Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0385 | 0.0265 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0076 | 0.0723 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.006 | 0.0526 | 0.4389 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0076 | 0.0723 | 0.0803 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0031 | 0.0171 | 0.017 |
Mycobacterium ulcerans | lipase LipD | 0.0076 | 0.0723 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0076 | 0.0723 | 0.1454 |
Onchocerca volvulus | 0.0076 | 0.0723 | 0.2119 | |
Mycobacterium leprae | conserved hypothetical protein | 0.0076 | 0.0723 | 0.5 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0071 | 0.0667 | 0.9196 |
Mycobacterium ulcerans | DNA polymerase IV | 0.006 | 0.0526 | 0.7194 |
Loa Loa (eye worm) | RNA binding protein | 0.0273 | 0.313 | 0.6279 |
Mycobacterium tuberculosis | Conserved protein | 0.0076 | 0.0723 | 0.0378 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0112 | 0.0182 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0273 | 0.313 | 0.6279 |
Trypanosoma brucei | unspecified product | 0.0041 | 0.0299 | 0.2414 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0076 | 0.0723 | 0.0562 |
Echinococcus multilocularis | geminin | 0.0733 | 0.8754 | 0.8732 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0076 | 0.0723 | 0.6101 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.006 | 0.0526 | 0.4389 |
Trichomonas vaginalis | esterase, putative | 0.0076 | 0.0723 | 0.1599 |
Loa Loa (eye worm) | acetyltransferase | 0.0149 | 0.1621 | 0.3231 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.006 | 0.0526 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.006 | 0.0526 | 0.4389 |
Schistosoma mansoni | hypothetical protein | 0.0134 | 0.1433 | 0.1616 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0214 | 0.2414 | 0.4833 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0071 | 0.0667 | 0.5611 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.006 | 0.0526 | 0.4389 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0076 | 0.0723 | 0.1416 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.006 | 0.0526 | 0.4389 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0171 | 0.0301 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0076 | 0.0723 | 0.6101 |
Brugia malayi | beta-lactamase | 0.0076 | 0.0723 | 0.1454 |
Leishmania major | hypothetical protein, conserved | 0.0076 | 0.0723 | 0.6101 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0123 | 0.1298 | 0.2577 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.006 | 0.0526 | 0.4389 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0134 | 0.1433 | 0.2882 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0385 | 0.0415 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0171 | 0.017 |
Brugia malayi | polk-prov protein | 0.0019 | 0.0022 | 0.0045 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0145 | 0.157 | 0.1644 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.006 | 0.0526 | 0.0577 |
Trypanosoma brucei | unspecified product | 0.0041 | 0.0299 | 0.2414 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0485 | 0.5723 | 1 |
Echinococcus multilocularis | dna polymerase kappa | 0.006 | 0.0526 | 0.0362 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0113 | 0.1171 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0031 | 0.0171 | 0.2122 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0134 | 0.1433 | 0.1284 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0031 | 0.0171 | 0.0016 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0149 | 0.1621 | 0.1476 |
Echinococcus granulosus | dna polymerase kappa | 0.006 | 0.0526 | 0.043 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.006 | 0.0526 | 0.4389 |
Brugia malayi | Pre-SET motif family protein | 0.0214 | 0.2414 | 0.4856 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0299 | 0.2414 |
Leishmania major | DNA polymerase kappa, putative | 0.006 | 0.0526 | 0.4389 |
Brugia malayi | RNA binding protein | 0.0273 | 0.313 | 0.6295 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.006 | 0.0526 | 0.4389 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0149 | 0.1621 | 0.3261 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0134 | 0.1433 | 0.1284 |
Echinococcus multilocularis | dna polymerase eta | 0.0113 | 0.1171 | 0.1017 |
Mycobacterium ulcerans | beta-lactamase | 0.0076 | 0.0723 | 1 |
Brugia malayi | TAR-binding protein | 0.0273 | 0.313 | 0.6295 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.006 | 0.0526 | 0.1019 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.029 | 0.3334 | 0.6706 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.006 | 0.0526 | 0.4389 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0113 | 0.1171 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.006 | 0.0526 | 0.4389 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0385 | 0.0415 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.006 | 0.0526 | 0.4389 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0076 | 0.0723 | 0.6101 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.006 | 0.0526 | 0.4389 |
Mycobacterium tuberculosis | Conserved protein | 0.0076 | 0.0723 | 0.0378 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0171 | 0.017 |
Loa Loa (eye worm) | TAR-binding protein | 0.0273 | 0.313 | 0.6279 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.006 | 0.0526 | 0.0577 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0076 | 0.0723 | 0.0378 |
Brugia malayi | beta-lactamase family protein | 0.0076 | 0.0723 | 0.1454 |
Plasmodium vivax | hypothetical protein, conserved | 0.0076 | 0.0723 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0134 | 0.1433 | 0.1616 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0134 | 0.1433 | 0.1484 |
Onchocerca volvulus | 0.0076 | 0.0723 | 0.2119 | |
Mycobacterium tuberculosis | Probable hydrolase | 0.0076 | 0.0723 | 0.0378 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0112 | 0.0786 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0723 | 0.1416 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.0112 | 0.1288 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.0112 | 0.0786 |
Plasmodium vivax | SET domain protein, putative | 0.0031 | 0.0171 | 0.2122 |
Leishmania major | DNA polymerase eta, putative | 0.0113 | 0.1171 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0134 | 0.1433 | 0.1616 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.006 | 0.0526 | 0.4389 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0723 | 0.1416 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0076 | 0.0723 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0733 | 0.8754 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0112 | 0.0786 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0076 | 0.0723 | 0.0378 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.004 | 0.0287 | 0.5262 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.006 | 0.0526 | 0.4389 |
Schistosoma mansoni | tar DNA-binding protein | 0.0273 | 0.313 | 0.3559 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0299 | 0.2414 |
Onchocerca volvulus | 0.0244 | 0.2776 | 1 | |
Mycobacterium tuberculosis | Conserved protein | 0.0076 | 0.0723 | 0.0378 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0112 | 0.0786 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0385 | 0.0415 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0723 | 0.1416 |
Echinococcus multilocularis | tar DNA binding protein | 0.0273 | 0.313 | 0.301 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0076 | 0.0723 | 0.0378 |
Leishmania major | DNA polymerase eta, putative | 0.0071 | 0.0667 | 0.5611 |
Giardia lamblia | DINP protein human, muc B family | 0.006 | 0.0526 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.0385 | 0.0732 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.006 | 0.0526 | 0.0362 |
Echinococcus granulosus | GPCR family 2 | 0.0134 | 0.1433 | 0.1484 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0273 | 0.313 | 0.6295 |
Trypanosoma brucei | unspecified product | 0.006 | 0.0526 | 0.4389 |
Mycobacterium ulcerans | hypothetical protein | 0.0076 | 0.0723 | 1 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0044 | 0.0332 | 0.4424 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0171 | 0.017 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0076 | 0.0723 | 0.0378 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0723 | 0.1416 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0076 | 0.0723 | 0.0378 |
Toxoplasma gondii | ABC1 family protein | 0.0076 | 0.0723 | 1 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0112 | 0.0226 |
Echinococcus granulosus | dna polymerase eta | 0.0113 | 0.1171 | 0.1179 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.0385 | 0.0774 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0424 | 0.4971 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0076 | 0.0723 | 0.1599 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0076 | 0.0723 | 0.1599 |
Brugia malayi | beta-lactamase family protein | 0.0076 | 0.0723 | 0.1454 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.006 | 0.0526 | 0.4389 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.006 | 0.0526 | 0.1059 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.0112 | 0.1288 |
Schistosoma mansoni | tar DNA-binding protein | 0.0273 | 0.313 | 0.3559 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0723 | 0.1416 |
Loa Loa (eye worm) | hypothetical protein | 0.0424 | 0.4971 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0733 | 0.8754 | 1 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0685 | 0.8167 | 0.9317 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0685 | 0.8167 | 0.9328 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0044 | 0.0332 | 0.4424 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0385 | 0.0217 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0134 | 0.1433 | 0.1484 |
Mycobacterium leprae | Probable lipase LipE | 0.0076 | 0.0723 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0299 | 0.2414 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0076 | 0.0723 | 0.1599 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.006 | 0.0526 | 0.4389 |
Schistosoma mansoni | hypothetical protein | 0.029 | 0.3334 | 0.3792 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0044 | 0.0332 | 0.0204 |
Echinococcus multilocularis | GPCR, family 2 | 0.0134 | 0.1433 | 0.1284 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.004 | 0.0287 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.006 | 0.0526 | 0.0794 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0076 | 0.0723 | 0.0378 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0112 | 0.3403 |
Schistosoma mansoni | tar DNA-binding protein | 0.0273 | 0.313 | 0.3559 |
Schistosoma mansoni | DNA polymerase eta | 0.0113 | 0.1171 | 0.1316 |
Trichomonas vaginalis | set domain proteins, putative | 0.0244 | 0.2776 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0112 | 0.3403 |
Onchocerca volvulus | 0.0076 | 0.0723 | 0.2119 | |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0076 | 0.0723 | 0.0803 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0076 | 0.0723 | 0.0658 |
Schistosoma mansoni | hypothetical protein | 0.0134 | 0.1433 | 0.1616 |
Brugia malayi | Pre-SET motif family protein | 0.0031 | 0.0171 | 0.0344 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0723 | 0.1416 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0385 | 0.0265 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0134 | 0.1433 | 0.2851 |
Echinococcus granulosus | tar DNA binding protein | 0.0273 | 0.313 | 0.3458 |
Schistosoma mansoni | tar DNA-binding protein | 0.0273 | 0.313 | 0.3559 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.006 | 0.0526 | 0.043 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.006 | 0.0526 | 0.4389 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0076 | 0.0723 | 0.1599 |
Loa Loa (eye worm) | hypothetical protein | 0.029 | 0.3334 | 0.6691 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.006 | 0.0526 | 0.4389 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.006 | 0.0526 | 0.0794 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0424 | 0.4971 | 1 |
Echinococcus granulosus | geminin | 0.0733 | 0.8754 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0385 | 0.0217 |
Schistosoma mansoni | tar DNA-binding protein | 0.0273 | 0.313 | 0.3559 |
Loa Loa (eye worm) | beta-lactamase | 0.0076 | 0.0723 | 0.1416 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0424 | 0.4971 | 1 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0149 | 0.1621 | 0.1831 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0113 | 0.1171 | 0.2355 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0076 | 0.0723 | 0.1599 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0685 | 0.8167 | 0.8135 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.1433 | 0.2851 |
Mycobacterium ulcerans | DNA polymerase IV | 0.006 | 0.0526 | 0.7194 |
Brugia malayi | MH2 domain containing protein | 0.0123 | 0.1298 | 0.261 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.1171 | 0.2321 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0134 | 0.1433 | 0.2882 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0123 | 0.1298 | 0.2577 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0044 | 0.0332 | 0.4424 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 23 uM | Cytotoxicity against human HeLa cells after 48 hrs by WST8 colorimetric assay | ChEMBL. | 19938815 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.