1 0.0032 0.0167 0.4961
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0156 0.03
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0156 0.03
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0042 0.0064
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0076 0.1838
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0156 0.0566
Schistosoma mansoni hypothetical protein 0.0039 0.0229 0.0442
Brugia malayi TAR-binding protein 0.0073 0.0489 0.1774
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0016 0.0049 0.0031
Echinococcus granulosus mothers against decapentaplegic 6 0.0011 0.0009 0.0011
Entamoeba histolytica hypothetical protein 0.0026 0.0121 0.1528
Echinococcus multilocularis tar DNA binding protein 0.0073 0.0489 0.0808
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0046 0.0071
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0195 0.032
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0042 0.0064
Leishmania major heat shock protein 83-1 0.0032 0.0167 0.4961
Echinococcus granulosus X box binding protein 1 0.0279 0.2087 0.4083
Echinococcus multilocularis microtubule associated protein 2 0.0669 0.5106 0.849
Loa Loa (eye worm) beta-lactamase 0.0035 0.0195 0.0709
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0167 0.2253
Loa Loa (eye worm) transcription factor SMAD2 0.0364 0.274 1
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0076 0.1838
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0011 0.0009 0.003
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0313 0.1123
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0195 0.1074
Brugia malayi nuclear hormone receptor 0.0014 0.0033 0.0108
Giardia lamblia Heat shock protein HSP 90-alpha 0.0032 0.0167 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0115 0.0186
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.0116
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0156 0.03
Schistosoma mansoni Smad4 0.0011 0.0009 0.0011
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0126 0.0449
Trypanosoma brucei Heat shock protein 83, putative 0.0032 0.0167 0.4961
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.004 0.0236 0.0456
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0014 0.0027 0.0047
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0015 0.0039 0.0059
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0015 0.0039 0.0069
Echinococcus multilocularis mothers against decapentaplegic 2 0.0011 0.0009 0.0009
Schistosoma mansoni glutamate receptor NMDA 0.004 0.0236 0.0456
Loa Loa (eye worm) hypothetical protein 0.0035 0.0195 0.0709
Schistosoma mansoni nuclear receptor 0.0014 0.0033 0.0058
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0076 0.0049
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0038 0.0218 0.0238
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0156 0.0254
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0156 0.0566
Loa Loa (eye worm) hypothetical protein 0.0026 0.0126 0.0456
Leishmania major heat shock protein 83-1 0.0032 0.0167 0.4961
Brugia malayi MH2 domain containing protein 0.0011 0.0009 0.002
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0167 0.4961
Loa Loa (eye worm) hypothetical protein 0.0016 0.0046 0.0164
Echinococcus granulosus cytochrome P450 2K1 0.0016 0.0049 0.009
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0156 0.0254
Loa Loa (eye worm) hypothetical protein 0.0026 0.0126 0.0456
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0046 0.0157
Mycobacterium tuberculosis Probable dehydrogenase 0.0089 0.0611 0.0819
Schistosoma mansoni smad1 5 8 and 0.0025 0.0115 0.0219
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0102
Leishmania major heat shock protein 83-1 0.0032 0.0167 0.4961
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0489 0.0951
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.0033 0.0058
Loa Loa (eye worm) hypothetical protein 0.0035 0.0195 0.0709
Schistosoma mansoni ATP-binding cassette transporter 0.004 0.0236 0.0456
Brugia malayi Niemann-Pick C1 protein precursor 0.0095 0.0662 0.2408
Loa Loa (eye worm) MH1 domain-containing protein 0.0011 0.0009 0.0027
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.0116
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0016 0.0049 0.0031
Leishmania major heat shock protein 83-1 0.0032 0.0167 0.4961
Leishmania major heat shock protein 83-1 0.0032 0.0167 0.4961
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0016 0.0049 0.0022
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0195 0.0235
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0027 0.0157
Echinococcus granulosus Niemann Pick C1 protein 0.0095 0.0662 0.1292
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0111 0.0087
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0195 0.0235
Brugia malayi Endoplasmin precursor 0.0032 0.0167 0.0598
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0016 0.0049 0.0022
Schistosoma mansoni peroxidasin 0.0026 0.0126 0.0241
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0076 0.1838
Echinococcus multilocularis glutamate receptor 2 0.004 0.0236 0.0387
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0042 0.0642
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0115 0.0415
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0076 0.0274
Schistosoma mansoni glutamate receptor kainate 0.004 0.0236 0.0456
Trypanosoma brucei heat shock protein, putative 0.0032 0.0167 0.4961
Brugia malayi Smad1 0.0025 0.0115 0.0408
Schistosoma mansoni glutamate receptor AMPA 0.004 0.0236 0.0456
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0089 0.0611 0.0819
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0156 0.0559
Toxoplasma gondii NADPH-glutathione reductase 0.0014 0.0027 0.0088
Schistosoma mansoni Smad4 0.0011 0.0009 0.0011
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0128 0.3604
Echinococcus granulosus geminin 0.033 0.2482 0.4858
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.0033 0.0108
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0089 0.0611 0.0819
Brugia malayi nuclear receptor NHR-88 0.003 0.0156 0.0559
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0016 0.0049 0.0031
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0016 0.0049 0.0031
Onchocerca volvulus 0.0148 0.107 0.5877
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0016 0.0049 0.0022
Echinococcus multilocularis glutamate receptor 2 0.004 0.0236 0.0387
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0111 0.0118
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0076 0.1838
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0156 0.0254
Echinococcus multilocularis survival motor neuron protein 1 0.0273 0.2035 0.3381
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0313 1
Brugia malayi CXXC zinc finger family protein 0.0033 0.0179 0.0644
Trichomonas vaginalis glutathione reductase, putative 0.0014 0.0027 0.0151
Brugia malayi hypothetical protein 0.0014 0.0033 0.0108
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0011 0.0015
Brugia malayi RNA recognition motif domain containing protein 0.0073 0.0489 0.1774
Schistosoma mansoni smad 0.0025 0.0115 0.0219
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0015 0.0039 0.0059
Loa Loa (eye worm) hypothetical protein 0.0095 0.0662 0.2414
Echinococcus multilocularis GPCR, family 2 0.0034 0.0189 0.0309
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0167 0.0272
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.004 0.0236 0.0456
Loa Loa (eye worm) hypothetical protein 0.0026 0.0126 0.0456
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0167 0.0272
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0076 0.1838
Loa Loa (eye worm) hypothetical protein 0.0074 0.0498 0.1815
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0156 0.0559
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0016 0.0049 0.0031
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0195 0.5936
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0189 0.0364
Schistosoma mansoni hypothetical protein 0.0472 0.3577 0.7003
Onchocerca volvulus 0.0026 0.0126 0.0676
Echinococcus multilocularis heat shock protein 0.0032 0.0167 0.0272
Trypanosoma brucei cytochrome P450, putative 0.0026 0.0128 0.3604
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0016 0.0049 0.0022
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0046 0.0084
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0167 0.032
Schistosoma mansoni microtubule-associated protein tau 0.0669 0.5106 1
Echinococcus multilocularis heat shock protein 90 0.0025 0.0117 0.019
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0156 0.0559
Brugia malayi MH1 domain containing protein 0.0025 0.0115 0.0408
Onchocerca volvulus 0.0035 0.0195 0.1058
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0043 0.0253 0.0904
Echinococcus multilocularis X box binding protein 1 0.0279 0.2087 0.3467
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0076 0.0068
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0042 0.1234
Brugia malayi Inositol-1 0.0043 0.0253 0.0912
Loa Loa (eye worm) hypothetical protein 0.003 0.0156 0.0566
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0016 0.0049 0.0031
Brugia malayi MH2 domain containing protein 0.0025 0.0115 0.0408
Brugia malayi tailless protein 0.0014 0.0033 0.0108
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0332 0.0546
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0111 0.3045
Trypanosoma cruzi heat shock protein 90, putative 0.0025 0.0117 0.3249
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0076 0.1838
Echinococcus granulosus cpg binding protein 0.0035 0.0194 0.0374
Schistosoma mansoni endoplasmin 0.0032 0.0167 0.0321
Loa Loa (eye worm) hypothetical protein 0.0018 0.0064 0.0228
Toxoplasma gondii heat shock protein 90, putative 0.0032 0.0167 0.0593
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0042 0.0642
Schistosoma mansoni hypothetical protein 0.0074 0.0498 0.097
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0156 0.0559
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0111 0.0087
Loa Loa (eye worm) brahma associated protein 0.001 0.0003 0.0008
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0111 0.1383
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0115 0.0219
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0156 0.0566
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0332 0.0643
Echinococcus granulosus glutamate NMDA receptor subunit 0.004 0.0236 0.0456
Loa Loa (eye worm) hypothetical protein 0.0026 0.0126 0.0456
Schistosoma mansoni cpg binding protein 0.0035 0.0194 0.0374
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0043 0.0253 0.0226
Treponema pallidum heat shock protein 90 0.0025 0.0117 0.009
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0195 0.1074
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0016 0.0049 0.0022
Echinococcus multilocularis dnaJ subfamily B 0.0472 0.3577 0.5946
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0042 0.0075
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0073 0.0489 0.178
Schistosoma mansoni glutamate receptor AMPA 0.004 0.0236 0.0456
Loa Loa (eye worm) heat shock protein 90 0.0032 0.0167 0.0606
Brugia malayi follicle stimulating hormone receptor 0.027 0.2014 0.7347
Loa Loa (eye worm) hypothetical protein 0.005 0.0312 0.1133
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.0498 0.1808
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0167 0.032
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.0167 0.4961
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0156 0.0254
Plasmodium falciparum heat shock protein 90, putative 0.0013 0.0023 0.0633
Brugia malayi Glutamate receptor 2 precursor 0.004 0.0236 0.085
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.004 0.0236 0.0387
Schistosoma mansoni thyroid hormone receptor 0.003 0.0156 0.03
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.0116
Schistosoma mansoni hypothetical protein 0.0026 0.0121 0.023
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0033 0.0058
Brugia malayi nuclear receptor NHR-88 0.0014 0.0033 0.0108
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0167 0.4961
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0316 0.0613
Brugia malayi Hsp90 protein 0.0013 0.0023 0.0072
Loa Loa (eye worm) hypothetical protein 0.0026 0.0126 0.0456
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.0033 0.0058
Plasmodium vivax endoplasmin, putative 0.0032 0.0167 0.5281
Onchocerca volvulus 0.0035 0.0195 0.1058
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0332 0.0546
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0026 0.0121 0.0195
Loa Loa (eye worm) hypothetical protein 0.003 0.0156 0.0566
Schistosoma mansoni smad1 5 8 and 0.0025 0.0115 0.0219
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1301 1 1
Echinococcus granulosus GPCR family 2 0.0034 0.0189 0.0364
Toxoplasma gondii heat shock protein 75, putative 0.0013 0.0023 0.0071
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.024 0.0394
Echinococcus multilocularis smad 0.0025 0.0115 0.0186
Brugia malayi hypothetical protein 0.0026 0.0121 0.0429
Trichomonas vaginalis heat shock protein, putative 0.0013 0.0023 0.0126
Loa Loa (eye worm) hypothetical protein 0.0119 0.0843 0.3074
Schistosoma mansoni hypothetical protein 0.0056 0.0354 0.0687
Trypanosoma brucei heat shock protein, putative 0.0032 0.0167 0.4961
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0253 0.7916
Loa Loa (eye worm) hypothetical protein 0.0109 0.0765 0.2787
Loa Loa (eye worm) glutamate receptor 2 0.004 0.0236 0.0857
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.0225 0.6949
Loa Loa (eye worm) DR-78 0.0014 0.0033 0.0116
Schistosoma mansoni heat shock protein 0.0013 0.0023 0.0038
Loa Loa (eye worm) hypothetical protein 0.0035 0.0195 0.0709
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0033 0.0058
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0064 0.1949
Leishmania major heat shock protein 83-1 0.0032 0.0167 0.4961
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0313 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0076 0.1838
Loa Loa (eye worm) hypothetical protein 0.0018 0.0064 0.0228
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0126 0.0456
Schistosoma mansoni glutamate receptor NMDA 0.004 0.0236 0.0456
Entamoeba histolytica hypothetical protein 0.0026 0.0121 0.1528
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0189 0.0309
Schistosoma mansoni smad1 5 8 and 0.0025 0.0115 0.0219
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0016 0.0049 0.0022
Loa Loa (eye worm) hypothetical protein 0.0024 0.0111 0.0402
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0015 0.0039 0.0069
Loa Loa (eye worm) hypothetical protein 0.0026 0.0126 0.0456
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0016 0.0049 0.0031
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.024 0.0464
Loa Loa (eye worm) glutamate receptor 1 0.004 0.0236 0.0857
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0026 0.0121 0.023
Loa Loa (eye worm) hypothetical protein 0.0026 0.0126 0.0456
Trypanosoma cruzi Heat shock protein 83, putative 0.0032 0.0167 0.4961
Echinococcus granulosus inositol monophosphatase 1 0.0043 0.0253 0.0489
Schistosoma mansoni peroxidasin 0.0026 0.0126 0.0241
Brugia malayi mothers against decapentaplegic homolog 3 0.0011 0.0009 0.002
Mycobacterium tuberculosis Conserved protein 0.0035 0.0195 0.0235
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0195 0.0235
Loa Loa (eye worm) hypothetical protein 0.0051 0.0316 0.115
Loa Loa (eye worm) hypothetical protein 0.0035 0.0195 0.0709
Onchocerca volvulus 0.0024 0.0111 0.0595
Trypanosoma brucei unspecified product 0.002 0.0076 0.1838
Schistosoma mansoni hypothetical protein 0.0034 0.0189 0.0364
Onchocerca volvulus 0.0014 0.0033 0.0163
Brugia malayi Calcitonin receptor-like protein seb-1 0.0109 0.0765 0.2781
Loa Loa (eye worm) hypothetical protein 0.0026 0.0126 0.0456
Brugia malayi MH2 domain containing protein 0.0364 0.274 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0046 0.0164
Plasmodium falciparum endoplasmin, putative 0.0019 0.0073 0.2237
Onchocerca volvulus 0.003 0.0156 0.0842
Mycobacterium leprae Probable lipase LipE 0.0035 0.0195 0.0205
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.0033 0.0108
Schistosoma mansoni hypothetical protein 0.0034 0.0189 0.0364
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0111 0.0084
Echinococcus granulosus glutamate receptor 2 0.0025 0.012 0.0229
Leishmania major cytochrome p450-like protein 0.0016 0.0049 0.091
Plasmodium vivax heat shock protein 90, putative 0.0013 0.0023 0.0633
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0025 0.0117 0.0096
Loa Loa (eye worm) hypothetical protein 0.0035 0.0195 0.0709
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0195 0.5936
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0126 0.0449
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0016 0.0049 0.0022
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0156 0.03
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0089 0.0611 0.0791
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0167 0.2253
Brugia malayi hypothetical protein 0.0016 0.0046 0.0157
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0111 0.3045
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0156 0.03
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0033 0.0163
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0195 0.0235
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0043 0.0253 0.3595
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0016 0.0049 0.0022
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0056 0.004
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0126 0.0456
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0253 0.139
Brugia malayi steroid hormone receptor 0.003 0.0156 0.0559
Schistosoma mansoni endoplasmin 0.0032 0.0167 0.0321
Trypanosoma brucei heat shock protein, putative 0.0032 0.0167 0.4961
Brugia malayi hypothetical protein 0.0119 0.0843 0.3068
Brugia malayi isocitrate dehydrogenase 0.0015 0.0042 0.014
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.0042 0.002
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.004 0.0236 0.0387
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0025 0.0117 0.0126
Loa Loa (eye worm) hypothetical protein 0.003 0.0156 0.0566
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0195 0.0235
Echinococcus granulosus microtubule associated protein 2 0.0669 0.5106 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0156 0.03
Schistosoma mansoni smad 0.0011 0.0009 0.0011
Giardia lamblia Grp94/Hsp90 0.0025 0.0117 0.6437
Echinococcus granulosus glutamate receptor subunit protein glur 0.0015 0.0039 0.0069
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0033 0.0049
Loa Loa (eye worm) hypothetical protein 0.0148 0.107 0.3903
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0156 0.0559
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0189 0.0309
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0042 0.0642
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0489 0.0951
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0056 0.004
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0229 0.0442
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0016 0.0049 0.0022
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0056 0.004
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0786 0.6014 1
Echinococcus granulosus Smad4 0.0025 0.0115 0.0219
Loa Loa (eye worm) nuclear factor I 0.0014 0.0029 0.0102
Loa Loa (eye worm) heat shock protein 75 0.0013 0.0023 0.0079
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0126 0.0456
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0189 0.0679
Mycobacterium ulcerans lipase LipD 0.0035 0.0195 0.0168
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0167 0.032
Brugia malayi Pre-SET motif family protein 0.0215 0.1589 0.5795
Schistosoma mansoni hypothetical protein 0.0279 0.2087 0.4083
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0016 0.0049 0.0022
Brugia malayi RNA binding protein 0.0073 0.0489 0.1774
Loa Loa (eye worm) hypothetical protein 0.003 0.0156 0.0566
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.0116
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0089 0.0611 0.0819
Onchocerca volvulus Peroxidase homolog 0.0026 0.0126 0.0676
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0016 0.0049 0.0031
Onchocerca volvulus 0.0245 0.1819 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.0843 0.3074
Schistosoma mansoni patched 1 0.0041 0.024 0.0464
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0076 0.1838
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0195 0.1074
Leishmania major heat shock protein 83-1 0.0032 0.0167 0.4961
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0033 0.0049
Plasmodium falciparum glutathione reductase 0.0014 0.0027 0.0781
Leishmania major heat shock protein 83-1 0.0032 0.0167 0.4961
Plasmodium falciparum heat shock protein 90, putative 0.0013 0.0023 0.0633
Brugia malayi hypothetical protein 0.0014 0.0033 0.0108
Echinococcus multilocularis nmda type glutamate receptor 0.0015 0.0039 0.0059
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0098 0.0186
Loa Loa (eye worm) hypothetical protein 0.0024 0.0111 0.0402
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0098 0.0158
Leishmania major cytochrome p450-like protein 0.0026 0.0128 0.3604
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0156 0.0559
Echinococcus multilocularis NMDA receptor 0.0015 0.0039 0.0059
Loa Loa (eye worm) hypothetical protein 0.0273 0.2035 0.7426
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0016 0.0049 0.0031
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0195 0.0376
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.0116
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.0033 0.0108
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0128 0.0462
Loa Loa (eye worm) hypothetical protein 0.0016 0.0046 0.0164
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0067 0.1517
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0027 0.0157
Onchocerca volvulus 0.0031 0.0167 0.09
Leishmania major heat shock protein 83-1 0.0032 0.0167 0.4961
Mycobacterium tuberculosis Conserved protein 0.0035 0.0195 0.0235
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0111 0.0084
Brugia malayi heat shock protein 90 0.0032 0.0167 0.0598
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0029 0.0199
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0115 0.0415
Loa Loa (eye worm) hypothetical protein 0.003 0.0156 0.0566
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0027 0.0157
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0014 0.0027 0.0781
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0076 0.1838
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.0476 0.0926
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0025 0.0117 0.0223
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0016 0.0049 0.0022
Loa Loa (eye worm) TAR-binding protein 0.0073 0.0489 0.178
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0111 0.0084
Loa Loa (eye worm) follicle stimulating hormone receptor 0.027 0.2014 0.7349
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0076 0.0267
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0111 0.0118
Onchocerca volvulus 0.0056 0.0354 0.193
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.0116
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0064 0.0036
Loa Loa (eye worm) cytochrome P450 0.0016 0.0049 0.0176
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0167 0.4961
Echinococcus granulosus heat shock protein 0.0032 0.0167 0.0321
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.004 0.0236 0.0387
Brugia malayi nuclear hormone receptor 0.003 0.0156 0.0559
Brugia malayi cytochrome P450 0.0016 0.0049 0.0168
Brugia malayi Pre-SET motif family protein 0.0031 0.0167 0.0597
Echinococcus granulosus Protein patched homolog 1 0.0041 0.024 0.0464
Brugia malayi Glutamate receptor 1 precursor 0.004 0.0236 0.085
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0195 0.0376
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0016 0.0049 0.0031
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0013 0.0023 0.0108
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0064 0.0051
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0126 0.0676
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0014 0.0027 0.0781
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0016 0.0049 0.0031
Mycobacterium tuberculosis Probable reductase 0.0089 0.0611 0.0819
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0156 0.0842
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0027 0.0157
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0156 0.0254
Echinococcus multilocularis expressed conserved protein 0.009 0.0618 0.1022
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0156 0.03
Mycobacterium ulcerans heat shock protein 90 0.0025 0.0117 0.009
Trypanosoma brucei unspecified product 0.0014 0.0029 0.0199
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0064 0.006
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0253 0.7916
Loa Loa (eye worm) hypothetical protein 0.0016 0.0046 0.0164
Trypanosoma cruzi heat shock protein 85, putative 0.0025 0.0117 0.3249
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0042 0.0139
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0195 0.1074
Schistosoma mansoni cytochrome P450 0.0016 0.0049 0.009
Loa Loa (eye worm) MH2 domain-containing protein 0.0011 0.0009 0.0027
Loa Loa (eye worm) hypothetical protein 0.0016 0.0046 0.0164
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0027 0.0157
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0156 0.0559
Loa Loa (eye worm) hypothetical protein 0.0035 0.0195 0.0709
Schistosoma mansoni hypothetical protein 0.033 0.2482 0.4858
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0115 0.0219
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0489 0.0951
Echinococcus granulosus smad 0.0025 0.0115 0.0219
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0014 0.0027 0.0088
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.0116
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0313 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0156 0.0254
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0115 0.0186
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0111 0.0395
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0489 0.0951
Loa Loa (eye worm) hypothetical protein 0.003 0.0156 0.0566
Echinococcus granulosus dna polymerase kappa 0.002 0.0076 0.0143
Entamoeba histolytica hypothetical protein 0.0026 0.0121 0.1528
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0033 0.0163
Echinococcus multilocularis Niemann Pick C1 protein 0.0095 0.0662 0.1097
Leishmania major heat shock protein 83-1 0.0032 0.0167 0.4961
Onchocerca volvulus Peroxidase homolog 0.0026 0.0126 0.0676
Onchocerca volvulus Huntingtin homolog 0.0119 0.0843 0.4626
Schistosoma mansoni nuclear hormone receptor 0.003 0.0156 0.03
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0076 0.0143
Mycobacterium ulcerans beta-lactamase 0.0035 0.0195 0.0168
Loa Loa (eye worm) MH2 domain-containing protein 0.0364 0.274 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0076 0.0143
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0111 0.0395
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0042 0.014
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0095 0.0662 1
Trypanosoma brucei unspecified product 0.0014 0.0029 0.0199
Echinococcus granulosus tar DNA binding protein 0.0073 0.0489 0.0951
Schistosoma mansoni survival motor neuron protein 0.0056 0.0354 0.0687
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0332 0.0643
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0016 0.0049 0.091
Plasmodium vivax heat shock protein 86, putative 0.0032 0.0167 0.5281
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0076 0.042
Schistosoma mansoni cpg binding protein 0.0033 0.0179 0.0345
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0367 0.2764 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0126 0.0456
Echinococcus granulosus peroxidasin 0.0026 0.0126 0.0241
Loa Loa (eye worm) hypothetical protein 0.0026 0.0126 0.0456
Brugia malayi Cytochrome P450 family protein 0.0026 0.0128 0.0454
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0156 0.0842
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.0033 0.0058
Toxoplasma gondii thioredoxin reductase 0.0039 0.0225 0.0802
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0195 0.0235
Plasmodium falciparum thioredoxin reductase 0.0039 0.0225 0.7142
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0013 0.0023 0.0038
Loa Loa (eye worm) hypothetical protein 0.0031 0.0167 0.0604
Schistosoma mansoni hypothetical protein 0.0015 0.0039 0.0069
Loa Loa (eye worm) hypothetical protein 0.003 0.0156 0.0566
Brugia malayi Cytochrome P450 family protein 0.006 0.039 0.1414
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 0.0873
Echinococcus granulosus dna polymerase eta 0.002 0.0076 0.0143
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0167 0.0592
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0332 0.0643
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0313 1
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.0033 0.0116
Brugia malayi nuclear receptor RXR 0.0016 0.0046 0.0157
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0014 0.0027 0.0157
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0014 0.0027 0.0157
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0016 0.0049 0.0031
Loa Loa (eye worm) thioredoxin reductase 0.0039 0.0225 0.0816
Plasmodium falciparum glutathione reductase 0.0039 0.0225 0.7142
Onchocerca volvulus 0.0026 0.0126 0.0676
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0156 0.0566
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0076 0.1838
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0126 0.0456
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0016 0.0049 0.0031
Brugia malayi ecdysteroid receptor 0.003 0.0156 0.0559
Loa Loa (eye worm) hypothetical protein 0.0026 0.0126 0.0456
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0042 0.0075
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0042 0.0064
Schistosoma mansoni transcription factor LCR-F1 0.0026 0.0121 0.023
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0489 0.0951
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.0033 0.0049
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.004 0.0236 0.0387
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0156 0.0566
Brugia malayi ecdysone receptor 0.0014 0.0033 0.0108
Plasmodium falciparum heat shock protein 90 0.0032 0.0167 0.5281
Onchocerca volvulus 0.0033 0.0179 0.097
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0076 0.1838
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0195 0.0205
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0167 0.032
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0056 0.004
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0156 0.0559
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0042 0.0642
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0115 0.0219
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0076 0.1838
Brugia malayi beta-lactamase 0.0035 0.0195 0.0702
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.0033 0.0116
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0156 0.0566
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0042 0.0064
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0156 0.0842
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0179 0.0651
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0195 0.0168
Leishmania major DNA polymerase kappa, putative 0.002 0.0076 0.1838
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0156 0.03
Trichomonas vaginalis esterase, putative 0.0035 0.0195 0.1074
Mycobacterium tuberculosis Conserved protein 0.0035 0.0195 0.0235
Onchocerca volvulus Dual oxidase homolog 0.0026 0.0126 0.0676
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0076 0.1838
Schistosoma mansoni hypothetical protein 0.033 0.2482 0.4858
Trichomonas vaginalis mercuric reductase, putative 0.0014 0.0027 0.0151
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0167 0.0918
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0016 0.0049 0.091
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.0116
Trichomonas vaginalis set domain proteins, putative 0.0245 0.1819 1
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.0934 0.7159 1
Loa Loa (eye worm) cytochrome P450 family protein 0.006 0.039 0.142
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0014 0.0027 0.0024
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0111 0.0084
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0038 0.0218 0.0267
Leishmania major hypothetical protein, conserved 0.0035 0.0195 0.5936
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0076 0.0143
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0033 0.0108
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0016 0.0049 0.0031
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0014 0.0027 0.0781
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0015 0.0039 0.0069
Onchocerca volvulus 0.0035 0.0195 0.1058
Schistosoma mansoni hypothetical protein 0.0039 0.0229 0.0442
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0042 0.0147
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0156 0.03
Echinococcus multilocularis Niemann Pick C1 protein 0.0136 0.098 0.1625
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0016 0.0049 0.0022
Leishmania major cytochrome p450-like protein 0.0016 0.0049 0.091
Schistosoma mansoni DNA polymerase eta 0.002 0.0076 0.0143
Leishmania major DNA polymerase eta, putative 0.002 0.0076 0.1838
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0156 0.03
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0156 0.03
Schistosoma mansoni glutamate receptor kainate 0.004 0.0236 0.0456
Brugia malayi MH1 domain containing protein 0.0025 0.0115 0.0408
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0011 0.0036
Loa Loa (eye worm) hypothetical protein 0.002 0.0076 0.0274
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0099 0.0688 0.0899
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0014 0.0027 0.0088
Schistosoma mansoni hypothetical protein 0.0023 0.0098 0.0186
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0014 0.0027 0.0157
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.024 0.0873
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0156 0.0559
Loa Loa (eye worm) RNA binding protein 0.0073 0.0489 0.178
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1301 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0313 1
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0025 0.0117 0.009
Echinococcus granulosus heat shock protein 90 0.0032 0.0167 0.0321
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0015 0.0039 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0156 0.0559
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0099 0.0688 0.0927
Echinococcus granulosus FTZ F1 alpha 0.003 0.0156 0.03
Schistosoma mansoni heat shock protein 0.0032 0.0167 0.0321
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0076 0.1838
Loa Loa (eye worm) hypothetical protein 0.0024 0.0111 0.0402
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0014 0.0027 0.0157
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0195 0.0235
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.0033 0.0116
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0195 0.1074
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0156 0.03
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0016 0.0049 0.0022
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.0934 0.7159 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0076 0.0835
Echinococcus multilocularis tumor protein p63 0.0347 0.2609 0.4335
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0016 0.0049 0.0022
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0156 0.03
Brugia malayi hypothetical protein 0.0033 0.0175 0.0627
Echinococcus multilocularis dna polymerase eta 0.002 0.0076 0.0121
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.0033 0.0058
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0313 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0156 0.0566
Brugia malayi conserved hypotetical protein 0.0014 0.0033 0.0108
Toxoplasma gondii Hsp90 domain-containing protein 0.0013 0.0023 0.0071
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0111 0.0395
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0117 0.0645
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.024 0.1321
Echinococcus multilocularis 0.0016 0.0049 0.0077
Leishmania major heat shock protein 83-1 0.0032 0.0167 0.4961
Toxoplasma gondii heat shock protein HSP90 0.0032 0.0167 0.0593
Plasmodium vivax SET domain protein, putative 0.0031 0.0167 0.5271
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0189 0.0679
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0033 0.0058
Echinococcus granulosus expressed conserved protein 0.009 0.0618 0.1204
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0156 0.0559
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0016 0.0049 0.0022
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0156 0.03
Loa Loa (eye worm) endoplasmin 0.0032 0.0167 0.0606
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0016 0.0049 0.0022
Schistosoma mansoni hypothetical protein 0.0016 0.0049 0.009
Echinococcus multilocularis cpg binding protein 0.0035 0.0194 0.0317
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0128 0.0462
Schistosoma mansoni coup transcription factor 0.003 0.0156 0.03
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.0033 0.0049
Echinococcus granulosus dnaJ subfamily B 0.0472 0.3577 0.7003
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0076 0.0068
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0167 0.032
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0046 0.0157
Trypanosoma brucei heat shock protein, putative 0.0032 0.0167 0.4961
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0126 0.0676
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0064 0.1949
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0076 0.0049
Brugia malayi Cytochrome P450 family protein 0.0026 0.0128 0.0454
Schistosoma mansoni zinc finger protein 0.0014 0.0033 0.0058
Brugia malayi Thioredoxin reductase 0.0039 0.0225 0.0809
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0014 0.0027 0.0157
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0014 0.0027 0.0781
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0195 0.6194
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0016 0.0049 0.091
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0016 0.0049 0.0031
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0128 0.3604
Leishmania major trypanothione reductase 0.0039 0.0225 0.6949
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0156 0.03
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.1664 0.2294
Echinococcus multilocularis endoplasmin 0.0025 0.0117 0.019
Loa Loa (eye worm) hypothetical protein 0.0026 0.0126 0.0456
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0156 0.0559
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0195 0.0376
Schistosoma mansoni hypothetical protein 0.0034 0.0189 0.0364
Brugia malayi beta-lactamase family protein 0.0035 0.0195 0.0702
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0109 0.0765 0.2787
Mycobacterium ulcerans hypothetical protein 0.0024 0.0111 0.0084
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0076 0.0121
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0014 0.0027 0.0157
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0099 0.0688 0.0927
Leishmania major heat shock protein 83-1 0.0032 0.0167 0.4961
Onchocerca volvulus Chorion peroxidase homolog 0.0026 0.0126 0.0676
Brugia malayi beta-lactamase family protein 0.0035 0.0195 0.0702
Trichomonas vaginalis inositol monophosphatase, putative 0.0043 0.0253 0.139
Echinococcus multilocularis dna polymerase kappa 0.002 0.0076 0.0121
Trypanosoma brucei heat shock protein, putative 0.0032 0.0167 0.4961
Leishmania major heat shock protein 83-1 0.0032 0.0167 0.4961
Loa Loa (eye worm) hypothetical protein 0.0026 0.0126 0.0456
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0332 0.1199
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0156 0.0559
Giardia lamblia DINP protein human, muc B family 0.002 0.0076 0.3498
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.0116
Trichomonas vaginalis heat shock protein, putative 0.0019 0.0073 0.0399
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0253 0.7916
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0367 0.2764 0.2761
Echinococcus multilocularis mothers against decapentaplegic 6 0.0011 0.0009 0.0009
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0253 0.7916
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0111 0.0084
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.004 0.0236 0.0456
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0016 0.0049 0.0031
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0156 0.03
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0042 0.1234
Echinococcus multilocularis heat shock protein 90 0.0032 0.0167 0.0272
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0156 0.0559
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.0033 0.0058
Mycobacterium ulcerans hypothetical protein 0.0035 0.0195 0.0168
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0076 0.1838
Brugia malayi Cytochrome P450 family protein 0.0016 0.0049 0.0168
Loa Loa (eye worm) inositol-1 0.0043 0.0253 0.0919
Schistosoma mansoni inositol monophosphatase 0.0043 0.0253 0.0489
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0111 0.0084
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0367 0.2764 0.2744
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0674 0.1314
Schistosoma mansoni hypothetical protein 0.0039 0.0229 0.0442
Schistosoma mansoni inositol monophosphatase 0.0043 0.0253 0.0489
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0156 0.0566
Schistosoma mansoni hypothetical protein 0.0039 0.0229 0.0442
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0195 0.0702
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0046 0.0084
Loa Loa (eye worm) Smad1 0.0025 0.0115 0.0415
Brugia malayi Blistered cuticle protein 3 0.0026 0.0126 0.0449
Echinococcus granulosus survival motor neuron protein 1 0.0273 0.2035 0.3982
Echinococcus granulosus mothers against decapentaplegic 2 0.0011 0.0009 0.0011
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.001 0.0003 0.0008
Echinococcus granulosus heat shock protein 90 0.0025 0.0117 0.0223
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0195 0.0168
Leishmania major heat shock protein 83-1 0.0032 0.0167 0.4961
Echinococcus granulosus nmda type glutamate receptor 0.0015 0.0039 0.0069
Schistosoma mansoni Smad4 0.0025 0.0115 0.0219
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0003 0.0018
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0014 0.0027 0.0157
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0126 0.0449
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0014 0.0027 0.0157
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0126 0.0449
Loa Loa (eye worm) glutathione reductase 0.0039 0.0225 0.0816
Loa Loa (eye worm) hypothetical protein 0.0026 0.0126 0.0456
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0033 0.0058
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0016 0.0049 0.0022
Plasmodium vivax glutathione reductase, putative 0.0039 0.0225 0.7142
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0027 0.0157
Echinococcus multilocularis geminin 0.033 0.2482 0.4125
Loa Loa (eye worm) hypothetical protein 0.0018 0.0064 0.0228
Leishmania major heat shock protein 83-1 0.0032 0.0167 0.4961
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0014 0.0027 0.0047
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.0116
Trypanosoma brucei trypanothione reductase 0.0039 0.0225 0.6949
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0189 0.0686
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0016 0.0049 0.0031
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0046 0.0084
Leishmania major hypothetical protein, conserved 0.005 0.0313 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0043 0.0253 0.0226
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0332 0.0643
Echinococcus granulosus tumor protein p63 0.0347 0.2609 0.5106
Brugia malayi MH2 domain containing protein 0.0025 0.0115 0.0408
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0016 0.0049 0.091
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.0033 0.0058
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0015 0.0039 0.0059
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0126 0.0449
Brugia malayi nuclear receptor RXR 0.0014 0.0033 0.0108
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.001 0.0025
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0167 0.4961
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0076 0.1838
Entamoeba histolytica hypothetical protein 0.0026 0.0121 0.1528
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0111 0.1383
Leishmania major heat shock protein 83-1 0.0032 0.0167 0.4961
Echinococcus granulosus glutamate receptor 2 0.004 0.0236 0.0456
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0033 0.0108
Echinococcus multilocularis protein dispatched 1 0.0047 0.0285 0.0469
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0156 0.0254
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0076 0.1838
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0332 0.1206
Loa Loa (eye worm) hypothetical protein 0.003 0.0156 0.0566
Loa Loa (eye worm) hypothetical protein 0.0018 0.0064 0.0228
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0029 0.0199
Echinococcus multilocularis inositol monophosphatase 1 0.0043 0.0253 0.0415
Echinococcus multilocularis protein patched 0.0041 0.024 0.0394
Plasmodium falciparum thioredoxin reductase 0.0014 0.0027 0.0781
Schistosoma mansoni nuclear receptor 0.0014 0.0033 0.0058
Trypanosoma cruzi trypanothione reductase, putative 0.0014 0.0027 0.0157
Schistosoma mansoni thyroid hormone receptor 0.003 0.0156 0.03
Brugia malayi nuclear receptor NHR-67 0.0014 0.0033 0.0108
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0189 0.0364
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0195 0.5936
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0014 0.0027 0.0157
Toxoplasma gondii cytochrome p450 superfamily protein 0.0016 0.0049 0.0167
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0039 0.0225 0.0277
Trypanosoma brucei heat shock protein, putative 0.0032 0.0167 0.4961
Onchocerca volvulus 0.0014 0.0033 0.0163
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0016 0.0049 0.0022
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0016 0.0049 0.0031
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0042 0.0642
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0016 0.0049 0.0031
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0016 0.0049 0.0022
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0156 0.03
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.0116
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.004 0.0236 0.0387
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0109 0.0765 0.2781
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0014 0.0027 0.004
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0025 0.0117 0.3249
Brugia malayi glutathione reductase 0.0039 0.0225 0.0809
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0152 0.0292
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.0033 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0156 0.0559
Loa Loa (eye worm) hypothetical protein 0.005 0.0313 0.114
Loa Loa (eye worm) CYP4Cod1 0.0026 0.0128 0.0462
Echinococcus multilocularis glutamate receptor 2 0.0025 0.012 0.0194
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0016 0.0049 0.0022
Echinococcus multilocularis Smad4 0.0025 0.0115 0.0186
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0117 0.0645
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0229 0.0375
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0026 0.0128 0.01
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0013 0.0023 0.0033
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0016 0.0049 0.0031
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0076 0.1838
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0014 0.0027 0.0157
Trypanosoma brucei heat shock protein, putative 0.0032 0.0167 0.4961
Onchocerca volvulus Huntingtin homolog 0.0119 0.0843 0.4626
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0076 0.1838
Brugia malayi hypothetical protein 0.0026 0.0126 0.0449
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0111 0.0084
Echinococcus granulosus Niemann Pick C1 protein 0.0136 0.098 0.1914
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0332 0.0643
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.1589 0.5798
Onchocerca volvulus 0.0051 0.0316 0.1723
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0253 0.139
Toxoplasma gondii ABC1 family protein 0.0035 0.0195 0.0696
Loa Loa (eye worm) hypothetical protein 0.0018 0.0064 0.0228
Schistosoma mansoni glutamate receptor kainate 0.004 0.0236 0.0456
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0089 0.0611 0.0819
Plasmodium vivax heat shock protein, putative 0.0013 0.0023 0.0633
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0117 0.0645
Plasmodium vivax thioredoxin reductase, putative 0.0039 0.0225 0.7142
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.004 0.0236 0.0456
Loa Loa (eye worm) hypothetical protein 0.0016 0.0046 0.0164
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0033 0.0049
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0076 0.042
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0016 0.0049 0.091
Loa Loa (eye worm) blistered cuticle protein 3 0.0026 0.0126 0.0456
Loa Loa (eye worm) hypothetical protein 0.0034 0.0189 0.0686
Trypanosoma brucei heat shock protein, putative 0.0032 0.0167 0.4961
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0167 0.4961
Brugia malayi CHE-14 protein 0.0041 0.024 0.0866
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.0033 0.0108
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0195 0.0709
Brugia malayi hypothetical protein 0.0148 0.107 0.3898
Echinococcus granulosus endoplasmin 0.0025 0.0117 0.0223
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0418 0.1501
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0033 0.0058
Brugia malayi Peroxidasin 0.0026 0.0126 0.0449
Giardia lamblia Heat shock protein HSP 90-alpha 0.0025 0.0117 0.6437
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0011 0.0013
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0076 0.0267
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0042 0.0139
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0354 0.128
Schistosoma mansoni hypothetical protein 0.0034 0.0189 0.0364
Schistosoma mansoni heat shock protein 0.0032 0.0167 0.0321
Brugia malayi hypothetical protein 0.0016 0.0046 0.0157
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0156 0.0254
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0367 0.2764 0.3818
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0076 0.1838

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 3.8 nM Displacement of [3H]-25-6981 from N-methyl-D-aspartate glutamate receptor ChEMBL. 11514163
Ki (binding) = 3.8 nM Displacement of [3H]-25-6981 from N-methyl-D-aspartate glutamate receptor ChEMBL. 11514163
Ki (binding) = 305 nM In vitro binding affinity towards Alpha-1 adrenergic receptor by displacing [3H]-prazosin radioligand ChEMBL. 11514163
Ki (binding) = 305 nM In vitro binding affinity towards Alpha-1 adrenergic receptor by displacing [3H]-prazosin radioligand ChEMBL. 11514163
Selectivity ratio (binding) = 80 Selectivity ratio of alpha1 receptor to that of NMDA was determined ChEMBL. 11514163

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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