TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 580.68 | Formula: C32H36N8O3
H donors: 6 H acceptors: 4 LogP: 1.49 Rotable bonds: 14
Rule of 5 violations (Lipinski): 3
SMILES: N[C@H](C(=O)N1C[C@H]([C@@H](C1)C(=O)NCCc1c[nH]c2c1cccc2)C(=O)NCCc1nc[nH]c1)Cc1c[nH]c2c1cccc2
InChi: 1S/C32H36N8O3/c33-27(13-21-15-38-29-8-4-2-6-24(21)29)32(43)40-17-25(26(18-40)31(42)36-12-10-22-16-34-19-39-22)30(41)35-11-9-20-14-37-28-7-3-1-5-23(20)28/h1-8,14-16,19,25-27,37-38H,9-13,17-18,33H2,(H,34,39)(H,35,41)(H,36,42)/t25-,26-,27+/m1/s1
InChiKey: UHVQXPLXVUMDCZ-PFBJBMPXSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0015	0.0464	0.0036
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.2236	0.4418
Mycobacterium tuberculosis	Probable bacterioferritin BfrA	0.0027	0.2224	0.3631
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.8041	1
Onchocerca volvulus		0.0052	0.5928	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0464	0.0916
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0015	0.0464	0.0045
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0015	0.0464	0.0036
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0015	0.043	0.0546
Leishmania major	cathepsin L-like protease	0.0017	0.0742	0.041
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0052	0.5928	1
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0046	0.506	0.4839
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.1879	0.3713
Leishmania major	cysteine peptidase A (CPA)	0.0017	0.0742	0.041
Plasmodium vivax	acyl-CoA synthetase, putative	0.0038	0.396	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0038	0.396	0.6421
Plasmodium falciparum	acyl-CoA synthetase	0.0038	0.396	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0742	0.1466
Loa Loa (eye worm)	hypothetical protein	0.0038	0.396	0.6421
Leishmania major	cathepsin L-like protease	0.0066	0.8041	1
Leishmania major	cathepsin L-like protease	0.0017	0.0742	0.041
Schistosoma mansoni	apoferritin-2	0.0027	0.2224	0.1874
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0015	0.0464	0.0045
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.506	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0052	0.5928	1
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0052	0.5928	1
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0036	0.3651	0.4232
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0046	0.506	0.6084
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0052	0.5928	0.5745
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0017	0.0742	0.0326
Loa Loa (eye worm)	hypothetical protein	0.0033	0.315	0.4949
Leishmania major	4-coumarate:coa ligase-like protein	0.0052	0.5928	0.7223
Trypanosoma cruzi	cysteine peptidase, putative	0.0017	0.0742	0.041
Echinococcus multilocularis	cysteine protease	0.0017	0.0742	0.0326
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0742	0.1466
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.5468	0.9163
Onchocerca volvulus		0.0017	0.0742	0.0568
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0461	0.0033
Brugia malayi	Papain family cysteine protease containing protein	0.0017	0.0742	0.0326
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0015	0.043	0.0546
Echinococcus multilocularis	cathepsin L cysteine protease	0.0017	0.0742	0.0326
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.3288	0.6498
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.8041	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.396	0.6421
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0019	0.1017	0.0772
Schistosoma mansoni	hypothetical protein	0.0015	0.0461	0.0033
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0046	0.506	0.4839
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0017	0.0742	0.0326
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.5468	0.5264
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.1873	0.3702
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0464	0.0916
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0078	1	1
Mycobacterium ulcerans	bacterioferritin BfrB	0.0027	0.2224	0.3263
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0015	0.043	0.0546
Schistosoma mansoni	hypothetical protein	0.0015	0.0461	0.0033
Leishmania major	cathepsin L-like protease	0.0066	0.8041	1
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0461	0.0033
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0022	0.1415	0.1295
Schistosoma mansoni	ferritin	0.0027	0.2224	0.1874
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0742	0.1466
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.0742	0.0326
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0742	0.0326
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0036	0.3642	0.6071
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0015	0.043	0.0546
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0742	0.1466
Brugia malayi	AMP-binding enzyme family protein	0.0052	0.5928	0.5745
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0017	0.0742	0.0885
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.3288	0.6498
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.506	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.3288	0.6498
Echinococcus granulosus	GPCR family 2	0.0015	0.0461	0.0033
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0017	0.0742	0.0326
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.3645	0.7204
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0052	0.5928	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.396	0.6421
Loa Loa (eye worm)	fibroinase	0.0017	0.0742	0.0568
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0046	0.506	0.4839
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0461	0.0033
Echinococcus multilocularis	ferritin	0.0027	0.2224	0.1874
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.8041	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0742	0.1466
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.2277	0.4499
Loa Loa (eye worm)	phosphatidylinositol 3	0.0015	0.0464	0.0062
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0052	0.5928	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0017	0.0742	0.0568
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0046	0.506	0.6084
Onchocerca volvulus		0.0017	0.0742	0.0568
Loa Loa (eye worm)	hypothetical protein	0.0052	0.5928	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.8041	1
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0046	0.506	0.6084
Echinococcus multilocularis	cysteine protease	0.0017	0.0742	0.0326
Onchocerca volvulus		0.0017	0.0742	0.0568
Entamoeba histolytica	hypothetical protein	0.0078	1	1
Leishmania major	cathepsin L-like protease	0.0017	0.0742	0.041
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.4049	0.8002
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0052	0.5928	1
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0015	0.0464	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0048	0.5468	0.9163
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0015	0.043	0.0546
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.3288	0.6498
Loa Loa (eye worm)	ctsf protein	0.0017	0.0742	0.0568
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.8041	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.5928	1
Onchocerca volvulus		0.0017	0.0742	0.0568
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0038	0.396	0.6617
Onchocerca volvulus	Cathepsin L homolog	0.0017	0.0742	0.0568
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.5468	0.5264
Schistosoma mansoni	hypothetical protein	0.0015	0.0461	0.0033
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0015	0.043	0.0546
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0046	0.506	0.4839
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0034	0.3288	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.3645	0.7204
Entamoeba histolytica	hypothetical protein	0.0078	1	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0461	0.0058
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0052	0.5928	0.5745
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0742	0.1466
Plasmodium vivax	vivapain-2	0.0017	0.0742	0.0885
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0015	0.0464	0.0045
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0015	0.0464	0.0036
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0015	0.0464	0.0045
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.1873	0.3702
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0742	0.1466
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0015	0.0464	0.0045
Entamoeba histolytica	hypothetical protein	0.0078	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0742	0.1466
Wolbachia endosymbiont of Brugia malayi	bacterioferritin/cytochrome b1	0.0027	0.2224	0.5
Mycobacterium ulcerans	acyl-CoA synthetase	0.0052	0.5928	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.1879	0.3713
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0036	0.3642	0.6071
Mycobacterium ulcerans	acyl-CoA synthetase	0.0052	0.5928	1
Mycobacterium ulcerans	hypothetical protein	0.0052	0.5928	1
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0015	0.043	0.0546
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0038	0.396	0.5
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0015	0.043	0.0546
Schistosoma mansoni	apoferritin-2	0.0027	0.2224	0.1874
Onchocerca volvulus		0.0017	0.0742	0.0568
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0742	0.1466
Entamoeba histolytica	hypothetical protein	0.0078	1	1
Onchocerca volvulus		0.0017	0.0742	0.0568
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0017	0.0742	0.1466
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0461	0.0033
Plasmodium vivax	vivapain-2	0.0017	0.0742	0.0885
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.3645	0.7204
Leishmania major	4-coumarate:coa ligase-like protein	0.0052	0.5928	0.7223
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0461	0.0033
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0742	0.0326
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0017	0.0742	0.0885
Mycobacterium tuberculosis	Bacterioferritin BfrB	0.0027	0.2224	0.3631
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.2784	0.5501
Trichomonas vaginalis	antibiotic synthetase, putative	0.0015	0.043	0.0849
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0046	0.506	0.4839
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0742	0.1466
Leishmania major	cathepsin L-like protease	0.0017	0.0742	0.041
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0046	0.506	0.6084
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0017	0.0742	0.0326
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0742	0.1466
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.8041	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.8041	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0742	0.1466
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0015	0.043	0.0546
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0464	0.0916
Echinococcus multilocularis	expressed protein	0.0027	0.2224	0.1874
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0742	0.1466
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0742	0.1466
Treponema pallidum	bacterioferrin (TpF1)	0.0027	0.2224	0.5
Trypanosoma cruzi	cysteine peptidase, putative	0.0066	0.8041	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0066	0.8041	1
Entamoeba histolytica	cysteine protease, putative	0.0017	0.0742	0.0326
Echinococcus granulosus	cathepsin l1	0.0017	0.0742	0.0326
Schistosoma mansoni	cathepsin F (C01 family)	0.0017	0.0742	0.0326
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0742	0.1466
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0017	0.0742	0.0568
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.3288	0.6498
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.1879	0.3713
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0464	0.0916
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0742	0.1466
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0742	0.1466
Schistosoma mansoni	ferritin	0.0027	0.2224	0.1874
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.8041	1
Onchocerca volvulus	Cathepsin L homolog	0.0017	0.0742	0.0568
Schistosoma mansoni	transcription factor LCR-F1	0.0078	1	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.315	0.2843
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0036	0.3651	0.4232
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.3645	0.7204
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0742	0.1466
Schistosoma mansoni	hypothetical protein	0.0078	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.2277	0.4499
Mycobacterium ulcerans	bacterioferritin BfrA	0.0027	0.2224	0.3263
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0017	0.0742	0.0885
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.3645	0.7204
Schistosoma mansoni	hypothetical protein	0.0033	0.315	0.2843
Giardia lamblia	GTOR	0.0046	0.506	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.506	1
Schistosoma mansoni	ferritin light chain	0.0027	0.2224	0.1874
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.8041	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0066	0.8041	1
Schistosoma mansoni	hypothetical protein	0.0015	0.0461	0.0033
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0036	0.3642	0.6071
Trypanosoma cruzi	major cysteine proteinase, putative	0.0051	0.5923	0.7217
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.8041	1
Trichomonas vaginalis	ferritin, putative	0.0027	0.2224	0.4394
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.3288	0.6498
Schistosoma mansoni	ferritin	0.0027	0.2224	0.1874
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0052	0.5928	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.396	0.6421
Loa Loa (eye worm)	hypothetical protein	0.0052	0.5928	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0464	0.0916
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0461	0.0058
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.0742	0.0326
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.1879	0.3713
Mycobacterium leprae	PROBABLE BACTERIOFERRITIN BFRA	0.0027	0.2224	0.3263
Brugia malayi	AMP-binding enzyme family protein	0.0052	0.5928	0.5745
Onchocerca volvulus		0.0017	0.0742	0.0568
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0017	0.0742	0.1466
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0742	0.0326
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0015	0.043	0.0546
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0078	1	1
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0046	0.506	0.6084
Toxoplasma gondii	cathepsin CPL	0.0017	0.0742	0.1093
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0742	0.1466
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0742	0.0326
Loa Loa (eye worm)	phosphatidylinositol 3	0.0046	0.506	0.8423
Entamoeba histolytica	acyl-coA synthetase, putative	0.0052	0.5928	0.5745
Loa Loa (eye worm)	cysteine protease	0.0017	0.0742	0.0568
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0046	0.506	0.4839
Echinococcus granulosus	expressed protein	0.0027	0.2224	0.1874
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0052	0.5928	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0742	0.1466
Trypanosoma cruzi	cysteine peptidase, putative	0.0066	0.8041	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0742	0.0568
Schistosoma mansoni	ferritin light chain	0.0027	0.2224	0.1874
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0742	0.0326
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0742	0.0326
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0015	0.0464	0.0045
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0742	0.1466
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.1873	0.3702
Loa Loa (eye worm)	hypothetical protein	0.0038	0.396	0.6421
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.3288	0.6498
Leishmania major	cathepsin L-like protease	0.0066	0.8041	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0461	0.0033
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0015	0.043	0.0546
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.8041	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0052	0.5928	0.7223
Brugia malayi	AMP-binding enzyme family protein	0.0052	0.5928	0.5745
Echinococcus granulosus	ferritin	0.0027	0.2224	0.1874
Schistosoma mansoni	ferritin	0.0027	0.2224	0.1874
Onchocerca volvulus	Cathepsin F homolog	0.0017	0.0742	0.0568
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0046	0.506	0.6084
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.006	0.7183	0.8872
Trypanosoma cruzi	target of rapamycin kinase 3	0.0036	0.3651	0.4232
Trichomonas vaginalis	antibiotic synthetase, putative	0.0015	0.043	0.0849
Schistosoma mansoni	cathepsin F (C01 family)	0.0017	0.0742	0.0326
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0036	0.3642	0.6071
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0742	0.1466
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0742	0.1466
Echinococcus multilocularis	cathepsin L cysteine protease	0.0017	0.0742	0.0326
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0461	0.0033
Leishmania major	cathepsin L-like protease	0.0017	0.0742	0.041
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0052	0.5928	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.2236	0.4418
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.2634	0.5205
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.2277	0.4499

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1830362

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1119836