TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 203.197 | Formula: C10H9N3O2
H donors: 1 H acceptors: 3 LogP: 2.15 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O/N=C/c1onc(n1)Cc1ccccc1
InChi: 1S/C10H9N3O2/c14-11-7-10-12-9(13-15-10)6-8-4-2-1-3-5-8/h1-5,7,14H,6H2/b11-7+
InChiKey: JWKSAWPOFNEFCT-YRNVUSSQSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	serine threonine protein kinase nrc	0.0028	0.0006	0.002
Schistosoma mansoni	dual specificity kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	protein kinase C mu	0.0028	0.0006	0.0006
Loa Loa (eye worm)	flap endonuclease-1	0.0029	0.0007	0.0006
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0028	0.0006	0.0005
Echinococcus granulosus	twitchin	0.0028	0.0006	0.002
Echinococcus granulosus	cyclin dependent kinase 9	0.0028	0.0006	0.002
Loa Loa (eye worm)	CK1/WORM6 protein kinase	0.0028	0.0006	0.0005
Echinococcus granulosus	casein kinase i	0.0028	0.0006	0.002
Echinococcus granulosus	CDC7 cell division cycle 7	0.0028	0.0006	0.002
Echinococcus granulosus	Cell division cycle 2 protein kinase	0.0028	0.0006	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Echinococcus granulosus	phosphorylase kinase gamma subunit	0.0028	0.0006	0.002
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.0028	0.0006	0.0005
Brugia malayi	Bromodomain containing protein	0.0084	0.0061	0.0055
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Loa Loa (eye worm)	CAMK/DAPK/DAPK protein kinase	0.0028	0.0006	0.0005
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0028	0.0006	0.002
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0028	0.0006	0.0005
Leishmania major	trypanothione reductase	0.0053	0.003	1
Trichomonas vaginalis	esterase, putative	0.004	0.0018	1
Echinococcus multilocularis	CDC7 cell division cycle 7	0.0028	0.0006	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus granulosus	agc family protein kinase	0.0028	0.0006	0.002
Loa Loa (eye worm)	CMGC/CDK protein kinase	0.0028	0.0006	0.0005
Echinococcus multilocularis	cyclin g associated kinase	0.0028	0.0006	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus multilocularis	serine:threonine protein kinase NIM1	0.0028	0.0006	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0028	0.0006	0.0005
Echinococcus multilocularis	protein kinase, core	0.0028	0.0006	0.002
Echinococcus multilocularis	expressed conserved protein	0.0028	0.0006	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus granulosus	cyclin dependent kinase 7	0.0028	0.0006	0.002
Echinococcus granulosus	cyclin dependent kinase 1	0.0028	0.0006	0.002
Loa Loa (eye worm)	STE/STE20/TAO protein kinase	0.0028	0.0006	0.0005
Echinococcus granulosus	beta LACTamase domain containing family member	0.004	0.0018	0.0059
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0028	0.0006	0.002
Brugia malayi	latrophilin 2 splice variant baaae	0.0038	0.0016	0.001
Schistosoma mansoni	flap endonuclease-1	0.0026	0.0004	0.0004
Plasmodium falciparum	thioredoxin reductase	0.0053	0.003	1
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0028	0.0006	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus granulosus	Serine:threonine protein kinase PINK1	0.0028	0.0006	0.002
Echinococcus multilocularis	dual specificity mitogen activated protein	0.0028	0.0006	0.002
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0006	0.0005
Loa Loa (eye worm)	CAMK/CAMKL/SNRK protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0028	0.0006	0.0005
Echinococcus multilocularis	rac serine:threonine kinase	0.0028	0.0006	0.002
Echinococcus granulosus	dual specificity protein kinase clk2	0.0028	0.0006	0.002
Echinococcus multilocularis	Cyclin dependent kinase 2 associated protein	0.3135	0.3041	1
Echinococcus granulosus	cGMP dependent protein kinase	0.0028	0.0006	0.002
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0028	0.0006	0.0005
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0028	0.0006	0.002
Loa Loa (eye worm)	CK1 protein kinase	0.0028	0.0006	0.0005
Echinococcus granulosus	rho-associated protein kinase 1	0.0028	0.0006	0.002
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0029	0.0007	0.0344
Plasmodium falciparum	flap endonuclease 1	0.0029	0.0007	0.0344
Loa Loa (eye worm)	AGC/DMPK/ROCK protein kinase	0.0028	0.0006	0.0005
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0028	0.0006	0.002
Mycobacterium leprae	Probable lipase LipE	0.004	0.0018	0.1133
Mycobacterium tuberculosis	Probable hydrolase	0.004	0.0018	0.0524
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0006	0.0005
Echinococcus multilocularis	microtubule associated serine:threonine protein	0.0028	0.0006	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0257	0.023	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.0018	0.0018
Echinococcus multilocularis	citron Rho interacting kinase	0.0028	0.0006	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus multilocularis	leucine rich repeat serine:threonine protein	0.0028	0.0006	0.002
Echinococcus multilocularis	serine threonine protein kinase	0.0028	0.0006	0.002
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0028	0.0006	0.002
Toxoplasma gondii	ABC1 family protein	0.004	0.0018	0.4872
Echinococcus multilocularis	casein kinase I alpha	0.0028	0.0006	0.002
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0006	0.0005
Echinococcus multilocularis	serine:threonine protein kinase MARK2	0.0028	0.0006	0.002
Echinococcus granulosus	aurora kinase A	0.0028	0.0006	0.002
Loa Loa (eye worm)	CK1/TTBKL protein kinase	0.0028	0.0006	0.0005
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0028	0.0006	0.002
Mycobacterium ulcerans	esterase/lipase LipP	0.004	0.0018	1
Echinococcus multilocularis	serine:threonine protein kinase PAK 3	0.0028	0.0006	0.002
Echinococcus granulosus	protein kinase core	0.0028	0.0006	0.002
Echinococcus multilocularis	kinase protein	0.0028	0.0006	0.002
Echinococcus granulosus	Cyclin dependent kinase 2 associated protein	0.3135	0.3041	1
Loa Loa (eye worm)	CAMK/CAMKL/PASK protein kinase	0.0028	0.0006	0.0005
Schistosoma mansoni	kinase	0.0028	0.0006	0.0006
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.004	0.0018	0.0017
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Loa Loa (eye worm)	PEK/PEK protein kinase	0.0028	0.0006	0.0005
Echinococcus granulosus	mitogen activated protein kinase 15	0.0028	0.0006	0.002
Echinococcus granulosus	serine:threonine protein kinase MARK2	0.0028	0.0006	0.002
Echinococcus multilocularis	cyclin dependent kinase	0.0028	0.0006	0.002
Loa Loa (eye worm)	serine/threonine protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	TLK protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	CK1/TTBKL protein kinase	0.0028	0.0006	0.0005
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Loa Loa (eye worm)	serine/threonine protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0006	0.0005
Echinococcus multilocularis	casein kinase ii subunit alpha	0.0028	0.0006	0.002
Loa Loa (eye worm)	IRE protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	TKL/LRRK protein kinase	0.0028	0.0006	0.0005
Onchocerca volvulus	Diphthamide biosynthesis protein 7 homolog	0.3135	0.3041	1
Echinococcus multilocularis	serine:threonine protein kinase 36	0.0028	0.0006	0.002
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Echinococcus multilocularis	serine:threonine kinase SAD 1	0.0028	0.0006	0.002
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Echinococcus granulosus	protein kinase C gamma type	0.0028	0.0006	0.002
Echinococcus multilocularis	dual specificity	0.0028	0.0006	0.002
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Echinococcus multilocularis	serine threonine protein kinase	0.0028	0.0006	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Loa Loa (eye worm)	CK1/TTBK protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0006	0.0005
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus granulosus	serine/threonine protein kinase	0.0028	0.0006	0.002
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Chlamydia trachomatis	serine/threonine protein kinase	0.0028	0.0006	0.5
Loa Loa (eye worm)	STE/STE7/MEK7 protein kinase	0.0028	0.0006	0.0005
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Echinococcus multilocularis	titin	0.0028	0.0006	0.002
Echinococcus multilocularis	protein kinase c epsilon type	0.0028	0.0006	0.002
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Echinococcus granulosus	mitogen activated protein kinase 14	0.0028	0.0006	0.002
Loa Loa (eye worm)	AUR protein kinase	0.0028	0.0006	0.0005
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Onchocerca volvulus		0.004	0.0018	0.0039
Echinococcus granulosus	calcium activated potassium channel	0.0028	0.0006	0.002
Echinococcus granulosus	protein kinase	0.0028	0.0006	0.002
Mycobacterium tuberculosis	Conserved protein	0.004	0.0018	0.0524
Echinococcus granulosus	serine:threonine protein kinase 3	0.0028	0.0006	0.002
Loa Loa (eye worm)	CK1/WORM6 protein kinase	0.0028	0.0006	0.0005
Echinococcus multilocularis	cyclin dependent kinase 19	0.0028	0.0006	0.002
Loa Loa (eye worm)	glutathione reductase	0.0053	0.003	0.0029
Loa Loa (eye worm)	CK1/WORM6 protein kinase	0.0028	0.0006	0.0005
Echinococcus granulosus	serine:threonine protein kinase PAK 4	0.0028	0.0006	0.002
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.0028	0.0006	0.0005
Loa Loa (eye worm)	CMGC/CDK/CRK7 protein kinase	0.0028	0.0006	0.0005
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0134	0.011	1
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.0028	0.0006	0.002
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0006	0.0005
Echinococcus multilocularis	cyclin dependent kinase 9	0.0028	0.0006	0.002
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0028	0.0006	0.0005
Echinococcus granulosus	serine threonine protein kinase	0.0028	0.0006	0.002
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0028	0.0006	0.0005
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.004	0.0018	1
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Trypanosoma brucei	hypothetical protein, conserved	0.004	0.0018	0.4872
Echinococcus granulosus	serine:threonine protein kinase	0.0028	0.0006	0.002
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0028	0.0006	0.002
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0028	0.0006	0.0005
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0028	0.0006	0.002
Echinococcus granulosus	serine:threonine protein kinase PAK 1	0.0028	0.0006	0.002
Echinococcus granulosus	serine:threonine protein kinase 36	0.0028	0.0006	0.002
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Loa Loa (eye worm)	plk/plk-unclassified protein kinase	0.0028	0.0006	0.0005
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus multilocularis	serine:threonine protein kinase WNK1	0.0028	0.0006	0.002
Echinococcus multilocularis	casein kinase I gamma	0.0028	0.0006	0.002
Echinococcus granulosus	cyclin dependent kinase 5	0.0028	0.0006	0.002
Chlamydia trachomatis	serine/threonine-protein kinase	0.0028	0.0006	0.5
Loa Loa (eye worm)	TBCK protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	CK1/DUAL protein kinase	0.0028	0.0006	0.0005
Echinococcus granulosus	STE20:SPS1 proline alanine rich protein	0.0028	0.0006	0.002
Loa Loa (eye worm)	STE/STE20/MST protein kinase	0.0028	0.0006	0.0005
Echinococcus granulosus	TBC domain containing protein kinase	0.0028	0.0006	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus multilocularis	protein KINase family member (kin 1)	0.0028	0.0006	0.002
Loa Loa (eye worm)	CK1/WORM6 protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	CK1/CK1/CK1-A protein kinase	0.0028	0.0006	0.0005
Echinococcus multilocularis	Serine:threonine protein kinase PRP4	0.0028	0.0006	0.002
Brugia malayi	glutathione reductase	0.0053	0.003	0.0024
Echinococcus granulosus	3'partial\|mitogen activated protein kinase kinase kinase	0.0028	0.0006	0.002
Echinococcus multilocularis	serine:threonine protein kinase greatwall	0.0028	0.0006	0.002
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0028	0.0006	0.002
Loa Loa (eye worm)	CMGC/MAPK/JNK protein kinase	0.0028	0.0006	0.0005
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0028	0.0006	0.002
Loa Loa (eye worm)	CMGC/CK2 protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	AGC/YANK protein kinase	0.0028	0.0006	0.0005
Echinococcus multilocularis	serine:threonine protein kinase MAK	0.0028	0.0006	0.002
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus multilocularis	3 phosphoinositide dependent protein kinase 1	0.0028	0.0006	0.002
Echinococcus multilocularis	wee1 protein kinase	0.0028	0.0006	0.002
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase I	0.0028	0.0006	0.002
Echinococcus granulosus	serine:threonine protein kinase tousled	0.0028	0.0006	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0025	0.0003	0.0011
Echinococcus granulosus	dual specificity	0.0028	0.0006	0.002
Loa Loa (eye worm)	STE/STE20/PAKB protein kinase	0.0028	0.0006	0.0005
Echinococcus granulosus	dual specificity mitogen activated protein	0.0028	0.0006	0.002
Loa Loa (eye worm)	AGC protein kinase	0.0028	0.0006	0.0005
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0028	0.0006	0.002
Schistosoma mansoni	dual specificity kinase	0.0028	0.0006	0.0006
Echinococcus granulosus	rho-associated protein kinase	0.0028	0.0006	0.002
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0028	0.0006	0.0005
Echinococcus granulosus	serine:threonine protein kinase ULK3	0.0028	0.0006	0.002
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0028	0.0006	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus multilocularis	serine:threonine protein kinase LATS2	0.0028	0.0006	0.002
Loa Loa (eye worm)	WEE protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	AUR protein kinase	0.0028	0.0006	0.0005
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0028	0.0006	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Loa Loa (eye worm)	STE/STE20/KHS protein kinase	0.0028	0.0006	0.0005
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Loa Loa (eye worm)	VPS15 protein kinase	0.0028	0.0006	0.0005
Echinococcus granulosus	glycogen synthase kinase 3	0.0028	0.0006	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Brugia malayi	Bromodomain containing protein	0.0043	0.002	0.0015
Echinococcus granulosus	dual specificity mitogen activated protein	0.0028	0.0006	0.002
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Giardia lamblia	Flap structure-specific endonuclease	0.0029	0.0007	1
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0028	0.0006	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus granulosus	AP2 associated protein kinase 1	0.0028	0.0006	0.002
Loa Loa (eye worm)	CMGC/DYRK/HIPK protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0006	0.0005
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0028	0.0006	0.0005
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0028	0.0006	0.002
Echinococcus granulosus	cyclin dependent kinase 6	0.0028	0.0006	0.002
Echinococcus multilocularis	phosphorylase kinase gamma subunit	0.0028	0.0006	0.002
Echinococcus multilocularis	cell cycle related kinase	0.0028	0.0006	0.002
Loa Loa (eye worm)	CAMK/TSSK protein kinase	0.0028	0.0006	0.0005
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0028	0.0006	0.002
Loa Loa (eye worm)	CMGC/CDK/CDK9 protein kinase	0.0028	0.0006	0.0005
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0028	0.0006	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus granulosus	eukaryotic translation initiation factor 2 alpha	0.0028	0.0006	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0028	0.0006	0.002
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Echinococcus granulosus	5'partial\|3'partial\|mitogen activated protein kinase kinase kinase	0.0028	0.0006	0.002
Echinococcus granulosus	dual specificity mitogen activated protein	0.0028	0.0006	0.002
Echinococcus multilocularis	serine:threonine protein kinase	0.0028	0.0006	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Loa Loa (eye worm)	CK1/WORM6 protein kinase	0.0028	0.0006	0.0005
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0028	0.0006	0.002
Schistosoma mansoni	bromodomain containing protein	0.0071	0.0048	0.0048
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0028	0.0006	0.002
Loa Loa (eye worm)	STE/STE20/SLK protein kinase	0.0028	0.0006	0.0005
Echinococcus multilocularis	Serine:threonine protein kinase PINK1	0.0028	0.0006	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0028	0.0006	0.002
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0028	0.0006	0.0005
Echinococcus granulosus	cyclin g associated kinase	0.0028	0.0006	0.002
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	0.0028	0.0006	0.0006
Echinococcus granulosus	mitogen activated protein kinase	0.0028	0.0006	0.002
Echinococcus granulosus	casein kinase I delta	0.0028	0.0006	0.002
Echinococcus granulosus	cyclin dependent kinase 17	0.0028	0.0006	0.002
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase	0.0028	0.0006	0.002
Echinococcus multilocularis	casein kinase i	0.0028	0.0006	0.002
Echinococcus granulosus	dual specificity	0.0028	0.0006	0.002
Loa Loa (eye worm)	STE/STE20/PAKA protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	CMGC/RCK/MAK protein kinase	0.0028	0.0006	0.0005
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0028	0.0006	0.002
Loa Loa (eye worm)	CMGC/CDK/CDK10 protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	CAMK/PHK protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	cmgc/cdk/pitslre protein kinase	0.0028	0.0006	0.0005
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0006	0.0005
Echinococcus multilocularis	nuclear receptor binding protein	0.0028	0.0006	0.002
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	hypothetical protein	0.004	0.0018	0.0017
Echinococcus multilocularis	serine:threonine protein kinase ULK3	0.0028	0.0006	0.002
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.0018	0.0018
Echinococcus granulosus	Microtubule-associated serine/threonine-protein kinase	0.0028	0.0006	0.002
Echinococcus granulosus	dual specificity	0.0028	0.0006	0.002
Echinococcus granulosus	TGF beta receptor type 1	0.0028	0.0006	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Loa Loa (eye worm)	CAMK/TSSK protein kinase	0.0028	0.0006	0.0005
Echinococcus granulosus	proto oncogene serine:threonine protein kinase	0.0028	0.0006	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Trichomonas vaginalis	penicillin-binding protein, putative	0.004	0.0018	1
Loa Loa (eye worm)	AUR protein kinase	0.0028	0.0006	0.0005
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0028	0.0006	0.002
Loa Loa (eye worm)	AGC/PKG protein kinase	0.0028	0.0006	0.0005
Echinococcus multilocularis	glycogen synthase kinase 3	0.0028	0.0006	0.002
Echinococcus multilocularis	serine:threonine protein kinase 3	0.0028	0.0006	0.002
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0028	0.0006	0.0005
Echinococcus granulosus	serine:threonine protein kinase 17A	0.0028	0.0006	0.002
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0028	0.0006	0.0005
Entamoeba histolytica	Flap nuclease, putative	0.0029	0.0007	1
Echinococcus granulosus	activin receptor type	0.0028	0.0006	0.002
Loa Loa (eye worm)	thioredoxin reductase	0.0053	0.003	0.0029
Schistosoma mansoni	dual specificity serine/threonine tyrosine kinase	0.0028	0.0006	0.0006
Echinococcus granulosus	cyclin dependent kinase 9	0.0028	0.0006	0.002
Loa Loa (eye worm)	camk/dcamkl protein kinase	0.0028	0.0006	0.0005
Echinococcus granulosus	calcium:calmodulin dependent protein kinase I	0.0028	0.0006	0.002
Echinococcus multilocularis	serine:threonine protein kinase NLK	0.0028	0.0006	0.002
Echinococcus granulosus	glycogen synthase kinase 3 beta	0.0028	0.0006	0.002
Echinococcus granulosus	Protein kinase C brain isozyme	0.0028	0.0006	0.002
Echinococcus multilocularis	serine:threonine protein kinase	0.0028	0.0006	0.002
Echinococcus granulosus	protein kinase c epsilon type	0.0028	0.0006	0.002
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase 7	0.0028	0.0006	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Loa Loa (eye worm)	CK1/WORM6 protein kinase	0.0028	0.0006	0.0005
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus multilocularis	agc family protein kinase	0.0028	0.0006	0.002
Echinococcus granulosus	wee1 protein kinase	0.0028	0.0006	0.002
Echinococcus multilocularis	dual specificity serine:threonine tyrosine	0.0028	0.0006	0.002
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0006	0.0005
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0018	1
Echinococcus multilocularis	serine:threonine protein kinase receptor R3	0.0028	0.0006	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Loa Loa (eye worm)	CK1/WORM6 protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	CMGC/CDK/CDK8 protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	STE/STE20/PAKA protein kinase	0.0028	0.0006	0.0005
Echinococcus granulosus	homeodomain interacting protein kinase 3	0.0028	0.0006	0.002
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0033	0.0032
Loa Loa (eye worm)	NAK/BIKE protein kinase	0.0028	0.0006	0.0005
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0134	0.011	0.4621
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0028	0.0006	0.0005
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus granulosus	NDR protein kinase	0.0028	0.0006	0.002
Loa Loa (eye worm)	ULK/ULK protein kinase	0.0028	0.0006	0.0005
Schistosoma mansoni	protein kinase C mu	0.0028	0.0006	0.0006
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	MAGUK homolog	0.0028	0.0006	0.0006
Echinococcus granulosus	casein kinase I gamma	0.0028	0.0006	0.002
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.0028	0.0006	0.002
Loa Loa (eye worm)	ULK protein kinase	0.0028	0.0006	0.0005
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0053	0.003	0.0099
Loa Loa (eye worm)	CMGC/MAPK/JNK protein kinase	0.0028	0.0006	0.0005
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0028	0.0006	0.002
Trichomonas vaginalis	penicillin-binding protein, putative	0.004	0.0018	1
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus granulosus	scy1 protein 2	0.0028	0.0006	0.002
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0028	0.0006	0.002
Echinococcus granulosus	dual specificity	0.0028	0.0006	0.002
Echinococcus multilocularis	AP2 associated protein kinase 1	0.0028	0.0006	0.002
Schistosoma mansoni	cAMP-dependent protein kinase catalytic subunit	0.0028	0.0006	0.0006
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0025	0.0003	0.0003
Echinococcus multilocularis	aurora kinase A	0.0028	0.0006	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus granulosus	protein kinase shaggy	0.0028	0.0006	0.002
Echinococcus granulosus	flap endonuclease 1	0.0029	0.0007	0.0023
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0006	0.0005
Echinococcus granulosus	tau tubulin kinase 1	0.0028	0.0006	0.002
Loa Loa (eye worm)	CMGC/CDK protein kinase	0.0028	0.0006	0.0005
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0028	0.0006	0.002
Echinococcus granulosus	serine:threonine protein kinase ULK4	0.0028	0.0006	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus granulosus	cyclin dependent kinase 10	0.0028	0.0006	0.002
Echinococcus granulosus	G protein coupled receptor kinase 1	0.0028	0.0006	0.002
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	hypothetical protein	0.004	0.0018	0.0017
Echinococcus multilocularis	eukaryotic translation initiation factor 2 alpha	0.0028	0.0006	0.002
Loa Loa (eye worm)	CK1/WORM6 protein kinase	0.0028	0.0006	0.0005
Echinococcus granulosus	cell cycle related kinase	0.0028	0.0006	0.002
Echinococcus multilocularis	cyclin dependent kinase 7	0.0028	0.0006	0.002
Echinococcus multilocularis	dual specificity mitogen activated protein	0.0028	0.0006	0.002
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0028	0.0006	0.0005
Echinococcus granulosus	vaccinia related kinase 1	0.0028	0.0006	0.002
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0018	0.4872
Loa Loa (eye worm)	CAMK/CAMKL/NUAK protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0023	0.0022
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0016	0.0015
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	hypothetical protein	0.0038	0.0016	0.0016
Brugia malayi	beta-lactamase family protein	0.004	0.0018	0.0012
Echinococcus granulosus	agc family protein kinase	0.0028	0.0006	0.002
Echinococcus multilocularis	STE20 kinase adapter protein beta	0.0028	0.0006	0.002
Echinococcus multilocularis	Serine:threonine protein kinase PFTAIRE 1	0.0028	0.0006	0.002
Loa Loa (eye worm)	CK1/WORM6 protein kinase	0.0028	0.0006	0.0005
Mycobacterium tuberculosis	Probable lipase LipD	0.004	0.0018	0.0524
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0028	0.0006	0.0005
Onchocerca volvulus		0.004	0.0018	0.0039
Loa Loa (eye worm)	TKL/MLK/LZK protein kinase	0.0028	0.0006	0.0005
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.004	0.0018	0.0059
Mycobacterium ulcerans	lipase LipD	0.004	0.0018	1
Echinococcus multilocularis	serine:threonine protein kinase Chk2	0.0028	0.0006	0.002
Schistosoma mansoni	lipoxygenase	0.0054	0.0032	0.0032
Loa Loa (eye worm)	TKL/STKR/TYPE2 protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	CK1/WORM6 protein kinase	0.0028	0.0006	0.0005
Mycobacterium tuberculosis	Probable oxidoreductase	0.0134	0.011	0.4621
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0006	0.0005
Loa Loa (eye worm)	NAK/GAK protein kinase	0.0028	0.0006	0.0005
Brugia malayi	Flap endonuclease-1	0.0029	0.0007	0.0001
Loa Loa (eye worm)	NEK/NEK6 protein kinase	0.0028	0.0006	0.0005
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0067	0.0044	0.0144
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0028	0.0006	0.002
Echinococcus granulosus	serine threonine protein kinase	0.0028	0.0006	0.002
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus multilocularis	serine:threonine protein kinase SIK3	0.0028	0.0006	0.002
Echinococcus multilocularis	agc family protein kinase	0.0028	0.0006	0.002
Loa Loa (eye worm)	CAMK/CAMKL/LKB protein kinase	0.0028	0.0006	0.0005
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Echinococcus multilocularis	dual specificity	0.0028	0.0006	0.002
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0121	0.0096	0.4033
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus granulosus	proto oncogene serine:threonine protein kinase	0.0028	0.0006	0.002
Echinococcus multilocularis	serine:threonine protein kinase:endoribonuclease	0.0028	0.0006	0.002
Mycobacterium tuberculosis	Probable esterase LipL	0.004	0.0018	0.0524
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Loa Loa (eye worm)	CAMK/DAPK/DAPK protein kinase	0.0028	0.0006	0.0005
Echinococcus multilocularis	cyclin dependent kinase 9	0.0028	0.0006	0.002
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0028	0.0006	0.002
Echinococcus multilocularis	casein kinase I delta	0.0028	0.0006	0.002
Loa Loa (eye worm)	WNK protein kinase	0.0028	0.0006	0.0005
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Loa Loa (eye worm)	serine/threonine protein kinase	0.0028	0.0006	0.0005
Echinococcus multilocularis	maternal embryonic leucine zipper kinase	0.0028	0.0006	0.002
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0029	0.0007	0.0344
Brugia malayi	Thioredoxin reductase	0.0053	0.003	0.0024
Schistosoma mansoni	serine/threonine-protein kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0029	0.0007	0.0344
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Loa Loa (eye worm)	STE/STE20/MSN protein kinase	0.0028	0.0006	0.0005
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0028	0.0006	0.002
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0006	0.0005
Echinococcus multilocularis	homeodomain interacting protein kinase 3	0.0028	0.0006	0.002
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0006	0.0005
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0028	0.0006	0.002
Loa Loa (eye worm)	haspin protein kinase	0.0028	0.0006	0.0005
Echinococcus multilocularis	serine:threonine protein kinase ULK4	0.0028	0.0006	0.002
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0056	0.0033	0.0032
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Mycobacterium tuberculosis	Probable lipase LipE	0.004	0.0018	0.0524
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Loa Loa (eye worm)	CK1 protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	CMGC/DYRK/PRP4 protein kinase	0.0028	0.0006	0.0005
Echinococcus granulosus	cyclin dependent kinase	0.0028	0.0006	0.002
Echinococcus multilocularis	cyclin dependent kinase 1	0.0028	0.0006	0.002
Brugia malayi	beta-lactamase family protein	0.004	0.0018	0.0012
Echinococcus granulosus	cyclin dependent kinase 1	0.0028	0.0006	0.002
Loa Loa (eye worm)	TKL/IRAK protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	serine/threonine protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0028	0.0006	0.0005
Mycobacterium ulcerans	hypothetical protein	0.004	0.0018	1
Echinococcus granulosus	protein KINase family member kin 1	0.0028	0.0006	0.002
Schistosoma mansoni	serine/threonine kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	atypical protein kinase C	0.0028	0.0006	0.0006
Loa Loa (eye worm)	STE/STE11/MEKK2 protein kinase	0.0028	0.0006	0.0005
Echinococcus multilocularis	expressed protein	0.0028	0.0006	0.002
Schistosoma mansoni	serine/threonine-protein kinase	0.0028	0.0006	0.0006
Echinococcus granulosus	serine:threonine protein kinase PAK 3	0.0028	0.0006	0.002
Echinococcus multilocularis	casein kinase I alpha	0.0028	0.0006	0.002
Echinococcus granulosus	c-Jun N-terminal kinases	0.0028	0.0006	0.002
Echinococcus multilocularis	myosin light chain kinase, smooth muscle	0.0028	0.0006	0.002
Loa Loa (eye worm)	STE/STE20/STLK protein kinase	0.0028	0.0006	0.0005
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Echinococcus multilocularis	rho associated protein kinase	0.0028	0.0006	0.002
Loa Loa (eye worm)	STE/STE20/FRAY protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	BUB protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	hypothetical protein	0.004	0.0018	0.0017
Leishmania major	hypothetical protein, conserved	0.004	0.0018	0.4872
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0028	0.0006	0.002
Loa Loa (eye worm)	AGC/MAST/MAST protein kinase	0.0028	0.0006	0.0005
Echinococcus granulosus	casein kinase I alpha	0.0028	0.0006	0.002
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0028	0.0006	0.0005
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0028	0.0006	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus granulosus	serine:threonine protein kinase MAK	0.0028	0.0006	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	CK1/WORM6 protein kinase	0.0028	0.0006	0.0005
Echinococcus multilocularis	dual specificity	0.0028	0.0006	0.002
Echinococcus multilocularis	STE20 serine:threonine protein kinase	0.0028	0.0006	0.002
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.004	0.0018	0.0012
Loa Loa (eye worm)	beta-lactamase	0.004	0.0018	0.0017
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Plasmodium vivax	flap endonuclease 1, putative	0.0029	0.0007	0.0344
Echinococcus multilocularis	MAP kinase activated protein kinase 2	0.0028	0.0006	0.002
Echinococcus multilocularis	mitogen activated protein kinase	0.0028	0.0006	0.002
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0028	0.0006	0.0005
Echinococcus granulosus	5' AMP activated protein kinase catalytic	0.0028	0.0006	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.0028	0.0006	0.002
Loa Loa (eye worm)	NAK/MPSK protein kinase	0.0028	0.0006	0.0005
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Onchocerca volvulus		0.004	0.0018	0.0039
Echinococcus multilocularis	tau tubulin kinase 1	0.0028	0.0006	0.002
Echinococcus multilocularis	dual specificity mitogen activated protein	0.0028	0.0006	0.002
Echinococcus granulosus	serine:threonine protein kinase PAK 3	0.0028	0.0006	0.002
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0028	0.0006	0.0005
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus multilocularis	glycogen synthase kinase 3 beta	0.0028	0.0006	0.002
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0121	0.0096	0.4033
Echinococcus multilocularis	serine:threonine protein kinase PAK 3	0.0028	0.0006	0.002
Schistosoma mansoni	cGMP-dependent protein kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	hypothetical protein	0.0023	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0006	0.0005
Echinococcus multilocularis	peripheral plasma membrane protein CASK	0.0028	0.0006	0.002
Echinococcus granulosus	serine:threonine protein kinase	0.0028	0.0006	0.002
Echinococcus multilocularis	serine:threonine protein kinase 11	0.0028	0.0006	0.002
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0056	0.0055
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0028	0.0006	0.002
Loa Loa (eye worm)	CMGC/MAPK/NMO protein kinase	0.0028	0.0006	0.0005
Echinococcus multilocularis	casein kinase I alpha	0.0028	0.0006	0.002
Loa Loa (eye worm)	CK1/CK1/CK1-A protein kinase	0.0028	0.0006	0.0005
Echinococcus multilocularis	serine threonine protein kinase sik serine threonine protein kinase par	0.0028	0.0006	0.002
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0018	1
Loa Loa (eye worm)	CK1/TTBK protein kinase	0.0028	0.0006	0.0005
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Loa Loa (eye worm)	STE/STE11/MEKK4 protein kinase	0.0028	0.0006	0.0005
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Echinococcus multilocularis	activin receptor type	0.0028	0.0006	0.002
Loa Loa (eye worm)	hypothetical protein	0.004	0.0018	0.0017
Mycobacterium tuberculosis	Conserved protein	0.004	0.0018	0.0524
Loa Loa (eye worm)	SCY1 protein kinase	0.0028	0.0006	0.0005
Echinococcus granulosus	p21 activated protein kinase 1 Dpak1	0.0028	0.0006	0.002
Echinococcus granulosus	NDR protein kinase	0.0028	0.0006	0.002
Echinococcus granulosus	maternal embryonic leucine zipper kinase	0.0028	0.0006	0.002
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.004	0.0018	0.0524
Echinococcus multilocularis	casein kinase I delta	0.0028	0.0006	0.002
Echinococcus multilocularis	death associated protein kinase 1	0.0028	0.0006	0.002
Loa Loa (eye worm)	CK1/WORM6 protein kinase	0.0028	0.0006	0.0005
Trypanosoma brucei	trypanothione reductase	0.0053	0.003	1
Mycobacterium tuberculosis	Probable reductase	0.0121	0.0096	0.4033
Echinococcus multilocularis		0.0028	0.0006	0.002
Echinococcus multilocularis	vaccinia related kinase 1	0.0028	0.0006	0.002
Loa Loa (eye worm)	CAMK protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	CAMK/CAMKL/NIM1 protein kinase	0.0028	0.0006	0.0005
Schistosoma mansoni	myotonic dystrophy kinase-related cdc42-binding kinase	0.0028	0.0006	0.0006
Loa Loa (eye worm)	camk/mapkapk/mnk protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0006	0.0005
Echinococcus granulosus	serine:threonine protein kinase MARK2	0.0028	0.0006	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Mycobacterium leprae	conserved hypothetical protein	0.004	0.0018	0.1133
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0056	0.0033	0.0027
Loa Loa (eye worm)	CAMK/CASK protein kinase	0.0028	0.0006	0.0005
Echinococcus granulosus	casein kinase I alpha	0.0028	0.0006	0.002
Echinococcus granulosus	3-phosphoinositide-dependent protein kinase 1	0.0028	0.0006	0.002
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0028	0.0006	0.002
Loa Loa (eye worm)	STE/STE7/MEK1 protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	hypothetical protein	0.004	0.0018	0.0017
Loa Loa (eye worm)	CK1/VRK protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0006	0.0005
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus multilocularis	serine:threonine protein kinase PAK 4	0.0028	0.0006	0.002
Loa Loa (eye worm)	STE/STE7/MEK3 protein kinase	0.0028	0.0006	0.0005
Echinococcus multilocularis	agc family protein kinase	0.0028	0.0006	0.002
Echinococcus multilocularis	dual specificity mitogen activated protein	0.0028	0.0006	0.002
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0054	0.0032	0.0104
Toxoplasma gondii	thioredoxin reductase	0.0053	0.003	1
Echinococcus granulosus	mitogen activated protein kinase 3	0.0028	0.0006	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus multilocularis	serine:threonine protein kinase ULK2	0.0028	0.0006	0.002
Loa Loa (eye worm)	serine/threonine protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	CMGC/MAPK protein kinase	0.0028	0.0006	0.0005
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0028	0.0006	0.002
Loa Loa (eye worm)	CAMK/TSSK protein kinase	0.0028	0.0006	0.0005
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0028	0.0006	0.002
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Loa Loa (eye worm)	CAMK/CAMKL/BRSK protein kinase	0.0028	0.0006	0.0005
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0028	0.0006	0.002
Schistosoma mansoni	kinase	0.0028	0.0006	0.0006
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0028	0.0006	0.0005
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0018	1
Loa Loa (eye worm)	CK1/WORM6 protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	CAMK/CAMKL/MARK protein kinase	0.0028	0.0006	0.0005
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0028	0.0006	0.002
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0028	0.0006	0.002
Echinococcus multilocularis	calcium activated potassium channel	0.0028	0.0006	0.002
Echinococcus granulosus	MAP kinase activated protein kinase 2	0.0028	0.0006	0.002
Echinococcus multilocularis	protein kinase	0.0028	0.0006	0.002
Echinococcus multilocularis	dual specificity	0.0028	0.0006	0.002
Loa Loa (eye worm)	CAMK/PSK protein kinase	0.0028	0.0006	0.0005
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0121	0.0096	0.4033
Echinococcus granulosus	Serine:threonine protein kinase PFTAIRE 1	0.0028	0.0006	0.002
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0028	0.0006	0.002
Loa Loa (eye worm)	SCY1 protein kinase	0.0028	0.0006	0.0005
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus granulosus	protein kinase	0.0028	0.0006	0.002
Echinococcus multilocularis	scy1 protein 2	0.0028	0.0006	0.002
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Echinococcus multilocularis	c Jun NH2 terminal kinase	0.0028	0.0006	0.002
Mycobacterium tuberculosis	Probable dehydrogenase	0.0121	0.0096	0.4033
Loa Loa (eye worm)	NRBP protein kinase	0.0028	0.0006	0.0005
Echinococcus multilocularis	rho associated protein kinase 1	0.0028	0.0006	0.002
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0028	0.0006	0.002
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0028	0.0006	0.0005
Echinococcus multilocularis	proto oncogene serine:threonine protein kinase	0.0028	0.0006	0.002
Echinococcus multilocularis	cyclin dependent kinase 1	0.0028	0.0006	0.002
Echinococcus multilocularis	proto oncogene serine:threonine protein kinase	0.0028	0.0006	0.002
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0006	0.0005
Plasmodium vivax	hypothetical protein, conserved	0.004	0.0018	0.4872
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.004	0.0018	0.0059
Trichomonas vaginalis	flap endonuclease-1, putative	0.0029	0.0007	0.0706
Schistosoma mansoni	serine/threonine protein kinase	1.0256	0.9997	1
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus granulosus	serine:threonine protein kinase 11	0.0028	0.0006	0.002
Schistosoma mansoni	ste20-related kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus granulosus	dual specificity serine:threonine tyrosine	0.0028	0.0006	0.002
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0028	0.0006	0.002
Echinococcus granulosus	cyclin dependent kinase 11B	0.0028	0.0006	0.002
Loa Loa (eye worm)	CK1/TTBK protein kinase	0.0028	0.0006	0.0005
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0054	0.0032	0.0104
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0028	0.0006	0.0005
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Plasmodium vivax	thioredoxin reductase, putative	0.0053	0.003	1
Echinococcus granulosus	agc family protein kinase	0.0028	0.0006	0.002
Echinococcus granulosus	dual specificity mitogen activated protein	0.0028	0.0006	0.002
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	STE/STE7 protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	CMGC/CDK/CDK4 protein kinase	0.0028	0.0006	0.0005
Echinococcus multilocularis	wee1 protein kinase	0.0028	0.0006	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus granulosus	Serine:threonine protein kinase PRP4	0.0028	0.0006	0.002
Echinococcus multilocularis	mitogen activated protein kinase 15	0.0028	0.0006	0.002
Echinococcus multilocularis	dual specificity	0.0028	0.0006	0.002
Echinococcus multilocularis	myosin iiia	0.0028	0.0006	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus granulosus	citron Rho interacting kinase	0.0028	0.0006	0.002
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0028	0.0006	0.002
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0021	0.0019
Mycobacterium ulcerans	beta-lactamase	0.004	0.0018	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0028	0.0006	0.002
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0006	0.0005
Schistosoma mansoni	P21-activated kinase pak	0.0028	0.0006	0.0006
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0028	0.0006	0.0005
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus granulosus	fetal alzheimer antigen falz	0.0025	0.0003	0.0011
Echinococcus multilocularis	agc family protein kinase	0.0028	0.0006	0.002
Brugia malayi	beta-lactamase	0.004	0.0018	0.0012
Schistosoma mansoni	dual specificity kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0028	0.0006	0.002
Echinococcus multilocularis	ribosomal protein S6 kinase delta 1	0.0028	0.0006	0.002
Loa Loa (eye worm)	CAMK/CAMKL/AMPK protein kinase	0.0028	0.0006	0.0005
Schistosoma mansoni	P38 MAPk	0.0028	0.0006	0.0006
Echinococcus granulosus	serine:threonine protein kinase SIK3	0.0028	0.0006	0.002
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0028	0.0006	0.0005
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0028	0.0006	0.002
Echinococcus multilocularis	tau tubulin kinase 1	0.0028	0.0006	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus multilocularis	proto oncogene serine:threonine protein kinase	0.0028	0.0006	0.002
Echinococcus multilocularis	cyclin dependent kinase 17	0.0028	0.0006	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus granulosus	STE20 serine:threonine protein kinase	0.0028	0.0006	0.002
Echinococcus granulosus	dual specificity mitogen activated protein	0.0028	0.0006	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	titin	0.0028	0.0006	0.0006
Echinococcus granulosus	serine/threonine-protein kinase greatwall	0.0028	0.0006	0.002
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0006	0.0005
Loa Loa (eye worm)	CK1/TTBKL protein kinase	0.0028	0.0006	0.0005
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.0028	0.0006	0.0005
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0028	0.0006	0.002
Loa Loa (eye worm)	CMGC/DYRK/DYRK2 protein kinase	0.0028	0.0006	0.0005
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0028	0.0006	0.002
Echinococcus multilocularis	cyclin dependent kinase 5	0.0028	0.0006	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus granulosus	protein kinase c iota type	0.0028	0.0006	0.002
Echinococcus granulosus	serine:threonine protein kinase N2	0.0028	0.0006	0.002
Echinococcus multilocularis	serine threonine protein kinase	0.0028	0.0006	0.002
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0028	0.0006	0.0005
Echinococcus granulosus	casein kinase I delta	0.0028	0.0006	0.002
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0028	0.0006	0.002
Loa Loa (eye worm)	TTK protein kinase	0.0028	0.0006	0.0005
Echinococcus granulosus	serine:threonine kinase SAD 1	0.0028	0.0006	0.002
Echinococcus multilocularis	protein kinase shaggy	0.0028	0.0006	0.002
Loa Loa (eye worm)	TKL/MLK/MLK protein kinase	0.0028	0.0006	0.0005
Echinococcus multilocularis	kinase protein	0.0028	0.0006	0.002
Echinococcus granulosus	serine:threonine protein kinase N2	0.0028	0.0006	0.002
Loa Loa (eye worm)	CK1/TTBKL protein kinase	0.0028	0.0006	0.0005
Echinococcus multilocularis	Cell division cycle 2 protein kinase	0.0028	0.0006	0.002
Echinococcus multilocularis	cyclin dependent kinase 11B	0.0028	0.0006	0.002
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0028	0.0006	0.002
Plasmodium falciparum	glutathione reductase	0.0053	0.003	1
Schistosoma mansoni	peptidase	0.0028	0.0006	0.0006
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus granulosus	mitogen activated protein kinase 11	0.0028	0.0006	0.002
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0028	0.0006	0.002
Loa Loa (eye worm)	CMGC/SRPK protein kinase	0.0028	0.0006	0.0005
Echinococcus multilocularis	dual specificity protein kinase clk2	0.0028	0.0006	0.002
Loa Loa (eye worm)	hypothetical protein	0.004	0.0018	0.0017
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	sodium/chloride dependent transporter	0.0028	0.0006	0.0006
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus multilocularis	serine:threonine protein kinase SIK1	0.0028	0.0006	0.002
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0028	0.0006	0.002
Loa Loa (eye worm)	CAMK/TRBL protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0028	0.0006	0.0005
Loa Loa (eye worm)	PEK/HRI protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	CAMK protein kinase	0.0028	0.0006	0.0005
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0053	0.003	0.1075
Loa Loa (eye worm)	CK1/TTBKL protein kinase	0.0028	0.0006	0.0005
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0121	0.0096	0.8728
Echinococcus granulosus	titin	0.0028	0.0006	0.002
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0029	0.0007	0.0344
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	hypothetical protein	0.3135	0.3041	0.3041
Echinococcus granulosus	5'partial\|STE20 kinase adapter protein beta	0.0028	0.0006	0.002
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0028	0.0006	0.002
Echinococcus multilocularis	PAK box P21 Rho binding	0.0028	0.0006	0.002
Echinococcus multilocularis	p21 activated protein kinase 1 Dpak1	0.0028	0.0006	0.002
Echinococcus granulosus	ribosomal protein S6 kinase delta 1	0.0028	0.0006	0.002
Echinococcus granulosus	serine:threonine protein kinase Chk2	0.0028	0.0006	0.002
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0028	0.0006	0.002
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0028	0.0006	0.0005
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0028	0.0006	0.002
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Echinococcus granulosus	peripheral plasma membrane protein CASK	0.0028	0.0006	0.002
Echinococcus granulosus	dual specificity	0.0028	0.0006	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Loa Loa (eye worm)	TKL/LISK/TESK protein kinase	0.0028	0.0006	0.0005
Echinococcus granulosus	Serine:threonine protein kinase PLK4	0.0028	0.0006	0.002
Echinococcus multilocularis	TBC domain containing protein kinase	0.0028	0.0006	0.002
Echinococcus multilocularis	serine:threonine protein kinase TAO1	0.0028	0.0006	0.002
Loa Loa (eye worm)	STE/STE7/MEK4 protein kinase	0.0028	0.0006	0.0005
Schistosoma mansoni	P21-activated kinase pak	0.0028	0.0006	0.0006
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0028	0.0006	0.002
Loa Loa (eye worm)	CMGC/CDK/CDK7 protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	NEK/NEK8 protein kinase	0.0028	0.0006	0.0005
Echinococcus granulosus	serine:threonine protein kinase ULK2	0.0028	0.0006	0.002
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	0.0028	0.0006	0.0005
Brugia malayi	Protein kinase domain containing protein	1.0256	0.9997	0.9997
Loa Loa (eye worm)	STE/STE20/YSK protein kinase	0.0028	0.0006	0.0005
Echinococcus granulosus	agc family protein kinase	0.0028	0.0006	0.002
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0134	0.011	0.4621
Echinococcus multilocularis	serine:threonine protein kinase tousled	0.0028	0.0006	0.002
Echinococcus granulosus	cyclin dependent kinase 16	0.0028	0.0006	0.002
Echinococcus multilocularis	serine:threonine protein kinase 17A	0.0028	0.0006	0.002
Loa Loa (eye worm)	CAMK/CAMKL/MELK protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	STE/STE11/ASK protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	NEK protein kinase	0.0028	0.0006	0.0005
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus multilocularis	serine:threonine protein kinase MARK2	0.0028	0.0006	0.002
Echinococcus multilocularis	cyclin dependent kinase 16	0.0028	0.0006	0.002
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0028	0.0006	0.0005
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Loa Loa (eye worm)	camk/mapkapk/mapkapk protein kinase	0.0028	0.0006	0.0005
Echinococcus granulosus	thioredoxin glutathione reductase	0.0053	0.003	0.0099
Loa Loa (eye worm)	serine/threonine protein kinase	0.0028	0.0006	0.0005
Echinococcus granulosus	agc family protein kinase	0.0028	0.0006	0.002
Loa Loa (eye worm)	CAMKK/META protein kinase	0.0028	0.0006	0.0005
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Loa Loa (eye worm)	CK1 protein kinase	0.0028	0.0006	0.0005
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0028	0.0006	0.002
Loa Loa (eye worm)	IKK protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	CK1 protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0025	0.0024
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0028	0.0006	0.0005
Echinococcus granulosus	casein kinase ii subunit alpha	0.0028	0.0006	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Loa Loa (eye worm)	CK1/CK1/CK1-D protein kinase	0.0028	0.0006	0.0005
Echinococcus granulosus	eukaryotic translation initiation factor 2 alpha	0.0028	0.0006	0.002
Loa Loa (eye worm)	STE/STE7/MEK7 protein kinase	0.0028	0.0006	0.0005
Echinococcus granulosus	proto oncogene serine:threonine protein kinase	0.0028	0.0006	0.002
Echinococcus granulosus	expressed protein	0.0028	0.0006	0.002
Echinococcus granulosus	serine/threonine-protein kinase greatwall	0.0028	0.0006	0.002
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0028	0.0006	0.0005
Echinococcus multilocularis	STE20:SPS1 proline alanine rich protein	0.0028	0.0006	0.002
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Echinococcus granulosus	serine:threonine protein kinase WNK1	0.0028	0.0006	0.002
Plasmodium vivax	glutathione reductase, putative	0.0053	0.003	1
Echinococcus multilocularis	flap endonuclease 1	0.0029	0.0007	0.0023
Loa Loa (eye worm)	CAMK/CAMKL/CHK1 protein kinase	1.0256	0.9997	1
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	CK1 protein kinase	0.0028	0.0006	0.0005
Loa Loa (eye worm)	CDC7 protein kinase	0.0028	0.0006	0.0005
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	serine/threonine kinase	0.0028	0.0006	0.0006
Loa Loa (eye worm)	STE/STE7/MEK4 protein kinase	0.0028	0.0006	0.0005
Schistosoma mansoni	hypothetical protein	0.0028	0.0006	0.0006
Echinococcus granulosus	death associated protein kinase 1	0.0028	0.0006	0.002
Loa Loa (eye worm)	CK1 protein kinase	0.0028	0.0006	0.0005
Echinococcus granulosus	serine:threonine protein kinase	0.0028	0.0006	0.002
Echinococcus multilocularis	serine:threonine protein kinase greatwall	0.0028	0.0006	0.002
Loa Loa (eye worm)	CK1/TTBKL protein kinase	0.0028	0.0006	0.0005
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0028	0.0006	0.0005
Echinococcus granulosus	serine:threonine protein kinase SIK1	0.0028	0.0006	0.002
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.004	0.0018	0.0524
Echinococcus granulosus	dual specificity	0.0028	0.0006	0.002
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Loa Loa (eye worm)	CMGC/MAPK protein kinase	0.0028	0.0006	0.0005
Echinococcus granulosus	cyclin dependent kinase 1	0.0028	0.0006	0.002
Echinococcus granulosus	serine:threonine protein kinase:endoribonuclease	0.0028	0.0006	0.002
Echinococcus multilocularis	twitchin	0.0028	0.0006	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	MAPk	0.0028	0.0006	0.0006
Echinococcus multilocularis	beta LACTamase domain containing family member	0.004	0.0018	0.0059
Schistosoma mansoni	deleted in oral cancer 1/cdk2-associated protein-like	0.3135	0.3041	0.3042
Echinococcus granulosus	tau tubulin kinase 1	0.0028	0.0006	0.002
Echinococcus multilocularis	serine:threonine protein kinase	0.0028	0.0006	0.002
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0121	0.0096	0.4033
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0028	0.0006	0.002
Echinococcus granulosus	TGF-beta receptor type-1	0.0028	0.0006	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Echinococcus multilocularis	cyclin dependent kinase 6	0.0028	0.0006	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0028	0.0006	0.0005
Echinococcus multilocularis	TGF beta receptor type 1	0.0028	0.0006	0.002
Echinococcus granulosus	titin	0.0028	0.0006	0.002
Echinococcus multilocularis	5' AMP activated protein kinase catalytic	0.0028	0.0006	0.002
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0028	0.0006	0.002
Echinococcus granulosus	casein kinase I alpha	0.0028	0.0006	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus multilocularis	serine:threonine protein kinase	0.0028	0.0006	0.002
Echinococcus multilocularis	protein kinase c iota type	0.0028	0.0006	0.002
Echinococcus multilocularis	cyclin dependent kinase 10	0.0028	0.0006	0.002
Echinococcus granulosus	cyclin dependent kinase 19	0.0028	0.0006	0.002
Echinococcus granulosus	serine:threonine protein kinase NLK	0.0028	0.0006	0.002
Chlamydia trachomatis	serine/threonine protein kinase	0.0028	0.0006	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus granulosus	serine:threonine protein kinase	0.0028	0.0006	0.002
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0067	0.0044	0.0144
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0028	0.0006	0.002
Echinococcus multilocularis	cyclin dependent kinase 1	0.0028	0.0006	0.002
Echinococcus granulosus	nuclear receptor binding protein	0.0028	0.0006	0.002
Echinococcus granulosus	wee1 protein kinase	0.0028	0.0006	0.002
Echinococcus multilocularis	dual specificity	0.0028	0.0006	0.002
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0028	0.0006	0.0005
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0056	0.0033	0.0027
Schistosoma mansoni	tyrosine kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Echinococcus granulosus	leucine rich repeat serine:threonine protein	0.0028	0.0006	0.002
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.004	0.0018	0.0524
Echinococcus multilocularis	cyclin dependent kinase 1	0.0028	0.0006	0.002
Echinococcus granulosus	serine threonine protein kinase sik	0.0028	0.0006	0.002
Echinococcus multilocularis	agc family protein kinase	0.0028	0.0006	0.002
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0028	0.0006	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	protein kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	kinase	0.0028	0.0006	0.0006
Echinococcus multilocularis	Serine:threonine protein kinase PLK4	0.0028	0.0006	0.002
Echinococcus granulosus	myosin light chain kinase smooth muscle	0.0028	0.0006	0.002
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0028	0.0006	0.0005
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0028	0.0006	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0006	0.0006
Loa Loa (eye worm)	CMGC/CLK protein kinase	0.0028	0.0006	0.0005
Echinococcus granulosus	myosin iiia	0.0028	0.0006	0.002
Echinococcus granulosus	serine:threonine protein kinase TAO1	0.0028	0.0006	0.002
Echinococcus granulosus	serine:threonine protein kinase NIM1	0.0028	0.0006	0.002
Trypanosoma cruzi	trypanothione reductase, putative	0.0053	0.003	1
Schistosoma mansoni	kinase	0.0028	0.0006	0.0006
Echinococcus multilocularis	eukaryotic translation initiation factor 2 alpha	0.0028	0.0006	0.002
Mycobacterium tuberculosis	Conserved protein	0.004	0.0018	0.0524
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0018	0.4872
Echinococcus multilocularis	dual specificity mitogen activated protein	0.0028	0.0006	0.002
Loa Loa (eye worm)	CMGC/CDK protein kinase	0.0028	0.0006	0.0005

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 1 mM	In vitro reversible inhibition of eel acetylcholinesterase.	ChEMBL.	3783578
IC50 (binding)	> 1 mM	Reactivation of human acetylcholinesterase	ChEMBL.	3783578
IC50 (binding)	> 1 mM	In vitro reversible inhibition of eel acetylcholinesterase.	ChEMBL.	3783578
IC50 (binding)	> 1 mM	Reactivation of human acetylcholinesterase	ChEMBL.	3783578
kHOX (functional)	= 49.6 M-1 min-1	In vitro rate of EPMP-inhibited acetylcholinesterase reactivation, by the protonated (oxime) form.	ChEMBL.	3783578
kHOX (functional)	= 49.6 M-1 min-1	In vitro rate of EPMP-inhibited acetylcholinesterase reactivation, by the protonated (oxime) form.	ChEMBL.	3783578
kHOX (functional)	= 116 M-1 min-1	In vitro rate of EPMP-inhibited acetylcholinesterase reactivation, by the protonated (oxime) form.	ChEMBL.	3783578
kHOX (functional)	= 116 M-1 min-1	In vitro rate of EPMP-inhibited acetylcholinesterase reactivation, by the protonated (oxime) form.	ChEMBL.	3783578
KOX (functional)	= 158 M-1 min-1	In vitro rate of EPMP-inhibited acetylcholinesterase reactivation, by anionic (oximate) form.	ChEMBL.	3783578
KOX (functional)	= 158 M-1 min-1	In vitro rate of EPMP-inhibited acetylcholinesterase reactivation, by anionic (oximate) form.	ChEMBL.	3783578
KOX (functional)	= 368 M-1 min-1	In vitro rate of EPMP-inhibited acetylcholinesterase reactivation by anionic (oximate) form.	ChEMBL.	3783578
KOX (functional)	= 368 M-1 min-1	In vitro rate of EPMP-inhibited acetylcholinesterase reactivation by anionic (oximate) form.	ChEMBL.	3783578
logD	= 2.18	Compound was tested for the ratio of octanol / buffer partition coefficient for 0.1M, pH 7.6 phosphate buffer	ChEMBL.	3783578
pKa	= 7.94	Compound as tested for the hydroxyimine methyl acid dissociation constant (pKa)	ChEMBL.	3783578

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL70182

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 111973