Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 5 (sodium/glucose cotransporter), member 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0044 | 0.091 | 0.043 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0044 | 0.091 | 0.3199 |
Giardia lamblia | DINP protein human, muc B family | 0.0044 | 0.091 | 0.5 |
Echinococcus multilocularis | solute carrier family 5 | 0.0181 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0073 | 0.2844 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0044 | 0.091 | 0.5 |
Schistosoma mansoni | inositol transporter | 0.0181 | 1 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0044 | 0.091 | 0.3199 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.0181 | 1 | 1 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.0181 | 1 | 1 |
Schistosoma mansoni | inositol transporter | 0.0181 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0044 | 0.091 | 0.3199 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0044 | 0.091 | 0.3199 |
Schistosoma mansoni | sodium/solute symporter | 0.0046 | 0.1046 | 0.015 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0044 | 0.091 | 0.5 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.0181 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0044 | 0.091 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0044 | 0.091 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0044 | 0.091 | 0.043 |
Leishmania major | DNA polymerase kappa, putative | 0.0044 | 0.091 | 0.043 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0073 | 0.2844 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0044 | 0.091 | 0.043 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.0181 | 1 | 1 |
Onchocerca volvulus | 0.0046 | 0.1046 | 0.5 | |
Echinococcus granulosus | dna polymerase eta | 0.0073 | 0.2844 | 0.2128 |
Toxoplasma gondii | transporter, solute:sodium symporter (SSS) family protein | 0.0046 | 0.1046 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0073 | 0.2844 | 0.2128 |
Leishmania major | DNA polymerase eta, putative | 0.0073 | 0.2844 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.2844 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0044 | 0.091 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0044 | 0.091 | 0.3199 |
Brugia malayi | Sodium:solute symporter family protein | 0.0046 | 0.1046 | 0.0706 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0044 | 0.091 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0044 | 0.091 | 0.043 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0044 | 0.091 | 0.3199 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1046 | 0.0706 |
Echinococcus granulosus | solute carrier family 5 | 0.0181 | 1 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0073 | 0.2844 | 1 |
Echinococcus multilocularis | high affinity choline transporter 1 | 0.0046 | 0.1046 | 0.015 |
Brugia malayi | GH02984p | 0.0046 | 0.1046 | 0.0706 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0044 | 0.091 | 0.5 |
Echinococcus granulosus | sodium coupled monocarboxylate transporter 1 | 0.0046 | 0.1046 | 0.015 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0044 | 0.091 | 0.3199 |
Echinococcus multilocularis | sodium coupled monocarboxylate transporter 1 | 0.0046 | 0.1046 | 0.015 |
Schistosoma mansoni | high-affinity choline transporter | 0.0046 | 0.1046 | 0.015 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0044 | 0.091 | 0.3199 |
Trypanosoma brucei | unspecified product | 0.0044 | 0.091 | 0.3199 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1046 | 0.0706 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0044 | 0.091 | 0.043 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0044 | 0.091 | 0.3199 |
Echinococcus granulosus | high affinity choline transporter 1 | 0.0046 | 0.1046 | 0.015 |
Schistosoma mansoni | DNA polymerase eta | 0.0073 | 0.2844 | 0.2128 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0044 | 0.091 | 0.3199 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0044 | 0.091 | 0.3199 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0044 | 0.091 | 0.3199 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0044 | 0.091 | 0.3199 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 37.9 nM | Inhibition of human SGLT2 expressed in CHOK1 cells assessed as inhibition of glucose uptake | ChEMBL. | 20302302 |
IC50 (binding) | = 100000 nM | Inhibition of human SGLT1 expressed in CHOK1 cells assessed as inhibition of glucose uptake | ChEMBL. | 20302302 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.