Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glycogen synthase kinase 3 beta | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.6462 | 0.6462 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0058 | 0.9001 | 0.9001 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.2326 | 0.2326 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.6462 | 0.6462 |
Brugia malayi | intracellular kinase | 0.0058 | 0.9001 | 0.9001 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0058 | 0.9001 | 0.5 |
Trypanosoma cruzi | glycogen synthase kinase 3, putative | 0.0058 | 0.9001 | 1 |
Toxoplasma gondii | cell-cycle-associated protein kinase GSK, putative | 0.0058 | 0.9001 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0058 | 0.9001 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0058 | 0.9001 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0058 | 0.9001 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.2326 | 0.2326 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 1 | 1 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0058 | 0.9001 | 0.9001 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Leishmania major | glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 | 0.0058 | 0.9001 | 1 |
Onchocerca volvulus | 0.0058 | 0.9001 | 0.5 | |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0058 | 0.9001 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 1 | 1 |
Plasmodium vivax | glycogen synthase kinase 3, putative | 0.0058 | 0.9001 | 1 |
Plasmodium falciparum | glycogen synthase kinase 3 | 0.0058 | 0.9001 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Giardia lamblia | Kinase, CMGC GSK | 0.0058 | 0.9001 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0062 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.6462 | 0.6462 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 1 | 1 |
Schistosoma mansoni | glycogen synthase kinase 3-related (gsk3) (cmgc group III) | 0.0058 | 0.9001 | 0.8698 |
Giardia lamblia | Kinase, CMGC GSK | 0.0058 | 0.9001 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0058 | 0.9001 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.6462 | 0.6462 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.198 uM | Inhibition of human recombinant GSK3-beta using gamma[33P]-ATP after 30 mins by scintillation proximity assay | ChEMBL. | 20167481 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.